The Architecture Of Persistence

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The Architecture of Persistence

Author : David Fannon
Publisher : Routledge
ISBN 13 : 1000410471
Total Pages : 383 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis The Architecture of Persistence by : David Fannon

Download or read book The Architecture of Persistence written by David Fannon and published by Routledge. This book was released on 2021-08-24 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Architecture of Persistence argues that continued human use is the ultimate measure of sustainability in architecture, and that expanding the discourse about adaptability to include continuity as well as change offers the architectural manifestation of resilience. Why do some buildings last for generations as beloved and useful places, while others do not? How can designers today create buildings that remain useful into the future? While architects and theorists have offered a wide range of ideas about building for change, this book focuses on persistent architecture: the material, spatial, and cultural processes that give rise to long-lived buildings. Organized in three parts, this book examines material longevity in the face of constant physical and cultural change, connects the dimensions of human use and contemporary program, and discusses how time informs the design process. Featuring dozens of interviews with people who design and use buildings, and a close analysis of over a hundred historic and contemporary projects, the principles of persistent architecture introduced here address urgent challenges for contemporary practice while pointing towards a more sustainable built environment in the future. The Architecture of Persistence: Designing for Future Use offers practitioners, students, and scholars a set of principles and illustrative precedents exploring architecture’s unique ability to connect an instructive past, a useful present, and an unknown future.

The Architecture of Persistence

Author : David J. Fannon
Publisher :
ISBN 13 : 9780367486372
Total Pages : 294 pages
Book Rating : 4.4/5 (863 download)

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Book Synopsis The Architecture of Persistence by : David J. Fannon

Download or read book The Architecture of Persistence written by David J. Fannon and published by . This book was released on 2021 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Architecture of Persistence argues that continued human use is the ultimate measure of sustainability in architecture, and that expanding the discourse about adaptability to include continuity as well as change offers the architectural manifestation of resilience. Why do some buildings last for generations as beloved and useful places, while others do not? How can designers today create buildings that remain useful into the future? While architects and theorists have offered a wide range of ideas about building for change, this book focuses on persistent architecture: the material, spatial, and cultural processes that give rise to long-lived buildings. Organized in three parts, this book examines material longevity in the face of constant physical and cultural change, connects the dimensions of human use and contemporary program, and discusses how time informs the design process. Featuring dozens of interviews with people who design and use buildings, and a close analysis of over a hundred historic and contemporary projects, the principles of persistent architecture introduced here address urgent challenges for contemporary practice while pointing towards a more sustainable built environment in the future. The Architecture of Persistence: Designing for Future Use offers practitioners, students, and scholars a set of principles and illustrative precedents exploring architecture's unique ability to connect an instructive past, a useful present, and an unknown future.

Persistence in the Enterprise

Author : Roland Barcia
Publisher : Addison-Wesley Professional
ISBN 13 : 0132704382
Total Pages : 467 pages
Book Rating : 4.1/5 (327 download)

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Book Synopsis Persistence in the Enterprise by : Roland Barcia

Download or read book Persistence in the Enterprise written by Roland Barcia and published by Addison-Wesley Professional. This book was released on 2008-05-01 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Definitive Guide to Today’s Leading Persistence Technologies Persistence in the Enterprise is a unique, up-to-date, and objective guide to building the persistence layers of enterprise applications. Drawing on their extensive experience, five leading IBM® Web development experts carefully review the issues and tradeoffs associated with persistence in large-scale, business-critical applications. The authors offer a pragmatic, consistent comparison of each leading framework--both proprietary and open source. Writing for IT managers, architects, administrators, developers, and testers, the authors address a broad spectrum of issues, ranging from coding complexity and flexibility to scalability and licensing. In addition, they demonstrate each framework side by side, via a common example application. With their guidance, you’ll learn how to define your persistence requirements, choose the most appropriate solutions, and build systems that maximize both performance and value. Coverage includes Taking an end-to-end application architecture view of persistence Understanding business drivers, IT requirements, and implementation issues Driving your persistence architecture via functional, nonfunctional, and domain requirements Modeling persistence domains Mapping domain models to relational databases Building a yardstick for comparing persistence frameworks and APIs Selecting the right persistence technologies for your applications Comparing JDBCTM, Apache iBATIS, Hibernate Core, Apache OpenJPA, and pureQuery The companion web site includes sample code that implements the common example used throughout the technology evaluation chapters, 5-9. The IBM Press developerWorks® Series is a unique undertaking in which print books and the Web are mutually supportive. The publications in this series are complemented by resources on the developerWorks Web site on ibm.com. Icons throughout the book alert the reader to these valuable resources.

Persistent Modelling

Author : Phil Ayres
Publisher : Routledge
ISBN 13 : 1136621768
Total Pages : 215 pages
Book Rating : 4.1/5 (366 download)

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Book Synopsis Persistent Modelling by : Phil Ayres

Download or read book Persistent Modelling written by Phil Ayres and published by Routledge. This book was released on 2012-06-25 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from some of the world’s most advanced thinkers on this subject, this book is essential reading for anyone looking at new ways of thinking about the digital within architecture. It speculates upon implications of Persistent Modelling for architectural practice, reconsidering the relationship between architectural representation and architectural artefact particularly in the fields of responsive and adaptive architectures.

Security and Persistence

Author : John Rosenberg
Publisher : Springer Science & Business Media
ISBN 13 : 1447131789
Total Pages : 402 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Security and Persistence by : John Rosenberg

Download or read book Security and Persistence written by John Rosenberg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: During a short visit to Bremen in December 1989 John Rosenberg had several discussions with me about computer architecture. Although we had previously worked together for more than a decade in Australia we had not seen each other for over a year, following my move to Bremen in 1988. Meanwhile John was spending a year on study leave at the University of St. Andrews in Scotland with Professor Ron Morrison and his persistent programming research group. From our conversations it was quite clear that John was having a most fruitful time in St. Andrews and was gaining valuable new insights into the world of persistent programming. He was very keen to explore the significance of these insights for the MONADS Project, which we had been jOintly directing since the early 1980s. MONADS was not about persistent programming. In fact it had quite different origins, in the areas of software engineering and information protection. In an earlier stage of the project our ideas on these themes had led us into the world of computer architecture and even hardware deSign, in our attempts to provide an efficient base machine for our software ideas. The most important practical result of this phase of the project had been the development of the MONADS-PC, a mini computer which would be better compared with say a V tv

Java Persistence with Spring Data and Hibernate

Author : Catalin Tudose
Publisher : Simon and Schuster
ISBN 13 : 1638351856
Total Pages : 614 pages
Book Rating : 4.6/5 (383 download)

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Book Synopsis Java Persistence with Spring Data and Hibernate by : Catalin Tudose

Download or read book Java Persistence with Spring Data and Hibernate written by Catalin Tudose and published by Simon and Schuster. This book was released on 2023-04-18 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master Java persistence using the industry-leading tools Spring Data and Hibernate. In Java Persistence with Spring Data and Hibernate you will learn: Mapping persistent classes, value types, and inheritance Mapping collections and entity associations Processing transactions with Spring Data and Hibernate Creating fetch plans, strategies, and profiles Filtering data Building Spring Data REST projects Using Java persistence with non-relational databases Querying JPA with QueryDSL Testing Java persistence applications Java Persistence with Spring Data and Hibernate teaches you the ins-and-outs of Java persistence with hands-on examples using Spring Data, JPA, and Hibernate. The book carefully analyzes the capabilities of the major Java persistence tools, and guides you through the most common use cases. By comparing and contrasting the alternatives, you’ll find it easy to choose the right tool choice for your applications. You’ll learn how to make and utilize mapping strategies, about the different approach to transactions for both Hibernate and Spring Data, and even how to efficiently test Java persistence applications. The practical techniques are demonstrated with both relational and non-relational databases. Forewords by Dmitry Aleksandrov and Mohamed Taman. About the technology Effectively managing application data is essential for any serious application. Spring Data and Hibernate bridge the gap between object-oriented code and relational data stores, radically simplifying Java persistence. By implementing the Java Persistence API (JPA) standard, these powerful tools help you avoid common bugs related to state and application data storage. About the book Java Persistence with Spring Data and Hibernate explores Java persistence using industry-standard tools. Hands-on examples introduce object-relational mapping and guide you through different mapping strategies to suit your needs. Covering transactions, persistent application testing, and non-relational databases, this book is your go-to resource for managing data in Java applications. What's inside Mapping persistent classes, value types, and inheritance Creating fetch plans, strategies, and profiles Building Spring Data REST projects Querying JPA with QueryDSL About the reader For intermediate Java programmers. About the author Catalin Tudose has more than 20 years of experience in the Java community. Christian Bauer, Gavin King, and Gary Gregory are the authors of Java Persistence with Hibernate, Second Edition, on which this book is based. Table of Contents PART 1 - GETTING STARTED WITH ORM 1 Understanding object/relational persistence 2 Starting a project 3 Domain models and metadata 4 Working with Spring Data JPA PART 2 - MAPPING STRATEGIES 5 Mapping persistent classes 6 Mapping value types 7 Mapping inheritance 8 Mapping collections and entity associations 9 Advanced entity association mappings PART 3 - TRANSACTIONAL DATA PROCESSING 10 Managing data 11 Transactions and concurrency 12 Fetch plans, strategies, and profiles 13 Filtering data PART 4 - BUILDING JAVA PERSISTENCE APPLICATIONS WITH SPRING 14 Integrating JPA and Hibernate with Spring 15 Working with Spring Data JDBC 16 Working with Spring Data REST PART 5 - BUILDING JAVA PERSISTENCE APPLICATIONS WITH SPRING 17 Working with Spring Data MongoDB 18 Working with Hibernate OGM PART 6 - WRITING QUERIES AND TESTING JAVA PERSISTENCE APPLICATIONS 19 Querying JPA with Querydsl 20 Testing Java persistence applications

Java Persistence with Hibernate

Author : Gary Gregory
Publisher : Simon and Schuster
ISBN 13 : 1638355223
Total Pages : 1053 pages
Book Rating : 4.6/5 (383 download)

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Book Synopsis Java Persistence with Hibernate by : Gary Gregory

Download or read book Java Persistence with Hibernate written by Gary Gregory and published by Simon and Schuster. This book was released on 2015-10-27 with total page 1053 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summary Java Persistence with Hibernate, Second Edition explores Hibernate by developing an application that ties together hundreds of individual examples. In this revised edition, authors Christian Bauer, Gavin King, and Gary Gregory cover Hibernate 5 in detail with the Java Persistence 2.1 standard (JSR 338). All examples have been updated for the latest Hibernate and Java EE specification versions. About the Technology Purchase of the print book includes a free eBook in PDF, Kindle, and ePub formats from Manning Publications. Persistence—the ability of data to outlive an instance of a program—is central to modern applications. Hibernate, the most popular Java persistence tool, offers automatic and transparent object/relational mapping, making it a snap to work with SQL databases in Java applications. About the Book Java Persistence with Hibernate, Second Edition explores Hibernate by developing an application that ties together hundreds of individual examples. You'll immediately dig into the rich programming model of Hibernate, working through mappings, queries, fetching strategies, transactions, conversations, caching, and more. Along the way you'll find a well-illustrated discussion of best practices in database design and optimization techniques. In this revised edition, authors Christian Bauer, Gavin King, and Gary Gregory cover Hibernate 5 in detail with the Java Persistence 2.1 standard (JSR 338). All examples have been updated for the latest Hibernate and Java EE specification versions. What's Inside Object/relational mapping concepts Efficient database application design Comprehensive Hibernate and Java Persistence reference Integration of Java Persistence with EJB, CDI, JSF, and JAX-RS * Unmatched breadth and depth About the Reader The book assumes a working knowledge of Java. About the Authors Christian Bauer is a member of the Hibernate developer team and a trainer and consultant. Gavin King is the founder of the Hibernate project and a member of the Java Persistence expert group (JSR 220). Gary Gregory is a principal software engineer working on application servers and legacy integration. Table of Contents PART 1 GETTING STARTED WITH ORM Understanding object/relational persistence Starting a project Domain models and metadata PART 2 MAPPING STRATEGIES Mapping persistent classes Mapping value types Mapping inheritance Mapping collections and entity associations Advanced entity association mappings Complex and legacy schemas PART 3 TRANSACTIONAL DATA PROCESSING Managing data Transactions and concurrency Fetch plans, strategies, and profiles Filtering data PART 4 WRITING QUERIES Creating and executing queries The query languages Advanced query options Customizing SQL

eWork and eBusiness in Architecture, Engineering and Construction

Author : Attila Dikbas
Publisher : Taylor & Francis
ISBN 13 : 1134241267
Total Pages : 698 pages
Book Rating : 4.1/5 (342 download)

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Book Synopsis eWork and eBusiness in Architecture, Engineering and Construction by : Attila Dikbas

Download or read book eWork and eBusiness in Architecture, Engineering and Construction written by Attila Dikbas and published by Taylor & Francis. This book was released on 2004-08-15 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biannually since 1994, the European Conference on Product and Process Modelling in the Building and Construction Industry has provided a review of research, given valuable future work outlooks, and provided a communication platform for future co-operative research and development at both European and global levels.This volume, of special interest t

Programming Persistent Memory

Author : Steve Scargall
Publisher : Apress
ISBN 13 : 1484249321
Total Pages : 384 pages
Book Rating : 4.4/5 (842 download)

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Book Synopsis Programming Persistent Memory by : Steve Scargall

Download or read book Programming Persistent Memory written by Steve Scargall and published by Apress. This book was released on 2020-01-09 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beginning and experienced programmers will use this comprehensive guide to persistent memory programming. You will understand how persistent memory brings together several new software/hardware requirements, and offers great promise for better performance and faster application startup times—a huge leap forward in byte-addressable capacity compared with current DRAM offerings. This revolutionary new technology gives applications significant performance and capacity improvements over existing technologies. It requires a new way of thinking and developing, which makes this highly disruptive to the IT/computing industry. The full spectrum of industry sectors that will benefit from this technology include, but are not limited to, in-memory and traditional databases, AI, analytics, HPC, virtualization, and big data. Programming Persistent Memory describes the technology and why it is exciting the industry. It covers the operating system and hardware requirements as well as how to create development environments using emulated or real persistent memory hardware. The book explains fundamental concepts; provides an introduction to persistent memory programming APIs for C, C++, JavaScript, and other languages; discusses RMDA with persistent memory; reviews security features; and presents many examples. Source code and examples that you can run on your own systems are included. What You’ll Learn Understand what persistent memory is, what it does, and the value it brings to the industry Become familiar with the operating system and hardware requirements to use persistent memory Know the fundamentals of persistent memory programming: why it is different from current programming methods, and what developers need to keep in mind when programming for persistence Look at persistent memory application development by example using the Persistent Memory Development Kit (PMDK)Design and optimize data structures for persistent memoryStudy how real-world applications are modified to leverage persistent memoryUtilize the tools available for persistent memory programming, application performance profiling, and debugging Who This Book Is For C, C++, Java, and Python developers, but will also be useful to software, cloud, and hardware architects across a broad spectrum of sectors, including cloud service providers, independent software vendors, high performance compute, artificial intelligence, data analytics, big data, etc.

Cultural Change and Persistence

Author : W. Ascher
Publisher : Springer
ISBN 13 : 0230117333
Total Pages : 480 pages
Book Rating : 4.2/5 (31 download)

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Book Synopsis Cultural Change and Persistence by : W. Ascher

Download or read book Cultural Change and Persistence written by W. Ascher and published by Springer. This book was released on 2010-12-12 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the ways that traditional cultural practices either change or persist in the face of social and economic development, whether the latter proceeds primarily from internal or external forces.

Persistence Best Practices for Java Applications

Author : Otavio Santana
Publisher : Packt Publishing Ltd
ISBN 13 : 1837637660
Total Pages : 202 pages
Book Rating : 4.8/5 (376 download)

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Book Synopsis Persistence Best Practices for Java Applications by : Otavio Santana

Download or read book Persistence Best Practices for Java Applications written by Otavio Santana and published by Packt Publishing Ltd. This book was released on 2023-08-25 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide for designing and delivering reliable and high-performing persistence layers using Java in the cloud-native age Purchase of the print or Kindle book includes a free PDF eBook Key Features Uncover database patterns for designing readable and maintainable architectures and Java applications Master various techniques to overcome application and architecture persistence challenges Discover painless application modernization with change-data-capture powered by cloud-native technologies Book Description Having a solid software architecture breathes life into tech solutions. In the early stages of an application's development, critical decisions need to be made, such as whether to go for microservices, a monolithic architecture, the event-driven approach, or containerization. In Java contexts, frameworks and runtimes also need to be defi ned. But one aspect is often overlooked – the persistence layer – which plays a vital role similar to that of data stores in modern cloud-native solutions. To optimize applications and data stores, a holistic understanding of best practices, technologies, and existing approaches is crucial. This book presents well-established patterns and standards that can be used in Java solutions, with valuable insights into the pros and cons of trending technologies and frameworks used in cloud-native microservices, alongside good Java coding practices. As you progress, you'll confront the challenges of cloud adoption head-on, particularly those tied to the growing need for cost reduction through stack modernization. Within these pages, you'll discover application modernization strategies and learn how enterprise data integration patterns and event-driven architectures enable smooth modernization processes with low-to-zero impact on the existing legacy stack. What you will learn Gain insights into data integration in Java services and the inner workings of frameworks Apply data design patterns to create a more readable and maintainable design system Understand the impact of design patterns on program performance Explore the role of cloud-native technologies in modern application persistence Optimize database schema designs and leverage indexing strategies for improved performance Implement proven strategies to handle data storage, retrieval, and management efficiently Who this book is for If you're a developer, engineer, or software architect working in the field of software development, particularly with a focus on Java solutions, this book is for you.

Scientific Information Bulletin

Author :
Publisher :
ISBN 13 :
Total Pages : 686 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Scientific Information Bulletin by :

Download or read book Scientific Information Bulletin written by and published by . This book was released on 1989 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Buildings Used

Author : Nora Lefa
Publisher : Routledge
ISBN 13 : 1000691039
Total Pages : 298 pages
Book Rating : 4.0/5 (6 download)

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Book Synopsis Buildings Used by : Nora Lefa

Download or read book Buildings Used written by Nora Lefa and published by Routledge. This book was released on 2019-09-12 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Buildings Used takes the reader on an exploration into the impact of use on buildings and users. While most histories and theories of architecture focus on a building’s conception, design, and realization, this book argues that its identity is formed after its completion through use; and that the cultural and psychological effects of its use on those inhabiting it are profound. Across eight investigative chapters, authors Nora Lefa and Pavlos Lefas propose that use should not be understood merely as function. Instead, this book argues that we also use buildings by creating, destroying or appropriating them, and discusses a series of philosophical, cultural and design issues related to use. Buildings Used would appeal to students and scholars in architectural theory, history and cultural studies.

Scala Reactive Programming

Author : Rambabu Posa
Publisher : Packt Publishing Ltd
ISBN 13 : 1787282872
Total Pages : 540 pages
Book Rating : 4.7/5 (872 download)

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Book Synopsis Scala Reactive Programming by : Rambabu Posa

Download or read book Scala Reactive Programming written by Rambabu Posa and published by Packt Publishing Ltd. This book was released on 2018-02-28 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Build fault-tolerant, robust, and distributed applications in Scala Key Features - Understand and use the concepts of reactive programming to build distributed systems running on multiple nodes. - Learn how reactive architecture reduces complexity throughout the development process. - Get to grips with functional reactive programming and Reactive Microservices. Book Description Reactive programming is a scalable, fast way to build applications, and one that helps us write code that is concise, clear, and readable. It can be used for many purposes such as GUIs, robotics, music, and others, and is central to many concurrent systems. This book will be your guide to getting started with Reactive programming in Scala. You will begin with the fundamental concepts of Reactive programming and gradually move on to working with asynchronous data streams. You will then start building an application using Akka Actors and extend it using the Play framework. You will also learn about reactive stream specifications, event sourcing techniques, and different methods to integrate Akka Streams into the Play Framework. This book will also take you one step forward by showing you the advantages of the Lagom framework while working with reactive microservices. You will also learn to scale applications using multi-node clusters and test, secure, and deploy your microservices to the cloud. By the end of the book, you will have gained the knowledge to build robust and distributed systems with Scala and Akka. What you will learn Understand the fundamental principles of Reactive and Functional programming Develop applications utilizing features of the Akka framework Explore techniques to integrate Scala, Akka, and Play together Learn about Reactive Streams with real-time use cases Develop Reactive Web Applications with Play, Scala, Akka, and Akka Streams Develop and deploy Reactive microservices using the Lagom framework and ConductR Who this book is for This book is for Scala developers who would like to build fault-tolerant, scalable distributed systems. No knowledge of Reactive programming is required.

Sun Certified Enterprise Architect for J2EE Technology Study Guide

Author : Mark Cade
Publisher : Prentice Hall Professional
ISBN 13 : 9780130449160
Total Pages : 228 pages
Book Rating : 4.4/5 (491 download)

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Book Synopsis Sun Certified Enterprise Architect for J2EE Technology Study Guide by : Mark Cade

Download or read book Sun Certified Enterprise Architect for J2EE Technology Study Guide written by Mark Cade and published by Prentice Hall Professional. This book was released on 2002 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first authoritative study guide for Sun's challenging new J2EE architecture certification exams, written by the exam's lead developers and assessors. This guide offers start-to-finish guidance and comprehensive background for architecting J2EE enterprise solutions.

Object Orientation with Parallelism and Persistence

Author : Burkhard Freitag
Publisher : Springer Science & Business Media
ISBN 13 : 1461314372
Total Pages : 245 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Object Orientation with Parallelism and Persistence by : Burkhard Freitag

Download or read book Object Orientation with Parallelism and Persistence written by Burkhard Freitag and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Both object orientation and parallelism are modern programming paradigms which have gained much popularity in the last 10-15 years. Object orientation raises hopes for increased productivity of software generation and maintenance methods. Parallelism can serve to structure a problem but also promises faster program execution. The two areas of computing science in which these paradigms play the most prominent role are programming languages and databases. In programming languages, one can take an academic approach with a primary focus on the generality of the semantics of the language constructs which support the respective paradigm. In databases, one is willing to restrict the power of the constructs in the interest of increased efficiency. Inter- and intra-object parallelism have received an increasing amount of attention in the last few years by researchers in the area of object- oriented programming. At first glance, an object is very similar to a process which offers services to other processes and demands services from them. It has, however, transpired that object-oriented concepts cause problems when combined with parallelism. In programming languages, the introduction of parallelism and the synchronization constraints it brings with it can get in the way of code reusability. In databases, the combination of object orientation and parallelism requires, for example, a generalization of the transaction model, new approaches to the specification of information systems, an implementation model of object communication, and the design of an overall system architecture. There has been insufficient communication between researchers in programming languages and in databases on these issues. Object Orientation with Parallelism and Persistence grew out of a Dagstuhl Seminar of the same title in April 1995 whose goal it was to put the new research area `object orientation with parallelism' on an interdisciplinary basis. Object Orientation with Parallelism and Persistence will be of interest to researchers and professionals working in software engineering, programming languages, and database systems.

Biomedical Informatics for Cancer Research

Author : Michael F. Ochs
Publisher : Springer Science & Business Media
ISBN 13 : 1441957146
Total Pages : 293 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Biomedical Informatics for Cancer Research by : Michael F. Ochs

Download or read book Biomedical Informatics for Cancer Research written by Michael F. Ochs and published by Springer Science & Business Media. This book was released on 2010-04-06 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: view, showing that multiple molecular pathways must be affected for cancer to develop, but with different specific proteins in each pathway mutated or differentially expressed in a given tumor (The Cancer Genome Atlas Research Network 2008; Parsons et al. 2008). Different studies demonstrated that while widespread mutations exist in cancer, not all mutations drive cancer development (Lin et al. 2007). This suggests a need to target only a deleterious subset of aberrant proteins, since any tre- ment must aim to improve health to justify its potential side effects. Treatment for cancer must become highly individualized, focusing on the specific aberrant driver proteins in an individual. This drives a need for informatics in cancer far beyond the need in other diseases. For instance, routine treatment with statins has become widespread for minimizing heart disease, with most patients responding to standard doses (Wilt et al. 2004). In contrast, standard treatment for cancer must become tailored to the molecular phenotype of an individual tumor, with each patient receiving a different combination of therapeutics aimed at the specific aberrant proteins driving the cancer. Tracking the aberrations that drive cancers, identifying biomarkers unique to each individual for molecular-level di- nosis and treatment response, monitoring adverse events and complex dosing schedules, and providing annotated molecular data for ongoing research to improve treatments comprise a major biomedical informatics need.