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Test No 474 Mammalian Erythrocyte Micronucleus Test
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Book Synopsis Test No. 474: Mammalian Erythrocyte Micronucleus Test by : OECD
Download or read book Test No. 474: Mammalian Erythrocyte Micronucleus Test written by OECD and published by OECD Publishing. This book was released on 1997-07-21 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 474: Mammalian Erythrocyte Micronucleus Test by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 474: Mammalian Erythrocyte Micronucleus Test written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals, usually rodents (mice or rats).
Book Synopsis OPPTS 870.5395 Mammalian Erythrocyte Micronucleus Test by :
Download or read book OPPTS 870.5395 Mammalian Erythrocyte Micronucleus Test written by and published by . This book was released on 1998 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis GB 15193.5-2014 Translated English of Chinese Standard (GB 15193.5-2014, GB15193.5-2014) by : https://www.chinesestandard.net
Download or read book GB 15193.5-2014 Translated English of Chinese Standard (GB 15193.5-2014, GB15193.5-2014) written by https://www.chinesestandard.net and published by https://www.chinesestandard.net. This book was released on 2024-06-07 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Standard specifies the basic test methods and technical requirements for mammalian erythrocyte micronucleus test. This Standard is applicable to the evaluation of the genotoxicity of test substances.
Book Synopsis Genotoxicity Assessment by : Alok Dhawan
Download or read book Genotoxicity Assessment written by Alok Dhawan and published by Humana Press. This book was released on 2013-07-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals. In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetic toxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences.
Book Synopsis Statistical Evaluation of Mutagenicity Test Data by : David J. Kirkland
Download or read book Statistical Evaluation of Mutagenicity Test Data written by David J. Kirkland and published by Cambridge University Press. This book was released on 2008-01-03 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This rigorous and practical account of the interpretation of mutagenicity test data draws upon the expertise of toxicologists and statisticians. Chemicals, such as drugs, food additives and pesticides, all need careful screening to eliminate potentially mutagenic compounds.
Book Synopsis Test No. 487: In Vitro Mammalian Cell Micronucleus Test by : OECD
Download or read book Test No. 487: In Vitro Mammalian Cell Micronucleus Test written by OECD and published by OECD Publishing. This book was released on 2010-07-23 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells. Micronuclei may originate from acentric chromosome fragments (i.e. lacking a centromere), or whole chromosomes that are ...
Book Synopsis Experimental Psychopharmacology by : Andrew J. Greenshaw
Download or read book Experimental Psychopharmacology written by Andrew J. Greenshaw and published by Springer Science & Business Media. This book was released on 1987-04-07 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychopharmacology may be defined as the study of the effects of drugs on behavior. As an established scientific discipline, this is a relatively new area of research. Despite its short history, however, psychopharmacology has achieved a considerable degree of sophistication in the variety of experi mental approaches that are currently employed. Consequently, the interpretation of data accumulated through the use of various experimental laboratory techniques has become increasingly difficult and complex. Numerous excelIent texts and review articles are available that serve to outline recent progress in psychopharmacology (particularly the Handbook of Psychopharmacology series, edited by L. L. Iversen, S. D. Iversen, and S. H. Synder). Volumes such as these serve to usefully review the available litera ture without attempting a critical appraisal of the utility and limitations of methods and the difficulties of interpreting empirical data. Such conceptual and methodological problems are now an issue of paramount importance in studying the behavioral effects of drugs. The present volume can be regarded as a "conceptual cookbook" that examines the utility and limitations of various experimental approaches commonly taken in psychopharmacology. This practically oriented text should prove particularly useful for pharmacologists and neurochemists who have no formal training in behavioral research and require an intro duction to the actuallaboratory practice of the field. In addition, the useful and informative treatment of current issues in psychopharmacology will undoubtedly appeal to the majority of active researchers.
Book Synopsis Genotoxicity and DNA Repair by : L. María Sierra
Download or read book Genotoxicity and DNA Repair written by L. María Sierra and published by Humana Press. This book was released on 2014-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the “OECD guidelines for the testing of chemicals”, this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab. Authoritative and invaluable, Genotoxicity and DNA Repair: A Practical Approach aims to aid scientists in their pursuit of forwarding this vital field of study.
Book Synopsis Biological Dosimetry by : W. G. Eisert
Download or read book Biological Dosimetry written by W. G. Eisert and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: In October 1982, a small international symposium was held at the Gesellschaft fUr Strahlen- und Umweltforschung mbH (GSF) in Munich as a satellite meeting of the IX International Conference on Analytical Cytology. The symposium focussed on cytometric approaches to biological dosimetry, and was, to the best of our knowledge, the first meeting on this subject ever held. There was strong encouragement from the 75 attendees and from others to publish a proceedings of the symposium. Hence this book, containing 30 of the 36 presentations, has been assembled. Dosimetry, the accurate and systematic determination of doses, usually refers to grams of substance administered or rads of ionization or some such measure of exposure of a patient, a victim or an experimental system. The term also can be used to describe the quantity of an ultimate, active agent as delivered to the appropriate target material within a biological system. Thus, for mutagens, one can speak of DNA dosimetry, meaning the number of adducts produced in the DNA of target cells such as bone-mar row stem cells or spermatogonia.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 471: Bacterial Reverse Mutation Test by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 471: Bacterial Reverse Mutation Test written by OECD and published by OECD Publishing. This book was released on 1997-07-21 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshifts. The principle of this bacterial reverse mutation test ...
Author :Organisation for Economic Co-operation and Development Publisher :Organisation for Economic Co-operation and Development ; [Montréal : Renouf] ISBN 13 :9789264122215 Total Pages : pages Book Rating :4.1/5 (222 download)
Book Synopsis OECD Guidelines for Testing of Chemicals by : Organisation for Economic Co-operation and Development
Download or read book OECD Guidelines for Testing of Chemicals written by Organisation for Economic Co-operation and Development and published by Organisation for Economic Co-operation and Development ; [Montréal : Renouf]. This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genetic Toxicology Testing by : Ray Proudlock
Download or read book Genetic Toxicology Testing written by Ray Proudlock and published by Academic Press. This book was released on 2016-05-28 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in your genetic toxicology tests. Genetic Toxicology Testing: A Laboratory Manual is an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own. - Offers practical and consistent guidance on the most commonly-performed tests and procedures in a genetic toxicology lab - Describes standard genetic toxicology assays, their methodology, reagents, suppliers, and analysis of their results - Includes guidance on general approaches: formulation for in vitro assays, study monitoring, and Good Laboratory Practice (GLP) - Serves as an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own lab
Book Synopsis The Micronucleus Assay in Toxicology by : Michael Fenech
Download or read book The Micronucleus Assay in Toxicology written by Michael Fenech and published by Royal Society of Chemistry. This book was released on 2019-07-26 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concerns about the adverse health effects of chemicals and radiation present in the environment and at workplaces have created the need for better detection systems to assess their potential to cause DNA damage in humans and other organisms across ecosystems. The Micronucleus Assay in Toxicology is the first comprehensive volume concerning the use of micronucleus assays in genetic toxicology. It succinctly explains the mechanisms by which genotoxins cause micronucleus formation and its relation to diseases. Furthermore, it describes the methods which are currently used for the analyses of micronuclei in different types of cells in human in vivo biomonitoring studies, routine in vivo tests with rodents, in vitro studies with human and mammalian cells, environmental monitoring with invertebrates and vertebrates such as molluscs, fish and, also, in plant bioassays. Moreover, this book also focuses on the use of the micronucleus technique in other research areas, including the detection of DNA damage caused by important groups of genotoxic carcinogens (heavy metals, industrial chemicals, cytotoxic drugs, pesticides, ionising radiation, etc.) as well as study designs, statistical analyses, international regulatory guidelines, and the development of automated scoring devices for this assay. This book will serve as both, a reference and a guide to students, and investigators in biomedical, biochemical and pharmaceutical sciences interested in gaining a better understanding of the biology of micronuclei and their application in measuring DNA damage caused by natural or man-made genotoxins.
Book Synopsis Environmental Toxicology by : Luis M. Botana
Download or read book Environmental Toxicology written by Luis M. Botana and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-05-22 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic and inorganic chemicals frequently exhibit toxic, mutagenic, carcinogenic, or sensitizing properties when getting in contact with the environment. This comprehensive introduction discusses risk assessment and analysis, environmental fate, transport, and breakdown pathways of chemicals, as well as methods for prevention and procedures for decontamination.
Book Synopsis The Medicinal Chemist's Guide to Solving ADMET Challenges by : Patrick Schnider
Download or read book The Medicinal Chemist's Guide to Solving ADMET Challenges written by Patrick Schnider and published by Royal Society of Chemistry. This book was released on 2021-08-27 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is a complex science that lies at the very heart of drug discovery. Poor solubility, complex metabolism, tissue retention and slow elimination are just some of the properties of investigational compounds that present a challenge to the design and conduct of ADMET studies. Medicinal chemistry experience and knowledge relating to how a lead structure was modified to solve a specific problem is generally very challenging to retrieve. Presented in a visual and accessible style, this book provides rapid solutions to overcome the universal challenges to optimizing ADMET.
Book Synopsis Biomedical Applications and Toxicity of Nanomaterials by : P. V. Mohanan
Download or read book Biomedical Applications and Toxicity of Nanomaterials written by P. V. Mohanan and published by Springer Nature. This book was released on 2023-05-08 with total page 771 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the recent trends on the biological applications of nanomaterials, methods for their preparation, and techniques for their characterization. Further, the book examines the fundamentals of nanotoxicity, methods to assess the toxicity of engineered nanomaterials, approaches to reduce toxicity during synthesis. It also provides an overview of the state of the art in the application of Artificial intelligence-based methodologies for evaluation of toxicity of drugs and nanoparticles. The book further discusses nanocarrier design, routes of various nanoparticle administration, nano based drug delivery systems, and the toxicity challenges associated with each drug delivery method. It presents the latest advances in the interaction of nanoparticles with the cellular environment and assess nanotoxicity of these engineered nanoparticles. The book also explores the comparative and mechanistic genotoxicity assessment of the nanomaterials. This book is useful source of information for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, and drugs.
