Temporally And Spatially Resolved Quantification Of Hemodynamic Forces And Endothelial Mechanics

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Temporally and Spatially Resolved Quantification of Hemodynamic Forces and Endothelial Mechanics

Author : Lori M. Lambert
Publisher :
ISBN 13 : 9781339638768
Total Pages : 138 pages
Book Rating : 4.6/5 (387 download)

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Book Synopsis Temporally and Spatially Resolved Quantification of Hemodynamic Forces and Endothelial Mechanics by : Lori M. Lambert

Download or read book Temporally and Spatially Resolved Quantification of Hemodynamic Forces and Endothelial Mechanics written by Lori M. Lambert and published by . This book was released on 2016 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium is a thin layer of endothelial cells that line the interior surface of an artery. Due to their direct contact with blood flow, endothelial cells experience varying hemodynamic forces and respond to these forces by altering their morphology. When plaque and other substances accumulate in the walls of arteries, i.e., atherosclerosis, endothelial cells have abnormal responses to blood flow. Studying atherosclerosis progression is, therefore, a two-fold investigation into 1) the hemodynamic forces that cause endothelial responses, and 2) the biological and mechanical responses of endothelial cells. The ultimate goal of this study was to develop an experimental method that was able to temporally and spatially quantify hemodynamic forces and endothelial mechanics.

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

Author : Wolfgang B. Liedtke, MD, PH.D.
Publisher : CRC Press
ISBN 13 : 1420005847
Total Pages : 502 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by : Wolfgang B. Liedtke, MD, PH.D.

Download or read book TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades written by Wolfgang B. Liedtke, MD, PH.D. and published by CRC Press. This book was released on 2006-09-29 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st

Improving Assessments of Hemodynamics and Vascular Disease

Author : Magnus Ziegler
Publisher : Linköping University Electronic Press
ISBN 13 : 9176850986
Total Pages : 64 pages
Book Rating : 4.1/5 (768 download)

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Book Synopsis Improving Assessments of Hemodynamics and Vascular Disease by : Magnus Ziegler

Download or read book Improving Assessments of Hemodynamics and Vascular Disease written by Magnus Ziegler and published by Linköping University Electronic Press. This book was released on 2019-04-24 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: Blood vessels are more than simple pipes, passively enabling blood to pass through them. Their form and function are dynamic, changing with both aging and disease. This process involves a feedback loop wherein changes to the shape of a blood vessel affect the hemodynamics, causing yet more structural adaptation. This feedback loop is driven in part by the hemodynamic forces generated by the blood flow, and the distribution and strength of these forces appear to play a role in the initiation, progression, severity, and the outcome of vascular diseases. Magnetic Resonance Imaging (MRI) offers a unique platform for investigating both the form and function of the vascular system. The form of the vascular system can be examined using MR-based angiography, to generate detailed geometric analyses, or through quantitative techniques for measuring the composition of the vessel wall and atherosclerotic plaques. To complement these analyses, 4D Flow MRI can be used to quantify the functional aspect of the vascular system, by generating a full time-resolved three-dimensional velocity field that represents the blood flow. This thesis aims to develop and evaluate new methods for assessing vascular disease using novel hemodynamic markers generated from 4D Flow MRI and quantitative MRI data towards the larger goal of a more comprehensive non-invasive examination oriented towards vascular disease. In Paper I, we developed and evaluated techniques to quantify flow stasis in abdominal aortic aneurysms to measure this under-explored aspect of aneurysmal hemodynamics. In Paper II, the distribution and intensity of turbulence in the aorta was quantified in both younger and older men to understand how aging changes this aspect of hemodynamics. A method to quantify the stresses generated by turbulence that act on the vessel wall was developed and evaluated using simulated flow data in Paper III, and in Paper V this method was utilized to examine the wall stresses of the carotid artery. The hemodynamics of vascular disease cannot be uncoupled from the anatomical changes the vessel wall undergoes, and therefore Paper IV developed and evaluated a semi-automatic method for quantifying several aspects of vessel wall composition. These developments, taken together, help generate more valuable information from imaging data, and can be pooled together with other methods to form a more comprehensive non-invasive examination for vascular disease.

Hemodynamic Forces and Endothelial Mechanobiology in Vascular Diseases

Author : Chih-Yu Yang
Publisher : Frontiers Media SA
ISBN 13 : 2889768511
Total Pages : 153 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Hemodynamic Forces and Endothelial Mechanobiology in Vascular Diseases by : Chih-Yu Yang

Download or read book Hemodynamic Forces and Endothelial Mechanobiology in Vascular Diseases written by Chih-Yu Yang and published by Frontiers Media SA. This book was released on 2022-08-29 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Angiogenesis Assays

Author : Carolyn A. Staton
Publisher : John Wiley & Sons
ISBN 13 : 047002934X
Total Pages : 410 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Angiogenesis Assays by : Carolyn A. Staton

Download or read book Angiogenesis Assays written by Carolyn A. Staton and published by John Wiley & Sons. This book was released on 2007-01-11 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.

Annual Update in Intensive Care and Emergency Medicine 2016

Author : Jean-Louis Vincent
Publisher : Springer
ISBN 13 : 3319273493
Total Pages : 488 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Annual Update in Intensive Care and Emergency Medicine 2016 by : Jean-Louis Vincent

Download or read book Annual Update in Intensive Care and Emergency Medicine 2016 written by Jean-Louis Vincent and published by Springer. This book was released on 2016-03-23 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Annual Update compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

Cell Migration

Author : Jun-Lin Guan
Publisher : Springer Science & Business Media
ISBN 13 : 1592598609
Total Pages : 359 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Cell Migration by : Jun-Lin Guan

Download or read book Cell Migration written by Jun-Lin Guan and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of classic, novel, and state-of-the-art methods for the study of cell migration in cultured cells, different model organisms, and specialized cells in normal development and disease. Highlights include basic assays that apply to all cell migration studies in vitro, assays in various model organisms, and assays for cancer cells, endothelial cells, and neurons both in vitro and in animal models. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

An Introduction to Biomechanics

Author : Jay D. Humphrey
Publisher : Springer Science & Business Media
ISBN 13 : 1489903259
Total Pages : 642 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis An Introduction to Biomechanics by : Jay D. Humphrey

Download or read book An Introduction to Biomechanics written by Jay D. Humphrey and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed to meet the needs of undergraduate students, "Introduction to Biomechanics" takes the fresh approach of combining the viewpoints of both a well-respected teacher and a successful student. With an eye toward practicality without loss of depth of instruction, this book seeks to explain the fundamental concepts of biomechanics. With the accompanying web site providing models, sample problems, review questions and more, Introduction to Biomechanics provides students with the full range of instructional material for this complex and dynamic field.

Technical Problems in Patients on Hemodialysis

Author : Maria Goretti Penido
Publisher : BoD – Books on Demand
ISBN 13 : 9533074035
Total Pages : 316 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Technical Problems in Patients on Hemodialysis by : Maria Goretti Penido

Download or read book Technical Problems in Patients on Hemodialysis written by Maria Goretti Penido and published by BoD – Books on Demand. This book was released on 2011-12-07 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of technical aspects in treatment of hemodialysis patients. Authors have contributed their most interesting findings in dealing with hemodialysis from the aspect of the tools and techniques used.Each chapter has been thoroughly revised and updated so the readers are acquainted with the latest data and observations in the area, where several aspects are to be considered. The book is comprehensive and not limited to a partial discussion of hemodialysis. To accomplish this we are pleased to have been able to summarize state of the art knowledge in each chapter of the book.

Measuring Oxidants and Oxidative Stress in Biological Systems

Author : Lawrence J. Berliner
Publisher : Springer Nature
ISBN 13 : 303047318X
Total Pages : 237 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Measuring Oxidants and Oxidative Stress in Biological Systems by : Lawrence J. Berliner

Download or read book Measuring Oxidants and Oxidative Stress in Biological Systems written by Lawrence J. Berliner and published by Springer Nature. This book was released on 2020-08-08 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.

Studies on Atherosclerosis

Author : Martin Rodriguez-Porcel
Publisher : Springer
ISBN 13 : 1489976930
Total Pages : 149 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Studies on Atherosclerosis by : Martin Rodriguez-Porcel

Download or read book Studies on Atherosclerosis written by Martin Rodriguez-Porcel and published by Springer. This book was released on 2016-12-22 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the role free radicals and antioxidants within the development of vascular disease, examining fundamental research and translating preclinical knowledge to clinical trials. The expertly authored chapters describe the relationship of oxidative stress to atherosclerosis and the cardiovascular system, exploring its role in cardiac fibrosis, renovascular disease, hypertension, and regulation of blood pressure and cerebral vascular tone. The concluding chapter discusses the current state of clinical research, contextualizing clinical trials within the existing theoretical framework and analyzing attempts to preserve oxidant stress under various conditions. With its concise and authoritative analysis of pre-clinical research and clinical results, Studies in Atherosclerosis – part of the bestselling Oxidative Stress in Basic Research and Clinical Practice series – is essential for researchers and clinicians focusing in cardiology, nephrology, or oxidative stress.

Elementary Fluid Mechanics

Author : Tsutomu Kambe
Publisher : World Scientific
ISBN 13 : 9812706674
Total Pages : 403 pages
Book Rating : 4.8/5 (127 download)

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Book Synopsis Elementary Fluid Mechanics by : Tsutomu Kambe

Download or read book Elementary Fluid Mechanics written by Tsutomu Kambe and published by World Scientific. This book was released on 2007 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes the fundamental OC physicalOCO aspects of fluid flows for beginners of fluid mechanics in physics, mathematics and engineering, from the point of view of modern physics. It also emphasizes the dynamical aspects of fluid motions rather than the static aspects, illustrating vortex motions, waves, geophysical flows, chaos and turbulence. Beginning with the fundamental concepts of the nature of flows and the properties of fluids, the book presents fundamental conservation equations of mass, momentum and energy, and the equations of motion for both inviscid and viscous fluids. In addition to the fundamentals, this book also covers water waves and sound waves, vortex motions, geophysical flows, nonlinear instability, chaos, and turbulence. Furthermore, it includes the chapters on superfluids and the gauge theory of fluid flows. The material in the book emerged from the lecture notes for an intensive course on Elementary Fluid Mechanics for both undergraduate and postgraduate students of theoretical physics given in 2003 and 2004 at the Nankai Institute of Mathematics (Tianjin) in China. Hence, each chapter may be presented separately as a single lecture."

Basic Sciences for MCEM

Author : Chetan Trivedy
Publisher : CRC Press
ISBN 13 : 0340985011
Total Pages : 771 pages
Book Rating : 4.3/5 (49 download)

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Book Synopsis Basic Sciences for MCEM by : Chetan Trivedy

Download or read book Basic Sciences for MCEM written by Chetan Trivedy and published by CRC Press. This book was released on 2016-05-15 with total page 771 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a dedicated resource for those sitting the Part A of the MCEM (Membership of the College of Emergency Medicine) examination. It forms an essential revision guide for emergency trainees who need to acquire a broad understanding of the basic sciences, which underpin their approach to clinical problems in the emergency department. Common clinical scenarios are used to highlight the essential underlying basic science principles, providing a link between clinical management and a knowledge of the underlying anatomical, physiological, pathological and biochemical processes. Multiple choice questions with reasoned answers are used to confirm the candidates understanding and for self testing. Unlike other recent revision books which provide MCQ questions with extended answers, this book uses clinical cases linked to the most recent basic science aspects of the CEM syllabus to provide a book that not only serves as a useful revision resource for the Part A component of the MCEM examination, but also a unique way of understanding the processes underlying common clinical cases seen every day in the emergency department. This book is essential for trainees sitting the Part A of the MCEM exam and for clinicians and medical students who need to refresh their knowledge of basic sciences relevant to the management of clinical emergencies.

Dissertation Abstracts International

Author :
Publisher :
ISBN 13 :
Total Pages : 806 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Dissertation Abstracts International by :

Download or read book Dissertation Abstracts International written by and published by . This book was released on 2004 with total page 806 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biomechanics of Coronary Atherosclerotic Plaque

Author :
Publisher : Academic Press
ISBN 13 : 0128171960
Total Pages : 688 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Biomechanics of Coronary Atherosclerotic Plaque by :

Download or read book Biomechanics of Coronary Atherosclerotic Plaque written by and published by Academic Press. This book was released on 2020-03-15 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomechanics of Coronary Atherosclerotic Plaque: From Model to Patient, First Edition, is the first comprehensive text to focus on important biomechanical studies conducted in the last decade that have increased our understanding of coronary atherosclerotic plaque initiation, growth, and rupture, as well as improving the design of medical devices and clinical interventions, including surgical procedures. The book provides students, researchers, engineers, clinicians, and interventional cardiologists with an overview of the main topics related to the biomechanics of atherosclerosis, in a single volume written by several experts in the field. This volume is part of the Biomechanics of Living Organs book series. The biomechanics of human soft tissues and organs has been an emerging research field since the publication of Y.C. Fung’s original book series in the 1990s. The publication of such books entirely dedicated to a specific biomechanical subject is necessary to advance scientific research in the field of biomechanics and to transfer important knowledge to future generations. Therefore, this series of volumes on the biomechanics of living organs has been created. This series began in July 2017 with the publication of a first volume on the fundamentals of Hyperelastic Constitutive Laws for Finite Element Modeling of Living Organs. The current volume on the Biomechanics of Coronary Atherosclerotic Plaque, is the latest in this new series. Presents the main computational fluid dynamic studies performed, describing blood flow in healthy and pathological artery branches, including in coronary bifurcations Highlights the correlation between plaque initiation regions and blood shear stress amplitude Discusses the main biomechanical and mechanobiological models to highlight the importance of quantifying the residual and peak cap stresses and the presence of μ-calcifications to evaluate the risk of plaque rupture Introduces the most recent intravascular imaging biomarker techniques (elastography, palpography and modulography)

Selected papers of the "1st International Conference on Nanofluids (ICNf)"

Author : Patrice Estellé
Publisher : MDPI
ISBN 13 : 3039366629
Total Pages : 150 pages
Book Rating : 4.0/5 (393 download)

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Book Synopsis Selected papers of the "1st International Conference on Nanofluids (ICNf)" by : Patrice Estellé

Download or read book Selected papers of the "1st International Conference on Nanofluids (ICNf)" written by Patrice Estellé and published by MDPI. This book was released on 2020-12-10 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue of Energies has emerged as a result of the 1st International Conference on Nanofluids (https://icnf2019.com/), which was organized under the auspices of Nanouptake COST Action (Overcoming Barriers to Nanofluids Market Uptake, http://www.nanouptake.eu/) in Castelló (Spain), in June 2019. The foci of ICNf2019 were the production and the characterisation of nanofluids for different areas of applications in the energy fields, namely heat transfer, storage of thermal energy, boiling, and solar systems, as well as industrial applications and health and safety issues. The first conference edition on this topic gathered more than 200 participants from 45 different countries. More than 125 contributions were presented in the nine sections of the congress. Some selected authors were invited to send extended versions of their work to the Energies ICNf2019 Special Issue. After a careful review process, nine articles from six different countries were selected for compilation in this Special Issue: a total of seven full research papers and two reviews. These papers cover a broad range of fundamental and applied research aspects on nanoﬂuid science and development, and reﬂect the current investigations, knowledge, and challenges encountered in the use of nanofluids for energy applications.

Manual of Neurosonology

Author : László Csiba
Publisher : Cambridge University Press
ISBN 13 : 1107659159
Total Pages : 333 pages
Book Rating : 4.1/5 (76 download)

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Book Synopsis Manual of Neurosonology by : László Csiba

Download or read book Manual of Neurosonology written by László Csiba and published by Cambridge University Press. This book was released on 2016-04-28 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurosonology is non-invasive, portable, and has excellent temporal resolution, making it a valuable and increasingly popular tool for the diagnosis and monitoring of neurological conditions when compared to other imaging techniques. This guide looks beyond the use of neurovascular ultrasound in stroke to encompass a wide range of other neurological diseases and emergencies. It offers a practical approach to the examination of patients, interpretation of ultrasound studies, and the application of neurosonology to the development of management and treatment strategies. Each chapter incorporates a thorough and clear procedural methodology alongside scanning tips for trainees; this step-by-step approach is further enhanced by example images and focused diagnostic questions. Authored and edited by international experts, this practical manual of neurosonology is an invaluable resource for neurologists, neurosurgeons, intensivists, radiologists, and ultrasonographers.