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Telomerase Inhibition And Chemosensitization Of Prostate Cancer Cells
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Book Synopsis Telomerase Inhibition and Chemosensitization of Prostate Cancer Cells by :
Download or read book Telomerase Inhibition and Chemosensitization of Prostate Cancer Cells written by and published by . This book was released on 2004 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: We hypothesize that telomerase inhibition (telomere shortening) can sensitize human tumor cells to existing anticancer drugs. During the period of the grant we made the following findings-: 1) 2'-methoxy ethyl oligonucleotides inhibit - -telomerase in prostate cancer cells, cause telomeres to shorten, and cause cell- proliferation to decrease; -2) Cell proliferation in culture is -more pronounced when cells are grown under conditions that mimic tumor growth; 3) Cell proliferation is dramatically reduced in a xenograft model using LNCAP cells, and 4) We did not observe significant synergy with standard chemotherapy agents. The ability of relatively short-term treatments with telomerase inhibitors to slow tumor growth in vivo suggests that telomerase inhibitors are a reasonable approach to prostate cancer therapy.
Book Synopsis Inhibition of Telomerase as a Therapeutic Target for the Treatment of Prostate Cancer by :
Download or read book Inhibition of Telomerase as a Therapeutic Target for the Treatment of Prostate Cancer written by and published by . This book was released on 2005 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malignant prostate cells must divide many times to form a tumor, metastasize or recur after therapy. Critical for this type of endless cell division is an enzyme named telomerase. This enzyme is usually dormant in most normal tissues, but is resurrected in prostate cancer cells by yet unknown genetic changes. Since the enzyme is required for survival of cancer cells but is not present in most normal cells, inhibition of telomerase may specifically target prostate cancer cells. We have shown that impeding the function of telomerase by expressing a mutated version of this protein kills prostate cancer cells in an experimental setting. We now wish to translate this finding into a more practical application by searching for smaller molecules capable of inhibiting telomerase activity. The approach we propose to take is one that capitalizes on reagents already in hand. First, we have mapped parts of telomerase that are extremely sensitive to even small disruptions. We now wish to find molecules that bind to these sensitive regions, as such regions represent the most attractive parts of the protein to target for inhibition. We will therefore screen millions upon millions of small molecules, termed peptides, for those few that adhere to these regions of the telomerase enzyme. Such peptides could serve as a blueprint to develop even more clinically relevant inhibitors of telomerase.
Book Synopsis Telomeres and Telomerase in Cancer by : Keiko Hiyama
Download or read book Telomeres and Telomerase in Cancer written by Keiko Hiyama and published by Springer Science & Business Media. This book was released on 2009-03-18 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.
Book Synopsis Regulation of Telomerase by Genistein in Human Prostate Cancer Cells by : My N. Chau
Download or read book Regulation of Telomerase by Genistein in Human Prostate Cancer Cells written by My N. Chau and published by . This book was released on 2008 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mechanism for genistein-induced activation of STAT3 was then determined. A physiological concentration of genistein activated signaling proteins upstream of STAT3 including JAK2, Akt, Src, and MAPK p44/42 in human prostate cancer cells. Specific shRNA inhibition of these signaling proteins in stable STAT3 reporter prostate cancer cells reduced STAT3 reporter activity and cancer cell proliferation. Genistein treatment of cells with the signaling proteins inhibited did not increase STAT3 reporter activity and cancer cell proliferation to the level observed in genistein treated control cells, indicating that JAK2, Akt, Src, and MAPK p44/42 are necessary for genistein-induced activation of STAT3. The data collectively suggests that physiologically achievable concentrations of genistein enhance cancer cell proliferation by increasing telomerase activity via STAT3 activation mediated by upstream signaling proteins. The result that physiological concentrations of genistein promote prostate cancer cell growth indicates that prudence should be exercised when genistein is considered for chemotherapeutic purposes as unfavorable effects in individuals with prostate cancer is possible.
Book Synopsis Molecular Mechanisms of Prostate Cancer Progression by :
Download or read book Molecular Mechanisms of Prostate Cancer Progression written by and published by . This book was released on 2005 with total page 57 pages. Available in PDF, EPUB and Kindle. Book excerpt: In studies to define the mechanisms involved in the progression of immortal, non-tumorigenic prostate cells to a tumorigenic state, we have found that molecular chaperones are elevated, which causes increased telomerase activity. In order to determine the importance of the chaperone increase during prostate cancer progression, we have taken a 2-pronged approach, using both genetic and pharmacologic approaches: 1-define whether ectopic chaperone expression results in transformation, and 2-determine whether chaperones are targets for prostate cancer therapy. The hsf-1 transcription factor has been over-expressed in non-tumorigenic prostate cells, resulting in increased hsp90 and hsp70 expression, an upregulation of telomerase, and no effect on tumorigenicity. However, preliminary data suggests that hsf-1 may directly effect telomerase expression, which would further define the regulation of telomerase during cancer progression. Using both a pharmacologic (radicicol, a specific hsp90 inhibitor) and genetic (siRNA to hsp90) approaches, prostate cancer cell lines exhibit only a transient decline in telomerase activity but a significant decrease in telomeres, which we have shown to be directly damaged by free radicals produced as a result of deregulation of the nitric oxide synthase pathway.
Book Synopsis Telomerase Inhibition by : Lucy Andrews
Download or read book Telomerase Inhibition written by Lucy Andrews and published by Springer Science & Business Media. This book was released on 2007-11-29 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a compendium of the most recent and advanced methods applied to the rapidly expanding field of telomerase inhibition. The techniques described provide the researcher with a diverse and comprehensive set of tools for the study of telomerase inhibition. The volume is aimed at biochemists, molecular biologists, cancer researchers, and geneticists.
Book Synopsis Role of Nutraceuticals in Cancer Chemosensitization by :
Download or read book Role of Nutraceuticals in Cancer Chemosensitization written by and published by Academic Press. This book was released on 2017-10-18 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Role of Nutraceuticals in Chemoresistance to Cancer, Volume Two, focuses on nutraceuticals, the compounds derived from natural sources, which are usually multi-targeted as a means to overcome chemoresistance. This book discusses the role of several compounds related to nutraceuticals and chemoresistance, such as curcumin, resveratrol, indole 3-carbinol, tocotrienols, ursolic acid, fisetin, celastrol, gambogic, butein, catechins and silymarin. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use nutraceuticals as a sensitizing agent for chemotherapy. Brings updated information on natural compounds used as specific inhibitors of cell signaling pathways as reviewed by experts in the field Presents experts analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches for the readers to use in their own investigations
Book Synopsis Cancer Cell Chemoresistance And Chemosensitization by : Ajaikumar B Kunnumakkara
Download or read book Cancer Cell Chemoresistance And Chemosensitization written by Ajaikumar B Kunnumakkara and published by World Scientific. This book was released on 2018-02-14 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the significant advances in cancer therapy made through constant evaluation and analysis of treatment aftereffects, the disease still remains one of the foremost causes of mortality worldwide killing more than 12 million people annually. The prime reason behind the failure of conventional chemotherapeutics which are used as the chief regimen in the comprehensive treatment of cancers is the development of chemoresistance. It can be either intrinsic or acquired and is primarily mediated via different key regulators like MDR, MAPK, NF-κB, PI3K/Akt, Wnt signaling pathways etc. Thus, agents which can target these regulatory elements or pathways and in turn sensitize cancer cells to chemotherapy holds immense prospect. However, there is barely such comprehensive work available in scientific literature that explains how chemosensitization of cancer cells functions using different drug combinations and exhibit synergism. This book provides a detailed description of chemoresistance and chemosensitization, targets for chemosensitization and various approaches adapted in the process of chemosensitization. Furthermore, the book explicates the role of various chemosensitizers, both natural and synthetic in sensitizing cancer cells and also details the current research findings on chemosensitization of different cancer types in both pre-clinical and clinical settings.
Book Synopsis Multi-Targeted Approach to Treatment of Cancer by : Varsha Gandhi
Download or read book Multi-Targeted Approach to Treatment of Cancer written by Varsha Gandhi and published by Springer. This book was released on 2015-01-29 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, clinicians and basic scientists from USA, India, and other countries discuss the rationales and clinical experiences with targeted approaches to treat, prevent, or manage cancer. Cancer is a hyperproliferative disorder that is regulated by multiple genes and multiple cell signaling pathways. Genomics, proteomics, and metabolomics have revealed that dysregulation of dozens of genes and their products occur in any given cell type that ultimately leads to cancer. These discoveries are providing unprecedented opportunities to tackle cancer by multi-faceted approaches that target these underpinnings. This book emphasizes a multi-targeted approach to treating cancer, the focus of the 5th International Conference on Translational Cancer Research that was held in Vigyan Bhawan, Delhi (India) from Feb 6-9, 2014.
Book Synopsis Advanced Therapy of Prostate Disease by : Martin I. Resnick
Download or read book Advanced Therapy of Prostate Disease written by Martin I. Resnick and published by PMPH-USA. This book was released on 2000 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Therapy of Prostate Disease, from the inital to post-surgical psychological concerns, this book is a complete guide to every step of prostate disease treatment. First, it describes the physical exam in detail, as well as laboratory and imaging techniques that can confirm a diagnosis. Then, the pros and cons of treatment methods for every type and variation of prostate cancer and benign conditions are discussed. Post-surgical treatment (including behavioral issues) is also outlined.
Book Synopsis Nutraceuticals and Cancer by : Fazlul H. Sarkar
Download or read book Nutraceuticals and Cancer written by Fazlul H. Sarkar and published by Springer Science & Business Media. This book was released on 2011-11-22 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about Nutraceuticals in cancer therapy, specifically targeted and Adjuvant therapy. It shows several approaches for possibly reducing systemic toxicity. This book illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in the prevention and/or treatment of human malignancies known to be mediated through alterations in multiple molecular targets. This book contains sixteen chapters which begin with historical perspective on the value of natural agents in the prevention of human malignancies followed by a series of current topics on multiple nutraceuticals targeting multiple cancers. This collection would likely be useful for bringing newer generations with broader perspectives in launching cutting-edge innovative molecular research, which would certainly help in designing targeted clinical trials in order to realize the dream of customize strategies for the prevention and/or treatment of human malignancies without causing any systemic toxicity. Moreover, the knowledge gained would allow novel utilization of nutraceuticals as adjunct to both conventional chemotherapy and radiation therapy in order to improve the overall quality of life and survival of patients diagnosed with cancers.
Book Synopsis Chemosensitizing Effect of Natural Products against Cancers: Applications in Enhancing Chemotherapy and Immunotherapy by : Nand K. Roy
Download or read book Chemosensitizing Effect of Natural Products against Cancers: Applications in Enhancing Chemotherapy and Immunotherapy written by Nand K. Roy and published by Frontiers Media SA. This book was released on 2022-10-11 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Biology of Prostate Cancer by : Manfred Wirth
Download or read book Molecular Biology of Prostate Cancer written by Manfred Wirth and published by Walter de Gruyter. This book was released on 2013-05-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cancer Chemotherapy by : Rachel Airley
Download or read book Cancer Chemotherapy written by Rachel Airley and published by John Wiley & Sons. This book was released on 2009-04-01 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a clear and accessible introduction to thescientific and clinical aspects of the creation, development andadministration of drugs or drug regimens used in the treatment ofcancer. Unique in its approach, this book enables the student togain an understanding of the pathological, physiological andmolecular processes governing malignancy, whilst also introducingthe role of health professionals and scientists in the research andtreatment of cancer. The book consolidates all the essentialinformation necessary for a full understanding of cancerchemotherapy, providing an informative, inexpensive and up-to-datecoverage of the subject aimed at an undergraduate level readership. Key Features: Incorporates numerous diagrams, tables and illustrations to aidunderstanding. Examines key pharmacological and pharmaceutical issues such asdosing, toxicity and preparation of anti-cancer drugs. Includes a key chapter of practice essay questions to easerevision. Comprehensive coverage of drugs currently in pre-clinical andclinical development. An indispensable text for undergraduate students studyingpharmacy and medicine as well as those doing courses such asmolecular biology, biomedical sciences and pharmacology which coveraspects of oncology.
Book Synopsis 2017 Oncology Nursing Drug Handbook by : Wilkes
Download or read book 2017 Oncology Nursing Drug Handbook written by Wilkes and published by Jones & Bartlett Learning. This book was released on 2016-11-29 with total page 1660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written especially for nurses caring for patients with cancer, the 2017 Oncology Nursing Drug Handbook uniquely expresses drug therapy in terms of the nursing process: nursing diagnoses, etiologies of toxicities, and key points for nursing assessment, intervention, and evaluation. Updated annually, this essential reference provides valuable information on effective symptom management, patient education, and chemotherapy administration. Completely revised and updated, the 2017 Oncology Nursing Drug Handbook includes separate chapters on molecular and immunologic/biologic targeted therapies. These chapters provide fundamental reviews to assist nurses in understanding the cellular communication pathways disrupted by cancer. It also offers simplified content, attention to understanding the immune checkpoint inhibitors, new information about immunotherapy, new drugs and their indications, and updated indications and side effects for recently FDA approved drugs. New drugs include: alectin
Book Synopsis Pancreatic Cancer by : Sanjay Srivastava
Download or read book Pancreatic Cancer written by Sanjay Srivastava and published by BoD – Books on Demand. This book was released on 2012-03-23 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with an overall understanding of the biology of pancreatic cancer, hereditary, complex signaling pathways and alternative therapies. The book explains nutrigenomics and epigenetics mechanisms such as DNA methylation, which may explain the etiology or progression of pancreatic cancer. Book also summarizes the molecular control of oncogenic pathways such as K-Ras and KLF4. Since pancreatic cancer metastasizes to vital organs resulting in poor prognosis, special emphasis is given to the mechanism of tumor cell invasion and metastasis. Role of nitric oxide and Syk kinase in tumor metastasis is discussed in detail. Prevention strategies for pancreatic cancer are also described. The molecular mechanisms of the anti-cancer effects of curcumin, benzyl isothiocyante and vitamin D are discussed in detail. Furthermore, this book covers the basic mechanisms of resistance of pancreatic cancer to chemotherapy drugs such as gemcitabine and 5-flourouracil.
Book Synopsis 2018 Oncology Nursing Drug Handbook by : Wilkes
Download or read book 2018 Oncology Nursing Drug Handbook written by Wilkes and published by Jones & Bartlett Learning. This book was released on 2017-12 with total page 1737 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written especially for nurses caring for patients with cancer, the 2018 Oncology Nursing Drug Handbook uniquely expresses drug therapy in terms of the nursing process: nursing diagnoses, etiologies of toxicities, and key points for nursing assessment, intervention, and evaluation. Updated annually, this essential reference provides valuable information on effective symptom management, patient education, and chemotherapy administration. Completely revised and updated, the 2018 Oncology Nursing Drug Handbook includes separate chapters on molecular and immunologic/biologic targeted therapies. These chapters provide fundamental reviews to assist nurses in understanding the cellular communication pathways disrupted by cancer. It also offers simplified content, attention to understanding the immune checkpoint inhibitors, new information about immunotherapy, new drugs and their indications, and updated indications and side effects for recently FDA approved drugs.
