Technical Report On The Toxicology And Carcinogenesis Study Of Genistein Cas No 446 72 0 In Sprague Dawley Rats Feed Study

Download Technical Report On The Toxicology And Carcinogenesis Study Of Genistein Cas No 446 72 0 In Sprague Dawley Rats Feed Study full books in PDF, epub, and Kindle. Read online Technical Report On The Toxicology And Carcinogenesis Study Of Genistein Cas No 446 72 0 In Sprague Dawley Rats Feed Study ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Technical Report on the Toxicology and Carcinogenesis Study of Genistein (CAS No. 446-72-0) in Sprague-Dawley Rats (Feed Study)

Author : D. A. Casciano
Publisher : DIANE Publishing
ISBN 13 : 1437900739
Total Pages : 242 pages
Book Rating : 4.4/5 (379 download)

DOWNLOAD NOW!

Book Synopsis Technical Report on the Toxicology and Carcinogenesis Study of Genistein (CAS No. 446-72-0) in Sprague-Dawley Rats (Feed Study) by : D. A. Casciano

Download or read book Technical Report on the Toxicology and Carcinogenesis Study of Genistein (CAS No. 446-72-0) in Sprague-Dawley Rats (Feed Study) written by D. A. Casciano and published by DIANE Publishing. This book was released on 2008-10 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genistein is an isoflavone that occurs in soy products incl. soy-based infant formulas. It is known as ¿environmental estrogens¿ which can affect the hormone activities and possibly reproductive function of wildlife and humans through exposure. Studies were conducted on 3 such chemicals to see if exposure to such chemicals could have any effect on animals¿ reproductive systems or development of cancers. Rats were exposed to genistein for part or all of the study period and examined at the end of 2 years. Exposure to Genistein for 2 years caused tumors of the mammary gland and pituitary gland in female rats. Exposure to Genistein for shorter durations was also assoc. with increased rates of pituitary gland and mammary gland tumors. Ill.

Multigenerational Reproductive Toxicology Study of Ethinyl Estradiol (CAS No. 57636) in SpragueDawley Rats (Feed Studies)

Author :
Publisher : DIANE Publishing
ISBN 13 : 1437942318
Total Pages : 316 pages
Book Rating : 4.4/5 (379 download)

DOWNLOAD NOW!

Book Synopsis Multigenerational Reproductive Toxicology Study of Ethinyl Estradiol (CAS No. 57636) in SpragueDawley Rats (Feed Studies) by :

Download or read book Multigenerational Reproductive Toxicology Study of Ethinyl Estradiol (CAS No. 57636) in SpragueDawley Rats (Feed Studies) written by and published by DIANE Publishing. This book was released on with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Environmental Health Perspectives

Author :
Publisher :
ISBN 13 :
Total Pages : 908 pages
Book Rating : 4.:/5 (334 download)

DOWNLOAD NOW!

Book Synopsis Environmental Health Perspectives by :

Download or read book Environmental Health Perspectives written by and published by . This book was released on 2007-08 with total page 908 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nutraceuticals

Author : Ramesh C Gupta
Publisher : Academic Press
ISBN 13 : 0128212462
Total Pages : 1397 pages
Book Rating : 4.1/5 (282 download)

DOWNLOAD NOW!

Book Synopsis Nutraceuticals by : Ramesh C Gupta

Download or read book Nutraceuticals written by Ramesh C Gupta and published by Academic Press. This book was released on 2021-01-27 with total page 1397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutraceuticals: Efficacy, Safety and Toxicity, Second Edition, brings together everything that is currently known about nutraceuticals and their potential toxic effects. The book introduces readers to nutraceuticals, herbal medicines, Ayurvedic medicines, prebiotics, probiotics, adaptogens, and their uses and specific applications. This essential reference discusses the mechanism of action for the judicious use of these nutraceuticals and the best tools for their evaluation before detailing the safety and toxicity of nutraceuticals and interactions with other therapeutic drugs. Finally, and crucially, regulatory aspects from around the world are covered. Completely revised and updated, this updated edition provides toxicologists, pharmacologists, pharmaceutical scientists, and those interested in medicinal plants and natural products with a comprehensive overview of the most effective tools upon which to evaluate the safety and toxicity of nutraceuticals, prebiotics, probiotics and alternative medicines. - Presents a completely revised and updated resource on the impact of nutraceuticals and various disease states such as diabetes and ophthalmic and dermal diseases - Grants an overview of the current state-of-the-science of nutraceuticals, their use and applications, and known adverse effects - Provides effective tools to evaluate the potential toxicity of any nutraceutical - Includes details of regulatory issues as written by international experts

Pharmacotherapeutic Botanicals for Cancer Chemoprevention

Author : Manish Kumar
Publisher : Springer Nature
ISBN 13 : 9811559996
Total Pages : 344 pages
Book Rating : 4.8/5 (115 download)

DOWNLOAD NOW!

Book Synopsis Pharmacotherapeutic Botanicals for Cancer Chemoprevention by : Manish Kumar

Download or read book Pharmacotherapeutic Botanicals for Cancer Chemoprevention written by Manish Kumar and published by Springer Nature. This book was released on 2020-07-20 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.

Inflammation, Oxidative Stress, and Cancer

Author : Ah-Ng Tony Kong
Publisher : CRC Press
ISBN 13 : 1466503718
Total Pages : 631 pages
Book Rating : 4.4/5 (665 download)

DOWNLOAD NOW!

Book Synopsis Inflammation, Oxidative Stress, and Cancer by : Ah-Ng Tony Kong

Download or read book Inflammation, Oxidative Stress, and Cancer written by Ah-Ng Tony Kong and published by CRC Press. This book was released on 2016-04-19 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and

Challenges in Endocrine Disruptor Toxicology and Risk Assessment

Author : Alberto Mantovani
Publisher : Royal Society of Chemistry
ISBN 13 : 1839160837
Total Pages : 539 pages
Book Rating : 4.8/5 (391 download)

DOWNLOAD NOW!

Book Synopsis Challenges in Endocrine Disruptor Toxicology and Risk Assessment by : Alberto Mantovani

Download or read book Challenges in Endocrine Disruptor Toxicology and Risk Assessment written by Alberto Mantovani and published by Royal Society of Chemistry. This book was released on 2020-12-08 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology – including interactions with other hormone pathways – has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer’s disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an increasing concern given the number commonly found in household products and the environment. This book will cover the mechanisms of EDC pathology across the spectrum of disease, as well as risk assessment and government and legal regulation to provide a holistic view of the current issues and cutting-edge research in the topic. With contributions from global leaders in the field, this book will be an ideal reference for toxicologists, endocrinologists and researchers interested in developmental biology, regulatory toxicology and the interface between environment and human health.

Technical Report Series

Author :
Publisher :
ISBN 13 :
Total Pages : 274 pages
Book Rating : 4.:/5 (9 download)

DOWNLOAD NOW!

Book Synopsis Technical Report Series by :

Download or read book Technical Report Series written by and published by . This book was released on 2008 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Aging and Vulnerability to Environmental Chemicals

Author : Bernard Weiss
Publisher : Royal Society of Chemistry
ISBN 13 : 1849734186
Total Pages : 505 pages
Book Rating : 4.8/5 (497 download)

DOWNLOAD NOW!

Book Synopsis Aging and Vulnerability to Environmental Chemicals by : Bernard Weiss

Download or read book Aging and Vulnerability to Environmental Chemicals written by Bernard Weiss and published by Royal Society of Chemistry. This book was released on 2012 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on how chemical agents may affect the health of aging populations.

Phytomicronutriments

Author : IFN
Publisher : Lavoisier
ISBN 13 : 274306417X
Total Pages : 410 pages
Book Rating : 4.7/5 (43 download)

DOWNLOAD NOW!

Book Synopsis Phytomicronutriments by : IFN

Download or read book Phytomicronutriments written by IFN and published by Lavoisier. This book was released on 2012-04-20 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cet ouvrage répond aux questionnements scientifiques posés sur les effets biologiques des phytomicronutriments (polyphénols, phytostérols, caroténoïdes, glucosinolates…), dans le double contexte de transition nutritionnelle et du vieillissement de la population, et dans le cadre du rôle potentiel de notre alimentation dans la gestion de notre santé. Fruit d'un travail collectif initié par l'Institut français pour la nutrition (IFN) Les phytomicronutriments présente : - une classification des différentes familles de phytomicronutriments, - les principaux facteurs de variation impactant sur les quantités ingérées et sur leur biodisponibilité, car les effets santé des phytomicronutriments dépendent de leurs niveaux de consommation et de leur biodisponibilité, - leur fonctionnalité puis leur impact dans des populations spécifiques (femmes ménopausées, sportifs et personnes âgées), - les bénéfices/risques de quelques classes de molécules, les plus étudiées : phyto-oestrogènes, phytostérols et caroténoïdes, - une illustration de la composition en phytomicronutriments dans des menus types et la possibilité de les repérer dans les aliments sur la base de la couleur de ces derniers. Cet ouvrage s'adresse aux scientifiques, aux professionnels de l'industrie alimentaire, aux professionnels de la santé, aux enseignants et aux étudiants dans le domaine de la nutrition et de la santé.

Endocrine Disruptors, Brain, and Behavior

Author : Heather B. Patisaul
Publisher : Oxford University Press
ISBN 13 : 0199935742
Total Pages : 273 pages
Book Rating : 4.1/5 (999 download)

DOWNLOAD NOW!

Book Synopsis Endocrine Disruptors, Brain, and Behavior by : Heather B. Patisaul

Download or read book Endocrine Disruptors, Brain, and Behavior written by Heather B. Patisaul and published by Oxford University Press. This book was released on 2017-04-10 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our world and bodies are becoming increasingly polluted with chemicals capable of interfering with our hormones and thus, possibly, our present and future neural and mental health. As authors Heather Patisaul and Scott Belcher outline, there is a large lack of data and evidence in this causal relationship, which begs a need for further study to accelerate progress in the endocrinology and neuroendocrinology fields. Endocrine Disruptors, Brain, and Behavior focuses on if and how these chemicals, known as endocrine disrupting compounds (EDCs), affect the development and function of the brain and might be contributing to neural disorders rapidly rising in prevalence. The book provides an overall synthesis of the EDC field, including its historical roots, major hypotheses, key findings, and research gaps. The authors explain why even the concept of endocrine disruption is controversial in some circles, how differing definitions of endocrine disruption and what constitutes an "adverse" outcome on the brain shape public policy, and where the current capacity by different stakeholders (industry, academia, regulatory agencies) to evaluate chemicals for safety in a regulatory context begins and ends. The book concludes with suggestions for future research needs and a summary of emerging technology which might prove capable of more effectively evaluating existing and emerging chemicals for endocrine disrupting properties. As such, it provides the context for interdisciplinary and innovative input from a broad spectrum of fields, including those well-schooled in neuroscience, evolutionary biology, brain, behavior, sex differences, and neuroendocrinology.

Annual Plan for Fiscal Year ...

Author : National Toxicology Program (U.S.)
Publisher :
ISBN 13 :
Total Pages : 208 pages
Book Rating : 4.E/5 ( download)

DOWNLOAD NOW!

Book Synopsis Annual Plan for Fiscal Year ... by : National Toxicology Program (U.S.)

Download or read book Annual Plan for Fiscal Year ... written by National Toxicology Program (U.S.) and published by . This book was released on 2001 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Toxicity Report on Reproductive Dose Range-Finding Study of Genistein (CAS No. 446-72-0) Administered in Feed to Sprague-Dawley Rats

Author : K. Barry Delclos
Publisher : DIANE Publishing
ISBN 13 : 1428988807
Total Pages : 320 pages
Book Rating : 4.4/5 (289 download)

DOWNLOAD NOW!

Book Synopsis Toxicity Report on Reproductive Dose Range-Finding Study of Genistein (CAS No. 446-72-0) Administered in Feed to Sprague-Dawley Rats by : K. Barry Delclos

Download or read book Toxicity Report on Reproductive Dose Range-Finding Study of Genistein (CAS No. 446-72-0) Administered in Feed to Sprague-Dawley Rats written by K. Barry Delclos and published by DIANE Publishing. This book was released on 2008-04 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genistein is a naturally occurring isoflavone that interacts with estrogen receptors & multiple other molecular targets. Human exposure to Genistein is through consumption of soy products, including soy-based infant formula & dietary supplements. A series of short-term studies with Genistein was conducted with two goals: to obtain data necessary to establish dose levels for subsequent multi-generation reproductive & chronic toxicity studies; & to evaluate the effects of Genistein on endpoints outside the reproductive tract. This report focuses on the reproductive & toxicology endpoints. Data obtained in separate evaluations of behavioral, neuroanatomical, neurochemical, & immunological endpoints are also discussed. Illustrations.

Endocrine Disruption and Human Health

Author : Philippa D. Darbre
Publisher : Academic Press
ISBN 13 : 0128011203
Total Pages : 390 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!

Book Synopsis Endocrine Disruption and Human Health by : Philippa D. Darbre

Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2015-03-21 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. - Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health - Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health - Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations

The Molecular Basis of Human Cancer

Author : William B. Coleman
Publisher : Humana Press
ISBN 13 : 1597454583
Total Pages : 868 pages
Book Rating : 4.5/5 (974 download)

DOWNLOAD NOW!

Book Synopsis The Molecular Basis of Human Cancer by : William B. Coleman

Download or read book The Molecular Basis of Human Cancer written by William B. Coleman and published by Humana Press. This book was released on 2016-11-11 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.

The Secret History of the War on Cancer

Author : Devra Davis
Publisher : PublicAffairs
ISBN 13 : 0465015689
Total Pages : 562 pages
Book Rating : 4.4/5 (65 download)

DOWNLOAD NOW!

Book Synopsis The Secret History of the War on Cancer by : Devra Davis

Download or read book The Secret History of the War on Cancer written by Devra Davis and published by PublicAffairs. This book was released on 2009-02-24 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the National Book Award finalist and author of "When Smoke Ran Like Water" comes this searing, haunting, and deeply personal account of how a major public health effort was diverted and distorted for private gain.

Drug Transporters in Drug Disposition, Effects and Toxicity

Author : Xiaodong Liu
Publisher : Springer Nature
ISBN 13 : 9811376476
Total Pages : 588 pages
Book Rating : 4.8/5 (113 download)

DOWNLOAD NOW!

Book Synopsis Drug Transporters in Drug Disposition, Effects and Toxicity by : Xiaodong Liu

Download or read book Drug Transporters in Drug Disposition, Effects and Toxicity written by Xiaodong Liu and published by Springer Nature. This book was released on 2019-09-30 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.