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Targeted Radionuclide Tumor Therapy
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Book Synopsis Targeted Radionuclide Therapy by : Tod W. Speer
Download or read book Targeted Radionuclide Therapy written by Tod W. Speer and published by Lippincott Williams & Wilkins. This book was released on 2012-03-28 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.
Book Synopsis Targeted Radionuclide Tumor Therapy by : Torgny Stigbrand
Download or read book Targeted Radionuclide Tumor Therapy written by Torgny Stigbrand and published by Springer Science & Business Media. This book was released on 2008-09-01 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. While considerable advances have been reported, there is still a signi- cant amount of work left to accomplish before our ambitions can be achieved. It now seems timely to review the accomplishments achieved to date and to clarify the challenges that remain. The choice of radionuclide, the conjugation p- cedure employed, and the selection of suitable targets were early issues that were faced by our field that still persist, however we can now tackle these obstacles with significantly better insight. The expanding array of new targeting molecules (recombinant antibodies, peptides and agents based upon alternate scaffolds) may increase the therapeutic efficacy or even modify the radiation sensitivity of the targeted tumor cell. The title of this book “Targeted Radionuclide Tumour Therapy – Biological Aspects” was selected to reinforce the concept that a major focus of this volume was devoted to understanding the biological effects of targeting and radiation. These important issues have not previously been the primary focus in this context. Furthermore, our rapidly expanding knowledge of different types of cell death and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future.
Book Synopsis Locoregional Radionuclide Cancer Therapy by : Franklin C.L. Wong
Download or read book Locoregional Radionuclide Cancer Therapy written by Franklin C.L. Wong and published by Springer Nature. This book was released on 2020-12-08 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews locoregional radionuclide cancer therapies (LRCT). Proving an increasingly viable alternative to radiotherapy, radionuclide therapy includes a diversity of choices of well characterized biochemical and physiologic target molecules. The delivery and retention of radionuclides may be monitored by advanced imaging for exact tissue localization and for real-time dosimetry to enable personalized precision medicine. Radiopharmaceuticals in human cancer therapies are typically delivered in systemic routes but can also be designed for locoregional routes to harness pharmacokinetic advantages of higher payload and lower systemic toxicities. This book explores the latest advancements and clinical considerations of the locoregional approach. Throughout the chapters, the clinical and scientific bases of cancer treatment and the locoregional use of radionculides are explored. Mathematical models of radiation dosimetry of locoregional radionculdies on tissues are studied using common models for multiple commercially available radionuclides. Rodent and canine tumor models of LRCT are compared for selected radionuclides and radiopharmaceuticals. The practical aspects of radiopharmaceuticals production, marketing, transport, as well as radiation protection are reviewed. Finally, the combination of LRCT with immunotherapy and other cancer therapies and prospective future use of LRCT are discussed. This is a guide for practicing nuclear physicians, interventional radiologists, radiation oncologists, radiation scientists, veterinarians and oncologists to expand their knowledge base and to prepare for designing locoregional radionuclide cancer therapies in animals and in humans.
Book Synopsis Advancing Nuclear Medicine Through Innovation by : National Research Council
Download or read book Advancing Nuclear Medicine Through Innovation written by National Research Council and published by National Academies Press. This book was released on 2007-09-11 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly 20 million nuclear medicine procedures are carried out each year in the United States alone to diagnose and treat cancers, cardiovascular disease, and certain neurological disorders. Many of the advancements in nuclear medicine have been the result of research investments made during the past 50 years where these procedures are now a routine part of clinical care. Although nuclear medicine plays an important role in biomedical research and disease management, its promise is only beginning to be realized. Advancing Nuclear Medicine Through Innovation highlights the exciting emerging opportunities in nuclear medicine, which include assessing the efficacy of new drugs in development, individualizing treatment to the patient, and understanding the biology of human diseases. Health care and pharmaceutical professionals will be most interested in this book's examination of the challenges the field faces and its recommendations for ways to reduce these impediments.
Book Synopsis Nuclear Medicine Therapy by : Cumali Aktolun
Download or read book Nuclear Medicine Therapy written by Cumali Aktolun and published by Springer Science & Business Media. This book was released on 2012-08-31 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Medicine Therapy presents the state of the art in targeted radionuclide therapy, both in clinical practice and contemporary clinical investigation and trials. With contributions from an internationally-distinguished group of physicians and scientists, the book is devoted entirely to the use of nuclear medicine techniques and technology for therapy of malignant and benign diseases. Individual chapters cover the scientific principles and clinical applications of radionuclide therapy and the state of clinical trials of agents currently under investigation in the therapy of tumors involving virtually every organ system. Due to overlapping interest in techniques, indications, and clinical use, the development of radionuclide therapy attracts considerable input from other medical specialists whose collaboration is essential, including radiation and medical oncologists, hematologists, diagnostic radiologists, hepatologists, endocrinologists, and rheumatologists. And because radionuclide therapy is a rapidly evolving field of nuclear medicine, it is the aim of this volume to appeal to all specialists involved in targeted radionuclide therapy and to contribute to the standardization of the practice globally.
Book Synopsis Therapeutic Nuclear Medicine by : Richard P. Baum
Download or read book Therapeutic Nuclear Medicine written by Richard P. Baum and published by Springer. This book was released on 2014-08-16 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent revolution in molecular biology offers exciting new opportunities for targeted radionuclide therapy. This up-to-date, comprehensive book, written by world-renowned experts, discusses the basic principles of radionuclide therapy, explores in detail the available treatments, explains the regulatory requirements, and examines likely future developments. The full range of clinical applications is considered, including thyroid cancer, hematological malignancies, brain tumors, liver cancer, bone and joint disease, and neuroendocrine tumors. The combination of theoretical background and practical information will provide the reader with all the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Careful attention is also paid to the role of the therapeutic nuclear physician in coordinating a diverse multidisciplinary team, which is central to the safe provision of treatment.
Book Synopsis Radiopharmaceuticals for Therapy by : F. F. (Russ) Knapp
Download or read book Radiopharmaceuticals for Therapy written by F. F. (Russ) Knapp and published by Springer. This book was released on 2016-01-20 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides detailed information on therapeutic radiopharmaceuticals and discusses emerging technologies which have potential for broad clinical implementation. Recent advances in molecular biology, radiopharmaceutical chemistry and radioisotope production have stimulated a new era for the use of radiopharmaceuticals for targeted radionuclide therapy (TRT). Emerging clinical trials include use of peptides and monoclonal antibodies radiolabeled with therapeutic radionuclides for cancer therapy. In addition, small molecules are used for the treatment of chronic diseases such as metastatic bone pain palliation and radiation synovectomy of inflammatory joints. In the interventional arena, therapy of primary and metastatic liver cancer and arterial restenosis following angioplasty of both the coronary and peripheral arteries are being explored. Reactor and accelerator production of therapeutic radioisotopes is also integrated into these discussions. The development and use of radiopharmaceutical targeting characteristics required for treatment of specific disease processes and how these are implemented for radiopharmaceutical design strategies are also described. Radiopharmaceuticals for Therapy will benefit audiences in nuclear medicine and radionuclide therapy and will thus prove an invaluable source of up-to-date information for students, radiopharmaceutical scientists and professionals working in the radiopharmacy and nuclear medicine specialties.
Book Synopsis Development and Optimization of Targeted Radionuclide Tumor Therapy Using Folate-based Radiopharmaceuticals by : Josefine Astrid Reber
Download or read book Development and Optimization of Targeted Radionuclide Tumor Therapy Using Folate-based Radiopharmaceuticals written by Josefine Astrid Reber and published by . This book was released on 2013 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Radiopharmaceuticals by : Michael J. Welch
Download or read book Handbook of Radiopharmaceuticals written by Michael J. Welch and published by John Wiley & Sons. This book was released on 2003-01-17 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, authoritative and up-to-date reference for the newcomer to radiopharmaceuticals and those already in the field. Radiopharmaceuticals are used to detect and characterise disease processes, or normal biological function, in living cells, animals or humans. Used as tracer molecules, they map the distribution, uptake and metabolism of the molecule in clinical studies, basic research or applied research. The area of radiopharmaceuticals is expanding rapidly. The number of PET centers in the world is increasing at 20% per year, and many drug companies are utilising PET and other forms of radiopharmaceutical imaging to evaluate products. * Readers will find coverage on a number of important topics such as radionuclide production, PET and drug development, and regulations * Explains how to use radiopharmaceuticals for the diagnosis and therapy of cancer and other diseases * The editors and a majority of the contributors are from the United States
Book Synopsis Somatostatin Analogues by : Alicja Hubalewska-Dydejczyk
Download or read book Somatostatin Analogues written by Alicja Hubalewska-Dydejczyk and published by John Wiley & Sons. This book was released on 2015-06-11 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring chapters from specialists in endocrinology, physiology, pathology, and nuclear medicine, this book provides a multidisciplinary approach to a wide variety of issues concerning somatostatin and its analogues. The book: Provides the most up-to-date coverage of somatostatin analog use in diagnostic and therapy Integrating the specialties of endocrinology, physiology, pathology, and nuclear medicine, providing the multidisciplinary approach to the topic Focuses on future applications, novel compounds, and areas for further research Covers topics by authors who are renowned experts and researchers in the field
Book Synopsis Nuclear Medicine in Oncology by : Gang Huang
Download or read book Nuclear Medicine in Oncology written by Gang Huang and published by Springer. This book was released on 2019-06-11 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces molecular imaging and Target Therapy in various cancers. The first part is the subjects and primary focused on the basics of nuclear physics, radiation dosimetry, nuclear medicine equipment and small animal imaging equipment. The second part is about the radiopharmaceutical and commonly used clinical radiopharmaceuticals, including positron emission imaging agent, single photon emission imaging agent, and radionuclide therapy agents as well as their radioactive preparation, quality control, and a brief clinical application were included. Also, this part introduces a number of new imaging agents which were potential value of clinical applications. In the third part, the clinical application of the conventional imaging agent 18F-FDG in different tumors and neurodegenerative diseases and 18F-Dopa imaging in the nervous system are discussed. Besides the clinical applications of 99mTc labeled radiopharmaceuticals in parathyroid disease, coronary heart disease, myocardial infarction, sentinel lymph node, metastatic bone tumors, liver and gallbladder disease in children are introduced. Finally, the applications of radionuclide 131I on treatments of Graves' disease and differentiated thyroid cancer and metastases are investigated respectively. This book is a useful reference for professionals engaged in nuclear medicine and clinical research, including clinical nuclear medicine physicians, nuclear medicine engineers and nuclear medicine pharmacists.
Book Synopsis Nuclear Medicine and Immunology by : Sara Harsini
Download or read book Nuclear Medicine and Immunology written by Sara Harsini and published by Springer Nature. This book was released on 2021-11-24 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the close connection between immunology and nuclear medicine, which has led to radioimmunoimaging and radioimmunotherapy (RIT). Molecular imaging with positron emission tomography (PET) and single-photon emission computed tomography (SPECT) is increasingly being used to diagnose, characterize, and monitor disease activity in the context of inflammatory disorders of known and unknown etiology, such as sarcoidosis, atherosclerosis, vasculitis, inflammatory bowel disease, rheumatoid arthritis, and degenerative joint disease. The first chapters discuss the various radiopharmaceutical agents and radiolabeled preparations that have been employed in inflammation imaging. Of these, FDG-PET imaging has been shown to have the great value in the detection of inflammation and has become the centerpiece of several initiatives over the last several years. This very powerful technique will play an increasingly important role in the management of patients with inflammatory conditions in the future. The book also explores the growing role of nuclear medicine and molecular imaging in the diagnosis and treatment of cancer. The rapid pace of change has been fueled by advances in our understanding of tumor biology, on the one hand, and the development of specifically targeted medical therapies, diagnostic agents, and radiotherapies, on the other. Written by leading international experts in the field, this book is an invaluable tool for nuclear medicine physicians, radiologists, oncologists, and immunologists.
Book Synopsis Radionuclide Therapy by : Recep Bekiş
Download or read book Radionuclide Therapy written by Recep Bekiş and published by Springer Nature. This book was released on 2022-08-01 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main purpose of this book is to create a reference for the indications, contraindications, patient selection, treatment practice, treatment side effect management, and follow-up of radionuclide treatments. Besides standard methods such as surgery, chemotherapy, radiotherapy, and hormone therapy, newly developed biological treatments, targeted treatments, personalized treatments, external beam radiotherapy, and targeted radionuclide treatments have begun to take their place in professional practice. Nuclear medicine, in addition to its role as a tracer of cancer, also assumes the role of treating with radioactive molecules directed to the cancer it traces. These traceable next-generation radionuclide treatments, whose efficacy and reliability have been proven and where diagnosis, treatment, and follow-up are carried out together, are increasingly included in oncology practice together with the new developed radiopharmaceuticals, ensuring a high rate of damage to cancer cells while protecting the surrounding normal tissues. Molecular cancer treatment will become more effective with individualized next-generation traceable radionuclide treatments, which will be shaped by genetic studies in the future. Radionuclide treatments for many cancer types and benign diseases are presented by experienced nuclear medicine experts in the light of their own experience and case studies, while systemic treatments in common cancer types and side effect management of these treatments are summarized by medical oncologists. This book will be of interest to nuclear medicine physicians as well as oncologists.
Book Synopsis Monte Carlo Modeling of Targeted Radionuclide Therapy of Micrometastases by : Mario Enrique Alcocer Avila
Download or read book Monte Carlo Modeling of Targeted Radionuclide Therapy of Micrometastases written by Mario Enrique Alcocer Avila and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted radionuclide therapy (TRT) is a cancer treatment modality in which radioactive isotopes are coupled to tumor-specific carrier molecules for the selective irradiation of tumor cells. The aim of this thesis is to provide an accurate description of the pattern of energy deposit by some of the most promising Auger electron- and alpha particle-emitting radionuclides currently considered for TRT, by means of accurate Monte Carlo track structure (MCTS) simulations. As part of this doctoral work, the TILDA-V code was extended and improved to include the full slowing-down of alpha particles in water. Radiation transport and dosimetry studies were performed to validate as a whole the capabilities of the latest version of TILDA-V for simulating the interactions of protons, alpha particles and electrons with biological matter. The code was extensively benchmarked against other numerical tools and available experimental data with satisfactory results. The effect on the simulations of changing the description of the biological medium (water versus DNA) was analyzed in detail as well. Furthermore, the various radionuclides of interest were evaluated by computing the absorbed dose to isolated tumor cells and to a small cell cluster representing a micrometastasis.The results of the present work will be valuable to the community of nuclear medicine to understand the relative merits of various radionuclides and to guide the choice of the most adapted radionuclide to arm a targeting molecule, taking into account the clinical setting in oncology.
Book Synopsis Radiopharmaceutical Chemistry by : Jason S. Lewis
Download or read book Radiopharmaceutical Chemistry written by Jason S. Lewis and published by Springer. This book was released on 2019-04-02 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (i.e. nuclear reactions in reactors), heavy element radiochemistry (i.e. the decomposition of radioactive waste), or solely on the clinical applications of radiopharmaceuticals (e.g. the use of PET tracers in oncology). This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic. The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like “The Production of Radionuclides” and “Basics of Radiochemistry”. The second section is the main focus of the book. In this section, each chapter’s author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a “Best of the Rest” chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including “Bioconjugation Methods,” “Click Chemistry in Radiochemistry”, and “Radiochemical Instrumentation.” This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas.
Book Synopsis Combination Targeted Radionuclide Therapy and Immunotherapy for Prostate Cancer by : Hemanth Kumar Potluri
Download or read book Combination Targeted Radionuclide Therapy and Immunotherapy for Prostate Cancer written by Hemanth Kumar Potluri and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: New treatments are needed for metastatic prostate cancer. While patients initially respond to therapies that block the androgen receptor signaling which is required for prostate cancer growth, nearly all patients ultimately develop resistance to androgen deprivation therapy. Immune checkpoint blockade has been highly successful in treating many cancer types which have proved resistant to other lines of therapy, but these treatments have not been successful as monotherapies for prostate cancer. In contrast, the role of radiation therapy for treating prostate cancer has continued to expand. In addition to the long history of treating localized disease with external beam radiation therapy (EBRT), systemic radiation treatments that are able to deliver therapeutic doses to all sites of metastatic disease with relative sparing of healthy tissues have recently been approved. This systemic radiation modality is called targeted radionuclide therapy (TRT). It has been shown that EBRT is capable of sensitizing poorly immunogenic tumors to respond to immunotherapy through several activating effects on immune populations within the tumor. However, it is unknown whether TRT agents, which are more appropriate for widely metastatic disease, can elicit similar effects on the prostate tumor microenvironment and enhance the efficacy of immunotherapies. In particular, we focused on characterizing NM600, an alkylphosphocholine TRT agent which is taken up by several tumor types, including prostate cancer, and can be radiolabeled with multiple different radiometals. The overarching hypothesis of this work is that TRT, delivered via NM600, can remodel the prostate tumor microenvironment, rendering it susceptible to treatment with immunotherapy. We first evaluated the effects of 90Y-labeled NM600 alone on mouse prostate tumor allograft models. We found that 90Y-NM600 elicited a dose-dependent anti-tumor response but did not cause tumor regression even at the highest tolerated doses. Within 90Y-NM600-treated tumors, we observed an initial infiltration of activated, effector memory CD8+ T cells, but observed high PD-1 and PD-L1 expression over time. Based on these data, we investigated the effects of 90Y-NM600 together with PD-1 blockade. We found that this combination did not significantly improve anti-tumor efficacy due to the activating effects of PD-1 blockade on regulatory T cells. Next, we evaluated 90Y-NM600 in combination with tumor-specific vaccination. Specifically, we used a DNA vaccine encoding the ligand-binding domain of the androgen receptor which our lab has shown to elicit antigen-specific CD8+ T cell responses in both rodent models and in humans. We hypothesized that since we found that TRT could increase CD8+ T cell infiltration and promote an effector memory CD8+ T cell response, treatment with this vaccine would favor antigen-specific CD8+ T cell infiltration into the tumor following TRT administration. We found that the combination of single treatment TRT at the highest tolerated dose and vaccine did not improve anti-tumor efficacy despite a further initial increase in effector memory CD8+ T cells in the tumors of combination treated animals. However, two doses of TRT given three weeks apart in combination with vaccine did appear to improve anti-tumor efficacy possibly through decreasing PD-1 and PD-L1 signaling. We also observed that while 6 Gy of TRT and 6 Gy of EBRT were equally ineffective at improving anti-tumor response in combination with vaccine, increasing the dose of EBRT to 12 Gy did result in an additive anti-tumor response. Finally, we compared the effects of NM600 labeled with different radioisotopes, specifically the beta emitter 177Lu and the alpha emitter 225Ac, on our prostate tumor models. We found that 225Ac-NM600 treatment elicited a stronger anti-tumor effect than 177Lu-NM600. 225Ac-NM600 treatment also resulted in a bias towards activated, memory CD8+ T cells with sustained depletion of Tregs within the tumor. This suggests that 225Ac-NM600 may be the superior choice of radioisotope for combination with immunotherapy. Overall, these data demonstrate that the efficacy of TRT and immunotherapy combinations appear to be heavily dependent on the dose, fractionation, and type of radiation used, as well as specific effects of the chosen immunotherapy on cell types whose presence are promoted by the radiation. Further investigation into radiation and immunotherapy combinations are warranted due to the highly translatable nature of these findings.
Book Synopsis Radionuclide Peptide Cancer Therapy by : Marco Chinol
Download or read book Radionuclide Peptide Cancer Therapy written by Marco Chinol and published by CRC Press. This book was released on 2016-04-19 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering lower toxicity and higher accuracy than conventional therapies, this source offers illustrative coverage of this new method to treat tumors associated with brain, breast, lung, and neuroendocrine cancers. Accompanied by a CD offering color images, radiolabeling procedures, and tips on radiopharmceutical administration, this source will off
