Targeted Drug Delivery Concepts And Design

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Targeted Drug Delivery : Concepts and Design

Author : Padma V. Devarajan
Publisher : Springer
ISBN 13 : 3319113550
Total Pages : 790 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Targeted Drug Delivery : Concepts and Design by : Padma V. Devarajan

Download or read book Targeted Drug Delivery : Concepts and Design written by Padma V. Devarajan and published by Springer. This book was released on 2014-12-08 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.

Drug Targeting And Delivery

Author : H.E. Junginger
Publisher : CRC Press
ISBN 13 : 9780132204682
Total Pages : 276 pages
Book Rating : 4.2/5 (46 download)

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Book Synopsis Drug Targeting And Delivery by : H.E. Junginger

Download or read book Drug Targeting And Delivery written by H.E. Junginger and published by CRC Press. This book was released on 1992-10-31 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a review of the structure and function of biological membranes and other cellular barriers used in drug transport. It discusses a range of concepts for drug delivery systems, treating the routes of drugs with regard to their characteristics: function, structure, uptake, mechanism and effect. The book also explores the interface between pharmaceutical technology and physiological principles in drug design, a field of increased importance to industry.

Advanced Drug Delivery

Author : Ashim Mitra
Publisher : John Wiley & Sons
ISBN 13 : 1118662849
Total Pages : 844 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Advanced Drug Delivery by : Ashim Mitra

Download or read book Advanced Drug Delivery written by Ashim Mitra and published by John Wiley & Sons. This book was released on 2013-08-26 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases. Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts: Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book. Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.

Design of Controlled Release Drug Delivery Systems

Author : Xiaoling Li
Publisher : McGraw Hill Professional
ISBN 13 : 0071588833
Total Pages : 453 pages
Book Rating : 4.0/5 (715 download)

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Book Synopsis Design of Controlled Release Drug Delivery Systems by : Xiaoling Li

Download or read book Design of Controlled Release Drug Delivery Systems written by Xiaoling Li and published by McGraw Hill Professional. This book was released on 2005-11-24 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of every drug delivery system is to deliver the precise amount of a drug at a pre-programmed rate to the desired location in order to achieve the drug level necessary for the treatment. An essential guide for biomedical engineers and pharmaceutical designers, this resource combines physicochemical principles with physiological processes to facilitate the design of systems that will deliver medication at the time and place it is most needed.

Targeted Drug Delivery

Author : Rudolph L. Juliano
Publisher : Springer Science & Business Media
ISBN 13 : 3642758622
Total Pages : 374 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Targeted Drug Delivery by : Rudolph L. Juliano

Download or read book Targeted Drug Delivery written by Rudolph L. Juliano and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chapters in this volume describe a powerful emerging approach for the therapy of disease. Targeted drug delivery, that is control of the kinetic behavior, tissue distribution, and subcellular localization of pharmaco logically active agents, offers an important means for improving the efficacy of a wide variety of drug therapies. This is particularly true for therapeutic approaches based on newer agents which are the products of recombinant DNA research. These agents, be they peptides, proteins, or oligonucleotides, tend to be larger, more complex, and less stable than traditional drugs. Thus they stand to benefit most from drug delivery systems which can protect them from premature degradation and which can carry them to critical target sites in the body. This volume examines several important aspects of the current state of drug delivery research; it also attempts to project future directions for this field. Successful approaches to drug targeting are based, first of all, on a sophisticated understanding of the biological barriers encountered by the drug-carrier complex as it moves from the portal of administration to the ultimate target site. A second aspect of successful drug delivery is appro priate matching of the disease entity with the pharmacologically active substance and with the delivery system. Thus it is important to be aware of the variety of delivery technologies which currently exist and to be sensitive to their strengths and limitations.

Smart Polymeric Nano-Constructs in Drug Delivery

Author : Suresh P Vyas
Publisher : Academic Press
ISBN 13 : 0323913997
Total Pages : 626 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Smart Polymeric Nano-Constructs in Drug Delivery by : Suresh P Vyas

Download or read book Smart Polymeric Nano-Constructs in Drug Delivery written by Suresh P Vyas and published by Academic Press. This book was released on 2022-11-12 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems. Provides comprehensive overview of the potential role of polymeric systems in drug delivery Explores the design, synthesis, and application of different smart material-based delivery systems Includes fundamental and clinical applications

Drug Targeting and Stimuli Sensitive Drug Delivery Systems

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
ISBN 13 : 0128136901
Total Pages : 836 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Drug Targeting and Stimuli Sensitive Drug Delivery Systems by : Alexandru Mihai Grumezescu

Download or read book Drug Targeting and Stimuli Sensitive Drug Delivery Systems written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2018-05-21 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Targeting and Stimuli Sensitive Drug Delivery Systems covers recent advances in the area of stimuli sensitive drug delivery systems, providing an up-to-date overview of the physical, chemical, biological and multistimuli-responsive nanosystems. In addition, the book presents an analysis of clinical status for different types of nanoplatforms. Written by an internationally diverse group of researchers, it is an important reference resource for both biomaterials scientists and those working in the pharmaceutical industry who are looking to help create more effective drug delivery systems. Shows how the use of nanomaterials can help target a drug to specific tissues and cells Explores the development of stimuli-responsive drug delivery systems Includes case studies to showcase how stimuli responsive nanosystems are used in a variety of therapies, including camptothecin delivery, diabetes and cancer therapy

Transformative Concepts for Drug Design: Target Wrapping

Author : Ariel Fernandez
Publisher : Springer Science & Business Media
ISBN 13 : 3642117929
Total Pages : 230 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Transformative Concepts for Drug Design: Target Wrapping by : Ariel Fernandez

Download or read book Transformative Concepts for Drug Design: Target Wrapping written by Ariel Fernandez and published by Springer Science & Business Media. This book was released on 2010-04-28 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of the enticing promises of the post-genomic era, the pharmaceutical world is in a state of disarray. Drug discovery seems now riskier and more uncertain than ever. Thus, projects get routinely terminated in mid-stage clinical trials, new targets are getting harder to find, and successful therapeutic agents are often recalled as unanticipated side effects are discovered. Exploiting the huge output of genomic studies to make safer drugs has proven to be much more difficult than anticipated. More than ever, the lead in the pharmaceutical industry depends on the ability to harness innovative research, and this type of innovation can only come from one source: fundamental knowledge. This book squarely addresses this crucial problem since it introduces fundamental discoveries in basic biomolecular research that hold potential to broaden the technological base of the pharmaceutical industry. The book takes a fresh and fundamental look at the problem of how to design an effective drug with controlled specificity. Since the novel transformative concepts are unfamiliar to most practitioners, the first part of this book explains matters very carefully starting from a fairly elementary physico-chemical level. The second part of the book is devoted to practical applications, aiming at nothing less than a paradigm shift in drug design. This book is addressed to scientists working at the cutting edge of research in the pharmaceutical industry, but the material is at the same time accessible to senior undergraduates or graduate students interested in drug discovery and molecular design.

Silk-based Drug Delivery Systems

Author : Elia Bari
Publisher : Royal Society of Chemistry
ISBN 13 : 1788017722
Total Pages : 243 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Silk-based Drug Delivery Systems by : Elia Bari

Download or read book Silk-based Drug Delivery Systems written by Elia Bari and published by Royal Society of Chemistry. This book was released on 2020-10-07 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin.

Nanocarriers for Drug Delivery

Author : Josimar O. Eloy
Publisher : Springer Nature
ISBN 13 : 3030633896
Total Pages : 347 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Nanocarriers for Drug Delivery by : Josimar O. Eloy

Download or read book Nanocarriers for Drug Delivery written by Josimar O. Eloy and published by Springer Nature. This book was released on 2021 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers basic aspects of different nanoparticles, including type of materials, lipid, polymeric and inorganic structures, synthesis strategies, as well as the main physicochemical characterization techniques. Moreover, this book addresses applications for both treatment and diagnosis of diseases, highlighting in vitro and in vivo findings and clinical evaluation. The chapters highlight the main barriers for drug delivery which can benefit from nanoencapsulation: the topical and oral routes. The main innovations in the field, such as gene therapy and functionalization of nanoparticles with a variety of moieties, including monoclonal antibodies for selective delivery, are discussed and illustrated with examples. Finally, the application of nanoparticles for drug delivery to cancer is reviewed considering toxicology and regulatory aspects.

Advanced Technology for Delivering Therapeutics

Author : Sabyasachi Maiti
Publisher : BoD – Books on Demand
ISBN 13 : 9535131214
Total Pages : 186 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Advanced Technology for Delivering Therapeutics by : Sabyasachi Maiti

Download or read book Advanced Technology for Delivering Therapeutics written by Sabyasachi Maiti and published by BoD – Books on Demand. This book was released on 2017-05-11 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of any novel drug delivery system is to provide therapeutic benefits to the patients by increasing duration of drug action, reducing dosing frequency, and controlling drug release rate at the target site, thereby reducing unwanted side effects. Advanced Technology for Delivering Therapeutics is a reference book that covers recent developments in the field of drug delivery science and technology. The purpose of this book is to bring together descriptions of some selective technologies including new and promising nanotechnology currently being investigated for drug delivery applications. This book is a useful source of information for graduate and post-graduate students of pharmacy and biomedical science; pharmaceutical

NOVEL DRUG DELIVERY SYSTEM

Author : Dr. N.G. Raghavendra Rao
Publisher : JEC PUBLICATION
ISBN 13 : 9358501693
Total Pages : 267 pages
Book Rating : 4.3/5 (585 download)

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Book Synopsis NOVEL DRUG DELIVERY SYSTEM by : Dr. N.G. Raghavendra Rao

Download or read book NOVEL DRUG DELIVERY SYSTEM written by Dr. N.G. Raghavendra Rao and published by JEC PUBLICATION. This book was released on with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fascinating world of "Novel Drug Delivery Systems" is yours to explore. In this book, we set out on a thrilling voyage through the constantly changing field of drug distribution, where groundbreaking discoveries and fresh ideas are revolutionizing how we use and perceive medication. It is our honor to expose to the enormous world of innovative drug delivery systems and explore their principles, uses, and promise to transform healthcare as the author of this comprehensive resource. This book's rigorous planning ensures a thorough comprehension of the subject matter by covering a broad variety of subjects that line up with the drug delivery systems curriculum. We go into the fundamentals of controlled medication delivery systems in Unit-I. We discuss controlled release formulation language, meanings, and justifications. We investigate the design concepts of diffusion, dissolution, and ion exchange for creating controlled release formulations. We also look at drug formulation-relevant physicochemical and biological characteristics. Polymers and the creation of formulations and we categorize polymers according to their characteristics and talk about their benefits for controlled release medication delivery systems. Methods for microencapsulation are introduced in Unit II. We explore implantable drug delivery devices and acquire understanding of mucosal drug delivery systems, including bioadhesion and mucoadhesion concepts. Transdermal drug delivery methods are examined in Unit-III, with an emphasis on skin penetration and the variables that affect it. We look into transdermal medication delivery system components and permeability enhancers. We also explore techniques for delivering gastroretentive drugs, such as floating and high-density systems, inflatable systems, and gastro sticky systems. We address nasal and pulmonary routes, formulation strategies, and delivery devices as we examine the Nasopulmonary drug delivery system. Targeted drug delivery is the subject of Unit-IV, which examines theories, methods, and the potential of liposomes, niosomes, nanoparticles, and monoclonal antibodies.

Drug Delivery

Author : Eric P. Holowka
Publisher : Springer
ISBN 13 : 1493919989
Total Pages : 355 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Drug Delivery by : Eric P. Holowka

Download or read book Drug Delivery written by Eric P. Holowka and published by Springer. This book was released on 2014-11-22 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current pharmaceutical and clinical approaches to the treatment of disease suffer from the inherent limitations in the specialization of drugs introduced to physiological systems. The interface of clinical and material sciences has allowed for a broad spectrum of creative approaches with the potential to alleviate these shortcomings. However, the synergy of these disciplines also presents problems in which nascent technology lacks the necessary evaluation within its intended clinical environment. Given the growing potential for materials science to address a number of unanswered therapeutic needs, it remains even more pressing to validate emerging drug delivery technologies in actual clinical environments. Drug Delivery: Materials Design and Clinical Perspective addresses the core fundamentals of drug delivery using material science and engineering principles, and then applies this knowledge using prominent examples from both the scientific literature and clinical practice. Each chapter focuses on a specific drug delivery technology, such as controlled-release materials, thin-film materials, or smart materials. Within each chapter, an initial section on “Engineering Concepts” reviews the relevant fundamental principles that guide rational design. The following section on “Materials Design” discusses how the design process applies engineering concepts for use in physiological systems. A third section on “Implementation” discusses current approaches in the literature which have demonstrated effective drug delivery in controlled environments. Finally, each chapter contains several sections on “Clinical Applications” which describe the validity of materials approaches from a clinical perspective; these sections review the safety and efficacy of drug delivery systems for specific, compelling medical applications. The book thereby bridges materials science with clinical medicine, and provides the reader with a bench-to-bedside view of novel drug delivery systems. · Provides a comprehensive description of drug delivery systems from a materials perspective · Includes a wide-ranging discussion of clinical applications of drug delivery systems · Presents separate chapters on controlled release materials, thin film materials, self-microemulsifying materials, smart materials, etc. · Covers fundamental engineering principles, rational materials design, implementation testing, and clinical applications for each material type

Nanotherapeutics

Author : Alf Lamprecht
Publisher : CRC Press
ISBN 13 : 9814241164
Total Pages : 292 pages
Book Rating : 4.8/5 (142 download)

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Book Synopsis Nanotherapeutics by : Alf Lamprecht

Download or read book Nanotherapeutics written by Alf Lamprecht and published by CRC Press. This book was released on 2016-04-19 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely book provides an overview of possible therapeutic applications. The first part of the book highlights general properties of and phenomena observed with nanoparticles, and the subsequent consequences for applications in drug delivery. The second part focuses on the therapeutic approaches that are possible through the use of nanoparticles, with each chapter discussing a specific disease (e.g., diabetes, cancer, inflammation) and the relevant therapeutic approaches based on the design of nanoparticulate drug delivery systems. From this concise book, readers will gain an insight into the basics of nanoparticle preparation and find a more detailed account of what is therapeutically feasible by using nanoparticle approaches.

Drug Delivery

Author : Anya M Hillery
Publisher : CRC Press
ISBN 13 : 1482217740
Total Pages : 634 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Drug Delivery by : Anya M Hillery

Download or read book Drug Delivery written by Anya M Hillery and published by CRC Press. This book was released on 2016-09-15 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive introduction to advanced drug delivery and targeting, covering their principles, current applications, and potential future developments. This edition has been updated to reflect significant trends and cutting-edge advances that have occurred since the first edition was published. All the original chapters have been retained, but the material therein has been updated. Eight new chapters have been added that deal with entirely new technologies and approaches. Features: Offers a comprehensive introduction to the fundamental concepts and underlying scientific principles of drug delivery and targeting Presents an in-depth analysis of the opportunities and obstacles afforded by the application of nanotechnologies for drug delivery and targeting Includes a revised and expanded section on the major epithelial routes of drug delivery currently under investigation Describes the most recent, emerging, and innovative technologies of drug delivery Provides real-life examples of the clinical translation of drug delivery technologies through the use of case studies Discusses the pertinent regulatory hurdles and safety issues of drug delivery and targeting systems—crucial considerations in order to achieve licensing approval for these new technologies

Retrometabolic Drug Design and Targeting

Author : Nicholas Bodor
Publisher : John Wiley & Sons
ISBN 13 : 1118407768
Total Pages : 546 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Retrometabolic Drug Design and Targeting by : Nicholas Bodor

Download or read book Retrometabolic Drug Design and Targeting written by Nicholas Bodor and published by John Wiley & Sons. This book was released on 2012-08-29 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.

Targeted Delivery of Small and Macromolecular Drugs

Author : Ajit S. Narang
Publisher : CRC Press
ISBN 13 : 1420087738
Total Pages : 630 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Targeted Delivery of Small and Macromolecular Drugs by : Ajit S. Narang

Download or read book Targeted Delivery of Small and Macromolecular Drugs written by Ajit S. Narang and published by CRC Press. This book was released on 2010-05-12 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice. Focusing on the delivery technologies that utilize both systemic and local rou