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Tactics Of Organic Synthesis
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Book Synopsis Strategies and Tactics in Organic Synthesis by : Michael Harmata
Download or read book Strategies and Tactics in Organic Synthesis written by Michael Harmata and published by Academic Press. This book was released on 2004-11-03 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title provides a forum for investigators to discuss their approach to the science and art of organic synthesis in a unique way. There are stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners.
Book Synopsis Strategies and Tactics in Organic Synthesis by : Thomas Lindberg
Download or read book Strategies and Tactics in Organic Synthesis written by Thomas Lindberg and published by Academic Press. This book was released on 2012-12-02 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategies and Tactics in Organic Synthesis, Volume 3 provides detailed accounts of interesting advances in the field of synthesis. This book discusses the tasks of multistep synthesis from finding the proper reagents, reaction, and conditions for individual steps to inventing new chemistry to fill gaps in existing synthetic methodology. Organized into 13 chapters, this volume begins with an overview of the development of redox glycosidation strategy through ester methylenation. This text then examines the development of computer-assisted molecular modeling with applications to a wide range of problems in biological and organic chemistry. Other chapters consider the medicinal significance of ginkgo tree, which has prompted systematic studies to correlate the claimed beneficial effects of its extracts to the active principles. This book discusses as well the biological potency of pentacyclic quassinoids. The final chapter deals with the economic synthesis of a penem antibacterial. This book is a valuable resource for chemists.
Book Synopsis Classics in Total Synthesis by : K. C. Nicolaou
Download or read book Classics in Total Synthesis written by K. C. Nicolaou and published by John Wiley & Sons. This book was released on 1996-04-11 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.
Download or read book Organic Synthesis written by W A Smit and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: The view of organic synthesis as "a concentrated expression of predictive ability and creative capacity" was advocated in the early 1950s. A concise and readable account of the role of synthesis in modern science, Organic Synthesis: The Science Behind the Art presents the general ideology of pursuits in the area of organic synthesis, and examines the methodologies that have evolved in the search for solutions to synthetic problems. This unique book details outstanding achievements of modern organic synthesis, not only for their scientific merits, but also for the aesthetic appeal of the target molecules chosen and the intrinsic beauty of the solutions to the problems posed. By judicious selection of data covering the main areas of synthetic explorations, this book serves to illustrate both the evolution of well-known approaches as well as recently emerged trends most likely to determine the future development of organic synthesis. Special attention is given to the consideration of principles of molecular design in promising and challenging areas of current research. Primarily aimed at advanced undergraduate and graduate students, Organic Synthesis: The Science Behind the Art will also be of interest to teachers, researchers and anyone requiring an introduction to the problems of organic synthesis.
Book Synopsis Strategies and Tactics in Organic Synthesis by : Michael Harmata
Download or read book Strategies and Tactics in Organic Synthesis written by Michael Harmata and published by Academic Press. This book was released on 2004-04-29 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.- Personal accounts of research in organic chemistry. - Written by internationally renowned scientists.- Details state of the art organic synthesis.
Book Synopsis From Biosynthesis to Total Synthesis by : Alexandros L. Zografos
Download or read book From Biosynthesis to Total Synthesis written by Alexandros L. Zografos and published by John Wiley & Sons. This book was released on 2016-04-18 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field
Book Synopsis Strategies and Tactics in Organic Synthesis by :
Download or read book Strategies and Tactics in Organic Synthesis written by and published by Elsevier. This book was released on 2004-08-13 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.- Personal accounts of research in organic chemistry. - Written by internationally renowned scientists. - Details state of the art organic synthesis.
Book Synopsis Molecular Rearrangements in Organic Synthesis by : Christian M. Rojas
Download or read book Molecular Rearrangements in Organic Synthesis written by Christian M. Rojas and published by John Wiley & Sons. This book was released on 2015-10-26 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed for practitioners of organic synthesis, this book helps chemists understand and take advantage of rearrangement reactions to enhance the synthesis of useful chemical compounds. Provides ready access to the genesis, mechanisms, and synthetic utility of rearrangement reactions Emphasizes strategic synthetic planning and implementation Covers 20 different rearrangement reactions Includes applications for synthesizing compounds useful as natural products, medicinal compounds, functional materials, and physical organic chemistry
Download or read book Organic Synthesis written by Paul Wyatt and published by John Wiley & Sons. This book was released on 2013-05-20 with total page 55 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Synthesis: Strategy and Control is the long-awaited sequel to Stuart Warren's bestseller Organic Synthesis: The Disconnection Approach, which looked at the planning behind the synthesis of compounds. This unique book now provides a comprehensive, practical account of the key concepts involved in synthesising compounds and focuses on putting the planning into practice. The two themes of the book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work. The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. * A comprehensive, practical account of the key concepts involved in synthesising compounds * Takes a mechanistic approach, which explains reactions and gives guidelines on how reactions might behave in different situations * Focuses on reactions that really work rather than those with limited application * Contains extensive, up-to-date references in each chapter Students and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.
Book Synopsis Workbook for Organic Synthesis by : Paul Wyatt
Download or read book Workbook for Organic Synthesis written by Paul Wyatt and published by Wiley. This book was released on 2008-07-08 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: This workbook accompanies Organic Synthesis: Strategy and Control, the bestselling advanced organic textbook Provides a complete course for advanced organic students and includes a graded set of problems, solutions and discussions to illustrate and develop the themes of each of the chapters in the textbook
Book Synopsis Strategies and Tactics in Organic Synthesis by : Thomas Lindberg
Download or read book Strategies and Tactics in Organic Synthesis written by Thomas Lindberg and published by Academic Press. This book was released on 1989-01-11 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a unique account of the synthesis of organic molecules. All of the contributors are acknowledged experts in organic synthesis.
Book Synopsis Strategies and Tactics in Organic Synthesis by : Thomas Lindberg
Download or read book Strategies and Tactics in Organic Synthesis written by Thomas Lindberg and published by Elsevier. This book was released on 2013-10-22 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a unique account of the synthesis of organic molecules. All of the contributors are acknowledged experts in organic synthesis.
Book Synopsis Strategies and Tactics in Organic Synthesis by : Michael F. Greaney
Download or read book Strategies and Tactics in Organic Synthesis written by Michael F. Greaney and published by Elsevier Inc. Chapters. This book was released on 2013-07-29 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt: This chapter describes the synthesis of two related sesquiterpenes, anislactone A and merrilactone A. We initially accessed a tetracyclic oxetane in the merrilactone series using a Paternò–Büchi reaction but found the compound to be too underfunctionalized to advance further. We then developed an approach based on reductive epoxide ring opening, whereby a fully elaborated C-ring epoxy-cyclopentane, containing five stereocenters, could undergo reductive epoxide cleavage when treated with Ti(III). The resulting tertiary radical then participates in a 5-exo-dig cyclization onto a pendant alkyne to afford the complete carbon skeleton of both natural products. From this point, orthogonal functionalization routes enabled the synthesis of both anislactone A and merrilactone A. A second-generation merrilactone A synthesis is then described, growing out of discoveries made over the course of the first route in the area of cyclopentannulation. An iodo-aldol method was used to develop an approach to the anislactone skeleton and succeeded in producing the BC bicycle with good stereocontrol and functional group tolerance. Further functionalization, however, did not prove possible due to excessive steric hindrance around the incorporated iodo group preventing any productive transformation. This problem was solved by switching the nucleophile in the tandem-aldol process to cyanide. The resulting domino cyanide-addition aldol cyclization was then successfully employed in the formal synthesis of merrilactone A, using a late-stage [2+2] photocycloaddition to access the D-ring.
Book Synopsis Introduction to Strategies for Organic Synthesis by : Laurie S. Starkey
Download or read book Introduction to Strategies for Organic Synthesis written by Laurie S. Starkey and published by John Wiley & Sons. This book was released on 2018-05-01 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the Gap Between Organic Chemistry Fundamentals and Advanced Synthesis Problems Introduction to Strategies of Organic Synthesis bridges the knowledge gap between sophomore-level organic chemistry and senior-level or graduate-level synthesis to help students more easily adjust to a synthetic chemistry mindset. Beginning with a thorough review of reagents, functional groups, and their reactions, this book prepares students to progress into advanced synthetic strategies. Major reactions are presented from a mechanistic perspective and then again from a synthetic chemist’s point of view to help students shift their thought patterns and teach them how to imagine the series of reactions needed to reach a desired target molecule. Success in organic synthesis requires not only familiarity with common reagents and functional group interconversions, but also a deep understanding of functional group behavior and reactivity. This book provides clear explanations of such reactivities and explicitly teaches students how to make logical disconnections of a target molecule. This new Second Edition of Introduction to Strategies for Organic Synthesis: Reviews fundamental organic chemistry concepts including functional group transformations, reagents, stereochemistry, and mechanisms Explores advanced topics including protective groups, synthetic equivalents, and transition-metal mediated coupling reactions Helps students envision forward reactions and backwards disconnections as a matter of routine Gives students confidence in performing retrosynthetic analyses of target molecules Includes fully-worked examples, literature-based problems, and over 450 chapter problems with detailed solutions Provides clear explanations in easy-to-follow, student-friendly language Focuses on the strategies of organic synthesis rather than a catalogue of reactions and modern reagents The prospect of organic synthesis can be daunting at the outset, but this book serves as a useful stepping stone to refresh existing knowledge of organic chemistry while introducing the general strategies of synthesis. Useful as both a textbook and a bench reference, this text provides value to graduate and advanced undergraduate students alike.
Book Synopsis Worked Solutions in Organic Chemistry by : James M. Coxon
Download or read book Worked Solutions in Organic Chemistry written by James M. Coxon and published by CRC Press. This book was released on 1997-12-18 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates and teaches the finer details of the tactics and strategies employed in the synthesis of organic molecules. As well as providing model answers to the problems, the book discusses, in detail, the reasons why particular strategies are chosen, and why, in given circumstances, alternative methods or routes may or may not be appropriate. As such it could be used as a stand alone volume for the teaching of organic chemistry with a modern and appropriate emphasis on synthesis. Extensive cross referencing to Principles of Organic Synthesis allows the two books to be used as companion volumes.
Book Synopsis The Way of Synthesis by : Tomas Hudlicky
Download or read book The Way of Synthesis written by Tomas Hudlicky and published by Wiley-VCH. This book was released on 2007-09-04 with total page 1032 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-colored textbook presents not only synthetic ways to design organic compounds, it also contains a compilation of the most important total synthesis of the last 50 years with a comparative view of multiple designs for the same targets. It explains different tactics and strategies, making it easy to apply to many problems, regardless of the synthetic question in hand. Following a historical view of the evolution of synthesis, the book goes on to look at principles and issues impacting synthesis and design as well as principles and issues of methods. The sections on comparative design cover classics in terpenes and alkaloid synthesis, while a further section covers such miscellaneous syntheses as Maytansine, Palytoxin, Brevetoxin B and Indinavir. The whole is rounded off with a look at future perspectives and, what makes this textbook extraordinairy, with personal recollections of the chemists, who synthesized these fascinating compounds. With its attractive layout highlighting key parts and tactics using a second color, this is a useful tool for organic chemists, lecturers and students in chemistry, as well as those working in the chemical industry. "I think, as will many organic chemists, that the Hudlicky book will be the Bible of synthetic organic chemistry, the past, the present and the future. A hallmark publication." (Victor Snieckus)
Book Synopsis Modern Organic Synthesis by : George S. Zweifel
Download or read book Modern Organic Synthesis written by George S. Zweifel and published by John Wiley & Sons. This book was released on 2017-03-13 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book bridges the gap between sophomore and advanced / graduate level organic chemistry courses, providing students with a necessary background to begin research in either an industry or academic environment. • Covers key concepts that include retrosynthesis, conformational analysis, and functional group transformations as well as presents the latest developments in organometallic chemistry and C–C bond formation • Uses a concise and easy-to-read style, with many illustrated examples • Updates material, examples, and references from the first edition • Adds coverage of organocatalysts and organometallic reagents
