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Systems Biological Approaches In Infectious Diseases
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Book Synopsis Systems Biological Approaches in Infectious Diseases by : Helena I. Boshoff
Download or read book Systems Biological Approaches in Infectious Diseases written by Helena I. Boshoff and published by Springer Science & Business Media. This book was released on 2007-01-15 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together the various fields of functional genomics and systems biology that provide information on metabolic function. There is special emphasis on the identification of drug targets. The book includes practical examples from the various "omic" sciences as well as theoretical examples of how integrated knowledge of these sciences can be applied to drug discovery. It is of interest to researchers in the pharmaceutical drug discovery environment.
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genetics and Evolution of Infectious Diseases by : Michel Tibayrenc
Download or read book Genetics and Evolution of Infectious Diseases written by Michel Tibayrenc and published by Elsevier. This book was released on 2010-12-17 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics and Evolution of Infectious Diseases is at the crossroads between two major scientific fields of the 21st century: evolutionary biology and infectious diseases. The genomic revolution has upset modern biology and has revolutionized our approach to ancient disciplines such as evolutionary studies. In particular, this revolution is profoundly changing our view on genetically driven human phenotypic diversity, and this is especially true in disease genetic susceptibility. Infectious diseases are indisputably the major challenge of medicine. When looking globally, they are the number one killer of humans and therefore the main selective pressure exerted on our species. Even in industrial countries, infectious diseases are now far less under control than 20 years ago. The first part of this book covers the main features and applications of modern technologies in the study of infectious diseases. The second part provides detailed information on a number of the key infectious diseases such as malaria, SARS, avian flu, HIV, tuberculosis, nosocomial infections and a few other pathogens that will be taken as examples to illustrate the power of modern technologies and the value of evolutionary approaches. Takes an integrated approach to infectious diseases Includes contributions from leading authorities Provides the latest developments in the field
Book Synopsis Systems Biology Approaches: Prevention, Diagnosis, and Understanding Mechanisms of Complex Diseases by : Sanket Joshi
Download or read book Systems Biology Approaches: Prevention, Diagnosis, and Understanding Mechanisms of Complex Diseases written by Sanket Joshi and published by Springer Nature. This book was released on with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Systems Biology by : Michael G. Katze
Download or read book Systems Biology written by Michael G. Katze and published by Springer Science & Business Media. This book was released on 2013-01-04 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies—oligonucleotide microarrays, mass spectrometry, and next-generation sequencing—and the analysis of this data through sophisticated mathematical algorithms. It is perhaps the use of mathematics, to integrate abundant and diverse types of data and to generate models of interconnected molecular networks, that best characterizes systems biology.
Book Synopsis Integrative Computational Systems Biology Approaches in Immunology and Medicine by : Lars Kaderali
Download or read book Integrative Computational Systems Biology Approaches in Immunology and Medicine written by Lars Kaderali and published by Frontiers Media SA. This book was released on 2019-04-09 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Computational Systems Biology by : Helder I Nakaya
Download or read book Computational Systems Biology written by Helder I Nakaya and published by Elsevier Inc. Chapters. This book was released on 2013-11-26 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Science and Applications of Synthetic and Systems Biology by : Institute of Medicine
Download or read book The Science and Applications of Synthetic and Systems Biology written by Institute of Medicine and published by National Academies Press. This book was released on 2011-12-30 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Book Synopsis What You Need to Know about Infectious Disease by : Madeline Drexler
Download or read book What You Need to Know about Infectious Disease written by Madeline Drexler and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Treating Infectious Diseases in a Microbial World by : National Research Council
Download or read book Treating Infectious Diseases in a Microbial World written by National Research Council and published by National Academies Press. This book was released on 2006-01-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.
Book Synopsis Systems Biology of Microbial Infection by : Reinhard Guthke
Download or read book Systems Biology of Microbial Infection written by Reinhard Guthke and published by Frontiers E-books. This book was released on with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: The systems biology of microbial infections aims at describing and analysing the confrontation of the host with bacterial and fungal pathogens. It intends to understand and to model the interaction of the host, in particular the immune system of humans or animals, with components of pathogens. This comprises experimental studies that provide spatio-temporal data from monitoring the response of host and pathogenic cells to perturbations or when interacting with each other, as well as the integrative analysis of genome-wide data from both the host and the pathogen. In perspective, the host-pathogen interaction should be described by a combination of spatio-temporal models with interacting molecular networks of the host and the pathogen. The aim is to unravel the main mechanisms of pathogenicity, to identify diagnostic biomarkers and potential drug targets, and to explore novel strategies for personalized therapy by computer simulations. Some microorganisms are part of the normal microbial flora, existing either in a mutualistic or commensal relationship with the host. Microorganisms become pathogenic if they posses certain physiological characteristics and virulence determinants as well as capabilities for immune evasion. Despite the different pathogenesis of infections, there are several common traits: (1) Before infection, pathogens must be able to overcome (epithelial) barriers. The infection starts by adhesion and colonization and is followed by entering of the pathogen into the host through the mucosa or (injured) skin. (2) Next, infection arises if the pathogen multiplies and overgrows the normal microbial flora, either at the place of entrance or in deeper tissue layers or organs. (3) After the growth phase, the pathogen damages the host’s cells, tissues and organs by producing toxins or destructive enzymes. Thus, systems biology of microbial infection comprises all levels of the pathogen and the host’s immune system. The investigation may start with the pathogen, its adhesion and colonization at the host, its interaction with host cell types e.g. epithelia cells, dendritic cells, macrophages, neutrophils, natural killer cells, etc. Because infection diseases are mainly found in patients with a weakened immune system, e.g. reduced activities of immune effector cells or defects in the epithelial barriers, systems biology of infection can also start with modelling of the immune defence including innate and adaptive immunity. Systems biological studies comprise both experimental and theoretical approaches. The experimental studies may be dedicated to reveal the relevance of certain genes or proteins in the above mentioned processes on the side of the pathogen and/or the host by applying functional and biochemical analyses based on knock-out mutants and knock- down experiments. At the theoretical, i.e. mathematical and computational, side systems biology of microbial infection comprises: (1) modelling of molecular mechanisms of bacterial or fungal infections, (2) modelling of non-protective and protective immune defences against microbial pathogens to generate information for possible immune therapy approaches, (3) modelling of infection dynamics and identification of biomarkers for diagnosis and for individualized therapy, (4) identifying essential virulence determinants and thereby predicting potential drug targets.
Book Synopsis Infectious Disease Modeling by : Xinzhi Liu
Download or read book Infectious Disease Modeling written by Xinzhi Liu and published by Springer. This book was released on 2017-02-25 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents infectious diseases modeled mathematically, taking seasonality and changes in population behavior into account, using a switched and hybrid systems framework. The scope of coverage includes background on mathematical epidemiology, including classical formulations and results; a motivation for seasonal effects and changes in population behavior, an investigation into term-time forced epidemic models with switching parameters, and a detailed account of several different control strategies. The main goal is to study these models theoretically and to establish conditions under which eradication or persistence of the disease is guaranteed. In doing so, the long-term behavior of the models is determined through mathematical techniques from switched systems theory. Numerical simulations are also given to augment and illustrate the theoretical results and to help study the efficacy of the control schemes.
Book Synopsis Janeway's Immunobiology by : Kenneth Murphy
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Book Synopsis Molecular Infection Biology by : Jörg Hinrich Hacker
Download or read book Molecular Infection Biology written by Jörg Hinrich Hacker and published by Wiley-Spektrum. This book was released on 2002-10-03 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume focuses on molecular methods and principles of prokaryotic and eukaryotic pathogens. The authors present the molecular and cellular aspects by focusing on the interactions between pathogenic microorganisms and their hosts. The publication begins with an overview of the most important and dangerous causative agents of infectious diseases. Next are discussions of how microbial "weapons," pathogenicity factors, protein secretion machines, and surface variation systems work, presenting the molecular and genetic methods that are used by scientists for their discovery and analysis. Furthermore, infectious diseases are discussed in light of the newly formed research areas of evolutionary and cellular microbiology and genomics. Future aspects on diagnostic techniques, therapy, and vaccine development are also presented.
Book Synopsis Viral Pathogenesis by : Michael G. Katze
Download or read book Viral Pathogenesis written by Michael G. Katze and published by Academic Press. This book was released on 2015-12-30 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis Provides a fresh perspective on the approaches used to understand how viruses cause disease Features molecular profiling techniques, whole genome sequencing, and innovative computational methods Highlights the use of contemporary approaches and the insights they provide to the field
Book Synopsis Infectious Disease: A Very Short Introduction by : Marta Wayne
Download or read book Infectious Disease: A Very Short Introduction written by Marta Wayne and published by OUP Oxford. This book was released on 2015-06-25 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: As doctors and biologists have learned, to their dismay, infectious disease is a moving target: new diseases emerge every year, old diseases evolve into new forms, and ecological and socioeconomic upheavals change the transmission pathways by which disease spread. By taking an approach focused on the general evolutionary and ecological dynamics of disease, this Very Short Introduction provides a general conceptual framework for thinking about disease. Ecology and evolution provide the keys to answering the 'where', 'why', 'how', and 'what' questions about any particular infectious disease: where did it come from? How is it transmitted from one person to another, and why are some individuals more susceptible than others? What biochemical, ecological, and evolutionary strategies can be used to combat the disease? Is it more effective to block transmission at the population level, or to block infection at the individual level? Through a series of case studies, Benjamin Bolker and Marta L. Wayne introduce the major ideas of infectious disease in a clear and thoughtful way, emphasising the general principles of infection, the management of outbreaks, and the evolutionary and ecological approaches that are now central to much research about infectious disease. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Book Synopsis The Immune System and Infectious Diseases by : Erwin Neter
Download or read book The Immune System and Infectious Diseases written by Erwin Neter and published by . This book was released on 1975 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt:
