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Systemic Treatment Of Non Small Cell Lung Cancer
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Book Synopsis Systemic Treatment of Non-Small Cell Lung Cancer by : Giuseppe Giaccone
Download or read book Systemic Treatment of Non-Small Cell Lung Cancer written by Giuseppe Giaccone and published by OUP Oxford. This book was released on 2012-05-31 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is the leading cause of cancer mortality worldwide, and non-small cell lung cancer (NSCLC) accounts for about 85% of all cases of lung cancer. Most patients present with advanced disease and five-year survival is low at about 15%. Surgery is the main treatment for early stage disease. If patients are deemed inoperable, systemic chemotherapy is considered. For patients with locally advanced disease, multimodality therapy is administered where chemotherapy is given in combination with definitive radiation therapy or surgery in selected cases. Cytotoxic chemotherapy regimens mainly consist of a platinum doublet. Biologic agents are increasingly being incorporated into treatment regimens. This pocketbook summarises the latest evidence-based and practical information on the use of systemic therapies in the management of non-small cell lung cancer (NSCLC), for early stage, locally advanced, and metastatic disease. Including contributions from leading thoracic oncologists from North America and Europe, the book covers the range of therapies currently available to clinicians including cytotoxic chemotherapy, biologic therapies, and other novel agents. This book will serve as an invaluable reference for all health care professionals involved in the management of patients with NSCLC.
Book Synopsis Advances in Systemic Therapy for Non-Small Cell Lung Cancer , An Issue of Thoracic Surgery Clinics by : Jessica Donington
Download or read book Advances in Systemic Therapy for Non-Small Cell Lung Cancer , An Issue of Thoracic Surgery Clinics written by Jessica Donington and published by Elsevier Health Sciences. This book was released on 2020-05-11 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Thoracic Surgery Clinics, guest edited by Drs. Jyoti Patel and Jessica Donington, is devoted to Advances in Systemic Therapy for Non-Small Cell Lung Cancer. Drs. Patel and Donington have assembled expert authors to review the following topics: Adjuvant and Neoadjuvant Immunotherapy; Combining Immunotherapy with Radiation in Lung Cancer; Adjuvant Chemotherapy; ALK Mutations; Molecular Targets Beyond the Big 3; Advances in Systemic Therapy; Liquid Biopsies in NSCLC; Combining Immunotherapy and Chemotherapy for NSCLC; ROS-1 Mutations; EGFR Mutations; and more!
Book Synopsis Fast Facts: Non-Small-Cell Lung Cancer by : Mary O'Brien
Download or read book Fast Facts: Non-Small-Cell Lung Cancer written by Mary O'Brien and published by Karger Medical and Scientific Publishers. This book was released on 2022-02-28 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite an overall decrease in tobacco use, lung cancer (80–85% of which is non-small-cell lung cancer [NSCLC]) is still the leading cause of cancer death in both men and women worldwide. Annual low-dose CT screening of high-risk individuals has the potential to detect early-stage tumors, which can usually be successfully treated with a combination of surgery, radiotherapy and chemotherapy and, in some cases, targeted therapy. However, most patients with NSCLC still present with advanced or metastatic disease. For these patients, initial therapy is guided by the tumor’s molecular characteristics and patient’s performance status. Targeted therapies have significantly improved clinical outcomes and, for some patients with no targetable genetic alterations, immunotherapy has demonstrated significant overall survival benefit. This insightful guide is designed to bring you up to speed with the latest developments and is important reading for all health professionals and medical trainees working in this fast-moving field. Table of Contents: • Prevention and screening • Diagnosis and staging • Surgery • Radiotherapy • Systemic therapy in non-metastatic NSCLC • Systemic therapy in advanced-stage/metastatic disease without a molecular driver • Personalized treatment in advanced NSCLC • Oligometastatic disease and brain metastases
Book Synopsis Targeted Therapies for Lung Cancer by : Ravi Salgia
Download or read book Targeted Therapies for Lung Cancer written by Ravi Salgia and published by Springer. This book was released on 2019-06-26 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.
Book Synopsis Epidemiology of Lung Cancer by : Jonathan M. Samet
Download or read book Epidemiology of Lung Cancer written by Jonathan M. Samet and published by CRC Press. This book was released on 1994-03-08 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a historical perspective on the etiology of lung cancer, this comprehensive reference presents an in-depth analysis of the epidemiology of cancer of the lung-describing the current understanding of risk factors and the use of epidemiological data to design programs for the control of this leading cause of death worldwide.
Book Synopsis Stereotactic Body Radiation Therapy by : Simon S. Lo
Download or read book Stereotactic Body Radiation Therapy written by Simon S. Lo and published by Springer Science & Business Media. This book was released on 2012-08-28 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.
Book Synopsis Systemic Treatment for Patients with Advanced Non-Small Cell Lung Cancer by : P. M. Ellis
Download or read book Systemic Treatment for Patients with Advanced Non-Small Cell Lung Cancer written by P. M. Ellis and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Histological Typing of Lung and Pleural Tumours by : W.D. Travis
Download or read book Histological Typing of Lung and Pleural Tumours written by W.D. Travis and published by Springer. This book was released on 1999 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: with contributions by Pathologists from 14 Countries
Book Synopsis Treatment for Non Small Cell Lung Cancer in Distinct Patient Populations by : Junji Uchino
Download or read book Treatment for Non Small Cell Lung Cancer in Distinct Patient Populations written by Junji Uchino and published by Frontiers Media SA. This book was released on 2022-02-24 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advances in Systemic Therapy for Non-Small Cell Lung Cancer, an Issue of Thoracic Surgery Clinics, Volume 30-2 by : Jessica Donington
Download or read book Advances in Systemic Therapy for Non-Small Cell Lung Cancer, an Issue of Thoracic Surgery Clinics, Volume 30-2 written by Jessica Donington and published by Elsevier. This book was released on 2020-05-05 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Thoracic Surgery Clinics, guest edited by Drs. Jyoti Patel and Jessica Donington, is devoted to Advances in Systemic Therapy for Non-Small Cell Lung Cancer. Drs. Patel and Donington have assembled expert authors to review the following topics: Adjuvant and Neoadjuvant Immunotherapy; Combining Immunotherapy with Radiation in Lung Cancer; Adjuvant Chemotherapy; ALK Mutations; Molecular Targets Beyond the Big 3; Advances in Systemic Therapy; Liquid Biopsies in NSCLC; Combining Immunotherapy and Chemotherapy for NSCLC; ROS-1 Mutations; EGFR Mutations; and more!
Book Synopsis Geriatric Oncology by : Martine Extermann
Download or read book Geriatric Oncology written by Martine Extermann and published by Springer. This book was released on 2020-01-30 with total page 1150 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended as a comprehensive resource for clinicians and researchers seeking in-depth information on geriatric oncology. The coverage encompasses epidemiology, the biology and (patho)physiology of aging and cancer, geriatric assessment and management, hematologic malignancies, solid tumors, issues in patient care, and research methods. Since cancer is a disease of aging and people are living longer, most cancer patients are now aged 70 and older. Yet the more we age, the more diverse we become in terms of our health, biologic fitness, and cancer behavior. Typically, however, general oncology clinical trials address only a selected healthier and younger population of patients. Geriatric oncology is the area of oncology that addresses these issues but while a wealth of knowledge has been accumulated, information is often difficult to retrieve or insufficiently detailed. The SpringerReference program, in which this book is published, offers an ideal format for overcoming these limitations since it combines thorough coverage with access to living editions constantly updated chapter by chapter via a dynamic peer-review process, ensuring that information remains current and pertinent.
Book Synopsis Systemic Treatments in Advanced-stage Non-small Cell Lung Cancer in California by : Frances Belda Maguire
Download or read book Systemic Treatments in Advanced-stage Non-small Cell Lung Cancer in California written by Frances Belda Maguire and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is the second most common cancer and the leading cancer-related cause of death in both men and women. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, comprising approximately 84% of all lung cancer. Approximately half of patients with NSCLC are diagnosed at an advanced stage when survival rates are very poor (5 year survival of 4.5% for distant disease). Systemic therapies are the primary treatment for patients with advanced-stage disease. In the past two decades, many new systemic therapies have been developed. These treatments have been shown to increase survival in clinical trials, but their use and effectiveness at the population-level is unknown. The present study was based on data collected by the California Cancer Registry (CCR), California’s statewide cancer surveillance system. The CCR collects types of systemic treatment in an unstructured free-text format. In Chapter 1, we manually reviewed treatment text fields in the CCR to determine first-line systemic therapies used in patients with stage IV NSCLC and associations with survival. Chapter 2 explored the relationship between systemic therapy use and source of health insurance. Finally, in Chapter 3, we developed a SAS-based text mining algorithm to extract treatment information from unstructured free-text fields and compared the results to manual review. Our findings indicate that the treatments associated with a significant survival advantage (tyrosine kinase inhibitors and bevacizumab combinations versus platinum doublets) for advanced-stage nonsquamous NSCLC were underutilized among the over 14,000 patients included in our study. Substantial disparities in the use of systemic therapies exist by health insurance type in California. Patients with Medicaid, military, or no insurance have significantly decreased odds of receiving tyrosine kinase inhibitors, bevacizumab combinations, or any systemic treatment at all. Our SAS-based text mining algorithm accurately detected systemic treatments administered to stage IV NSCLC patients, with Kappa ranging from 0.71 to 0.92, and may become a viable alternative to the considerable time involved in manual review of patient records. Our algorithm can be applied to other cancer types, potentially maximizing the utility of extant information in cancer registries for comparative effectiveness research.
Download or read book Lung Cancer written by Anne C. Chiang and published by Springer Nature. This book was released on 2021-09-30 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer has seen a paradigm shift in disease treatment over the past few years, with major changes in the therapeutic drugs now available as well as in the overall management approach. For targeted and immunotherapeutic approaches, understanding the biology of acquired resistance is a key strategy that has yielded productive advances in the subsequent treatment. Future advances also include incorporating biomarker data obtained from solid and liquid biopsies, as well as combination of immunotherapy with radiotherapy and in special populations such patients with CNS involvement.
Book Synopsis Lung Cancer, An Issue of Hematology/Oncology Clinics, E-Book by : Roy S. Herbst
Download or read book Lung Cancer, An Issue of Hematology/Oncology Clinics, E-Book written by Roy S. Herbst and published by Elsevier Health Sciences. This book was released on 2016-12-03 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics will focus on lung cancer; specifically, Genomics in lung cancer; Neoadjuvant and adjuvant therapy for NSCLC; Treatment of locally advanced NSCLC; First line systemic therapy for NSCLC; Second line chemotherapy and beyond for NSCLC; Treatment of EGFR mutant tumors; Treatment of ALK positive tumors; New targets in NSCLC; Immunotherapy; Advances in Small cell lung cancer; and many more!
Book Synopsis Thoracic Malignancies by : Steven E. Schild, MD
Download or read book Thoracic Malignancies written by Steven E. Schild, MD and published by Demos Medical Publishing. This book was released on 2010-03-08 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoracic Malignancies: Thoracic Malignancies is the first title in Radiation Medicine Rounds. These tumors take more lives than any others and they are among the most preventable of tumors. Thus it is crucial for the practitioner to be up-to-date on the latest insights regarding their management. Thoracic Malignancies addresses the multi-disciplinary nature of the care of these tumors. There is representation from radiation oncology, medical oncology, and surgery ensuring a well-rounded summarization of current practice. Included are chapters on lung cancer, esophageal cancer, and thymomas providing coverage of the vast majority of thoracic tumors. The multi-disciplinary nature of the articles provides readers with an up-to-date summary and a well-rounded review regarding these tumors and their care. Expert authors provide reviews and assessments of the most recent data and its implications for current clinical practice, along with insights into emerging new trends of importance for the near future. About the Series Radiation Medicine Rounds is an invited review publication providing a thorough analysis of new scientific, technologic, and clinical advances in all areas of radiation medicine. There is an emphasis throughout on multidisciplinary approaches to the specialty, as well as on quality and outcomes analysis. Published three times a year Radiation Medicine Rounds provides authoritative, thorough assessments of a wide range of Ïhot topicsÓ and emerging new data for the entire specialty of radiation medicine. Features of Radiation Medicine Rounds include: Editorial board of nationally recognized experts across the spectrum of radiation medicine In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Radiation Medicine Issues edited by an authority in specific subject area Focuses on major topics in Radiation Medicine with in-depth articles covering advances in radiation science radiation medicine technology, radiation medicine practice, and assessment of recent quality and outcomes studies Emphasizes multidisciplinary approaches to research and practice
Book Synopsis Precision Medicine in Cancer Therapy by : Daniel D. Von Hoff
Download or read book Precision Medicine in Cancer Therapy written by Daniel D. Von Hoff and published by Springer. This book was released on 2019-06-17 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest advances in precision medicine in some of the most common cancer types, including hematological, lung and breast malignancies. It also discusses emerging technologies that are making a significant impact on precision medicine in cancer therapy. In addition to describing specific approaches that have already entered clinical practice, the book explores new concepts and tools that are being developed. Precision medicine aims to deliver personalized healthcare tailored to a patient’s genetics, lifestyle and environment, and cancer therapy is one of the areas in which it has flourished in recent years. Documenting the latest advances, this book is of interest to physicians and clinical fellows in the front line of the war on cancer, as well as to basic scientists working in the fields of cancer biology, drug development, biomarker discovery, and biomedical engineering. The contributing authors include translational physicians with first-hand experience in precision patient care.
Book Synopsis Controversies in the Local Management of Lung Cancer by : John M. Varlotto
Download or read book Controversies in the Local Management of Lung Cancer written by John M. Varlotto and published by Frontiers Media SA. This book was released on 2018-08-30 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special edition of Frontiers in Oncology reviews the current efficacy and limitations of surgical and radiotherapeutic management of lung cancer and provides insight into how local management options may change in the future.
