Systemic Lupus Erythematosus: Pathogenesis and Treatment

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Publisher : American Medical Publishers
ISBN 13 : 9781639272136
Total Pages : 228 pages
Book Rating : 4.2/5 (721 download)

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Book Synopsis Systemic Lupus Erythematosus: Pathogenesis and Treatment by : Jasper Meyer

Download or read book Systemic Lupus Erythematosus: Pathogenesis and Treatment written by Jasper Meyer and published by American Medical Publishers. This book was released on 2021-11-16 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic lupus erythematosus (SLE) is a medical condition whereby the body's natural defense system targets the healthy tissues of the body. SLE is caused by a defect of the immune system that may arise due to a genetic susceptibility coupled with an environmental trigger. Vitamin D deficiency is another factor associated with lupus. Genetic studies show that SLE is an oligogenic trait with multiple genes contributing to it. The immune response once triggered produces antibodies against itself, and specifically the proteins in the cell nucleus. Since SLE involves a number of different organ systems and exhibit a multitude of symptoms, its treatment is ideally based on its severity. The treatment of SLE is aimed at preventing flares, reducing the severity of flares and their duration when they occur. Treatment can comprise of anti-malarial drugs, immunosuppressive drugs, analgesics and intravenous immunoglobulins. This book contains some path-breaking studies in systemic lupus erythematosus. Also included in this book is a detailed explanation of the pathogenesis and treatment of systemic lupus erythematosus. The topics covered herein offer the readers new insights in this condition.

Systemic Lupus Erythematosus

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Publisher :
ISBN 13 : 9789462995390
Total Pages : 185 pages
Book Rating : 4.9/5 (953 download)

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Book Synopsis Systemic Lupus Erythematosus by :

Download or read book Systemic Lupus Erythematosus written by and published by . This book was released on 2017 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Systemic Lupus Erythematosus - Predisposition Factors, Pathogenesis, Diagnosis, Treatment and Disease Models

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832511996
Total Pages : 264 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Systemic Lupus Erythematosus - Predisposition Factors, Pathogenesis, Diagnosis, Treatment and Disease Models by : Kutty Selva Nandakumar

Download or read book Systemic Lupus Erythematosus - Predisposition Factors, Pathogenesis, Diagnosis, Treatment and Disease Models written by Kutty Selva Nandakumar and published by Frontiers Media SA. This book was released on 2023-01-30 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pathogenesis of Systemic Lupus Erythematosus

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Author :
Publisher : Springer Nature
ISBN 13 : 3030851613
Total Pages : 192 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Pathogenesis of Systemic Lupus Erythematosus by : Alberta Hoi

Download or read book Pathogenesis of Systemic Lupus Erythematosus written by Alberta Hoi and published by Springer Nature. This book was released on 2021-11-15 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.

Lupus Erythematosus

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461411890
Total Pages : 266 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Lupus Erythematosus by : Peter H. Schur

Download or read book Lupus Erythematosus written by Peter H. Schur and published by Springer Science & Business Media. This book was released on 2012-07-06 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Often considered the prototypic autoimmune disease, Lupus is characterized by protean manifestations and affects a wide range of organ systems. Despite widespread availability of anti nuclear antibody testing and other technological diagnostic advances, the diagnosis of lupus can be elusive, difficult, and inexact. Treatment of the disease can also be challenging. Advances in immunology and biotechnology have led to a burgeoning world of new therapies in development that offer patients the real possibility of new therapies and physicians and scientists novel insights into the pathogenesis of this complicated immunological disease. Lupus Erythematosus: Clinical Evaluation and Treatment summarizes the clinical aspects of lupus facing the general clinician in the 21st century. In this invaluable, practical book, the reader will find introductory chapters regarding general diagnostic and treatment principles, followed by chapters addressing the lupus-specific organ manifestations. Special topics regarding pregnancy and comorbidities are also presented. Written by highly experienced physicians with special expertise in lupus, Lupus Erythematosus: Clinical Evaluation and Treatment is an indispensable reference for the common and not so common problems affecting patients with lupus.

Current Rheumatology Diagnosis & Treatment

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Author :
Publisher : McGraw-Hill/Appleton & Lange
ISBN 13 :
Total Pages : 532 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Current Rheumatology Diagnosis & Treatment by : John B. Imboden

Download or read book Current Rheumatology Diagnosis & Treatment written by John B. Imboden and published by McGraw-Hill/Appleton & Lange. This book was released on 2004 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: An ideal quick reference for primary care providers, specialists, and trainees, this accessible resource offers up-to-date assessment and management solutions for the entire range of rheumatologic diseases.

Systemic Lupus Erythematosus E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323070876
Total Pages : 607 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Systemic Lupus Erythematosus E-Book by : George Tsokos

Download or read book Systemic Lupus Erythematosus E-Book written by George Tsokos and published by Elsevier Health Sciences. This book was released on 2007-02-23 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find ‘one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment. Provides the very latest understanding of the pathogenesis of SLE. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more. Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage. Contains expert discussion of processes that are responsible for tissue injury - a hallmark of this text. Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAP's, and therapies on the horizon. Discusses the latest treatment options on disease modifying or disease controlling agents.

The Role of Regulatory T Cells and Interleukin-2 in the Pathogenesis and Treatment of Systemic Lupus Erythematosus

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Author :
Publisher :
ISBN 13 :
Total Pages : 92 pages
Book Rating : 4.:/5 (932 download)

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Book Synopsis The Role of Regulatory T Cells and Interleukin-2 in the Pathogenesis and Treatment of Systemic Lupus Erythematosus by :

Download or read book The Role of Regulatory T Cells and Interleukin-2 in the Pathogenesis and Treatment of Systemic Lupus Erythematosus written by and published by . This book was released on 2015 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neuropsychiatric Systemic Lupus Erythematosus

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Publisher :
ISBN 13 : 9783319764979
Total Pages : pages
Book Rating : 4.7/5 (649 download)

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Book Synopsis Neuropsychiatric Systemic Lupus Erythematosus by : Shunsei Hirohata

Download or read book Neuropsychiatric Systemic Lupus Erythematosus written by Shunsei Hirohata and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropsychiatric manifestation in systemic lupus erythematosus (NPSLE) is one of the most recalcitrant complications of the disease. According to the 1999 ACR nomenclature and case definitions, diffuse psychiatric/neuropsychological syndromes in NPSLE (anxiety disorder, acute confusional state, cognitive dysfunction, mood disorder, psychosis) (diffuse NPSLE) present psychiatric manifestations unlike neurologic syndromes (focal NPSLE) originating from focal CNS lesions, such as cerebrovascular disease, demyelinating syndrome, headache, aseptic meningitis, chorea, seizures and myelopathy. A number of studies have reported that diffuse NPSLE is usually associated with the presence of autoantibodies against neuronal cells in serum as well as in cerebrospinal fluid (CSF). Moreover, IL-6 has been shown to be elevated in CSF of patients with diffuse NPSLE. Recently, it has been demonstrated that the severity of blood-brain barrier damages plays a crucial role in the development of acute confusional state, the severest form of diffuse NPSLE through the accelerated entry of larger amounts of autoantibodies to NMDA receptor subunit NR2 into the CNS. Since the importance of autoantibodies in the NPSLE has been now evident, such an aggressive treatment, especially B cell depleting therapy, would make sense in that it would reduce the levels of pathogenic autoantibodies, leading to a better prognosis of NPSLE. As far as we know, no single book specifically dedicated to NPSLE alone has been published as yet. As mentioned above, NPSLE constitutes a vastly expanding field of research with increasing numbers of papers published annually. Therefore, we believe that an effort to collect and critically review these publications is invaluable. Such an effort will provide an important contribution to basic researchers as well as clinicians working in the field of neurology, rheumatology, psychiatry and internal medicine fields.

Lupus

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Publisher : Springer Science & Business Media
ISBN 13 : 1592597033
Total Pages : 727 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Lupus by : Gary M. Kammer

Download or read book Lupus written by Gary M. Kammer and published by Springer Science & Business Media. This book was released on 1999-05-04 with total page 727 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading basic and clinical investigators from around the world summarize the most recent research on the molecular and cellular origins of lupus. Their cutting-edge articles review the mechanisms underlying abnormal immunity and introduce the powerful new concept that a disorder of multiple genes underlies the abnormal immune response, leading directly to the development of lupus. This pathophysiology is shown to involve a wide variety of cell types, including T cells, B cells, natural killer cells, macrophages/monocytes, and endothelial cells. Over time, the resulting long-term inflammation causes irreversible cell destruction and, ultimately, organ failure. Lupus: Molecular and Cellular Pathogenesis is a masterful new synthesis of all the new knowledge emerging today about lupus. Its new perspectives will sharpen the focus of research and ultimately lead to better and more effective treatment.

Dubois' Lupus Erythematosus

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Author :
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781793940
Total Pages : 1516 pages
Book Rating : 4.7/5 (939 download)

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Book Synopsis Dubois' Lupus Erythematosus by : Daniel Jeffrey Wallace

Download or read book Dubois' Lupus Erythematosus written by Daniel Jeffrey Wallace and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 1516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established for forty years as the definitive reference on lupus, Dubois' Lupus Erythematosus is now in its thoroughly revised, updated Seventh Edition. More than ninety distinguished contributing authors—twenty of them new to this edition—provide comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. This edition focuses on evidence-based findings, treatment consensuses, and practical clinical information. New chapters cover cytokines and interferons, pathogenesis of atherosclerosis, immune tolerance, clinical indices in assessment of lupus, mixed connective tissue disease, reproductive issues, fibromyalgia, gender-related issues, and biomarkers.

Cohort Studies in Health Sciences

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Author :
Publisher :
ISBN 13 : 1789236940
Total Pages : 73 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Cohort Studies in Health Sciences by : René Mauricio Barría

Download or read book Cohort Studies in Health Sciences written by René Mauricio Barría and published by . This book was released on 2018-09 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Th2-Associated Immunity in The Pathogenesis of Systemic Lupus Erythematosus and Rheumatoid Arthritis

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889767027
Total Pages : 126 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Th2-Associated Immunity in The Pathogenesis of Systemic Lupus Erythematosus and Rheumatoid Arthritis by : Qingjun Pan

Download or read book Th2-Associated Immunity in The Pathogenesis of Systemic Lupus Erythematosus and Rheumatoid Arthritis written by Qingjun Pan and published by Frontiers Media SA. This book was released on 2022-08-04 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Role of Regulatory T Cells and Interleukin-2 in the Pathogenesis and Treatment of Systemic Lupus Erythematosus

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Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (929 download)

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Book Synopsis The Role of Regulatory T Cells and Interleukin-2 in the Pathogenesis and Treatment of Systemic Lupus Erythematosus by : Caroline Spee-Mayer

Download or read book The Role of Regulatory T Cells and Interleukin-2 in the Pathogenesis and Treatment of Systemic Lupus Erythematosus written by Caroline Spee-Mayer and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Systemic Lupus Erythematosus

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323044344
Total Pages : 602 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Systemic Lupus Erythematosus by : George C. Tsokos

Download or read book Systemic Lupus Erythematosus written by George C. Tsokos and published by Elsevier Health Sciences. This book was released on 2007-01-01 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find 'one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment. Provides the very latest understanding of the pathogenesis of SLE. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more. Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage. Contains expert discussion of processes that are responsible for tissue injury - a hallmark of this text. Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAP's, and therapies on the horizon. Discusses the latest treatment options on disease modifying or disease controlling agents.

Dubois' Lupus Erythematosus and Related Syndromes E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 1455728179
Total Pages : 783 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Dubois' Lupus Erythematosus and Related Syndromes E-Book by : Daniel Wallace

Download or read book Dubois' Lupus Erythematosus and Related Syndromes E-Book written by Daniel Wallace and published by Elsevier Health Sciences. This book was released on 2012-09-27 with total page 783 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognized for more than 45 years as the definitive text in the field, Dubois’ Lupus Erythematosus and Related Syndromes strikes the perfect balance between basic science and clinical expertise, providing the evidence-based findings, treatment consensuses, and practical clinical information you need to confidently diagnose and manage SLE. Broaden your understanding with comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. Experience clinical scenarios with vivid clarity through a heavily illustrated, full-color format which includes fundamental images of lupus rashes as well as graphs, algorithms, and differential diagnosis comparisons. Discover the latest in systemic lupus erythematosus with new chapters on important emerging topics such as socioeconomic and disability aspects; and rigorously updated chapters that include expanded coverage of the nervous system, and the most in-depth discussion of immunity and regulatory cells. Learn from the very best. World-renowned rheumatologists Drs. Daniel Wallace and Bevra Hannahs Hahn, along with new associate editors Drs. Michael Weisman, Ronald Van Vollenhoven, Nan Shen, and David Isenberg, present definitive coverage on new and rapidly changing areas in the field. Rely on it anytime, anywhere! Access the full text, image bank, and bonus online-only chapters at www.expertconsult.com. Dubois’ Lupus Erythematosus was first published in 1966. For the past forty years, the product has distinguished itself internationally as the go-to reference on lupus and related diseases. For rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on systemic lupus erythematosus (SLE) and related disorders, this product delivers a complete arsenal of information on SLE, connective tissue diseases, and the antiphospholipid syndromes.

Mechanisms by which SLE-Associated Genetic Variants Contribute to SLE Pathogenesis

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889633705
Total Pages : 130 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Mechanisms by which SLE-Associated Genetic Variants Contribute to SLE Pathogenesis by : José Carlos Crispín

Download or read book Mechanisms by which SLE-Associated Genetic Variants Contribute to SLE Pathogenesis written by José Carlos Crispín and published by Frontiers Media SA. This book was released on 2020-01-23 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: