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Author : Milena Kasprzyk
Publisher :
ISBN 13 :
Total Pages : 342 pages
Book Rating : 4.:/5 (387 download)
Download or read book Synthetic Studies Towards the Tridachione Family of Marine Natural Products written by Milena Kasprzyk and published by . This book was released on 2008 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Oscar Ortiz Escribano
Publisher :
ISBN 13 :
Total Pages : 356 pages
Book Rating : 4.:/5 (125 download)
Download or read book Synthetic Studies Towards the Marine Natural Product Amphidinolide H written by Oscar Ortiz Escribano and published by . This book was released on 2007 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kimberley Jade Powell
Publisher : Springer
ISBN 13 : 9783319369815
Total Pages : 136 pages
Book Rating : 4.3/5 (698 download)
Download or read book Synthetic and Biophysical Studies on the Tridachiahydropyrone Family of Natural Products written by Kimberley Jade Powell and published by Springer. This book was released on 2016-10-22 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis addresses fundamental scientific questions such as: How are complex natural products synthesized in vivo? Can we replicate these conditions in a laboratory environment? What is the biological function of such secondary metabolites? What are the biological origins of chirality? These issues are explored in an accessible manner using a multidisciplinary approach spanning chemistry, biology and physics to investigate an interesting family of complex natural products isolated from marine molluscs – the tridachiahydropyrones. The work has achieved: Elegant biomimetic syntheses of a number of the tridachiahydropyrone compounds in vitro using organic synthesis techniques The characterization of the interactions between these compounds and a range of model membrane systems using a series of fluorescence spectroscopic studies The investigation of the antioxidant and photoprotective properties of the compounds by means of biophysical assay techniques The synthesis of tridachiahydropyrone utilizing the model membrane systems as biomimetic reaction media.
Author : G. H. Churchill
Publisher :
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.:/5 (125 download)
Download or read book Synthetic Studies Towards the Marine Natural Product Diazonamide A written by G. H. Churchill and published by . This book was released on 2005 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : James Edward MacIntyre Booker
Publisher :
ISBN 13 :
Total Pages : 172 pages
Book Rating : 4.:/5 (125 download)
Download or read book Synthetic Studies Towards the Marine Natural Product Diazonamide A written by James Edward MacIntyre Booker and published by . This book was released on 2003 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alejandro Gil Escolano
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (18 download)
Download or read book Studies Toward the Synthesis of Marine Natural Products Phormidolides B-D written by Alejandro Gil Escolano and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine natural products (MNPs) are, undoubtedly, highly valuable starting points for drug-development programs. Generally, MNPs show a well-defined spatial orientation that have evolved for thousands of years to interact with their biological target and the special and unique conditions present in seas, lakes, oceans and rivers allow the biosynthesis of highly potent compunds. Nowadays, the processes to discover a new drug from MNPs are bio-assay guided, giving more importance to the biological results rather than to the molecular structure. After a molecular entity has shown to be biologically relevant the next step is to determine the structural and stereochemical information of such molecule. It is at this step where the project described in this doctoral thesis started. Phormidolides B, C and D (PM B-D) is a family of complex molecules that were isolated in 2010 by the pharmaceutical company Pharmamar S.A. during an expedition to collect samples in the Pemba Island (Madagascar). The extracts rendered a mixture of PM B-D that, once purified, were tested on an IC50 assay against three tumour cell lines. The results showed activity in the low micromolar range with a still unknown mechanism of action. After extensive HRMS, 1D-NMR and 2D-NMR techniques a possible structure was proposed. Following previous UB doctoral theses (Dr. Adriana Lorente and Dr. Janire Lamariano) this doctoral thesis describes, as a compendium of publications, several synthetic studies with the final objective of achieving a robust total synthesis to confirm the structural information of PM B-D by chemical synthesis. After a general introduction (Chapter 1), Chapter 2 (Org. Lett. 2015, 17, 6246.) describes an optimization for the synthesis of the macrocyclic core present in PM B-D. Chapter 3 (Chem. Eur. J. 2016, 21, 7033.) deals, for the first time, with the synthesis and introduction of the most challenging part of the molecule: the bromo-methoxy-diene (BMD) moiety present at the end of the polyhydroxylated chain. After this finding, Chapter 4 (Org. Lett., 2016, 18, 4485.) illustrates the enantioselective synthesis of the polyol chain present in Oscillariolide and Phormidolides, including the previously mentioned BMD moiety. Chapter 5 reports the preparation of the fatty acids present in PM C and D. Finally, after the previous synthetic optimizations, Chapter 6 describes the first synthetic approach for the construction of this large family of natural products using a highly convergent approach. Finally, as an annex a review article entitled "Role of the Nozaki-Hiayama-Kishi-Takai coupling in the synthesis of natural products" (Chem. Rev., 2017, 117, 8420.) is included to deeply explain the uses of this reaction used, as well, for the synthesis of phormidolide B-D. A section with the general conclusions extracted from this thesis is also included.
Author : Nihon Kagakkai
Publisher :
ISBN 13 :
Total Pages : 952 pages
Book Rating : 4.3/5 (91 download)
Download or read book Bulletin of the Chemical Society of Japan written by Nihon Kagakkai and published by . This book was released on 1997 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Derek H. R. Barton
Publisher : Pergamon
ISBN 13 :
Total Pages : 552 pages
Book Rating : 4.:/5 (318 download)
Download or read book R.B. Woodward Remembered written by Derek H. R. Barton and published by Pergamon. This book was released on 1982 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: R.B. Woodward, Professor of Science at Harvard University, who died in July 1979, was generally considered to be the greatest organic chemist of modern times. He was one of the founders of Tetrahedron and Tetrahedron Letters and this volume, containing papers from over 50 of the world's leading organic chemists, is dedicated to his memory. The contents cover all areas of modern organic chemistry and therefore present a synopsis of current research in this area of science.
Author : F. Pietra
Publisher : Birkhäuser
ISBN 13 : 3034875312
Total Pages : 289 pages
Book Rating : 4.0/5 (348 download)
Download or read book A Secret World written by F. Pietra and published by Birkhäuser. This book was released on 2013-12-01 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Underwater exploration is a fascinating activity because of the richness of sea life, the beautiful colors, and the contrast with terrestrial life. It can be done by diving or snorkeling -today there is fine equipment for diving and taking underwater pictures and, apart from being a source of pleasure, it forms the basis of modern ecological and behavioral marine studies. Diving is an emotional activity. The silence of the submarine world, only interrupted by breathing, has more than once evoked the monsters of the fabulous tales of my youth. Maybe because, although much time has elapsed since then, I still have a youth's ability to evaluate everything for the fascination it conveys. However, no more than that can be gained from underwater watehing. I am not saying that this is destined to be a futile exercise. Picasso watched sea urchins much in the same way while revealing their quintessence in his paintings at the Castle of Antibes. What I mean is that today marine life can also be viewed from the perspective of the natural products involved. This knowledge, subsequent to Picasso's time, adds much to the overall picture.
Author :
Publisher :
ISBN 13 :
Total Pages : 512 pages
Book Rating : 4.:/5 (3 download)
Download or read book Energy Research Abstracts written by and published by . This book was released on 1978 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : James B. McClintock
Publisher : CRC Press
ISBN 13 : 1420036602
Total Pages : 626 pages
Book Rating : 4.4/5 (2 download)
Download or read book Marine Chemical Ecology written by James B. McClintock and published by CRC Press. This book was released on 2001-06-13 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interdisciplinary field of marine chemical ecology is an expanding and dynamic science. It is no surprise that the breadth of marine organisms studied expanded in concert with developments in underwater technology. With its up-to-date subject reviews by experts, Marine Chemical Ecology is the most current, comprehensive book on the subject. The
Author : Dinesh Chandra Agrawal
Publisher : Springer
ISBN 13 : 9811059780
Total Pages : 557 pages
Book Rating : 4.8/5 (11 download)
Download or read book Medicinal Plants and Fungi: Recent Advances in Research and Development written by Dinesh Chandra Agrawal and published by Springer. This book was released on 2017-11-03 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the latest international research on different aspects of medicinal plants and fungi. Studies over the last decade have demonstrated that bioactive compounds isolated from medicinal fungi have promising antitumor, cardiovascular, immunomodulatory, anti-allergic, anti-diabetic, and hepatoprotective properties. In the light of these studies, the book includes chapters (mostly review articles) by eminent researchers from twelve countries across the globe working in different disciplines of medicinal plants and fungi. It discusses topics such as the prevention of major neurodegenerative and neurotoxic mechanisms by Centella asiatica; the medicinal properties and therapeutic applications of several mushrooms species found in different parts of the world; and fungal endophytes as a source of bioactive metabolites including anticancer and cardioprotective agents. There are also chapters on strategies for identifying bioactive secondary metabolites of fungal origin; the use of genomic information to explore the biotechnological potential of medicinal mushrooms; and solid state fermentation of agro-industrial and forestry residues for the production of medicinal mushrooms. It is a valuable resource for the researchers, professionals and students working in the area of medicinal plants and fungi.
Author : K. C. Nicolaou
Publisher : John Wiley & Sons
ISBN 13 : 3527292314
Total Pages : 826 pages
Book Rating : 4.5/5 (272 download)
Download or read book Classics in Total Synthesis written by K. C. Nicolaou and published by John Wiley & Sons. This book was released on 1996-04-11 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.
Author : Edwin Haslam
Publisher : Elsevier
ISBN 13 : 1483161188
Total Pages : 327 pages
Book Rating : 4.4/5 (831 download)
Download or read book The Shikimate Pathway written by Edwin Haslam and published by Elsevier. This book was released on 2014-05-20 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Shikimate Pathway gives a bird's eye view of the shikimate pathway and its implications for the life of a range of organisms. Topics covered in this book include the chemistry of intermediates in the shikimate pathway; biosynthesis of aromatic amino acids in this pathway; its metabolites; and its role in higher plants. This book is comprised of six chapters and begins by introducing the reader to shikimic acid, a natural product derived from the plant Illicium religiosum, along with the mechanistic and stereochemical aspects of the reactions of the shikimate pathway. The biosynthesis of aromatic amino acids from chorismate is also described, and then the discussion turns to the chemical properties and the detailed stereochemistry of intermediates and enzymes in the shikimate pathway. The next chapter examines the biosynthesis of isoprenoid quinones involved in electron transport and the folic acid group of co-enzymes in the shikimate pathway. The metabolism of the aromatic amino acids in microorganisms and higher organisms is considered, along with the biosynthesis and physiological functions of phenylpropanoid compounds and their derivatives in the shikimate pathway in higher plants. This book will be of general value to practitioners in the many and varied areas of biochemical research associated with metabolism.
Author : Philippe Jeanteur
Publisher : Springer Science & Business Media
ISBN 13 : 9783540852360
Total Pages : 284 pages
Book Rating : 4.8/5 (523 download)
Download or read book Epigenetics and Chromatin written by Philippe Jeanteur and published by Springer Science & Business Media. This book was released on 2008-09-10 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence. This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility. The other one deals with parental genomic imprinting, a process which allows to express a few selected genes from only one of the parental allele while extinguishing the other.
Author : David H. Evans
Publisher : CRC Press
ISBN 13 : 9780849384271
Total Pages : 552 pages
Book Rating : 4.3/5 (842 download)
Download or read book The Physiology of Fishes, Second Edition written by David H. Evans and published by CRC Press. This book was released on 1997-10-10 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: As in the bestselling first edition, The Physiology of Fishes, Second Edition is a comprehensive, state-of-the-art review of the major areas of research in modern fish physiology. This Second Edition is entirely revised, with 17 of the 18 chapters written by new authors. It also includes four entirely new chapters:
Author : Philippe Jeanteur
Publisher :
ISBN 13 : 9783662097298
Total Pages : 266 pages
Book Rating : 4.0/5 (972 download)
Download or read book Regulation of Alternative Splicing written by Philippe Jeanteur and published by . This book was released on 2014-01-15 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
