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Synthetic Studies Towards The Total Synthesis Of Altohyrtin A
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Book Synopsis Synthetic Studies Towards the Total Synthesis of Altohyrtin A by : Stuart Edward Bradley
Download or read book Synthetic Studies Towards the Total Synthesis of Altohyrtin A written by Stuart Edward Bradley and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Directed Towards the Total Synthesis of Altohyrtin A. by : Pierre D. Kary
Download or read book Studies Directed Towards the Total Synthesis of Altohyrtin A. written by Pierre D. Kary and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Total Synthesis of Altohyrtin A/Spongistatin 1 by : Rebecca Marsh Roth
Download or read book The Total Synthesis of Altohyrtin A/Spongistatin 1 written by Rebecca Marsh Roth and published by . This book was released on 1998 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Approaches Towards the Total Synthesis of Altohyrtin A. by : Elizabeth Anne O'Connor
Download or read book Approaches Towards the Total Synthesis of Altohyrtin A. written by Elizabeth Anne O'Connor and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Towards the Total Synthesis of Lancifodilactone G. by : Sanil Sreekumar
Download or read book Synthetic Studies Towards the Total Synthesis of Lancifodilactone G. written by Sanil Sreekumar and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents our studies towards the first total synthesis of the novel anti- HIV agent lancifodilactone G, which has a highly unusual aliphatic enol. The first chapter provides a survey of architecturally diverse nortriterpenoids that were isolated from the Schisandraceae family. A proposed biosynthetic pathway for lancifodilactone G and closely related natural products provides a rationale for the formation of the consecutive 7/8/5 fused carbo cycles that are unique to Schisandra nortriterpenoids. Chapter 1 goes on to outline the reported strategies to access the core of lancifodilactone G and concludes with a retrosynthetic analysis proposed by the Evans group, which includes a biosynthetically inspired single-pot polycyclisation reaction. Chapter 2 describes the highly stereocontrolled synthesis of the eastern fragment (F-G rings) using transition metal-mediated Pauson-Khand reaction. This chapter also reviews the metal-mediated diastereoselective Pauson-Khand reaction directed by the stereogenic centre at C2, with the ample illustration to total synthesis. Attempted strategies for the assembly of the bicyclic cyclopentanone motif via a dienyl Pauson-Khand reaction of silicon- and oxygen- tethered diene-enes are presented. The failure of these strategies at different stages of the synthesis resulted in the exploration of a classical Pauson-Khand approach, which successfully furnished the eastern fragment. Finally, a second-generation synthesis is described which provided the fully functionalised eastern fragment with improved efficiency and overall yield. Chapter 3 discusses the successful synthesis of the western fragment (B-C rings) using a diastereoselective [4+3] cycloaddition strategy. Attempted strategies for the synthesis of the key 2,3-disubstituted furan derivative are presented, which was achieved via a hetero Pauson- Khand reaction. This chapter includes a brief account of the classical [4+3] cycloaddition reactions of furans using an in situ generated oxyallyl cation and also employing vinyl carbenoids in the metal-catalysed version. The review also highlights the application of the [4+ 3] cycloaddition reaction in the expeditious assembly of functionalised 7-membered rings that occur in a number of important biologically active natural products. The third chapter goes on to describe the application of these cycloaddition reactions in the synthesis of the fully functionalised western fragment of Lancifodilactone G. Chapter 4 describes a model study aimed at expediting the synthesis of the western fragment using a rhodium-catalysed allylic substitution reaction. A brief mechanistic discussion on unique aspects of the allylic alkylation reaction is illustrated. Chapter 4 concludes by outlining the coupling strategy for eastern and western fragments and the end game studies for the completion of the synthesis of lancifodilactone G.
Book Synopsis The Application of Asymmetric Allylstannane Additions Towards the Total Synthesis of ( - )-colletol and Synthetic Studies Towards (+)-7- Deoxypancratistatin by : Jerry Anthony Murry
Download or read book The Application of Asymmetric Allylstannane Additions Towards the Total Synthesis of ( - )-colletol and Synthetic Studies Towards (+)-7- Deoxypancratistatin written by Jerry Anthony Murry and published by . This book was released on 1994 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Directed Towards the Total Asymmetric Synthesis of Altohyrtin A. by : Daniel John Watson
Download or read book Studies Directed Towards the Total Asymmetric Synthesis of Altohyrtin A. written by Daniel John Watson and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Towards the Total Synthesis of Phyllanthocin by : Andrew John King
Download or read book Synthetic Studies Towards the Total Synthesis of Phyllanthocin written by Andrew John King and published by . This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Toward a Total Synthesis of Anisatin by : Melvin Joseph Yu
Download or read book Synthetic Studies Toward a Total Synthesis of Anisatin written by Melvin Joseph Yu and published by . This book was released on 1985 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Part I. Total Synthesis and Structural Revision of (±)-Tricholomalides A and B. Part II. Synthetic Studies Towards (+)-Cortistatin A by : Zhang Wang
Download or read book Part I. Total Synthesis and Structural Revision of (±)-Tricholomalides A and B. Part II. Synthetic Studies Towards (+)-Cortistatin A written by Zhang Wang and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The first part describes the total synthesis and structural revision of (±)-tricholomalides A and B. The synthetic strategy started from a homo-Robinson annulation, followed by a ketene-olefin [2+2] cycloaddition to introduce the lactone ring. Then a Grignard-type reaction appended the isopropenyl moiety, and the synthesis of tricholomalides A and B was achieved. During the course of synthesis, the structures of tricholomalides A and B were revised. The second part describes the synthetic studies towards (+)-cortistatin A, especially the A ring functionalization. The C3 nitrogen was introduced by azide displacement, and C2 hydroxyl was built up by Luche reduction. The challenging C1 functionalization was achieved with bromine-induced methoxymethyl deprotection, and some interesting chemistry was found in this system. The synthetic endeavor set a promising stage for the total synthesis of cortistatin A.
Book Synopsis Synthetic Studies Toward the Total Synthesis of Alstomicine by : Yang Su Tran
Download or read book Synthetic Studies Toward the Total Synthesis of Alstomicine written by Yang Su Tran and published by . This book was released on 2006 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthetic Studies written by Qiang Han and published by . This book was released on 2005 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Directed Towards the Total Synthesis of Spongistatin 1 (altohyrtin A) and Pectenotoxin II. by : Glenn C. Micalizio
Download or read book Studies Directed Towards the Total Synthesis of Spongistatin 1 (altohyrtin A) and Pectenotoxin II. written by Glenn C. Micalizio and published by . This book was released on 2001 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Toward the Total Synthesis (±)-ajmaline and the Development Of, Investigation Into, and Application of a Phosphine-catalyzed [4+1] Annulation by : Brian Richard Blank
Download or read book Synthetic Studies Toward the Total Synthesis (±)-ajmaline and the Development Of, Investigation Into, and Application of a Phosphine-catalyzed [4+1] Annulation written by Brian Richard Blank and published by . This book was released on 2014 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several synthetic routes toward the synthesis of the indole alkaloid (±)-ajmaline have been explored. The retrosynthetic plan was devised around two key transformations, one being a tandem aza-Michael-Michael reaction, and the other a phosphine-catalyzed [4+2] annulation. While these approaches have not allowed for the completion of ajmaline, they have provided a great deal of insight into the chemistry of many intermediates. For example, it was discovered that following installation of the D-ring, functionalization of the tricyclic scaffold to deliver a precursor for the aza-Michael-Michael sequence was a futile undertaking. As such, the necessary functionality had to be installed prior to the [4+2] annulation. For this purpose, ethyl 3-allyl-1H-indole-2-carboxylate was prepared by way of a stepwise Japp-Klingemann reaction, and a subsequent Fischer indolization. Successful conversion of this compound into the N-sulfonyl imine required the employment of 2,6-lutidine to impede isomerization of the allyl moiety. This imine was converted into the tetrahydropyridine through a phosphine-catalyzed [4+2] annulation with ethyl 2-methyl-2,3-butadienoate. Cross-metathesis with methyl acrylate provided the first precursor to the desired aza-Michael-Michael reaction sequence. Unfortunately, only mono-Michael addition was observed when this substrate was employed in the reaction, providing a tetracyclic structure instead of the desired pentacyclic scaffold. As a result, we are currently pursuing tricyclic derivatives that feature either alternative Michael donors or an increased strength of the second Michael acceptor. A phosphine-catalyzed [4+1] annulative rearrangement has been developed to prepare 3-pyrrolines from allenylic carbamates through phosphonium diene intermediates. This methodology was employed to synthesize an array of 1,3-disubstituted- and 1,2,3-trisubstituted-3-pyrrolines, including the often difficult to prepare 2-alkyl variants. A mechanistic investigation employing allenylic acetates and mononucleophiles unexpectedly unveiled that a phosphine-catalyzed [4+1] reaction previously reported by Tong might not occur through a phosphonium diene as was proposed, but rather involves multiple mechanisms working in concert to construct cyclopentene products. Consequentially, our phosphine-catalyzed rearrangement is most likely the first reaction that unequivocally forms a phosphonium diene intermediate along the reaction pathway. Concise formal syntheses of pyrrolizidine alkaloids (±)-trachelanthamidine and (±)-supinidine were completed, demonstrating the synthetic utility of this newly developed reaction.
Book Synopsis Total Synthesis of (-)-Mitrephorone A and Synthetic Studies Towards (+)-Mollanol A, Diastereoselective Cycloisomerization of Cyclopropylidene Acylsilanes by : Matthieu J. R. Richter
Download or read book Total Synthesis of (-)-Mitrephorone A and Synthetic Studies Towards (+)-Mollanol A, Diastereoselective Cycloisomerization of Cyclopropylidene Acylsilanes written by Matthieu J. R. Richter and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards a Total Synthesis of Apicularen A by : Ian Stefanuti
Download or read book Studies Towards a Total Synthesis of Apicularen A written by Ian Stefanuti and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Organic Chemistry of Sugars by : Daniel E. Levy
Download or read book The Organic Chemistry of Sugars written by Daniel E. Levy and published by CRC Press. This book was released on 2005-09-21 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intrigued as much by its complex nature as by its outsider status in traditional organic chemistry, the editors of The Organic Chemistry of Sugars compile a groundbreaking resource in carbohydrate chemistry that illustrates the ease at which sugars can be manipulated in a variety of organic reactions. Each chapter contains numerous examples demonst