Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Synthetic Studies Toward The Total Synthesis Of Lomaiviticin A And B
Download Synthetic Studies Toward The Total Synthesis Of Lomaiviticin A And B full books in PDF, epub, and Kindle. Read online Synthetic Studies Toward The Total Synthesis Of Lomaiviticin A And B ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Synthetic Studies Toward the Total Synthesis of Lomaiviticin A and B by : Virginia Heather Sharron Grant
Download or read book Synthetic Studies Toward the Total Synthesis of Lomaiviticin A and B written by Virginia Heather Sharron Grant and published by . This book was released on 2006 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Toward the Total Synthesis of Alstomicine by : Yang Su Tran
Download or read book Synthetic Studies Toward the Total Synthesis of Alstomicine written by Yang Su Tran and published by . This book was released on 2006 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies on Dimeric Natural Products by : Andrea Lindsay Nold
Download or read book Studies on Dimeric Natural Products written by Andrea Lindsay Nold and published by . This book was released on 2009 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis is separated into two parts: the synthesis of the marinomycins and their monomeric counterparts, and the studies toward the total synthesis of the lomaiviticins. Background on antibiotic resistance, the isolation of the marinomycins by the Fenical lab, and our retrosynthetic analysis of the marinomycins is included in Chapter 1. In Chapter 2, our synthesis of the marinomycin monomeric counterparts, our attempted dimerizations to form the marinomycins, and our step-wise synthesis of the marinomycins is included. Chapter 3 focuses on the background of the lomaiviticins, including the isolation and structure determination of the kinamycins (a related family of natural products) and the lomaiviticins, approaches by other groups to the diazoparaquinone natural products, our original approach to the lomaiviticins (early-stage dimerization), and our modified approach to the lomaiviticins (late-stage dimerization). We then go on to synthesize the kinamycins (Chapter 4) as an elaborate model system of the lomaiviticin monomer, and use our acquired knowledge this approach to synthesize the lomaiviticin aglycon monomer, and explore a late-stage dimerization of this monomer (Chapter 5).
Book Synopsis Studies Toward the Total Synthesis of Dideoxy Lomaiviticinone by : Aleksandra Baranczak
Download or read book Studies Toward the Total Synthesis of Dideoxy Lomaiviticinone written by Aleksandra Baranczak and published by . This book was released on 2011 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Part I. Total Synthesis and Structural Revision of (±)-Tricholomalides A and B. Part II. Synthetic Studies Towards (+)-Cortistatin A by : Zhang Wang
Download or read book Part I. Total Synthesis and Structural Revision of (±)-Tricholomalides A and B. Part II. Synthetic Studies Towards (+)-Cortistatin A written by Zhang Wang and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The first part describes the total synthesis and structural revision of (±)-tricholomalides A and B. The synthetic strategy started from a homo-Robinson annulation, followed by a ketene-olefin [2+2] cycloaddition to introduce the lactone ring. Then a Grignard-type reaction appended the isopropenyl moiety, and the synthesis of tricholomalides A and B was achieved. During the course of synthesis, the structures of tricholomalides A and B were revised. The second part describes the synthetic studies towards (+)-cortistatin A, especially the A ring functionalization. The C3 nitrogen was introduced by azide displacement, and C2 hydroxyl was built up by Luche reduction. The challenging C1 functionalization was achieved with bromine-induced methoxymethyl deprotection, and some interesting chemistry was found in this system. The synthetic endeavor set a promising stage for the total synthesis of cortistatin A.
Book Synopsis Synthetic Studies Towards Aruncin B by : Aubert Ribaucourt
Download or read book Synthetic Studies Towards Aruncin B written by Aubert Ribaucourt and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward the Synthesis of Lomaiviticins A and B and Englerin A by : Srinivas Achanta
Download or read book Studies Toward the Synthesis of Lomaiviticins A and B and Englerin A written by Srinivas Achanta and published by . This book was released on 2009 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part II: Studies toward the total synthesis of englerin A. Englerin A is a new guaiane sesquiterpene isolated recently in 2008. It has been shown to be a selective renal cancer inhibitor. We envisioned the synthesis of englerin A via a novel strategy featuring Wagner-Meerwein rearrangement followed by intramolecular cation trapping. This chapter describes the stereoselective synthesis of the key cis-decalin intermediate from ( - )-carvone and the unsuccessful attempts to realize the skeletal rearrangement.
Book Synopsis Synthetic Studies Towards the Total Synthesis of Altohyrtin A by : Stuart Edward Bradley
Download or read book Synthetic Studies Towards the Total Synthesis of Altohyrtin A written by Stuart Edward Bradley and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Toward the Total Synthesis of Amphidinolide B1 by : Wei Zhang
Download or read book Synthetic Studies Toward the Total Synthesis of Amphidinolide B1 written by Wei Zhang and published by . This book was released on 2006 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Toward the Total Synthesis (±)-ajmaline and the Development Of, Investigation Into, and Application of a Phosphine-catalyzed [4+1] Annulation by : Brian Richard Blank
Download or read book Synthetic Studies Toward the Total Synthesis (±)-ajmaline and the Development Of, Investigation Into, and Application of a Phosphine-catalyzed [4+1] Annulation written by Brian Richard Blank and published by . This book was released on 2014 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several synthetic routes toward the synthesis of the indole alkaloid (±)-ajmaline have been explored. The retrosynthetic plan was devised around two key transformations, one being a tandem aza-Michael-Michael reaction, and the other a phosphine-catalyzed [4+2] annulation. While these approaches have not allowed for the completion of ajmaline, they have provided a great deal of insight into the chemistry of many intermediates. For example, it was discovered that following installation of the D-ring, functionalization of the tricyclic scaffold to deliver a precursor for the aza-Michael-Michael sequence was a futile undertaking. As such, the necessary functionality had to be installed prior to the [4+2] annulation. For this purpose, ethyl 3-allyl-1H-indole-2-carboxylate was prepared by way of a stepwise Japp-Klingemann reaction, and a subsequent Fischer indolization. Successful conversion of this compound into the N-sulfonyl imine required the employment of 2,6-lutidine to impede isomerization of the allyl moiety. This imine was converted into the tetrahydropyridine through a phosphine-catalyzed [4+2] annulation with ethyl 2-methyl-2,3-butadienoate. Cross-metathesis with methyl acrylate provided the first precursor to the desired aza-Michael-Michael reaction sequence. Unfortunately, only mono-Michael addition was observed when this substrate was employed in the reaction, providing a tetracyclic structure instead of the desired pentacyclic scaffold. As a result, we are currently pursuing tricyclic derivatives that feature either alternative Michael donors or an increased strength of the second Michael acceptor. A phosphine-catalyzed [4+1] annulative rearrangement has been developed to prepare 3-pyrrolines from allenylic carbamates through phosphonium diene intermediates. This methodology was employed to synthesize an array of 1,3-disubstituted- and 1,2,3-trisubstituted-3-pyrrolines, including the often difficult to prepare 2-alkyl variants. A mechanistic investigation employing allenylic acetates and mononucleophiles unexpectedly unveiled that a phosphine-catalyzed [4+1] reaction previously reported by Tong might not occur through a phosphonium diene as was proposed, but rather involves multiple mechanisms working in concert to construct cyclopentene products. Consequentially, our phosphine-catalyzed rearrangement is most likely the first reaction that unequivocally forms a phosphonium diene intermediate along the reaction pathway. Concise formal syntheses of pyrrolizidine alkaloids (±)-trachelanthamidine and (±)-supinidine were completed, demonstrating the synthetic utility of this newly developed reaction.
Book Synopsis Synthetic Studies Towards the Total Synthesis of Lancifodilactone G. by : Sanil Sreekumar
Download or read book Synthetic Studies Towards the Total Synthesis of Lancifodilactone G. written by Sanil Sreekumar and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents our studies towards the first total synthesis of the novel anti- HIV agent lancifodilactone G, which has a highly unusual aliphatic enol. The first chapter provides a survey of architecturally diverse nortriterpenoids that were isolated from the Schisandraceae family. A proposed biosynthetic pathway for lancifodilactone G and closely related natural products provides a rationale for the formation of the consecutive 7/8/5 fused carbo cycles that are unique to Schisandra nortriterpenoids. Chapter 1 goes on to outline the reported strategies to access the core of lancifodilactone G and concludes with a retrosynthetic analysis proposed by the Evans group, which includes a biosynthetically inspired single-pot polycyclisation reaction. Chapter 2 describes the highly stereocontrolled synthesis of the eastern fragment (F-G rings) using transition metal-mediated Pauson-Khand reaction. This chapter also reviews the metal-mediated diastereoselective Pauson-Khand reaction directed by the stereogenic centre at C2, with the ample illustration to total synthesis. Attempted strategies for the assembly of the bicyclic cyclopentanone motif via a dienyl Pauson-Khand reaction of silicon- and oxygen- tethered diene-enes are presented. The failure of these strategies at different stages of the synthesis resulted in the exploration of a classical Pauson-Khand approach, which successfully furnished the eastern fragment. Finally, a second-generation synthesis is described which provided the fully functionalised eastern fragment with improved efficiency and overall yield. Chapter 3 discusses the successful synthesis of the western fragment (B-C rings) using a diastereoselective [4+3] cycloaddition strategy. Attempted strategies for the synthesis of the key 2,3-disubstituted furan derivative are presented, which was achieved via a hetero Pauson- Khand reaction. This chapter includes a brief account of the classical [4+3] cycloaddition reactions of furans using an in situ generated oxyallyl cation and also employing vinyl carbenoids in the metal-catalysed version. The review also highlights the application of the [4+ 3] cycloaddition reaction in the expeditious assembly of functionalised 7-membered rings that occur in a number of important biologically active natural products. The third chapter goes on to describe the application of these cycloaddition reactions in the synthesis of the fully functionalised western fragment of Lancifodilactone G. Chapter 4 describes a model study aimed at expediting the synthesis of the western fragment using a rhodium-catalysed allylic substitution reaction. A brief mechanistic discussion on unique aspects of the allylic alkylation reaction is illustrated. Chapter 4 concludes by outlining the coupling strategy for eastern and western fragments and the end game studies for the completion of the synthesis of lancifodilactone G.
Book Synopsis Studies Toward the Total Synthesis of Calyculin A by : Samuel William Gerritz
Download or read book Studies Toward the Total Synthesis of Calyculin A written by Samuel William Gerritz and published by . This book was released on 1993 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Toward the Total Synthesis of Berkelic Acid and Lytophilippine A by : Nikola Stiasni
Download or read book Synthetic Studies Toward the Total Synthesis of Berkelic Acid and Lytophilippine A written by Nikola Stiasni and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Model Studies Toward the Total Synthesis of Lycolucine and the Development of Various Synthetic Methods by :
Download or read book Model Studies Toward the Total Synthesis of Lycolucine and the Development of Various Synthetic Methods written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A study directed at the total synthesis of lycolucine was carried out and discussed within. Various synthetic routes were attempted toward this end. The synthetic schemes all revolve around utilization of the well-established N-acylpyridinium salt chemistry as the foundational method of synthesis. One approach employs metathesis chemistry to attempt the construction of a key carbon-carbon bond. The development of a one-pot alkene homologation was discovered. This investigation reveals the ability to homologate terminal alkenes by one carbon utilizing the 2nd generation Grubbs catalyst. Various aromatic and non-aromatic substrates were used to demonstrate the scope of the reaction, with yields ranging from 65% to 86%. This work reveals the first example of a one-pot one carbon alkene homologation from an existing terminal alkene. A few synthetic methods, such as the formation of indolizidine scaffolds and amino alcohols, are also discussed. Various compounds were realized that could potentially lead to the development of more complex structures.
Book Synopsis Studies Towards the Total Synthesis of the Epothilones A and B. by : Jane Elaine Fletcher
Download or read book Studies Towards the Total Synthesis of the Epothilones A and B. written by Jane Elaine Fletcher and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Towards the Total Synthesis of Phyllanthocin by : Andrew John King
Download or read book Synthetic Studies Towards the Total Synthesis of Phyllanthocin written by Andrew John King and published by . This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Total Synthesis of Cylindricines A and B by : Julie Elizabeth Fields
Download or read book Total Synthesis of Cylindricines A and B written by Julie Elizabeth Fields and published by . This book was released on 1999 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download Synthetic Studies Toward the Total Synthesis (±)-ajmaline and the Development Of, Investigation Into, and Application of a Phosphine-catalyzed [4+1] Annulation PDF Online Free](https://books.google.com/books/content/images/frontcover/ULSjAQAACAAJ?fife=w200-h370)
