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Synthetic Studies Toward Phorboxazole
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Book Synopsis Synthetic Studies Towards One Gram of (+)-phorboxazole A and the Total Synthesis of 13-deoxy-14-o-alkenylphorboxazole by : Regina M. Meis
Download or read book Synthetic Studies Towards One Gram of (+)-phorboxazole A and the Total Synthesis of 13-deoxy-14-o-alkenylphorboxazole written by Regina M. Meis and published by . This book was released on 2005 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Towards Phorboxazole A by : Yingtao Lu
Download or read book Synthetic Studies Towards Phorboxazole A written by Yingtao Lu and published by . This book was released on 2003 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Toward Phorboxazole A by : Russell Drew Cink
Download or read book Synthetic Studies Toward Phorboxazole A written by Russell Drew Cink and published by . This book was released on 1998 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Toward Phorboxazole by : Nga M. Do
Download or read book Synthetic Studies Toward Phorboxazole written by Nga M. Do and published by . This book was released on 1998 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Towards the Marine Natural Product Phorboxazole A. by : James A. Tornos
Download or read book Synthetic Studies Towards the Marine Natural Product Phorboxazole A. written by James A. Tornos and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis I. Enhanced Synthesis and Diversification of the Phorboxazole Chemotype ; II. Synthetic Studies Towards the Marine Natural Product Isoobtusadiene by : Todd Matthew Hansen
Download or read book I. Enhanced Synthesis and Diversification of the Phorboxazole Chemotype ; II. Synthetic Studies Towards the Marine Natural Product Isoobtusadiene written by Todd Matthew Hansen and published by . This book was released on 2002 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward the Synthesis of Phorboxazole A by : Michael Philip Clark
Download or read book Studies Toward the Synthesis of Phorboxazole A written by Michael Philip Clark and published by . This book was released on 2001 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Towards the Marine Natural Product Phorboxazole A. by : Alleyn T. Plowright
Download or read book Synthetic Studies Towards the Marine Natural Product Phorboxazole A. written by Alleyn T. Plowright and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Towards the C31-C46 Side Chain Fragment of the Phorboxazoles by : Melissa Sue Ostroski
Download or read book Synthetic Studies Towards the C31-C46 Side Chain Fragment of the Phorboxazoles written by Melissa Sue Ostroski and published by . This book was released on 2003 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of Phorboxazoles A and B. by : E. A. Arnott
Download or read book Studies Towards the Total Synthesis of Phorboxazoles A and B. written by E. A. Arnott and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward the Total Synthesis of Phorboxazole A by : Punlop Kuntiyong
Download or read book Studies Toward the Total Synthesis of Phorboxazole A written by Punlop Kuntiyong and published by . This book was released on 2004 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies toward the total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, were conducted and resulted in a route to an advanced intermediate, C4-C32, for this purpose. A key feature of our approach is the stereoselective synthesis of two cis-2,6-disubstituted tetrahydropyrans present in the macrolide portion of phorboxazole A by palladium (II) mediated intramolecular alkoxy carbonylation. This provided the C20-C32 and C9-C19 tetrahydropyran subunits of phorboxazole A. An attempt at diastereoselective formation of the third C5-C9 trans-2,6-disubstituted tetrahydropyran by hydride reduction of a C9 hemiketal was complicated by reduction of the C7 exocyclic olefin. However, the C5-C9 tetrahydropyran was constructed by an intramolecular etherification sequence using a novel allylsilane as the source of C4-C8 of the macrolactone. The studies carried out in the course of this thesis have set in place a major segment of the phorboxazole A structure; they require only the addition of the C1-C3 unit and minor functional group modifications to complete the macrolide portion of the molecule.
Book Synopsis Segment-coupling Prins Reactions by : Justin Philip Vitale
Download or read book Segment-coupling Prins Reactions written by Justin Philip Vitale and published by . This book was released on 2003 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Synthesis of (+)-phorboxazole B by :
Download or read book Studies Towards the Synthesis of (+)-phorboxazole B written by and published by . This book was released on 2010 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Total Synthesis of Marine Natural Products by : Katharine Elaine McElhone
Download or read book Total Synthesis of Marine Natural Products written by Katharine Elaine McElhone and published by . This book was released on 1999 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of the Phorboxazoles by : Christopher Andrew Luckhurst
Download or read book Studies Towards the Total Synthesis of the Phorboxazoles written by Christopher Andrew Luckhurst and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies on Phorboxazole Tail Domain and Amphidinolide C by : Dimao Wu
Download or read book Synthetic Studies on Phorboxazole Tail Domain and Amphidinolide C written by Dimao Wu and published by . This book was released on 2012 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Marine natural products phorboxazoles, first isolated in 1995 from the Indian Ocean sponge Phorbas sp., displayed remarkable inhibition of cell growth against the a series of tumor cell lines. Among the most powerful cytostatic agents people have discovered, phorboxazoles have attracted organic chemistry community to engage in the campaign to open a synthetic route in replace of isolation from their natural source since the first total synthesis of phorboxazole A was reported by Forsyth and co-workers in 1998. As the synthetic art advanced in long term exploration, many analogues derived from phorboxazoles were designed, synthesized and investigated for structure-activity relationship (SAR) related with further optimized biological activities. Described herein is an enhanced synthesis of phorboxazole C31-C46 tail domain based on stereoselective vinylogous Mukaiyama aldol reaction and modified Julia olefination. Two reliable and practical routes arose from different sources of chiral skeleton were developed respectively. Several novel phorboxazole tail domain oxazole or non-oxazole analogues were prepared from the advanced ester precursor, ready for further bioassays.
Book Synopsis Progress Toward the Total Synthesis of Batrachotoxinin A and Phorboxazole B by : Amber Reilly
Download or read book Progress Toward the Total Synthesis of Batrachotoxinin A and Phorboxazole B written by Amber Reilly and published by . This book was released on 2010 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part I of this dissertation presents the studies directed toward the total synthesis of batrachotoxin. The general approach towards the synthesis of batrachotoxin involves preparation of the AB rings and the DE rings independently, followed by union of these two ring systems, subsequent closure of the C ring, and elaboration to the natural product. A deconjugative alkylation approach has thus far proved to be the most reliable route to the union of the AB rings to the DE rings, however other methods should be explored. Model studies and synthesis of advanced intermediates have provided a good foundation for future work towards the synthesis of batrachotoxin. Part II of this dissertation presents the studies directed toward the total synthesis of Phorboxazole B with an emphasis on efforts for uniting the side chain and macrocyclic core of the natural product by Wittig olefination. Model studies provided detailed insight into the conditions that would be optimal for union of these two advanced intermediates. While these model studies indicated a promising outcome and were even performed on highly elaborate model compounds, these conditions did not translate well in the union of the real side chain and macrocyle of Phorboxazole.
