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Author :
Publisher :
ISBN 13 :
Total Pages : 57 pages
Book Rating : 4.:/5 (938 download)
Download or read book Synthetic Studies of Nitrogen Containing Heterocycles, Particularly Pyrazole and Benzotriazine Derivatives written by and published by . This book was released on 2009 with total page 57 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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Publisher : Elsevier Science
ISBN 13 : 9780080449913
Total Pages : 12500 pages
Book Rating : 4.4/5 (499 download)
Download or read book Comprehensive Heterocyclic Chemistry III written by and published by Elsevier Science. This book was released on 2008-03-27 with total page 12500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Heterocyclic Chemistry III (CHEC-III) is a new 15-volume reference work which provides the first point of entry to the literature for all scientists interested in heterocyclic ring systems. Since publishing in 1984, Comprehensive Heterocyclic Chemistry (CHEC) has become the standard work on the subject, indispensable to all serious readers in the interdisciplinary areas where heterocycles are employed. CHEC-III builds on and complements the material in CHEC and CHEC-II and is designed to be used both alone and in conjunction with these two works. Written by leading scientists who have evaluated and summarized the most important data published over the last decade, Comprehensive Heterocyclic Chemistry III will be an invaluable addition to the reference library of those working with heterocyclic ring systems. Reviews advances in the properties, structure, synthesis, reactivity and applications of the most important heterocyclic ring systems Contains over 250 specialist reviews, logically organized by size and heteroatom content of the heterocyclic ring Saves researchers valuable time and effort through carefully structured critical reviews of the literature by experts
Author : Vakhid A. Mamedov
Publisher : Springer
ISBN 13 : 3319297732
Total Pages : 451 pages
Book Rating : 4.3/5 (192 download)
Download or read book Quinoxalines written by Vakhid A. Mamedov and published by Springer. This book was released on 2016-04-26 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the fundamental aspects of quinoxaline chemistry: synthesis, reactions, mechanisms, structure, properties, and uses. The first four chapters present a survey of the developments in quinoxaline chemistry since the publication of the monograph on “Condensed Pyrazines” by Cheeseman and Cookson in 1979. These chapters give comprehensive coverage of all the methods of the synthesis of quinoxalines and the important quinoxaline-containing ring systems such as thiazolo[3,4-a]-, pyrrolo[1,2-a]-, and imidazo[1,5-a]quinoxalines. Chapter five describes many new methods for the construction of quinoxaline macrocycles, which are important in applications such as optical devices and materials. The final chapter reviews all previously known rearrangements of heterocyclic systems that lead to benzimidazole derivatives. Mamedov critically analyses these transformations to reveal a novel acid-catalyzed rearrangement of quinoxalinones giving 2-heteroarylbenzimidazoles and 1-heteroarylbenzimidazolones in the presence of nucleophilic reactants (MAMEDOV Heterocycle Rearrangement). This book is of interest to researchers in the fields of heterocyclic and synthetic organic chemistry.
Author : Alexander F. Pozharskii
Publisher : John Wiley & Sons
ISBN 13 : 111997013X
Total Pages : 404 pages
Book Rating : 4.1/5 (199 download)
Download or read book Heterocycles in Life and Society written by Alexander F. Pozharskii and published by John Wiley & Sons. This book was released on 2011-03-31 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heterocycles in Life and Society is an introduction to the chemistry of heterocyclic compounds, focusing on their origin and occurrence in nature, biochemical significance and wide range of applications. Written in a readable and accessible style, the book takes a multidisciplinary approach to this extremely important area of organic chemistry. Topics covered include an introduction to the structure and properties of heterocycles; the key role of heterocycles in important life processes such as the transfer of hereditary information, how enzymes function, the storage and transport of bioenergy, and photosynthesis; applications of heterocycles in medicine, agriculture and industry; heterocycles in supramolecular chemistry; the origin of heterocycles on primordial Earth; and how heterocycles can help us solve 21st century challenges. For this second edition, Heterocycles in Life and Society has been completely revised and expanded, drawing on a decade of innovation in heterocyclic chemistry. The new edition includes discussions of the role of heterocycles in nanochemistry, green chemistry, combinatorial chemistry, molecular devices and sensors, and supramolecular chemistry. Impressive achievements include the creation of various molecular devices, the recording and storage of information, the preparation of new organic conductors, and new effective drugs and pesticides with heterocyclic structures. Much new light has been thrown on various life processes, while the chemistry of heterocycles has expanded to include new types of heterocyclic structures and reactions, and the use of heterocyclic molecules as ionic liquids and proton sponges. Heterocycles in Life and Society is an essential guide to this important field for students and researchers in chemistry, biochemistry, and drug discovery, and scientists at all levels wishing to expand their scientific horizon.
Author : Thomas F. DeRosa
Publisher : Elsevier
ISBN 13 : 0080480918
Total Pages : 701 pages
Book Rating : 4.0/5 (84 download)
Download or read book Significant Pharmaceuticals Reported in US Patents written by Thomas F. DeRosa and published by Elsevier. This book was released on 2010-07-07 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant Pharmaceuticals Reported in US Patents identifies the next generation of pharmaceuticals reported in US Patents. This "hands-on" title provides explicit laboratory methods for preparing the most recent and effective medications. Each entry documents the biological testing protocols used to evaluate a drug and the significance of the current treatment agent over previous methods. Pharmaceuticals are included in this review only if at least two of the following criteria were met: Effectiveness in treating an illness, Innovative, ease of preparation, synergy with existing Medications. Pharmaceuticals are reported for 27 separate classes of illness, including: AIDS, Alzheimer's Disease, Cardiovascular Disorders, Diabetes, Epilepsy, Hepatitis C, Osteoporosis, Obesity and Sleep Disorders. Significant Pharmaceuticals Reported in US Patents has been designed to be used as both a reference and synthetic guide for pharmaceutical, medicinal and organic chemists and graduate students. Researchers working in other areas will also find the information valuable as in many instances intermediates or the next generation pharmaceutical are readily convertible into other industrial products including: anti-oxidants, chemical additives, herbicides, polymer precursors, water purification agents. Clear structural depictions of reagents and chemical transformations have been supplied to permit the identification of other future applications. Identifies next generation pharmaceuticals Provides practical preparation methods for each active agent and derivatives Documents the analytical characterization and biological testing results of active agents
Author : Alan R. Katritzky
Publisher : Elsevier
ISBN 13 : 1483293424
Total Pages : 568 pages
Book Rating : 4.4/5 (832 download)
Download or read book Handbook of Heterocyclic Chemistry written by Alan R. Katritzky and published by Elsevier. This book was released on 2017-01-31 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a one-volume overall picture of the largest of the classical divisions of organic chemistry, suitable for the graduate or advanced undergraduate student, as well as for research workers, both specialists in the field and those engaged in another discipline and requiring knowledge of heterocyclic chemistry. It represents Volume 9 of Comprehensive Heterocyclic Chemistry and utilizes the general chapters which appear in the 8-volume work. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of modern heterocyclic chemistry available.
Author : Martin Oestreich
Publisher : John Wiley & Sons
ISBN 13 : 9780470716069
Total Pages : 608 pages
Book Rating : 4.7/5 (16 download)
Download or read book The Mizoroki-Heck Reaction written by Martin Oestreich and published by John Wiley & Sons. This book was released on 2009-02-11 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring the importance of Richard F. Heck’s carbon coupling reaction, this book highlights the subject of the 2010 Nobel Prize in Chemistry for palladium-catalyzed cross couplings in organic synthesis, and includes a foreword from Nobel Prize winner Richard F. Heck. The Mizoroki-Heck reaction is a palladium-catalyzed carbon–carbon bond forming process which is widely used in organic and organometallic synthesis. It has seen increasing use in the past decade as chemists look for strategies enabling the controlled construction of complex carbon skeletons. The Mizoroki-Heck Reaction is the first dedicated volume on this important reaction, including topics on: mechanisms of the Mizoroki-Heck reaction intermolecular Mizoroki-Heck reactions focus on regioselectivity and product outcome in organic synthesis waste-minimized Mizoroki-Heck reactions intramolecular Mizoroki-Heck reactions formation of heterocycles chelation-controlled Mizoroki-Heck reactions the Mizoroki-Heck reaction in domino processes oxidative heck-type reactions (Fujiwara-Moritani reactions) Mizoroki-Heck reactions with metals other than palladium ligand design for intermolecular asymmetric Mizoroki-Heck reactions intramolecular enantioselective Mizoroki-Heck reactions desymmetrizing Mizoroki-Heck reactions applications in combinatorial and solid phase syntheses, and the development of modern solvent systems and reaction techniques the asymmetric intramolecular Mizoroki-Heck reaction in natural product total synthesis Several chapters are devoted to asymmetric Heck reactions with particular focus on the construction of otherwise difficult-to-obtain sterically congested tertiary and quaternary carbons. Industrial and academic applications are highlighted in the final section. The Mizoroki-Heck Reaction will find a place on the bookshelves of any organic or organometallic chemist. “I am convinced that this book will rapidly become the most important reference text for research chemists in academia and industry who seek orientation in the rapidly growing and – for the layman – confusing field described as the “’Mizoroki–Heck reaction’.” (Synthesis, March 2010)
Author : Wolfgang Jahnke
Publisher : John Wiley & Sons
ISBN 13 : 3527608605
Total Pages : 391 pages
Book Rating : 4.5/5 (276 download)
Download or read book Fragment-based Approaches in Drug Discovery written by Wolfgang Jahnke and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.
Author : Henry Feuer
Publisher : John Wiley & Sons
ISBN 13 : 9780470191545
Total Pages : 768 pages
Book Rating : 4.1/5 (915 download)
Download or read book Nitrile Oxides, Nitrones and Nitronates in Organic Synthesis written by Henry Feuer and published by John Wiley & Sons. This book was released on 2008-01-02 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive systematization of current novel data in nitrile oxide chemistry, this book authoritatively covers systematic strategies currently used in the preparation and utilization of nitrile oxides, nitrones, and nitronates in organic synthesis. It covers factors governing their stability and includes in-depth information on stable and unstable nitrile oxides. With contributions from leading experts, this is a definitive reference for practicing professionals in organic or medicinal chemistry and an excellent text for students studying organic synthesis.
Author : Andrei Hent
Publisher : Academic Press
ISBN 13 : 0128128704
Total Pages : 884 pages
Book Rating : 4.1/5 (281 download)
Download or read book Strategies and Solutions to Advanced Organic Reaction Mechanisms written by Andrei Hent and published by Academic Press. This book was released on 2019-06-28 with total page 884 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategies and Solutions to Advanced Organic Reaction Mechanisms: A New Perspective on McKillop's Problems builds upon Alexander (Sandy) McKillop’s popular text, Solutions to McKillop’s Advanced Problems in Organic Reaction Mechanisms, providing a unified methodological approach to dealing with problems of organic reaction mechanism. This unique book outlines the logic, experimental insight and problem-solving strategy approaches available when dealing with problems of organic reaction mechanism. These valuable methods emphasize a structured and widely applicable approach relevant for both students and experts in the field. By using the methods described, advanced students and researchers alike will be able to tackle problems in organic reaction mechanism, from the simple and straight forward to the advanced. Provides strategic methods for solving advanced mechanistic problems and applies those techniques to the 300 original problems in the first publication Replaces reliance on memorization with the understanding brought by pattern recognition to new problems Supplements worked examples with synthesis strategy, green metrics analysis and novel research, where available, to help advanced students and researchers in choosing their next research project
Author : Nathan Brown
Publisher : John Wiley & Sons
ISBN 13 : 3527654321
Total Pages : 249 pages
Book Rating : 4.5/5 (276 download)
Download or read book Bioisosteres in Medicinal Chemistry written by Nathan Brown and published by John Wiley & Sons. This book was released on 2012-06-18 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
Author : Kurt Torssell
Publisher : Wiley-VCH
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.3/5 (91 download)
Download or read book Nitrile Oxides, Nitrones, and Nitronates in Organic Synthesis written by Kurt Torssell and published by Wiley-VCH. This book was released on 1988 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Vinny R. Sastri
Publisher : Elsevier
ISBN 13 : 0080536689
Total Pages : 1005 pages
Book Rating : 4.0/5 (85 download)
Download or read book Modern Aspects of Rare Earths and their Complexes written by Vinny R. Sastri and published by Elsevier. This book was released on 2003-12-09 with total page 1005 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to use rare earths successfully in various applications, a good understanding of the chemistry of these elements is of paramount importance. Nearly three to four decades have passed since titles such as The Rare Earths edited by F.H. Spedding and A.H. Daane, The chemistry of the Rare Earth Elements by N.E. Topp and Complexes of the Rare Earths by S.P. Sinha were published. There have been many international conferences and symposia on rare earths, as well as the series of volumes entitled Handbook of Physics and Chemistry of Rare Earths edited by K.A. Gschneidner and L. Eyring. Thus, there is a need for a new title covering modern aspects of rare earth complexes along with the applications. The present title consists of twelve chapters. 1. Introduction2. General aspects3. Stability of complexes4. Lanthanide complexes5. Structural chemistry of lanthanide compounds6. Organometallic complexes7. Kinetics and mechanisms of rare earths complexation8. Spectroscopy of lanthanide complexes9. Photoelectron spectroscopy of rare earths10. Lanthanide NMR shift reagents11. Environmental ecological biological aspects12. Applications The authors studied in schools headed by pioneers in rare earth chemistry, have a combined experience of one hundred and fifty years in inorganic chemistry, rare earth complex chemistry, nuclear and radiochemistry of rare earths and supramolecular chemistry. The present monograph is a product of this rich experience.
Author : Thomas M. Klapötke
Publisher : Springer
ISBN 13 : 3540722025
Total Pages : 292 pages
Book Rating : 4.5/5 (47 download)
Download or read book High Energy Density Materials written by Thomas M. Klapötke and published by Springer. This book was released on 2007-06-12 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Martin Sarter
Publisher : Wiley-Liss
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.3/5 (91 download)
Download or read book Benzodiazepine Receptor Inverse Agonists written by Martin Sarter and published by Wiley-Liss. This book was released on 1995-01-23 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive overview of the biochemical, pharmacological and behavioral research on benzodiazepine receptor (BZR) inverse agonists. Emphasis is given to psychopharmacological potential (including cognitive and motivational enhancement) andtreatment applications (ethanol-antagonism, movement disorders, head injury). The book contains black-and-white illustrations.
Author : Steven Howard
Publisher : Royal Society of Chemistry
ISBN 13 : 1782625658
Total Pages : 314 pages
Book Rating : 4.7/5 (826 download)
Download or read book Fragment-Based Drug Discovery written by Steven Howard and published by Royal Society of Chemistry. This book was released on 2015-06-17 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.
Author :
Publisher : Academic Press
ISBN 13 : 0128054344
Total Pages : 686 pages
Book Rating : 4.1/5 (28 download)
Download or read book Peptide, Protein and Enzyme Design written by and published by Academic Press. This book was released on 2016-08-27 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: De Novo Enzyme Design, the newest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume includes the design of metal binding maquettes, insertion of non-natural cofactors, Cu metallopeptides, non-covalent interactions in peptide assemblies, peptide binding and bundling, heteronuclear metalloenzymes, florinated peptides, De Novo imaging agents, and protein-protein interaction. Continues the legacy of this premier serial with quality chapters on de novo enzyme design Represents the newest volume in the Methods in Enzymology series, providing premier, quality chapters authored by leaders in the field Ideal reference for those interested in the study of enzyme design that looks at both structure and mechanism
