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![Download Synthesis of Unnatural [alpha] - Amino Acids PDF Online Free](https://books.google.com/books/content/images/frontcover/wVuI0AEACAAJ?fife=w200-h370)
Author : Richard John Middleton
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (112 download)
Download or read book Synthesis of Unnatural [alpha] - Amino Acids written by Richard John Middleton and published by . This book was released on 1996 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lorna J. Drummond
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (824 download)
Download or read book New Methodology for the Stereoselective Synthesis of Unnatural Alpha-amino Acids written by Lorna J. Drummond and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: New general methodology for the stereoselective synthesis of unnatural alpha-amino acids has been developed. Early work focussed on investigating methods for the generation of chiral allylic alcohols using cross-metathesis of a simple enone with various terminal alkenes, followed by an asymmetric ketone reduction. The allylic alcohols were then converted to protected allylic amines via Overman rearrangement chemistry. Oxidative alkene cleavage and hydrolysis of these intermediates generated a range of alpha-amino acid targets. Attempts were also made to apply the developed methodology to the synthesis of a simple alpha,alpha-disubstituted alpha-amino acid target. The Overman rearrangement was also applied to the generation of a late-stage intermediate which could be used in the synthesis of (2S,3S)-capreomycidine, a component of a number of peptides which exhibit antibacterial activity.
Author : Michael Smith
Publisher : CRC Press
ISBN 13 : 9780824796044
Total Pages : 392 pages
Book Rating : 4.7/5 (96 download)
Download or read book Methods of Non-a-Amino Acid Synthesis written by Michael Smith and published by CRC Press. This book was released on 1995-05-17 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides a comprehensive overview of, and the most common and useful methods for, the synthesis of non-alpha-amino acids, particularly amino acids that are key synthetic intermediates or important compounds in their own right. Attention is paid to acyclic amino acids C3-C10 including amino alkanoic carboxylic acids, aminoalkenoic acids and aminoalkynoic acids.
![Download Synthesis of Unnatural Enone-containing [alpha]-amino Acids PDF Online Free](https://books.google.com/books/content/images/frontcover/tKmgAQAACAAJ?fife=w200-h370)
Author : Lindsay S. Fowler
Publisher :
ISBN 13 :
Total Pages : 170 pages
Book Rating : 4.:/5 (784 download)
Download or read book Synthesis of Unnatural Enone-containing [alpha]-amino Acids written by Lindsay S. Fowler and published by . This book was released on 2011 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fast and efficient synthetic route was developed for the synthesis of a novel class of enone-containing alpha-amino acid. An amino acid-derived beta-ketophosphonate ester was subjected to Horner-Wadsworth-Emmons conditions using a variety of aldehydes to produce a diverse library of alpha, beta-unsaturated amino acids. E-Configured enone-containing amino acids were also deprotected using a two-stage approach to give the parent alpha-amino acids. A minor modification to the route enabled the synthesis of Z-configured enones via the Still-Gennari reaction. A small library of Z-enones was produced using various aldehydes. Enone-functionalised alpha-amino acids were employed as substrates for an intramolecular cyclisation reaction to generate 6-substituted-4-oxopipecolic acids. A diastereoselective one-pot reductive amination/cyclisation strategy was developed to gain access to the anti-diastereomer of the chiral N-heterocycles. A small selection of 6-substituted-4-oxopipecolic acids was synthesised. 6-Substituted-4-oxopipecolic acids were also reduced diastereoselectively to generate 4- hydroxypipecolic acid analogues.
Author : Valery P. Kukhar
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 432 pages
Book Rating : 4.3/5 (91 download)
Download or read book Fluorine-containing Amino Acids written by Valery P. Kukhar and published by John Wiley & Sons. This book was released on 1995-04-06 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, organo-fluorine chemistry has made a marked impact on the design and synthesis of a large variety of biologically active molecules, such as steroids, carbohydrates, amines, amino acids, peptides and other natural products. Naturally occurring amino acids play a pivotal role in living systems, and therefore synthetic fluorine-containing amino acids have been of significant interest to researchers working towards the understanding and modification of physiological processes. Fluorine-containing Amino Acids: is the first volume devoted to the synthesis and properties of fluorine-containing amino acids pays special attention to the preparation of enantiomerically pure acids (which are essential to the modern pharmaceutical industry) deals with a rapidly expanding field of research has been written by experienced researchers who are responsible for many developments in the field highlights the interdisciplinary nature of this topic Fluorine-containing Amino Acids is the only dedicated reference in this subject and will be essential for researchers in synthetic organic, peptide, natural product, and medicinal chemistry and biochemistry.
![Download The Synthesis of [alpha]-amino Acids with Unnatural Sidechains PDF Online Free](https://books.google.com/books/content/images/frontcover/UCkKtwAACAAJ?fife=w200-h370)
Author : Ross Andrew Matthews
Publisher :
ISBN 13 :
Total Pages : 82 pages
Book Rating : 4.:/5 (318 download)
Download or read book The Synthesis of [alpha]-amino Acids with Unnatural Sidechains written by Ross Andrew Matthews and published by . This book was released on 2008 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download Synthesis of Unnatural [alpha]-amino Acids Using Organozinc and Organocopper Chemistry PDF Online Free](https://books.google.com/books/content/images/frontcover/T2vWPQAACAAJ?fife=w200-h370)
Author : Tomás Carrillo Márquez
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (278 download)
Download or read book Synthesis of Unnatural [alpha]-amino Acids Using Organozinc and Organocopper Chemistry written by Tomás Carrillo Márquez and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Loredano Pollegioni
Publisher : Humana Press
ISBN 13 : 9781493958887
Total Pages : 409 pages
Book Rating : 4.9/5 (588 download)
Download or read book Unnatural Amino Acids written by Loredano Pollegioni and published by Humana Press. This book was released on 2016-08-23 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: Even though they are present in nature, non-proteinogenic amino acids are usually defined as unnatural or non-natural. Beside their structural diversity, interest in these compounds is due to their occurrence in nature, their biological properties, the analytical aspects, their use as probes, and their incorporation into peptides and proteins, among other reasons. Divided into five convenient sections, Unnatural Amino Acids: Methods and Protocols deals with enzymatic methods used to produce non-natural amino acids, aspects concerning the presence of unnatural amino acids in peptides with antimicrobial properties, genetic incorporation of unnatural amino acids into proteins (yeast and mammalian cells), and detection and quantification of D-amino acids and related enzymes. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Unnatural Amino Acids: Methods and Protocols serves as an ideal guide for scientists and contributes to directing the attention of researchers to the many fields of growing scientific interest in non-natural amino acids.
Author : R. M. Williams
Publisher : Elsevier
ISBN 13 : 1483292959
Total Pages : 429 pages
Book Rating : 4.4/5 (832 download)
Download or read book Synthesis of Optically Active Alpha-Amino Acids written by R. M. Williams and published by Elsevier. This book was released on 2013-10-22 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to review and critically evaluate the best new methods to synthesize alpha-amino acids in optically active form. There is so much new literature on amino acid synthesis that the experimentalist will undoubtedly have difficulty in selecting the most appropriate methodology for constructing the amino acid of immediate interest. This book is a guide for steering the scientist through the maze of existing reports on the subject and contains the most up-to-date critical reviews of methods of asymmetric synthesis of amino acids. In areas that are relatively new conceptually and less studied experimentally, an effort has been made to review the most salient works with an eye towards future development. Over 330 schemes and figures are presented with references for rapid visual retrieval of information. The book will be of great value to academic and industrial organic research chemists, especially those concerned with medicinal and agricultural chemistry, as well as to graduate and post graduate students, biochemists and biologists.
Author : Graham Barrett
Publisher : Springer Science & Business Media
ISBN 13 : 9400948328
Total Pages : 694 pages
Book Rating : 4.4/5 (9 download)
Download or read book Chemistry and Biochemistry of the Amino Acids written by Graham Barrett and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amino acids are featured in course syllabuses and in project and research work over a wide spectrum of subject areas in chemistry and biology. Chemists and biochemists using amino acids have many common needs when they turn to the literature for comprehensive information. Among these common interests, analytical studies, in particular, have undergone rapid development in recent years. All other chemical and biochemical aspects of amino acids - synthesis, properties and reactions, preparation of derivatives for use in peptide synthesis, racemization and other fundamental mechanistic knowledge - have been the subject of vigorous progress. This book offers a thorough treatment of all these developing areas, and is structured in the belief that biochemists, physiologists and others will profit from access to information on topics such as the physical chemistry of amino acid solutions, as well as from thorough coverage of amino acid metabolism, biosynthesis and enzyme inhibition; and that chemists will find relevant material in biological areas as well as in the analysis, synthesis and reactions of amino acids.
Author :
Publisher : Academic Press
ISBN 13 : 0080921639
Total Pages : 334 pages
Book Rating : 4.0/5 (89 download)
Download or read book Non-Natural Amino Acids written by and published by Academic Press. This book was released on 2009-07-24 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: By combining the tools of organic chemistry with those of physical biochemistry and cell biology, Non-Natural Amino Acids aims to provide fundamental insights into how proteins work within the context of complex biological systems of biomedical interest. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. With more than 400 volumes published, each Methods in Enzymology volume presents material that is relevant in today's labs -- truly an essential publication for researchers in all fields of life sciences. - Demonstrates how the tools and principles of chemistry combined with the molecules and processes of living cells can be combined to create molecules with new properties and functions found neither in nature nor in the test tube - Presents new insights into the molecular mechanisms of complex biological and chemical systems that can be gained by studying the structure and function of non-natural molecules - Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods
![Download Synthesis of Optically Active [alpha]-amino Acids PDF Online Free](https://books.google.com/books/content/images/frontcover/khfwAAAAMAAJ?fife=w200-h370)
Author : Robert Michael Williams
Publisher : Pergamon
ISBN 13 :
Total Pages : 436 pages
Book Rating : 4.3/5 (91 download)
Download or read book Synthesis of Optically Active [alpha]-amino Acids written by Robert Michael Williams and published by Pergamon. This book was released on 1989 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to review and critically evaluate the best new methods to synthesize alpha-amino acids in optically active form. There is so much new literature on amino acid synthesis that the experimentalist will undoubtedly have difficulty in selecting the most appropriate methodology for constructing the amino acid of immediate interest. This book is a guide for steering the scientist through the maze of existing reports on the subject and contains the most up-to-date critical reviews of methods of asymmetric synthesis of amino acids. In areas that are relatively new conceptually and less studied experimentally, an effort has been made to review the most salient works with an eye towards future development. Over 330 schemes and figures are presented with references for rapid visual retrieval of information. The book will be of great value to academic and industrial organic research chemists, especially those concerned with medicinal and agricultural chemistry, as well as to graduate and post graduate students, biochemists and biologists.
Author : Vadim A Soloshonok
Publisher : American Chemical Society
ISBN 13 :
Total Pages : 516 pages
Book Rating : 4.3/5 (91 download)
Download or read book Asymmetric Synthesis and Application of Alpha-Amino Acids written by Vadim A Soloshonok and published by American Chemical Society. This book was released on 2009-07-09 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the most recent and comprehensive collection of reviews on methodological developments in the field of alpha-amino acids.
Author : James C. Reid
Publisher :
ISBN 13 :
Total Pages : 30 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Synthesis of Labeled Alpha Amino Acids written by James C. Reid and published by . This book was released on 1949 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download Synthesis of Branched Α-[alpha-] and Β-amino[beta-amino] Acids Using C-nucleophile Additions to Imines and Nitrones PDF Online Free](https://books.google.com/books/content/images/frontcover/Y3zYRwAACAAJ?fife=w200-h370)
Author : Alevtina Baskakova
Publisher :
ISBN 13 : 9783832523268
Total Pages : 0 pages
Book Rating : 4.5/5 (232 download)
Download or read book Synthesis of Branched Α-[alpha-] and Β-amino[beta-amino] Acids Using C-nucleophile Additions to Imines and Nitrones written by Alevtina Baskakova and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Artificial peptides, containing alpha- and/or beta-amino acids with bulky substituents, can potentially possess some unusual properties, for example, decreased conformational ability or formation of stable secondary structures. Therefore, the preparation of such unnatural amino acids is of high interest. In this thesis, a route to enantiomerically pure 1-adamantylglycine was developed. The crucial step was the highly stereoselective addition of adamantylmagnesium bromide to the C=N bond of 2,3-O-cyclohexylidene-D-glyceraldehyde N-benzylnitrone effected in the presence of Lewis acid. Finally, 1-adamantylglycine was synthesized in 28 % yield over 6 steps. The routes to 9-aminofluorenylacetic and beta-aminobeta, beta-diphenylpropionic acids were proposed and they consist in the addition of allyl Grignard reagents to imines with various protecting groups, followed by oxidative transformation of the allyl group. Also some procedures for the preparation of 3,3-disubstituted 4-azetidinones, direct precursors of the corresponding beta-branched beta-amino acids, have been investigated.
Author : Michael Bryant Smith
Publisher : CRC Press
ISBN 13 : 1466577894
Total Pages : 244 pages
Book Rating : 4.4/5 (665 download)
Download or read book Methods of Non-α-Amino Acid Synthesis, Second Edition written by Michael Bryant Smith and published by CRC Press. This book was released on 2013-10-23 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although less common than α-amino acids, non-α-amino acids—where the amino group is not on the carbon immediately adjacent to the carboxyl group but is attached to another carbon in the chain (for example, the β, γ, δ carbon)—are components of biologically important molecules, are significant in the pharmaceutical industry, and are useful starting materials for many areas of organic chemistry. Since the publication of the first edition of this book nearly 20 years ago, synthetic work devoted to the preparation of non- α-amino acids has expanded greatly. Methods of Non-α-Amino Acid Synthesis, Second Edition has been extensively rewritten and reorganized, providing an up-to-date review of strategies and methods for non-α-amino acid synthesis, particularly those amino acids that are key synthetic intermediates or important compounds in their own right. It focuses on acyclic amino acids of C3–C10, but also aminoalkanoic carboxylic acids, aminoalkenoic acids, and aminoalkynoic acids. The new edition contains many updated references and has a greater emphasis on the biological importance of non-α-amino acids. In addition to an array of synthetic methods, the book offers discussions on why non-α-amino acids are important. The book covers synthetic methods that rely on substituent refunctionalization, the conversion of cyclic precursors to acyclic amino acids, conjugate addition reactions, and enolate anion reactions and condensation reactions that lead to non-α-amino acids. It also examines reactions and strategies that lead to good diastereoselectivity and enantioselectivity during synthesis. A chapter devoted to biologically important amino acids includes separate sections on GABA, GABOB, carnitine, DAVA, statine, and other significant amino acids as well as a new section on peptides and proteins that contain non-α-amino acids. The final chapter addresses aminocyclic and heterocyclic amino acids.
Author : Liam R. Marshall
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)
Download or read book Synthesis of Unnatural Amino Acids for the Design of Multi-metal Binding Α-helical Coiled Coils written by Liam R. Marshall and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
