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Synthesis Of Polyanhydrides For Controlled Drug Delivery
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Book Synopsis Synthesis of Polyanhydrides for Controlled Drug Delivery by : Brandon Michael Vogel
Download or read book Synthesis of Polyanhydrides for Controlled Drug Delivery written by Brandon Michael Vogel and published by . This book was released on 2003 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis is divided into three sections, all related to polyanhydride synthesis: first, attempts at the synthesis of polyanhydride-polyanhydride block copolymers, second, synthesis and characterization of polyethylene glycol containing aromatic polyanhydrides, and third, microwave polymerization of polyanhydrides. A strategy was developed to produce block copolymers of polyanhydrides using a hydroxyamide linker for the controlled release of proteins and higher molecular weight drugs. Block copolymers offer more control over micro structure than random copolymers, which allows for improved controlled release of proteins. The condensation polymerization of anhydrides typically yields random copolymers, therefore making the synthesis of block copolymers difficult. Methods of block copolymer synthesis explored consisted of end-functionalizing a short polyanhydride chain with hydroxylamine and ring opening polymerization through a macro-initiator. A discussion of the various methods explored is presented. Adding ethylene glycol segments to the monomers allows one to tailor the hydrophobicity of the polyanhydride, which in turn dictates the solubility of molecules within the polymer matrix and degradation rate of the polymer. Aromatic diacids were synthesized from chlorinated triethylene and pentaethylene glycols and hydroxy benzoic acid. The diacids were acetylated with acetic anhydride to produce homopolymers of polyanhydrides for the stabilization of proteins and drugs. The glycol containing polyanhydrides were characterized by NMR, GPC, DSC and dissolution testing. The release characteristics of the new polyanhydrides were evaluated with a hydrophilic (Acid Orange) and hydrophobic dye (Rhodamine B Base) and the release mechanisms were investigated. Microwave radiation was used to explore the high throughput synthesis of polyanhydrides for materials library characterization. Aliphatic diacids were acetylated in situ for two minutes in a closed reaction vessel before removal of excess acetic anhydride and subsequent polymerization, all in the microwave. Reaction conditions such as acetic anhydride equivalents, duration of microwave exposure and comparison to conventional polycondensation were explored. Microwave polymerization times of 6 to 8 minutes yielded optimum number average molecular weights in contrast to conventional polycondensation, which took between 1.5 to 2 hours under high vacuum. In conclusion, this thesis explored the synthesis and characterization of various polyanhydride-based homopolymers and copolymers by conventional as well as microwave techniques for controlled drug delivery applications.
Book Synopsis Synthesis and Characterization of Polyanhydrides for Controlled Drug Delivery Applications by : Amy Jo Sanders
Download or read book Synthesis and Characterization of Polyanhydrides for Controlled Drug Delivery Applications written by Amy Jo Sanders and published by . This book was released on 2002 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development and Synthesis of Novel Poly(beta-amino Acid) Drug Delivery Systems by : Ping Cao
Download or read book Development and Synthesis of Novel Poly(beta-amino Acid) Drug Delivery Systems written by Ping Cao and published by . This book was released on 2004 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Synthesis and Characterization of Polyanhydrides by : Brandon Michael Vogel
Download or read book The Synthesis and Characterization of Polyanhydrides written by Brandon Michael Vogel and published by . This book was released on 2004 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis is divided into four sections, all related to polyanhydride synthesis and characterization: first, the synthesis and characterization of polyethylene glycol containing aromatic polyanhydrides, second, the microwave polymerization of polyanhydrides, third the parallel synthesis and high-throughput dissolution screening, and finally preliminary investigations into the parallel investigation of blend phase behavior of a ternary polyanhydride blend. Oligomers of ethylene glycols were used to selectively modify the hydrophobicity of an aromatic polyanhydride. Aromatic diacids were synthesized from chlorinated triethylene and pentaethylene glycols and hydroxy benzoic acid. The diacids were acetylated with acetic anhydride to produce homopolymers of polyanhydrides for the stabilization of proteins and drugs. The glycol containing polyanhydrides were characterized by NMR, GPC, DSC and dissolution testing. The release characteristics of the new polyanhydrides were evaluated with a hydrophilic (Acid Orange) and hydrophobic dye (Rhodamine B Base) and the release mechanisms were investigated. Microwave radiation was used to explore the high throughput synthesis of polyanhydrides for materials library characterization. Aliphatic diacids were acetylated in situ for two minutes in a closed reaction vessel before removal of excess acetic anhydride and subsequent polymerization, all in the microwave. Reaction conditions such as acetic anhydride equivalents, duration of microwave exposure and comparision to conventional polycondensation were explored. Microwave polymerization times of 6 to 8 minutes yielded optimum number average molecular weights in contrast to conventional polycondensation, which took between 1.5 to 2 hours under high vacuum. A strategy was developed to synthesize copolymers of polyanhydrides using photolithographically generated microwells. The copolymers were characterized by NMR and spectroscopic FTIR as well as by parallel dissolution of a model dye from 25 copolymers using image analysis. Moreover, preliminary work was conducted on optical methods to investigate the phase behavior of a ternary blend of polyanhydrides in a parallel fashion. In conclusion, this thesis explored the synthesis and characterization of various polyanhydride-based homopolymers and copolymers by conventional as high-throughput techniques for controlled drug delivery applications.
Book Synopsis Synthesis of 1,1'-(hexane-1,6-diyl)bis(5-oxopyrrolidine-3-carboxylic Acid) as a Monomer for a Polyanhydride Drug Delivery System by : Scott L. Paradise
Download or read book Synthesis of 1,1'-(hexane-1,6-diyl)bis(5-oxopyrrolidine-3-carboxylic Acid) as a Monomer for a Polyanhydride Drug Delivery System written by Scott L. Paradise and published by . This book was released on 2012 with total page 51 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyanhydrides have been given much attention in the literature recently because of their desirable properties as controlled drug delivery solutions. Drug therapies could be loaded into a polyanhydride matrix and protected from denaturation and removal from the body while being slowly eluted as the polyanhydride degraded yielding a tailorable concentration profile in the bloodstream at therapeutic levels. To that end, this report discusses the synthesis of a novel monomer for polyanhydride synthesis: 1,1'-(hexane-1,6-diyl)bis(5-oxopyrrolidine-3-carboxylic acid) henceforth known as CPyH monomer for (carboxypyrrolidone)hexane monomer.
Book Synopsis Synthesis and Characterization of Bioerodible Polymers for Controlled Drug Release by : Howard Brian Rosen
Download or read book Synthesis and Characterization of Bioerodible Polymers for Controlled Drug Release written by Howard Brian Rosen and published by . This book was released on 1982 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of Biodegradable Polymer Micro- and Nanoparticles for Controlled Drug Delivery by Multiplexed Electrosprays by : Begoña Almería
Download or read book Synthesis of Biodegradable Polymer Micro- and Nanoparticles for Controlled Drug Delivery by Multiplexed Electrosprays written by Begoña Almería and published by . This book was released on 2012 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmaceutical Applications of Polymers for Drug Delivery by : David Jones
Download or read book Pharmaceutical Applications of Polymers for Drug Delivery written by David Jones and published by iSmithers Rapra Publishing. This book was released on 2004 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation The review focuses on the use of pharmaceutical polymer for controlled drug delivery applications. Examples of pharmaceutical polymers and the principles of controlled drug delivery are outlined and applications of polymers for controlled drug delivery are described. The field of controlled drug delivery is vast therefore this review aims to provide an overview of the applications of pharmaceutical polymers. The review is accompanied by approximately 250 abstracts taken from papers and books in the Rapra Polymer Library database, to facilitate further reading on this subject.
Book Synopsis Polymers for Controlled Drug Delivery by : Peter J. Tarcha
Download or read book Polymers for Controlled Drug Delivery written by Peter J. Tarcha and published by CRC Press. This book was released on 1990-11-21 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms. The book primarily discusses classes of polymers and polymeric vehicles, including particulates, such as latexes, coacervates, ion-exchange resins, and liposomes, as well as non-particulate vehicles such as enteric coatings, mediators, and bioadhesives. Other topics discussed include diffusion; biodegradation-controlled delivery; animal model studies for toxicity, metabolism, and elimination testing; and FDA requirements for clinical studies. Drug delivery researchers will find this book to be an invaluable reference tool.
Book Synopsis Polymers for Biomedicine by : Carmen Scholz
Download or read book Polymers for Biomedicine written by Carmen Scholz and published by John Wiley & Sons. This book was released on 2017-07-17 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlighting dynamic developments in polymer synthesis, this book focuses on the chemical techniques to synthesize and characterize biomedically relevant polymers and macromolecules. • Aids researchers developing polymers and materials for biomedical applications • Describes biopolymers from a synthetic perspective, which other similar books do not do • Covers areas that include: cationically-charged macromolecules, pseudo-peptides, polydrugs and prodrugs, controlled radical polymerization, self-assembly, polycondensates, and polymers for surface modification
Book Synopsis Polymers for Controlled Drug Delivery by : Peter J. Tarcha
Download or read book Polymers for Controlled Drug Delivery written by Peter J. Tarcha and published by CRC Press. This book was released on 2023-06-14 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms. The book primarily discusses classes of polymers and polymeric vehicles, including particulates, such as latexes, coacervates, ion-exchange resins, and liposomes, as well as non-particulate vehicles such as enteric coatings, mediators, and bioadhesives. Other topics discussed include diffusion; biodegradation-controlled delivery; animal model studies for toxicity, metabolism, and elimination testing; and FDA requirements for clinical studies. Drug delivery researchers will find this book to be an invaluable reference tool.
Book Synopsis Biodegradable Polyanhydrides for Controlled Drug Release by : Almudena Prudencio
Download or read book Biodegradable Polyanhydrides for Controlled Drug Release written by Almudena Prudencio and published by . This book was released on 2006 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lastly, a new synthetic methodology was developed to incorporate monofunctional phenolic antiseptics into a polymeric backbone as pendant group that expands the range of drugs that can be potentially incorporated while obtaining materials that may be useful as antiseptic coatings or topical disinfectants to prevent and control infection.
Book Synopsis Synthesis of Degradable Putrescine-based Poly(phosphoester-urethanes) for Controlled Drug Delivery and Tissue Scaffolding by : Bassil I. Dahiyat
Download or read book Synthesis of Degradable Putrescine-based Poly(phosphoester-urethanes) for Controlled Drug Delivery and Tissue Scaffolding written by Bassil I. Dahiyat and published by . This book was released on 1992 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Polyanhydride Blends as Drug Delivery Matrices to Control Biofilms, Bone and Nerve Regeneration by :
Download or read book Polyanhydride Blends as Drug Delivery Matrices to Control Biofilms, Bone and Nerve Regeneration written by and published by . This book was released on 2008 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biodegradable polyanhydrides were fabricated into disks, coatings, microspheres, and tubes for controlled drug delivery as well as enhanced thermal and mechanical properties. The polymer systems were evaluated as potential treatments for periodontal disease, orthopedic injuries, nerve regeneration, and biofilm formation. The polymers contained the non-steroidal anti-inflammatory drug (NSAID), salicylic acid and the antibiotic, ampicillin, in the polymer backbone, which are subsequently released as the polymers degrade. Significantly, the polymers can be fabricated into these different geometries that would not be possible with the drug molecules alone. This dissertation characterizes the in vitro degradation of the polyanhydrides specifically for the multiple applications. Polymer degradation was monitored by high pressure liquid chromatography (HPLC) for final degradation products. The effect of physically admixing additional drugs into the polymer matrix was studied as well, where the admixed drugs were delineated from the chemically incorporated drugs by HPLC. Accelerated in vitro degradation rates were developed using highly basic media. Mechanical and thermal properties were examined for potential orthopedic and nerve applications. The compliance and modulus of polymer blends and composites were measured to characterize the flexibility and strength of each system. Additionally, properties, such as glass transition temperature (Tg) and decomposition temperature (Td) were measured to monitor polymer changes as a result of processing and degradation. Overall, the fundamental chemical, thermal and mechanical properties of each polyanhydride system were monitored. This dissertation describes the optimization of controlled drug release rates for specific applications through composites and blends of ceramics (hydroxyapatite), drugs (antimicrobials and NSAIDs), and polymers (polyanhydrides).
Book Synopsis Natural and Synthetic Biomedical Polymers by : Sangamesh G. Kum bar
Download or read book Natural and Synthetic Biomedical Polymers written by Sangamesh G. Kum bar and published by Newnes. This book was released on 2014-01-21 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers are important and attractive biomaterials for researchers and clinical applications due to the ease of tailoring their chemical, physical and biological properties for target devices. Due to this versatility they are rapidly replacing other classes of biomaterials such as ceramics or metals. As a result, the demand for biomedical polymers has grown exponentially and supports a diverse and highly monetized research community. Currently worth $1.2bn in 2009 (up from $650m in 2000), biomedical polymers are expected to achieve a CAGR of 9.8% until 2015, supporting a current research community of approximately 28,000+. Summarizing the main advances in biopolymer development of the last decades, this work systematically covers both the physical science and biomedical engineering of the multidisciplinary field. Coverage extends across synthesis, characterization, design consideration and biomedical applications. The work supports scientists researching the formulation of novel polymers with desirable physical, chemical, biological, biomechanical and degradation properties for specific targeted biomedical applications. - Combines chemistry, biology and engineering for expert and appropriate integration of design and engineering of polymeric biomaterials - Physical, chemical, biological, biomechanical and degradation properties alongside currently deployed clinical applications of specific biomaterials aids use as single source reference on field. - 15+ case studies provides in-depth analysis of currently used polymeric biomaterials, aiding design considerations for the future
Book Synopsis Nanostructures for Oral Medicine by : Ecaterina Andronescu
Download or read book Nanostructures for Oral Medicine written by Ecaterina Andronescu and published by Elsevier. This book was released on 2017-04-11 with total page 1036 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructures for Oral Medicine presents an up-to-date examination of the applications and effects of nanostructured materials in oral medicine, with each chapter addressing recent developments, specific applications, and uses of nanostructures in the oral administration of therapeutic agents in dentistry. The book also includes coverage of the biocompatibility of nanobiomaterials and their remarkable potential in improving human health and in reducing environmental pollution. Emerging advances, such as Dr. Franklin Tay's concept of a new nanotechnology process of growing extremely small, mineral-rich crystals and guiding them into the demineralized gaps between collagen fibers to prevent the aging and degradation of resin-dentin bonding is also discussed. This work will be of great value to those who work in oral medicine, providing them with a resource to gain a greater understanding of how nanotechnology can help them create more efficient, cost-effective products. In addition, it will be of great interest to those who work in materials science who wish to gain a greater appreciation of how nanostructured materials are applied in this field. - Outlines the major uses of nanostructured materials for oral medicine, including the properties of each material discussed and how it should best be applied - Explores how nanostructured materials enable the creation of more effective drug delivery systems in oral medicine - Discusses how novel uses of nanostructured materials may be applied in oral medicine to create more effective devices
Book Synopsis Amphiphilic Polymers for Controlled Release by :
Download or read book Amphiphilic Polymers for Controlled Release written by and published by . This book was released on 2009 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
