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Synthesis Of Novel Phosphorothioate And Pyrophosphate Analysis Of Inositol Phosphates
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Book Synopsis Synthesis of Novel Phosphorothioate and Pyrophosphate Analysis of Inositol Phosphates by : Nicholas Jason Noble
Download or read book Synthesis of Novel Phosphorothioate and Pyrophosphate Analysis of Inositol Phosphates written by Nicholas Jason Noble and published by . This book was released on 1992 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Inositol Phosphates and Derivatives by : Allen Bernard Reitz
Download or read book Inositol Phosphates and Derivatives written by Allen Bernard Reitz and published by . This book was released on 1991 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume examines the synthesis, biochemistry, and pharmacological evaluation aspects of design compounds with therapeutic effects. Two overview chapters provide comprehensive background information on stereochemistry and nomenclature of inositol phosphates, basic biochemistry, synthetic challenges, and related pharmacology. Subsequent chapters describe novel methods of preparation, including the use of unusual starting materials and mediation by microorganisms, therapeutic potential and bioactivity, and structure-activity relationships.
Book Synopsis The Synthesis of Myo-inositol Phosphates and Phosphorothioates by : Stephen Joseph Mills
Download or read book The Synthesis of Myo-inositol Phosphates and Phosphorothioates written by Stephen Joseph Mills and published by . This book was released on 1991 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Inositol Phosphates Significance by : David C. Billington
Download or read book The Inositol Phosphates Significance written by David C. Billington and published by Wiley-VCH. This book was released on 1993 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: The transmission of messages across cell membranes is an essential process in complex organisms. The discovery of a new transmembrane signalling system, involving the production of inositol phosphates inside stimulated cells, has led to widespread interest in the chemical synthesis of the inositol phosphates and their analogues. This book provides a concise but comprehensive account of the methods of organic synthesis of inositol phosphates and supplements this with a general background treatment of the stereochemistry and nomenclature of the inositols. The biochemical importance and complexity of the system are also covered, as is the synthesis of inositol phosphate analogues. The book is intended for advanced undergraduate students, postgraduates and research workers in both university and industrial laboratories. '... an invaluable and well-written text for all those working on cellular secondary messengers ... the most comprehensive of all the reviews so far written in this very topical area.' Professor Steven V. Ley, Department of Chemistry, Cambridge University
Book Synopsis Studies in the Synthesis of Myo-inositol Phosphates by : Changsheng Liu
Download or read book Studies in the Synthesis of Myo-inositol Phosphates written by Changsheng Liu and published by . This book was released on 1990 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis and Biology of Inositol Phosphates and Thiophosphates by : A. M. Cooke
Download or read book Synthesis and Biology of Inositol Phosphates and Thiophosphates written by A. M. Cooke and published by . This book was released on 1991 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis myo-Inositol Phosphates, Phosphoinositides, and Signal Transduction by : B.B. Biswas
Download or read book myo-Inositol Phosphates, Phosphoinositides, and Signal Transduction written by B.B. Biswas and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: `The heterogeneity of topics ... is very ambitious, and the result is, overall, successful because of the high quality of the individual contributions ... highly recommended.' -American Scientist, from a review of a previous volume Volume 26 examines the emerging areas of signal transduction based on myoinositol phosphates and Ca2+ while focusing on plant and animal responses. Chapters explore synthesis, separation, and identification of different inositol phosphates.
Book Synopsis Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards by :
Download or read book Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards written by and published by . This book was released on 1993 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theses on any subject submitted by the academic libraries in the UK and Ireland.
Book Synopsis Chemistry and Application of H-Phosphonates by : Kolio D. Troev
Download or read book Chemistry and Application of H-Phosphonates written by Kolio D. Troev and published by Elsevier. This book was released on 2006-09-25 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry and Application of H-Phosphonates is an excellent source for those planning the synthesis of new phosphorus-containing compounds and in particular derivatives containing a phosphonate, phosphoramide or phosphonic acid diester group. The rich chemistry, low cost and easy availability of diesters of H-phosphonic acid makes them an excellent choice as synthone in a number of practically important reactions. Phosphonic acid esters are intermediates in the synthesis of important classes of compounds such as alpha-aminophosphonic acids, bisphosphonates, epoxyalkylphosphonates, alpha-hydroxyalkylphosphonates, phosphoramides, poly(alkylene H-phosphonate)s, poly(alkylene phosphate)s, nucleoside H-phosphonates. The synthesis of each of these compound classes is reviewed in detail. Alpha-Aminophosphonic acids are an important class of biologically active compounds, which have received an increasing amount of attention because they are considered to be structural analogues of the corresponding Alpha-amino acids. The utilities of alpha-aminophosphonates as peptide mimics, haptens of catalytic antibodies, enzyme inhibitors, inhibitors of cancers, tumours, viruses, antibiotics and pharmacologic agents are well documented. Alpha-Hydroxyalkanephosphonates are compounds of significant biological and medicinal applications. Dialkyl epoxyalkylphosphonates are of interest because of their use as intermediates in the synthesis of bioactive substances, and as modifiers of natural and synthetic polymers. Bisphosphonates are drugs that have been widely used in different bone diseases, and have recently been used successfully against many parasites. Poly(alkylene H-phosphonate)s and poly(alkylene phosphate)s are promising, biodegradable, water soluble, new polymer-carriers of drugs. Nucleoside H-phosphonates seem to be the most attractive candidates as starting materials in the chemical synthesis of DNA and RNA fragments. The 5’-hydrogen phosphonate-3’-azido-2’,3’-dideoxythimidine is one of the most significant anti-HIV prodrug, which is currently in clinical trials. Chapters review the synthesis; physical and spectral properties (1H, 13C, 31P and 17O NMR data); characteristic reactions; important classes of compounds based on these esters of H-phosphonic acid; their application as physiologically active substances, flame retardants, catalysts, heat and light stabilizers, lubricants, scale inhibitors, polymer-carriers of drugs; preparation of H-phosphonate diesters and general procedures for conducting the most important reactions. * provides ideas for the synthesis of phosphonates, phosphoramides and diesters of phosphonic acid (new phosphorus-containing compounds)* reviews structure, spectra and biological activity of H-phosphonates and their derivatives* examines new areas of application of phosphorus-containing compounds
Book Synopsis Phosphoinositides II: The Diverse Biological Functions by : Tamas Balla
Download or read book Phosphoinositides II: The Diverse Biological Functions written by Tamas Balla and published by Springer Science & Business Media. This book was released on 2012-02-28 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.
Book Synopsis Carbohydrate Chemistry by : R J Ferrier
Download or read book Carbohydrate Chemistry written by R J Ferrier and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrate Chemistry provides review coverage of all publications relevant to the chemistry of monosaccharides and oligosaccharides in a given year. The amount of research in this field appearing in the organic chemical literature is increasing because of the enhanced importance of the subject, especially in areas of medicinal chemistry and biology. In no part of the field is this more apparent than in the synthesis of oligosaccharides required by scientists working in glycobiology. Clycomedicinal chemistry and its reliance on carbohydrate synthesis is now very well established, for example, by the preparation of specific carbohydrate- based antigens, especially cancer-specific oligosaccharides and glycoconjugates. Coverage of topics such as nucleosides, amino-sugars, alditols and cyclitols also covers much research of relevance to biological and medicinal chemistry. Each volume of the series brings together references to all published work in given areas of the subject and serves as a comprehensive database for the active research chemist Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.
Book Synopsis Journal of the Chemical Society by :
Download or read book Journal of the Chemical Society written by and published by . This book was released on 1989 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis and Characterization of Glycosides by : Marco Brito-Arias
Download or read book Synthesis and Characterization of Glycosides written by Marco Brito-Arias and published by Springer Nature. This book was released on 2022-04-22 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third edition is a comprehensive and extended study about the best known approaches for preparing the main types of glycosides, covering the classic and more recent glycosylation reactions used for preparing simple and challenging glycosides currently used as potent antiviral and antineoplastic drugs, or fluorogenic substrates used for enzymatic detection in cell biology. Besides, this new edition provides more examples of the glycosidic methodologies followed for preparing complex glycoconjugates such as glycoproteins and glycosphingolipids and gangliosides used as adjuvants or as synthetic vaccines candidates. Also, additional mechanistic evidence is presented for better understanding of the glycosylation reaction, trying to identify the variables mainly depending on protecting and leaving groups, as well as catalyst and reaction condition which altogether directs the anomeric stereo control. A chapter on the glycoside hydrolysis is included in view of the increasing interest in the use of biomass as a natural and renewable source for obtaining important intermediates or products used in food or valuable materials. The author includes information in the characterization of glycosides section with the aim of giving additional tools for the structural assignment through NMR, X-Ray and mass spectra techniques.
Book Synopsis Multimodal Concepts for Integration of Cytotoxic Drugs by : Martin J. Brown
Download or read book Multimodal Concepts for Integration of Cytotoxic Drugs written by Martin J. Brown and published by Springer Science & Business Media. This book was released on 2006-08-06 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies. The second part comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented.
Book Synopsis Immunopharmacology by : Manzoor M. Khan
Download or read book Immunopharmacology written by Manzoor M. Khan and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.
Book Synopsis Fundamentals of Nuclear Pharmacy by : Gopal B. Saha
Download or read book Fundamentals of Nuclear Pharmacy written by Gopal B. Saha and published by Springer. This book was released on 2017-11-11 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently an estimated 17 million nuclear medicine procedures are performed each year in the US and constantly evolving, as new radiopharmaceuticals and imaging techniques are introduced for better diagnosis and treatment of human diseases. In keeping up with new developments, the Seventh Edition of Fundamentals of Nuclear Pharmacy chronicles the advancements in radiopharmaceuticals and their use in clinical applications. It discusses basic concepts such as the atom, radioactive decay, instrumentation and production of radionuclides, and explores the design, labeling, characteristics and quality control of radiopharmaceuticals. Radiation regulations and diagnostic and therapeutic applications of radiopharmaceuticals are detailed. Thoroughly updated, the Seventh Edition includes new topics such as alternative productions of 99Mo; production of 64Cu, 86Y, 89Zr, 177Lu, 223Ra; synthesis and clinical uses of new radiopharmaceuticals such as DaTscan, Xofigo, Amyvid, Neuraceq, Vizamyl, Axumin and 68Ga-DOTATATE; dosimetry of new radiopharmaceuticals; theranostic agents and translational medicine. It features numerous examples, diagrams, and images to further clarify the information and offers end- of-chapter questions to help readers assess their comprehension of the material. Recognized as a classic text on nuclear chemistry and pharmacy and acclaimed for its concise and easy-to-understand presentation, Fundamentals of Nuclear Pharmacy is an authoritative resource for nuclear medicine physicians, residents, students, and technologists.
Book Synopsis Carbohydrates in Drug Discovery and Development by : Vinod K. Tiwari
Download or read book Carbohydrates in Drug Discovery and Development written by Vinod K. Tiwari and published by Elsevier. This book was released on 2020-08-17 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrates in Drug Discovery and Development: Synthesis and Application examines important developments in the synthesis, biology and biomedical applications of carbohydrates, along with the therapeutic and pharmacological aspects of carbohydrate chemistry. In addition to the advancement in construction of oligosaccharides, chemists are also making strides in the ability to assemble glycopeptides and glycoproteins. This book covers advanced aspects of carbohydrates, starting with a brief introduction, nomenclature and classification that is followed by a discussion of glyosidic bond formation methodology, recent protocols for the synthesis of O-glycosides, N-glycosides, thioglycosides and C-glycosides, Intramolecular Aglycon Delivery (IAD), carbohydrate modification, and more. Written by a team of international experts actively working on different aspect of synthetic carbohydrate chemistry, this book is an invaluable resource for carbohydrate chemists, natural products chemists, medicinal chemists, synthetic organic chemists and biochemists working in industry and academia. Gives a practical, detailed overview on a wide range of carbohydrate systems relevant for drug discovery and development Highlights applications of functionalized carbohydrates and their use as synthons for the construction of various systems Covers recent developments in the synthesis of various glycohybrid molecules
