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Synthesis And Characterization Of Photon Upconverting Nanoparticles As Contrast Agents For Magnetic Resonance Imaging
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Book Synopsis Synthesis and Characterization of Photon Upconverting Nanoparticles as Contrast Agents for Magnetic Resonance Imaging by : Shanfeng Tang
Download or read book Synthesis and Characterization of Photon Upconverting Nanoparticles as Contrast Agents for Magnetic Resonance Imaging written by Shanfeng Tang and published by . This book was released on 2009 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cerium Oxide Nanoparticles and Gadolinium Integration by : Peter Eriksson
Download or read book Cerium Oxide Nanoparticles and Gadolinium Integration written by Peter Eriksson and published by Linköping University Electronic Press. This book was released on 2019-08-29 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt: A challenging task, in the area of magnetic resonance imaging is to develop contrast enhancers with built-in antioxidant properties. Oxidative stress is considered to be involved in the onset and progression of several serious conditions such as Alzheimer’s and Parkinson’s disease, and the possibility to use cerium-contained nanoparticles to modulate such inflammatory response has gained a lot of interest lately. The rare earth element gadolinium is, due to its seven unpaired f-electrons and high symmetry of the electronic state, a powerful element for contrast enhancement in magnetic resonance imaging. Chelates based on gadolinium are the most commonly used contrast agents worldwide. When introducing external contrast agents there is always a risk that it may trigger inflammatory responses, why there is an urgent need for new, tailor-made contrast agents. Small sized cerium oxide nanoparticles have electronic structures that allows coexistence of oxidation states 3+ and 4+ of cerium, which correlates to applicable redox reactions in biomedicine. Such cerium oxide nanoparticles have recently shown to exhibit antioxidant properties both in vitro and in vivo, via the mechanisms involving enzyme mimicking activity. This PhD project is a comprehensive investigation of cerium oxide nanoparticles as scaffold materials for gadolinium integration. Gadolinium is well adopted into the crystal structure of cerium oxide, enabling the combination of diagnostic and therapeutic properties into a single nanoparticle. The main focus of this thesis project is to design cerium oxide nanoparticles with gadolinium integration. A stepwise approach was employed as follows: 1) synthesis with controlled integration of gadolinium, 2) material characterization by means of composition crystal structure, size, and size distribution and 3) surface modification for stabilization. The obtained nanoparticles exhibit remarkable antioxidant capability in vitro and in vivo. They deliver strongly enhanced contrast per gadolinium in magnetic resonance imaging, compared to commercially available contrast agents. A soft shell of dextran is introduced to encapsulate the cerium oxide nanoparticles with integrated gadolinium, which protects and stabilizes the hard core and to increases their biocompatibility. The dextran-coating is clearly shown to reduce formation of a protein corona and it improves the dispersibility of the nanoparticles in cell media. Functionalization strategies are currently being studied to endow these nanoparticles with specific tags for targeting purposes. This will enable guidance of the nanoparticles to a specific tissue, for high local magnetic resonance contrast complemented with properties for on-site reduced inflammation. In conclusion, our cerium oxide nanoparticles with integrated gadolinium, exhibit combined therapeutic and diagnostic, i.e. theragnostic capabilities. This type of nanomaterial is highly promising for applications in the field of biomedical imaging.
Book Synopsis Synthesis and Characterization of Contrast Agents for Targeted Magnetic Resonance Imaging by : Federico A. Rojas-Quijano
Download or read book Synthesis and Characterization of Contrast Agents for Targeted Magnetic Resonance Imaging written by Federico A. Rojas-Quijano and published by . This book was released on 2008 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of contrast agents in the clinical setting has increased in recent years with the advent of novel imaging probes capable of reporting specific physiological changes, such as changes in pH or glucose levels, associated with the early development of certain malignancies. The need for early detection of such changes in vivo is addressed here with the design of molecular probes that accumulate in abnormal tissues via a change in oxidation state or non-covalent affinity. The potential of these agents for imaging applications will be discussed in terms of their relaxometric properties, thermodynamic stabilities and kinetic inertness. Furthermore, two of the probes reported here have the potential to work as optical imaging agents as well and their luminescent properties will be discussed from this perspective.
Book Synopsis Synthesis, Characterization and Sensing Application of Photon Upconverting Nanoparticles by : Manoj Kumar
Download or read book Synthesis, Characterization and Sensing Application of Photon Upconverting Nanoparticles written by Manoj Kumar and published by . This book was released on 2009 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Colloidal Upconverting Nanoparticle Systems for Integration in Targeting, Therapeutics and Imaging Applications by : Rafik Naccache
Download or read book Colloidal Upconverting Nanoparticle Systems for Integration in Targeting, Therapeutics and Imaging Applications written by Rafik Naccache and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design, Synthesis and Characterization of Novel Exogenous Smart/bioresponsive Contrast Agents for Magnetic Resonance and Optical Imaging by : Anurag Mishra
Download or read book Design, Synthesis and Characterization of Novel Exogenous Smart/bioresponsive Contrast Agents for Magnetic Resonance and Optical Imaging written by Anurag Mishra and published by . This book was released on 2008 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Bimodal Upconverting Nanoparticles for MRI and Optical Imaging by : Qian Ying Li
Download or read book Bimodal Upconverting Nanoparticles for MRI and Optical Imaging written by Qian Ying Li and published by . This book was released on 2016 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrating multiple functionalities into individual nanoscale materials is of tremendous importance in biomedicine, since this would expand the capabilities of nanoscale materials to perform multiple tasks. Here, fluorescence optical imaging and magnetic resonance imaging (MRI) are combined within the same nanoparticle based material. NaYF4: Tm3+, Yb3+, showed NIR to NIR upconversion, giving deep tissue penetration, which is an advantage in medical imaging. Their lanthanide ions (Tm3+/Yb3+) derived optical properties in the near infrared region of the spectrum, where tissue is maximally transparent. Multimodal properties may be imparted to NaYF4: Tm3+, Yb3+ via the functionalization of gadonium-tetraazacyclododecanetetraacetic acid (Gd-DOTA), a commercially available MRI contrast agent. Gd-DOTA was covalently bonded to the surface of the silica coated UCNPs using the click reaction. This imaging probe may be used for both MRI and fluorescent imaging. Another approach to achieve bimodalities is by doping Gd3+ ions into the systems of UCNPs, which provides both magnetic and optical properties. Ultra-small NaGdF4, Tm3+, Yb3+ of 5 nm was chosen since it is an excellent T1 contrast agent. The surface chemistry of nanoparticles has direct impact on its physiochemical properties. Therefore, it is aimed to design nanoparticle based blood pool contrast agent for disease diagnostics, which involved the functionalization the polyethylene glycol (PEG) polymer on the ultra-small UCNPs. Here we report the design and characterization of bimodal contrast agent, PEG coated ultra-small NaGdF4, Tm3+, Yb3+
Book Synopsis Nanobiomaterials in Medical Imaging by : Alexandru Grumezescu
Download or read book Nanobiomaterials in Medical Imaging written by Alexandru Grumezescu and published by William Andrew. This book was released on 2016-04-13 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanobiomaterials in Medical Imaging presents the latest developments in medical exploratory approaches using nanotechnology. Leading researchers from around the world discuss recent progress and state-of-the-art techniques. The book covers synthesis and surface modification of multimodal imaging agents, popular examples of nanoparticles and their applications in different imaging techniques, and combinatorial therapy for the development of multifunctional nanocarriers. The advantages and potential of current techniques are also considered. This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians. A valuable resource for researchers, practitioners and students working in biomedical, biotechnological and engineering fields A detailed guide to recent scientific progress, along with the latest application methods Presents innovative opportunities and ideas for developing or improving technologies in nanomedicine and medical imaging
Book Synopsis Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile by : Maria Contel
Download or read book Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile written by Maria Contel and published by MDPI. This book was released on 2019-10-01 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer treatment. These compounds are highly effective and selective in cancers resistant to cisplatin and other chemotherapeutic agents. Research in this area has recently exploded with a relevant number of patents and clinical trials, in addition to reports in scientific journals. Furthermore, in parallel to the synthesis of coordination and organometallic compounds comprising many different metals and unconventional platinum-based derivatives, researchers are focused on optimizing mechanistic and pharmacological features of promising drug candidates. This Special Issue aims to highlight the latest advances in anticancer metallodrugs with a focus on unconventional anticancer agents, as well as novel activation, targeting and delivery strategies aimed at improving their pharmacological profile.
Book Synopsis Emerging Sustainable Nanomaterials for Biomedical Applications by : Seema Garg
Download or read book Emerging Sustainable Nanomaterials for Biomedical Applications written by Seema Garg and published by Springer Nature. This book was released on with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook on the Physics and Chemistry of Rare Earths by :
Download or read book Handbook on the Physics and Chemistry of Rare Earths written by and published by Elsevier. This book was released on 2015-10-14 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook on the Physics and Chemistry of Rare Earths is a continuing series of books covering all aspects of rare earth science, including chemistry, life sciences, materials science, and physics. The handbook emphasizes rare earth elements [Sc, Y and the lanthanides (La through Lu)] but, when relevant, information also is included about the closely related actinide elements. The individual chapters are comprehensive, broad, up-to-date critical reviews written by highly experienced invited experts. The series, which was started in 1978 by Professor Karl A. Gschneidner, Jr., combines and integrates both the fundamentals and applications of these elements and now publishes two volumes a year. Covers all aspects of rare earth science, including chemistry, life sciences, materials science, and physics. Includes contributions from highly experienced, invited experts Provides comprehensive, up-to-date critical reviews of developments in the field Combines and integrates both the fundamentals and applications of rare earth elements
Book Synopsis Persistent Luminescence by : Vijay Kumar
Download or read book Persistent Luminescence written by Vijay Kumar and published by Springer Nature. This book was released on with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hybrid Nanomaterials written by Weibo Cai and published by CRC Press. This book was released on 2017-05-25 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, an unprecedented expansion in the field of nanomedicine has resulted in the development of new nanomaterials for diagnosis and therapy of various diseases such as cancer. This book covers the design, synthesis and applications of various functionally-hybridized nanomaterials for biomedical applications. It includes strategies for design and synthesis of hybrid nanomaterials, surface engineering of various nanoparticle-based hybrid nanosystems for cancer imaging and therapy, toxicity aspects of nanomaterials and the challenges in translation research of hybrid nanomaterials.
Book Synopsis The Synthesis and Characterization of Fluorescein Iron Dextran as a Contrast Agent for Magnetic Resonance Imaging by : Alexa Suzanne Walbran
Download or read book The Synthesis and Characterization of Fluorescein Iron Dextran as a Contrast Agent for Magnetic Resonance Imaging written by Alexa Suzanne Walbran and published by . This book was released on 1991 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Metal Oxide Nanoparticles for Contrast Enhancement in Magnetic Resonance Imaging by : Maria Ahrén
Download or read book Metal Oxide Nanoparticles for Contrast Enhancement in Magnetic Resonance Imaging written by Maria Ahrén and published by . This book was released on 2013 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Den här avhandlingen handlar om design och utveckling av nanopartiklar med ändamålet att producera ett nytt lovande kontrastmedel för magnetresonanstomografi (MRT). En nanopartikel är per definition en mycket liten partikel med en diameter i storleksordningen mindre än 100 nm. Den lilla storleken hos nanopartiklar får till följd att partikelns yta är mycket stor i förhållande till partikelns volym och det påverkar i högsta grad egenskaperna för materialet. Såväl de elektriska, magnetiska och optiska egenskaperna förändras och nanopartiklars unika karaktärer utnyttjas i en rad applikationer och i både medicinska och tekniska produkter.
Book Synopsis Chemoselective and Bioorthogonal Ligation Reactions by : W. Russ Algar
Download or read book Chemoselective and Bioorthogonal Ligation Reactions written by W. Russ Algar and published by John Wiley & Sons. This book was released on 2017-03-17 with total page 923 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely, one-stop reference is the first on an emerging and interdisciplinary topic. Covering both established and recently developed ligation chemistries, the book is divided into two didactic parts: a section that focuses on the details of bioorthogonal and chemoselective ligation reactions at the level of fundamental organic chemistry, and a section that focuses on applications, particularly in the areas of chemical biology, biomaterials, and bioanalysis, highlighting the capabilities and benefits of the ligation reactions. With chapters authored by outstanding scientists who range from trailblazers in the field to young and emerging leaders, this book on a highly interdisciplinary topic will be of great interest for biochemists, biologists, materials scientists, pharmaceutical chemists, organic chemists, and many others.
Book Synopsis Dextran Sulfate-Coated Iron Oxide Nanoparticles as Targeted MRI Contrast Agents for Neuroinflammation by : Martin Hall
Download or read book Dextran Sulfate-Coated Iron Oxide Nanoparticles as Targeted MRI Contrast Agents for Neuroinflammation written by Martin Hall and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis contains two distinct part: the first two chapters focus on research efforts towards the use of Dextran Sulfate-Coated Iron Oxide (SDIO) Nanoparticles as an MRI contrast agent for the diagnosis of brain inflammation, while the third chapter is a personal reflection on experiences from assisting with the development and initial implementation of an online, UC-wide Introduction to Research course. In Chapter 1, the synthesis and characterization of SDIO nanoparticles is described in detail. The synthetic work in this chapter showed great reproducibility with previous syntheses in our lab. New characterization efforts helped illuminate the physical and magnetic degradation process of SDIO nanoparticles in water and acidic solutions, intended to help guide future work into how the particles break down in vivo. Chapter 2 covers a series of cell studies that are intended as support for the potential future use of SDIO nanoparticles as an MRI contrast agent for diagnosing brain inflammation through receptor-specific uptake in activated microglia. While prior work in our lab has already shown promising results in using SDIO for this purpose in mice, several underlying questions and concerns needed to be addressed before continuing further with animal models. Firstly, possible off-target uptake by astrocytes was examined, as this could potentially cause background signal and false positives. Secondly, additional studies into the biocompatibility of SDIO nanoparticles with cortical cells were undertaken, to further assess whether the particles are a safe diagnostic tool. Chapter 3 details my personal involvement with the development and implementation of an online Introduction to Research course, under the guidance of Dr. Angelique Louie. My experiences with this course have proven incredibly valuable for personal development as I transition into my future career as a high school science teacher.
