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Synthesis And Characterization Of Iron Oxide Nanoparticles And Investigation Of Their Biocompatibility On Astrocyte Cultures
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Book Synopsis Synthesis and Characterization of Iron Oxide Nanoparticles and Investigation of Their Biocompatibility on Astrocyte Cultures by : Mark Geppert
Download or read book Synthesis and Characterization of Iron Oxide Nanoparticles and Investigation of Their Biocompatibility on Astrocyte Cultures written by Mark Geppert and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis and Characterization of Copper Oxide Nanoparticles and Investigation of Their Effects on the Vitality and Metabolism of Astrocytes by : Felix Bulcke
Download or read book Synthesis and Characterization of Copper Oxide Nanoparticles and Investigation of Their Effects on the Vitality and Metabolism of Astrocytes written by Felix Bulcke and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis and Characterization of Copper Oxide Nanoparticles and Investigation of Their Effects on the Vitality and Metabolism of Astrocytes by :
Download or read book Synthesis and Characterization of Copper Oxide Nanoparticles and Investigation of Their Effects on the Vitality and Metabolism of Astrocytes written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Iron Oxide Nanoparticles for Biomedical Applications by : Sophie Laurent
Download or read book Iron Oxide Nanoparticles for Biomedical Applications written by Sophie Laurent and published by Elsevier. This book was released on 2017-10-20 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization and Application begins with several chapters covering the synthesis, stabilization, physico-chemical characterization and functionalization of iron oxide nanoparticles. The second part of the book outlines the various biomedical imaging applications that currently take advantage of the magnetic properties of iron oxide nanoparticles. Brief attention is given to potential iron oxide based therapies, while the final chapter covers nanocytotoxicity, which is a key concern wherever exposure to nanomaterials might occur. This comprehensive book is an essential reference for all those academics and professionals who require thorough knowledge of recent and future developments in the role of iron oxide nanoparticles in biomedicine. Unlocks the potential of iron oxide nanoparticles to transform diagnostic imaging techniques Contains full coverage of new developments and recent research, making this essential reading for researchers and engineers alike Explains the synthesis, processing and characterization of iron oxide nanoparticles with a view to their use in biomedicine
Book Synopsis Dextran Sulfate-Coated Iron Oxide Nanoparticles as Targeted MRI Contrast Agents for Neuroinflammation by : Martin Hall
Download or read book Dextran Sulfate-Coated Iron Oxide Nanoparticles as Targeted MRI Contrast Agents for Neuroinflammation written by Martin Hall and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis contains two distinct part: the first two chapters focus on research efforts towards the use of Dextran Sulfate-Coated Iron Oxide (SDIO) Nanoparticles as an MRI contrast agent for the diagnosis of brain inflammation, while the third chapter is a personal reflection on experiences from assisting with the development and initial implementation of an online, UC-wide Introduction to Research course. In Chapter 1, the synthesis and characterization of SDIO nanoparticles is described in detail. The synthetic work in this chapter showed great reproducibility with previous syntheses in our lab. New characterization efforts helped illuminate the physical and magnetic degradation process of SDIO nanoparticles in water and acidic solutions, intended to help guide future work into how the particles break down in vivo. Chapter 2 covers a series of cell studies that are intended as support for the potential future use of SDIO nanoparticles as an MRI contrast agent for diagnosing brain inflammation through receptor-specific uptake in activated microglia. While prior work in our lab has already shown promising results in using SDIO for this purpose in mice, several underlying questions and concerns needed to be addressed before continuing further with animal models. Firstly, possible off-target uptake by astrocytes was examined, as this could potentially cause background signal and false positives. Secondly, additional studies into the biocompatibility of SDIO nanoparticles with cortical cells were undertaken, to further assess whether the particles are a safe diagnostic tool. Chapter 3 details my personal involvement with the development and implementation of an online Introduction to Research course, under the guidance of Dr. Angelique Louie. My experiences with this course have proven incredibly valuable for personal development as I transition into my future career as a high school science teacher.
Book Synopsis Colloidal Metal Oxide Nanoparticles by :
Download or read book Colloidal Metal Oxide Nanoparticles written by and published by Elsevier. This book was released on 2019-10-16 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colloidal Metal Oxide Nanoparticles: Synthesis, Characterization and Applications is a one-stop reference for anyone with an interest in the fundamentals, synthesis and applications of this interesting materials system. The book presents a simple, effective and detailed discussion on colloidal metal oxide nanoparticles. It begins with a general introduction of colloidal metal oxide nanoparticles, then delves into the most relevant synthesis pathways, stabilization procedures, and synthesis and characterization techniques. Final sections discuss promising applications, including bioimaging, biosensing, diagnostic, and energy applications—i.e., solar cells, supercapacitors and environment applications—i.e., the treatment of contaminated soil, water purification and waste remediation. Provides the most comprehensive resource on the topic, from fundamentals, to synthesis and characterization techniques Presents key applications, including biomedical, energy, electronic and environmental Discusses the most relevant techniques for synthesis, patterning and characterization
Book Synopsis Iron Oxide Nanoparticles and Their Applications by : Patricia Villegas
Download or read book Iron Oxide Nanoparticles and Their Applications written by Patricia Villegas and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron oxide nanoparticles demonstrate a number of unique properties, including superparamagnetism, biocompatibility, and non-toxicity, which make them an ideal candidate for a variety of applications, as described in this book. Chapter One deals with the recent advances in various synthetic procedures of iron oxide-based nanocomposites, their characterization methods, and their potential applications in energy storage devices, supercapacitors, fuel cells, and more. Chapter Two summarizes current applications of immobilized enzymes based on iron oxide magnetic nanoparticles and discusses future growth prospects. Chapter Three reviews the properties and applications of enzymatic sensors in exploiting tyrosinase, glucose oxidase, and other enzymes for sensing a broad range of biomedical species. Chapter Four discusses magnetic magnetite and maghemite iron oxide nanoparticles from a variety of perspectives. Chapter Five describes how nano iron oxides could be used to remove pollutants from the environment. Chapter Six provides a comprehensive review of the catalytic applications of iron oxide nanoparticles in organic synthesis, high temperature reactions, gas-phase processes, wastewater treatment and supercritical upgradation of heavy petroleum oils. Chapter Seven details the photocatalytic degradation of a class of toxic, aromatic pollutants, namely, phenols and substituted phenols using different types of photocatalysts in the nano size range for effective removal these compounds from water bodies. Lastly, Chapter Eight elucidates various magnetic nanomaterials-based adsorbents used in adsorption techniques for wastewater treatment.
Book Synopsis Biocompatible Hybrid Oxide Nanoparticles for Human Health by : Inna V. Melnyk
Download or read book Biocompatible Hybrid Oxide Nanoparticles for Human Health written by Inna V. Melnyk and published by Elsevier. This book was released on 2019-06-30 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biocompatible Hybrid Oxide Nanoparticles for Human Health: From Synthesis to Applications explores the synthesis, structure, properties and applications of functionalized oxide nanoparticles. The books shows the applications of materials depending on their composition and structure, with a focus on silicon, titanium and iron oxides, each of which was chosen because of their unique features, including silica because it is chemically resistant to most organic solvents, harmless to living organisms, can thicken flowable formulations, and increase the strength of materials, titania for its unique chemical, optical, electrophysical and bactericidal properties, and iron-containing materials because they possess important magnetic properties. Shows how oxide nanoparticles are being used to solve current problems in the fields of environmental protection, medicine, and in the creation of "smart" materials Includes case studies that explore the major characteristics and applications of silica, titania and iron oxide nanomaterials Discusses the use of biocompatible oxide nanostructures in the development of new sensing technology
Book Synopsis Iron Oxide Nanoparticle Surface Modification by : Richard Hoff
Download or read book Iron Oxide Nanoparticle Surface Modification written by Richard Hoff and published by . This book was released on 2019 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional nanomaterials can be engineered to aid in the diagnosis of diseases, enable efficient drug delivery, monitor treatment progress over time, and evaluate treatment outcomes. This strategy, known as theranostics, focuses on the combination of diagnostic and therapeutic techniques to provide new clinically safe and efficient personalized treatments. The evaluation of different nanomaterials' properties and their customization for specific medical applications has therefore been a significant area of interest within the scientific community. Iron oxide nanoparticles, specifically those based on iron (II, III) oxide (magnetite, Fe3O4), have been prominently investigated for biomedical, theranostic applications due to their documented superparamagnetism, high biocompatibility, and other unique physicochemical properties. The aim of this thesis is to establish a viable set of methods for preparing magnetite (iron oxide) nanoparticles through hydrothermal synthesis and modifying their surfaces with organic functional groups in order to both modulate surface chemistry and facilitate the attachment of molecules such as peptides via covalent bond formations. Modifying their surfaces with biomolecules such as peptides can further increase their uptake into cells, which is a necessary step in the mechanisms of their desired biomedical applications. The methods of nanoparticle synthesis, surface functionalization, and characterization involving electron microscopy (e.g., SEM, TEM), zeta potential measurements, size analysis (i.e., DLS), and FT-IR spectroscopy will be presented.
Book Synopsis Synthesis and Characterization of Iron Based Nanoparticles for Novel Applications by : Hafsa Khurshid
Download or read book Synthesis and Characterization of Iron Based Nanoparticles for Novel Applications written by Hafsa Khurshid and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The work in this thesis has been focused on the fabrication and characterization of iron based nanoparticles with controlled size and morphology with the aim: (i) to investigate their properties for potential applications in MICR toners and biomedical field and (ii) to study finite size effects on the magnetic properties of the nanoparticles. For the biomedical applications, core/shell structured iron/iron-oxide and hollow shell nanoparticles were synthesized by thermal decomposition of iron organometallic compounds [Fe(CO) 5] at high temperature. Core/shell structured iron/iron-oxide nanoparticles have been prepared in the presence of oleic acid and oleylamine. Particle size and composition was controlled by varying the reaction parameters during synthesis. The as-made particles are hydrophobic and not dispersible in water. Water dispersibility was achieved by ligand exchange a with double hydrophilic diblock copolymer. Relaxometery measurements of the transverse relaxation time T 2 of the nanoparticles solution at 3 Tesla confirm that the core/shell nanoparticles are an excellent MRI contrast agent using T 2 weighted imaging sequences. In comparison to conventionally used iron oxide nanoparticles, iron/iron-oxide core/shell nanoparticles offer four times stronger T 2 shortening effect at comparable core size due to their higher magnetization. The magnetic properties were studied as a function of particle size, composition and morphology. Hollow nanostructures are composed of randomly oriented grains arranged together to make a shell layer and make an interesting class of materials. The hollow morphology can be used as an extra degree of freedom to control the magnetic properties. Owing to their hollow morphology, they can be used for the targeted drug delivery applications by filling the drug inside their cavity. For the magnetic toners applications, particles were synthesized by chemically reducing iron salt using sodium borohydride and then coated with polyethylene glycol. Parameters such as the reactant concentrations and their flow rate were varied to study the effect of particle size, structure and crystallinity on the magnetic nanoparticles. Many different hydrophilic surfactants and polymers electrolytes were investigated for the particles' stability in water. PSSNa was found to be the best coating agent among all the other investigated polymer and surfactants for particles stability in water. Particles have an average size of 50 nm and magnetization above 150 emu/g. It is anticipated that owing to their high saturation magnetization and magneto crystalline anisotropy, the incorporations of PSSNa coated nanoparticles into the MICR toner can reduce the pigment loading and hence optimize the toner quality. The magnetic properties were studied as a function of particle size, composition and morphology. The saturation magnetization and coercivity was found to be strongly dependent on the particle size and morphology. The estimated effective anisotropy of the particles was found to be much higher than their bulk values because of their morphology and finite size effects. Core/shell particles below an average size of 12 nm display superparamagnetism and exchange bias phenomenon. The hollow morphology can be used as an extra degree of freedom to control magnetic properties. The enormously large number of pinned spins at the inner and outer surface and at the interface between the grain boundaries in hollow nanoparticles, gives rise to a very large value of effective anisotropy in these nanoparticles and measured hyteresis loops are minor loops. The surface spin disorder contribution to magnetic behavior is strongly influenced by the cooling field magnitude.
Book Synopsis Synthesis and Characterization of Fluorescent Iron Oxide Nanoparticles to Study Uptake and Intracellular Trafficking of Nanoparticles in Neural Cells by : Wiebke Willmann
Download or read book Synthesis and Characterization of Fluorescent Iron Oxide Nanoparticles to Study Uptake and Intracellular Trafficking of Nanoparticles in Neural Cells written by Wiebke Willmann and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization and Functionalization of Iron-oxide Nanoparticles for Use as Potential Agents for Cancer Thermotherapy by :
Download or read book Characterization and Functionalization of Iron-oxide Nanoparticles for Use as Potential Agents for Cancer Thermotherapy written by and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents experimental studies of iron oxide nanoparticle synthesis, functionalization, and intracellular hyperthermal effects on murine macrophages as a model in vitro system. Colloidal suspensions of magnetic nanoparticles (MNPs) are of particular interest in Magnetic Fluid Hyperthermia (MFH). Iron oxide nanoparticles (IONPs) have garnered great interest as economical, biocompatible hyperthermia agents due to their superparamagnetic activity. Here we seek to optimize the synthetic reproducibility and in vitro utilization of IONPs for application in MFH. We compared aqueous synthetic protocols and various protective coating techniques using various analytical techniques and in vitro assays to assess the biocompatibility and feasibility of the various preparations of nanoparticles. Using a co-precipitation of iron salts methodology, iron oxide nanoparticles (IONPs) with an average diameter of 6-8nm were synthesized and stabilized with carboxylates. By performing calorimetry measurements in an oscillating magnetic field (OMF) with a frequency of 500 kHz and field strength of 0.008Tesla the superparamagnetic behavior of these particles was confirmed. To further investigate these IONPs in a biological application, citric acid-stabilized particles, in conjunction with heat generated by these IONPs when exposed to an OMF, were assessed to determine their effects on cell viability in a RAW 267.4 murine macrophage model system. Our results show that 91.5-97% of cells that have ingested IONPs die follow exposure to an OMF. Importantly, neither the IONPs (at applicable concentrations) nor the OMF show cytotoxic effects. These particular particles have promising preliminary results as hyperthermic agents in both the current literature and simple, proof-of-concept experiments in our laboratory setting. We present experimental results for the synthesis, characterization, and utilization of iron oxide nanoparticles in MFH. Our results show that while IONPs have potential in MFH, efforts to advance IONPs from laboratory to clinical contexts, where reliable generative techniques and consistent performance properties are necessary, will require an understanding of the influence of the diverse intrinsic structural and magnetic characteristics as well as surface chemistry of nanoparticles, as well as the mechanisms of particle uptake and cell death due to intracellular hyperthermia.
Book Synopsis Chemical Synthesis and Characterization of Luminescent Iron Oxide Nanoparticles and Their Biomedical Applications by : Martin Onani
Download or read book Chemical Synthesis and Characterization of Luminescent Iron Oxide Nanoparticles and Their Biomedical Applications written by Martin Onani and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The syntheses and characterizations of biocompatible luminescent magnetic iron oxide nanoparticles has drawn particular attention as diagnostic and drug delivery tools for treatment of cancer and many other diseases. This chapter focuses on the chemical synthetic methods, magnetic and luminescent properties, including the biomedical applications of iron oxide nanomaterials and luminescent magnetic iron oxide-based nanocomposite materials. The influences of functionalizing with short ligands such as dopamine and L-cysteine on the magnetic properties of synthesized nanoparticles are described. The chapter contains some data on necessary reagents and protocols for bioconjugation aimed at cell culture and step by step the MTT assays used to evaluate cytotoxicity are also presented. In the final section of the chapter, we focus on the biomedical applications specifically for diagnosis and treatment of breast cancer treatment. This chapter also investigates the application of various characterization techniques for analysis of the structural, optical and magnetic properties of the iron oxide nanoparticles and as their nanocomposites.
Book Synopsis Characterization of Iron Oxide Nanoparticles (IONPs) for Brain Targeted Delivery by : Zhizhi Sun
Download or read book Characterization of Iron Oxide Nanoparticles (IONPs) for Brain Targeted Delivery written by Zhizhi Sun and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The restrictive nature of the brain endothelial cells that form the blood-brain barrier (BBB) limits both the paracellular and transcellular passage of many molecules into the brain. Therefore, effective treatment of brain disorders requires a focus on improving drug permeability across the BBB. This thesis focuses on characterization and optimization of iron oxide nanoparticles (IONPs) as a potential platform for drug delivery to the brain. Given concerns with metal toxicity in the brain, we first examined the biocompatibility and cellular uptake profile of positively and negatively charged IONPs in brain endothelial cells, astrocytes, and neurons. These in vitro studies showed both IONP formulations were well tolerated at concentrations less than 100ug/mL, and that positively charged IONPs have a greater uptake profile than negatively charged IONPs across all cell types examined. It is hypothesized that transient disruption of the BBB combined with the application of a magnetic field, a process we have termed "Magnetic Field Enhanced Covective Diffusion" (MFECD), could be used to enhance IONPs penetration of the BBB. Using the cell culture model of the BBB, disruption of tight junctions with a hyperosmotic mannitol solution resulted in significant increases in permeability for the negatively charged IONP. Even further enhancement of negatively charged IONP permeability was observed when an external magnetic field was applied. Positively charged IONPs showed no significant change in permeability to osmotic disruption or magnetic field. Encouraged by the in vitro permeability studies, the pharmacokinetic properties of negatively charged IONPs was examined in healthy mice under control conditions or following transient BBB disruption using lysophosphatidic acid (LPA). Under normal conditions, IONPs had half-life of 6 minutes and liver and spleen were the major organs of IONP deposition, with limited distribution to the brain. Treatment with LPA significantly enhanced the brain accumulation of IONPs. In addition, examination of microglia and astrocyte activation showed transient BBB disruption and enhanced IONP accumulation in the brain did not lead to inflammation or toxicity. Together, our findings suggest transient disruption of the BBB, alone or coupled with MFECD, may be a safe and effective method for increasing IONP delivery to the brain.
Download or read book Iron Oxides written by Arturo I. Martinez and published by Nova Science Publishers. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the most recent findings in science and technology of iron oxides based materials. It contains eight chapters written by research experts from different countries. The book covers recent results on superparamagnetic iron oxide nanoparticles used as contrast agents for molecular imaging and cell tracking; the synthesis and characterization of nanostructured iron oxides embedded in porous matrixes; the use of superparamagnetic nanoparticles in characterizing cardiac injury; application of iron oxide thin films in solar water splitting; the relation of photoresponse with different impurities in the iron oxide matrix; the use of coated iron oxide nanoparticles in cell and tissue engineering for designing strategies for cardiovascular medicine; and research on natural and man-made iron oxides nanoparticles focused on the natural iron oxides nanoparticles developed in plants and the impact of man-made iron oxide nanoparticles on the growth of plants. Additionally, the use of superparamagnetic iron oxide nanoparticles in magnetic resonant imaging, applied drug delivery, and photodynamic therapy are discussed. Finally, the application of both natural and synthetic iron oxides based adsorbents in arsenic removal is reviewed. For these characteristics, this book is useful for specialists working in multidisciplinary projects where iron oxides are involved, as well as to graduate students, and upper-level undergraduates undertaking research in this field.
Book Synopsis Synthesis, Surface Functionalization, and Biological Testing of Iron Oxide Nanoparticles for Development as a Cancer Therapeutic by : Stanley Eugene Gilliland (III)
Download or read book Synthesis, Surface Functionalization, and Biological Testing of Iron Oxide Nanoparticles for Development as a Cancer Therapeutic written by Stanley Eugene Gilliland (III) and published by . This book was released on 2015 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron oxide nanoparticles are highly researched for their use in biomedical applications such as drug delivery, diagnosis, and therapy. The inherent biodegradable and biocompatible nanoparticle properties make them highly advantageous in nanomedicine. The magnetic properties of iron oxide nanoparticles make them promising candidates for magnetic fluid hyperthermia applications. Designing an efficient iron oxide nanoparticle for hyperthermia requires synthetic, surface functionalization, stability, and biological investigations. This research focused on the following three areas: optimizing synthesis conditions for maximum radiofrequency induced magnetic hyperthermia, designing a simple and modifiable surface functionalization method for specific or broad biological stability, and in vitro and in vivo testing of surface functionalized iron oxide nanoparticles in delivering effective hyperthermia or radiotherapy. The benzyl alcohol modified seed growth method of synthesizing iron oxide nanoparticles using iron acetylacetonate as an iron precursor was investigated to identify significant nanoparticle properties that effect radiofrequency induced magnetic hyperthermia. Investigation of this synthesis under atmospheric conditions revealed a combination of thermal decomposition and oxidation-reduction mechanisms that can produce nanoparticles with larger crystallite sizes and decreased size distributions. Nanoparticles were easily surface functionalized with (3-Glycidyloxypropyl)trimethoxysilane (GLYMO) without the need for organic-aqueous phase transfer methods. The epoxy ring on GLYMO facilitated post-modifications via a base catalyzed epoxy ring opening to obtain nanoparticles with different terminal groups. Glycine, serine, [gamma]-aminobutryic acid (ABA), (S)-( - )-4-amino-2-hydroxybutyric acid (SAHBA), ethylenediamine, and tetraethylenepentamine were successful in modifying GLYMO coated-iron oxide nanoparticles to provide colloidal and varying biological stability while also allowing for further conjugation of chemotherapeutics or radiotherapeutics. The colloidal stability of cationic and anionic nanoparticles in several biologically relevant media was studied to address claims of increased cellular uptake for cationic nanoparticles. The surface functionalized iron oxide nanoparticles were investigated to determine effects on cellular uptake and viability. In vitro tests were used to confirm the ability of iron oxide nanoparticles to provide effective hyperthermia treatment. S-2-(4-Aminobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid (DOTA) was coupled to SAHBA and carboxymethylated polyvinyl alcohol surface functionalized iron oxide nanoparticles and radiolabeled with 177Lu. The capability of radiolabeled iron oxide nanoparticles for delivering radiation therapy to a U87MG murine orthotopic xenograft model of glioblastoma was initially investigated.
Book Synopsis Synthesis and Characterization of Magnetic Iron Oxide Nanoparticles by : Aidin Lak
Download or read book Synthesis and Characterization of Magnetic Iron Oxide Nanoparticles written by Aidin Lak and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
