Synthesis And Characterization Of Hybrid Drugs Based On Ruthenium Complex Moiety And Biologically Active Organic Compounds

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Synthesis and Characterization of Hybrid Drugs Based on Ruthenium Complex Moiety and Biologically Active Organic Compounds

Author : Michał Pawel Łomzik
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Synthesis and Characterization of Hybrid Drugs Based on Ruthenium Complex Moiety and Biologically Active Organic Compounds by : Michał Pawel Łomzik

Download or read book Synthesis and Characterization of Hybrid Drugs Based on Ruthenium Complex Moiety and Biologically Active Organic Compounds written by Michał Pawel Łomzik and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main goal of this thesis was synthesis and preliminary characterization of novel ruthenium(II) polypyridyl complexes bearing biologically active molecules as potential theranostic agents. Luminescence for the diagnostic applications, and cytotoxicity for the anticancer, therapeutic applications are considered as the theranostic properties. Four new ligands containing biologically active moieties - 5-(4-4'-methyl-[2,2'-bipyridine]-4-ylbut-1-yn-1-yl)pyridine-2-carbaldehyde semicarbazone (L1), 3-(5-4'-methyl-[2,2'-bipyridine]-4-ylpentyl)imidazolidine-2,4-dione (L2), 5,5-dimethyl-3-(5-4'-methyl-[2,2'-bipyridine]-4-ylpentyl)imidazolidine-2,4-dione (L3) and [1-(5-4'-methyl-[2,2'-bipyridine]-4-ylpentyl)-2,5-dioxoimidazolidin-4-yl]urea (L4) were synthesized and characterized. The ligands were used to obtain nine novel ruthenium(II) polypyridyl complexes. Six complexes were synthesized with ligand L1 ([Ru(bpy)2(L1)]2+, [Ru(Mebpy)2(L1)]2+, [Ru(tBubpy)2(L1)]2+, [Ru(Phbpy)2(L1)]2+, [Ru(dip)2(L1)]2+, [Ru(SO3dip)2(L1)]2-) and three with ligands L2, L3 and L4 ([Ru(bpy)2(L2)]2+, [Ru(bpy)2(L3)]2+, [Ru(bpy)2(L4)]2+) (bpy = 2,2'-bipyridine, Mebpy = 4,4'-dimethyl-2,2-bipyridine, tBubpy = 4,4'-tert-butyl-2,2'-bipyridine, Phbpy = 4,4'-diphenyl-2,2-bipyridine, dip = 4,7-diphenyl-1,10-phenantroline and SO3dip = 4,7-di-(4-sulfonatophenyl)-1,10-phenantroline). The spectroscopic and photophysical properties of those complexes were determined. The presence of ligands L1-L4 in the structure of the complex decreased luminescence quantum yield and luminescence lifetime in comparison with unmodified [Ru(bpy)3]2+ complex. The theoretical calculations have shown that ligands L1-L4 do not have influence on ruthenium core geometry. However, they increased the energy of the HOMO that resulted in a shorter band gap. The simulated electronic absorption spectra were in a good agreement with the experimental data. The interactions between the studied ruthenium complexes and human serum albumin (HSA) were investigated. All studied Ru(II) complexes exhibited strong affinity to HSA with the association constant 105 M-1s-1, which suggests formation of Ru complex-HSA adducts. It was also determined that ruthenium complexes most likely bind to the hydrophobic pocket of protein, located in Sudlow's site I in the subdomain II A. Preliminary cytotoxicity evaluation for the studied ruthenium complexes showed their cytotoxic activity towards cancer cell lines. Those results, together with good luminescence properties of the studied ruthenium complexes (luminescence lifetimes and luminescence quantum yield) make them interesting candidates for potential theranostic applications.

Ruthenium in Organic Synthesis

Author : Shun-Ichi Murahashi
Publisher : John Wiley & Sons
ISBN 13 : 3527605797
Total Pages : 398 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Ruthenium in Organic Synthesis by : Shun-Ichi Murahashi

Download or read book Ruthenium in Organic Synthesis written by Shun-Ichi Murahashi and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this comprehensive book, one of the leading experts, Shun-Ichi Murahashi, presents all the important facets of modern synthetic chemistry using Ruthenium, ranging from hydrogenation to metathesis. In 14 contributions, written by an international authorship, readers will find all the information they need about this fascinating and extraordinary chemistry. The result is a high quality information source and a indispensable reading for everyone working in organometallic chemistry. From the contents: Introduction (S.-I. Murahashi) Hydrogenation and Transfer Hydrogenation (M. Kitamura and R. Noyori) Oxidations (S.-I. Murahashi and N. Komiya) Carbon-Carbon Bond Formations via Ruthenacycle Intermediates (K. Itoh) Carbon-Carbon Bond Formation via pi-Allylruthenium Intermediates (T. Mitsudo) Olefin Metathesis (R. H. Grubbs) Cyclopropanation (H. Nishiyama) Nucleophilic Addition to Alkynes and Reactions via Vinylidene Intermediates (P. Dixneuf) Reactions via C-H Activation (N. Chatani) Lewis Acid Reactions (E. P. Kundig) Reactions with CO and CO2 (T. Mitsudo) Isomerization of Organic Substrates Catalyzed by Ruthenium Complexes (H. Suzuki) Radical Reactions (H. Nagashima) Bond Cleavage Reactions (S. Komiya)

Synthesis and Characterization of Ruthenium Complex Using Hypoxanthine as Ligand

Author : Chakravarthy B. Koricheria
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (98 download)

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Book Synopsis Synthesis and Characterization of Ruthenium Complex Using Hypoxanthine as Ligand by : Chakravarthy B. Koricheria

Download or read book Synthesis and Characterization of Ruthenium Complex Using Hypoxanthine as Ligand written by Chakravarthy B. Koricheria and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synthesis and Characterization of Cyclometalated Ruthenium (II) Complexes and Assessment of Their Potential as Pharmaceuticals

Author : Leslie Ann Morales
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (143 download)

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Book Synopsis Synthesis and Characterization of Cyclometalated Ruthenium (II) Complexes and Assessment of Their Potential as Pharmaceuticals by : Leslie Ann Morales

Download or read book Synthesis and Characterization of Cyclometalated Ruthenium (II) Complexes and Assessment of Their Potential as Pharmaceuticals written by Leslie Ann Morales and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclometalated Ruthenium (II) and RAPTA species were synthesized, characterized and evaluated on their photophysical properties and potential as anti-cancer agents. The binding affinity to yeast RNA of one of the newly synthesized compounds containing a thiophene group (LM5400) was compared to its literature precursor (Compound B) containing a phenyl group under gel electrophoresis. Results indicated that the bands of compounds; Compound A, LM3000, Compound B and LM5400 when incubated with yeast RNA, were similar to the control with the expectation of the band of LM5400 being more faint relative to the rest whenever samples were incubated for 24hrs. Photophysical experiments on cyclometalated ruthenium (II) compounds (CompoundA, LM3000, Compound B, LM5400) indicated that these compounds have an absorbance around 360 nm respectively but do not fluoresce due to extremely low emission values. Four hydrolysis studies were done on the cyclometalated ruthenium (II) species under various conditions and monitored via UV/Vis and H-NMR. Underall conditions, the absorbance and the NMR data the complexes with the j6-benzene ring (Compound A and LM3000) changed under aqueous and chloride solutions. In contrast, the absorbance of the complexes with the j6-cymene rings (Compound B and LM5400) only changed upon increased concentration. All compounds synthesized were characterized by NMR. Crystal structures were obtained for newly synthesized compounds, LM3000 and LM5400.

Structure Determination from Powder Diffraction Data

$Download Structure Determination from Powder Diffraction Data PDF Online Free$

Author : William I. F. David
Publisher : OUP Oxford
ISBN 13 : 0198500912
Total Pages : 358 pages
Book Rating : 4.1/5 (985 download)

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Book Synopsis Structure Determination from Powder Diffraction Data by : William I. F. David

Download or read book Structure Determination from Powder Diffraction Data written by William I. F. David and published by OUP Oxford. This book was released on 2002 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the properties of materials, from drugs and proteins to catalysts and ceramics, is almost always based on structural information. This book describes the new developments in the realm of powder diffraction which make it possible for scientists to obtain such information even from polycrystalline materials. Written and edited by experts active in the field, and covering both the fundamental and applied aspects of structure solution from powder diffraction data, this book guides both novices and experienced practitioners alike through the maze of possibilities.

Ruthenium(II) Polypyridyl Complexes as Potential Anticancer Drugs

Author : Yanling Chen
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (859 download)

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Book Synopsis Ruthenium(II) Polypyridyl Complexes as Potential Anticancer Drugs by : Yanling Chen

Download or read book Ruthenium(II) Polypyridyl Complexes as Potential Anticancer Drugs written by Yanling Chen and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on biological activities of ruthenium polypyridyl complexes (RPCs) continues to attract interest as these complexes have shown promising anticancer activity both in vitro and in vivo.1−3 The mononuclear RPC, [(phen)2Ru(tatpp)]2+ (MP) and related dinuclear complex [(phen)2Ru(tatpp)Ru(phen)2]4+ (P) have been shown to both intercalate with DNA and shown potentiated DNA cleavage under anaerobic and reducing conditions4−5, as well as shown good selectivity and cytotoxicity towards malignant cell lines in vitro and tumors in vivo.5 Both complexes contain the redox-active tatpp ligand which is thought to be an essential component for the observed biological activities. This thesis is focused on developing improvements to the stereoselective syntheses of the chiral complexes, [delta][delta]-P and [delta]-MP. It is also investigated the synthesis of a new analogue [(phen)2Ru(tadbp)]2+ (B) and its chiral form [delta]-B which contains a modified tatpp ligand that is only capable of binding one Ru ion. Moreover this thesis explores the ability of these large complexes to traverse the cell membranes and get into cells and cell nuclei by isolating treated cells and nuclei and determining their ruthenium content by graphite furnace atomic absorption method (GFAAS). The GFAAS data show that the two examined complexes [delta][delta]-P and [delta]-MP are able to quickly penetrate into cancer cells (H-358) and concentrate in nuclei, which is postulated due to their high binding affinity to DNA.

Synthesis and Characterization of a Photoactivatable Ruthenium (II) Complex Bearing 2,9-diphenyl-1,10-phenanthroline

Author : Najwa Mansour
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (128 download)

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Book Synopsis Synthesis and Characterization of a Photoactivatable Ruthenium (II) Complex Bearing 2,9-diphenyl-1,10-phenanthroline by : Najwa Mansour

Download or read book Synthesis and Characterization of a Photoactivatable Ruthenium (II) Complex Bearing 2,9-diphenyl-1,10-phenanthroline written by Najwa Mansour and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Metallo-Drugs: Development and Action of Anticancer Agents

Author : Astrid Sigel
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 311047073X
Total Pages : 588 pages
Book Rating : 4.1/5 (14 download)

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Book Synopsis Metallo-Drugs: Development and Action of Anticancer Agents by : Astrid Sigel

Download or read book Metallo-Drugs: Development and Action of Anticancer Agents written by Astrid Sigel and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-02-05 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

Medicinal Inorganic Chemistry

Author : Jonathan L. Sessler
Publisher :
ISBN 13 :
Total Pages : 480 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Medicinal Inorganic Chemistry by : Jonathan L. Sessler

Download or read book Medicinal Inorganic Chemistry written by Jonathan L. Sessler and published by . This book was released on 2005 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current diagnostic and therapeutic uses of metal-containing compounds in medicine, as well as the role of metals in disease.

Infrared and Raman Spectra of Inorganic and Coordination Compounds, Part A

Author : Kazuo Nakamoto
Publisher : John Wiley & Sons
ISBN 13 : 9780470405796
Total Pages : 350 pages
Book Rating : 4.4/5 (57 download)

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Book Synopsis Infrared and Raman Spectra of Inorganic and Coordination Compounds, Part A by : Kazuo Nakamoto

Download or read book Infrared and Raman Spectra of Inorganic and Coordination Compounds, Part A written by Kazuo Nakamoto and published by John Wiley & Sons. This book was released on 2008-12-22 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Sixth Edition of this classic work comprises the most comprehensive and current guide to infrared and Raman spectra of inorganic, organometallic, bioinorganic, and coordination compounds. From fundamental theories of vibrational spectroscopy to applications in a variety of compound types, this has been extensively updated. New topics include the theoretical calculations of vibrational frequencies (DFT method), chemical synthesis by matrix co-condensation reactions, time-resolved Raman spectroscopy, and more. This volume is a core reference for chemists and medical professionals working with infrared or Raman spectroscopies and an excellent textbook for graduate courses.

Mass Spectrometry in Medicinal Chemistry

Author : Klaus Wanner
Publisher : John Wiley & Sons
ISBN 13 : 352761091X
Total Pages : 460 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Mass Spectrometry in Medicinal Chemistry by : Klaus Wanner

Download or read book Mass Spectrometry in Medicinal Chemistry written by Klaus Wanner and published by John Wiley & Sons. This book was released on 2007-06-27 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.

Fundamentals of Ionic Liquids

Author : Douglas R. MacFarlane
Publisher : John Wiley & Sons
ISBN 13 : 352733999X
Total Pages : 275 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Fundamentals of Ionic Liquids by : Douglas R. MacFarlane

Download or read book Fundamentals of Ionic Liquids written by Douglas R. MacFarlane and published by John Wiley & Sons. This book was released on 2017-12-04 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts who have been part of this field since its beginnings in both research and academia, this textbook introduces readers to this evolving topic and the broad range of applications that are being explored. The book begins by examining what it is that defines ionic liquids and what sets them apart from other materials. Chapters describe the various types of ionic liquids and the different techniques used to synthesize them, as well as their properties and some of the methods used in their measurement. Further chapters delve into synthetic and electrochemical applications and their broad use as "Green" solvents. Final chapters examine important applications in a wide variety of contexts, including such devices as solar cells and batteries, electrochemistry, and biotechnology. The result is a must-have resource for any researcher beginning to work in this growing field, including senior undergraduates and postgraduates.

Catalytic Aerobic Oxidations

Author : Esteban Mejía
Publisher : Royal Society of Chemistry
ISBN 13 : 1839160349
Total Pages : 349 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Catalytic Aerobic Oxidations by : Esteban Mejía

Download or read book Catalytic Aerobic Oxidations written by Esteban Mejía and published by Royal Society of Chemistry. This book was released on 2020-07-14 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidation reactions are an important chemical transformation in both academia and industry. Among the major advances in the field has been the development of catalytic processes, which are not only selective and efficient, but also allow the replacement of common stoichiometric oxidants with molecular oxygen, ideally from air at atmospheric pressure. This results in processes with higher atom efficiency, where water is the only side product in line with the principles of green chemistry. Focusing on the use of molecular oxygen as the terminal oxidant, this book covers recent advances in both heterogeneous and homogeneous systems, with and without metals and on the “taming” of the highly reactive oxygen gas by use of micro-flow reactors and membranes. A useful reference for industrial and academic chemists working on oxidation processes, as well as green chemists.

Silver Micro-Nanoparticles

Author : Samir Kumar
Publisher : BoD – Books on Demand
ISBN 13 : 1839686596
Total Pages : 268 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Silver Micro-Nanoparticles by : Samir Kumar

Download or read book Silver Micro-Nanoparticles written by Samir Kumar and published by BoD – Books on Demand. This book was released on 2021-09-15 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the different methodologies for producing and synthesizing silver nanoparticles (AgNPs) of various shapes and sizes. It also provides an in-depth understanding of the new methods for characterizing and modifying the properties of AgNPs as well as their properties and applications in various fields. This book is a useful resource for a wide range of readers, including scientists, engineers, doctoral and postdoctoral fellows, and scientific professionals working in specialized fields such as medicine, nanotechnology, spectroscopy, analytical chemistry diagnostics, and plasmonics.

Photochemistry and Photophysics

Author : Vincenzo Balzani
Publisher : John Wiley & Sons
ISBN 13 : 3527334793
Total Pages : 516 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Photochemistry and Photophysics by : Vincenzo Balzani

Download or read book Photochemistry and Photophysics written by Vincenzo Balzani and published by John Wiley & Sons. This book was released on 2014-06-09 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ein Lehrbuch eines exzellenten Autorenteams mit wissenschaftlicher Erfahrung und der Kompetenz im Schreiben didaktischer Texte zu allen Facetten der Photochemie und Photophysik: Grundlagen sowie ausgewählte Beispielen moderner Anwendungen und aus der heutigen Forschung.

Indole Ring Synthesis

Author : Gordon W. Gribble
Publisher : John Wiley & Sons
ISBN 13 : 0470512180
Total Pages : 704 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Indole Ring Synthesis by : Gordon W. Gribble

Download or read book Indole Ring Synthesis written by Gordon W. Gribble and published by John Wiley & Sons. This book was released on 2016-08-08 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments. The indole ring continues to be discovered in natural products and to be employed in man-made pharmaceuticals and other materials. Given the enormous resurgence in indole ring synthesis over the past decade — highlighted by the power of transition metal catalysis — this authoritative guide addresses the need for a comprehensive presentation of the myriad of methods for constructing the indole ring, from the ancient to the modern, and from the obscure to the well-known. Following presentation of the classic indole ring syntheses and many newer methods, coverage continues with indole ring syntheses via pyrroles, indolines, oxindoles, isatins, radical and photochemical reactions, aryne cycloadditions. This extensive volume concludes with the modern transition metal–catalyzed indole ring syntheses that utilize copper, palladium, rhodium, gold, ruthenium, platinum, and other metals to fashion the indole ring Indole Ring Synthesis is a comprehensive, authoritative and up-to-date guide to the synthesis of this important heterocycle for organic chemists, pharmaceutical researchers and those interested in the chemistry of natural products.

Metal-based Anticancer Agents

Author : Angela Casini
Publisher : Royal Society of Chemistry
ISBN 13 : 1788017676
Total Pages : 370 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Metal-based Anticancer Agents by : Angela Casini

Download or read book Metal-based Anticancer Agents written by Angela Casini and published by Royal Society of Chemistry. This book was released on 2019-04-05 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. With contributions from global leaders in the field, this book will serve as a useful reference to established researchers as well as a practical guide to those new to metallodrugs, and postgraduate students of medicinal chemistry and metallobiology.