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Synthesis And Characterization Of Fluorescent Iron Oxide Nanoparticles To Study Uptake And Intracellular Trafficking Of Nanoparticles In Neural Cells
Download Synthesis And Characterization Of Fluorescent Iron Oxide Nanoparticles To Study Uptake And Intracellular Trafficking Of Nanoparticles In Neural Cells full books in PDF, epub, and Kindle. Read online Synthesis And Characterization Of Fluorescent Iron Oxide Nanoparticles To Study Uptake And Intracellular Trafficking Of Nanoparticles In Neural Cells ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Synthesis and Characterization of Fluorescent Iron Oxide Nanoparticles to Study Uptake and Intracellular Trafficking of Nanoparticles in Neural Cells by : Wiebke Willmann
Download or read book Synthesis and Characterization of Fluorescent Iron Oxide Nanoparticles to Study Uptake and Intracellular Trafficking of Nanoparticles in Neural Cells written by Wiebke Willmann and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization and Functionalization of Iron-oxide Nanoparticles for Use as Potential Agents for Cancer Thermotherapy by :
Download or read book Characterization and Functionalization of Iron-oxide Nanoparticles for Use as Potential Agents for Cancer Thermotherapy written by and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents experimental studies of iron oxide nanoparticle synthesis, functionalization, and intracellular hyperthermal effects on murine macrophages as a model in vitro system. Colloidal suspensions of magnetic nanoparticles (MNPs) are of particular interest in Magnetic Fluid Hyperthermia (MFH). Iron oxide nanoparticles (IONPs) have garnered great interest as economical, biocompatible hyperthermia agents due to their superparamagnetic activity. Here we seek to optimize the synthetic reproducibility and in vitro utilization of IONPs for application in MFH. We compared aqueous synthetic protocols and various protective coating techniques using various analytical techniques and in vitro assays to assess the biocompatibility and feasibility of the various preparations of nanoparticles. Using a co-precipitation of iron salts methodology, iron oxide nanoparticles (IONPs) with an average diameter of 6-8nm were synthesized and stabilized with carboxylates. By performing calorimetry measurements in an oscillating magnetic field (OMF) with a frequency of 500 kHz and field strength of 0.008Tesla the superparamagnetic behavior of these particles was confirmed. To further investigate these IONPs in a biological application, citric acid-stabilized particles, in conjunction with heat generated by these IONPs when exposed to an OMF, were assessed to determine their effects on cell viability in a RAW 267.4 murine macrophage model system. Our results show that 91.5-97% of cells that have ingested IONPs die follow exposure to an OMF. Importantly, neither the IONPs (at applicable concentrations) nor the OMF show cytotoxic effects. These particular particles have promising preliminary results as hyperthermic agents in both the current literature and simple, proof-of-concept experiments in our laboratory setting. We present experimental results for the synthesis, characterization, and utilization of iron oxide nanoparticles in MFH. Our results show that while IONPs have potential in MFH, efforts to advance IONPs from laboratory to clinical contexts, where reliable generative techniques and consistent performance properties are necessary, will require an understanding of the influence of the diverse intrinsic structural and magnetic characteristics as well as surface chemistry of nanoparticles, as well as the mechanisms of particle uptake and cell death due to intracellular hyperthermia.
Book Synopsis Iron Oxide Nanoparticles for Biomedical Applications by : Sophie Laurent
Download or read book Iron Oxide Nanoparticles for Biomedical Applications written by Sophie Laurent and published by Elsevier. This book was released on 2017-10-20 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization and Application begins with several chapters covering the synthesis, stabilization, physico-chemical characterization and functionalization of iron oxide nanoparticles. The second part of the book outlines the various biomedical imaging applications that currently take advantage of the magnetic properties of iron oxide nanoparticles. Brief attention is given to potential iron oxide based therapies, while the final chapter covers nanocytotoxicity, which is a key concern wherever exposure to nanomaterials might occur. This comprehensive book is an essential reference for all those academics and professionals who require thorough knowledge of recent and future developments in the role of iron oxide nanoparticles in biomedicine. Unlocks the potential of iron oxide nanoparticles to transform diagnostic imaging techniques Contains full coverage of new developments and recent research, making this essential reading for researchers and engineers alike Explains the synthesis, processing and characterization of iron oxide nanoparticles with a view to their use in biomedicine
Book Synopsis Synthesis and Characterization of Iron Oxide Nanoparticles and Investigation of Their Biocompatibility on Astrocyte Cultures by : Mark Geppert
Download or read book Synthesis and Characterization of Iron Oxide Nanoparticles and Investigation of Their Biocompatibility on Astrocyte Cultures written by Mark Geppert and published by . This book was released on 2012 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dextran Sulfate-Coated Iron Oxide Nanoparticles as Targeted MRI Contrast Agents for Neuroinflammation by : Martin Hall
Download or read book Dextran Sulfate-Coated Iron Oxide Nanoparticles as Targeted MRI Contrast Agents for Neuroinflammation written by Martin Hall and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis contains two distinct part: the first two chapters focus on research efforts towards the use of Dextran Sulfate-Coated Iron Oxide (SDIO) Nanoparticles as an MRI contrast agent for the diagnosis of brain inflammation, while the third chapter is a personal reflection on experiences from assisting with the development and initial implementation of an online, UC-wide Introduction to Research course. In Chapter 1, the synthesis and characterization of SDIO nanoparticles is described in detail. The synthetic work in this chapter showed great reproducibility with previous syntheses in our lab. New characterization efforts helped illuminate the physical and magnetic degradation process of SDIO nanoparticles in water and acidic solutions, intended to help guide future work into how the particles break down in vivo. Chapter 2 covers a series of cell studies that are intended as support for the potential future use of SDIO nanoparticles as an MRI contrast agent for diagnosing brain inflammation through receptor-specific uptake in activated microglia. While prior work in our lab has already shown promising results in using SDIO for this purpose in mice, several underlying questions and concerns needed to be addressed before continuing further with animal models. Firstly, possible off-target uptake by astrocytes was examined, as this could potentially cause background signal and false positives. Secondly, additional studies into the biocompatibility of SDIO nanoparticles with cortical cells were undertaken, to further assess whether the particles are a safe diagnostic tool. Chapter 3 details my personal involvement with the development and implementation of an online Introduction to Research course, under the guidance of Dr. Angelique Louie. My experiences with this course have proven incredibly valuable for personal development as I transition into my future career as a high school science teacher.
Book Synopsis Fluorescent Organic Nanoparticles by : Waseem A. Wani
Download or read book Fluorescent Organic Nanoparticles written by Waseem A. Wani and published by Springer. This book was released on 2018-09-27 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a critical review of recent advances in the development of fluorescent organic nanoparticles as materials of choice for the design and fabrication of sensors, bioimaging agents and drug delivery systems. The properties and functions of nanoparticles differ significantly from those of their parent entities or their bulk phases. Two of their most important features are their increased surface-to volume ratio, and the formation of surface structures differing from those in their bulk phases. In addition, the book discusses the synthesis of fluorescent conjugated polymers, self-assembled fluorescent nanoparticles, polydopamine nanoparticles, and aggregation-induced-emission or aggregation-induced-emission enhancement nanomaterials. In closing, the book provides an outlook on future research and development in fluorescent organic nanoparticles as smart materials with an impressive range of potential applications.
Book Synopsis Uptake and Metabolism of Iron Oxide Nanoparticles in Cultured Brain Cells by : Charlotte Petters
Download or read book Uptake and Metabolism of Iron Oxide Nanoparticles in Cultured Brain Cells written by Charlotte Petters and published by . This book was released on 2015 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemical Synthesis and Characterization of Luminescent Iron Oxide Nanoparticles and Their Biomedical Applications by : Martin Onani
Download or read book Chemical Synthesis and Characterization of Luminescent Iron Oxide Nanoparticles and Their Biomedical Applications written by Martin Onani and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The syntheses and characterizations of biocompatible luminescent magnetic iron oxide nanoparticles has drawn particular attention as diagnostic and drug delivery tools for treatment of cancer and many other diseases. This chapter focuses on the chemical synthetic methods, magnetic and luminescent properties, including the biomedical applications of iron oxide nanomaterials and luminescent magnetic iron oxide-based nanocomposite materials. The influences of functionalizing with short ligands such as dopamine and L-cysteine on the magnetic properties of synthesized nanoparticles are described. The chapter contains some data on necessary reagents and protocols for bioconjugation aimed at cell culture and step by step the MTT assays used to evaluate cytotoxicity are also presented. In the final section of the chapter, we focus on the biomedical applications specifically for diagnosis and treatment of breast cancer treatment. This chapter also investigates the application of various characterization techniques for analysis of the structural, optical and magnetic properties of the iron oxide nanoparticles and as their nanocomposites.
Book Synopsis New Approaches in Synthesis and Characterization Methods of Iron Oxide Nanoparticles by : Bogdan Stefan Vasile
Download or read book New Approaches in Synthesis and Characterization Methods of Iron Oxide Nanoparticles written by Bogdan Stefan Vasile and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have witnessed an extensive application of iron oxide nanoparticles within a wide variety of fields, including drug delivery, hyperthermia, biosensing, theranostics, and cell and molecular separation. Consequently, synthesis and characterization methods have continuously evolved to provide the possibility for controlling the physico-chemical and biological properties of the nanoparticles to better suit the envisaged applications. In this manner, this chapter aims to provide an extensive overview of the most recent progress made within the processes of iron oxide nanoparticle synthesis and characterization. Thus, the chapter will focus on novel and advanced approaches reported in the literature for obtaining standardized nanoparticles with controllable properties and effects. Specifically, it will emphasize the most recent progress made within the microwave-assisted, microfluidics, and green synthesis methods, as they have shown higher capacities of controlling the outcome nanoparticle properties.
Book Synopsis Cerium Oxide Nanoparticles and Gadolinium Integration by : Peter Eriksson
Download or read book Cerium Oxide Nanoparticles and Gadolinium Integration written by Peter Eriksson and published by Linköping University Electronic Press. This book was released on 2019-08-29 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt: A challenging task, in the area of magnetic resonance imaging is to develop contrast enhancers with built-in antioxidant properties. Oxidative stress is considered to be involved in the onset and progression of several serious conditions such as Alzheimer’s and Parkinson’s disease, and the possibility to use cerium-contained nanoparticles to modulate such inflammatory response has gained a lot of interest lately. The rare earth element gadolinium is, due to its seven unpaired f-electrons and high symmetry of the electronic state, a powerful element for contrast enhancement in magnetic resonance imaging. Chelates based on gadolinium are the most commonly used contrast agents worldwide. When introducing external contrast agents there is always a risk that it may trigger inflammatory responses, why there is an urgent need for new, tailor-made contrast agents. Small sized cerium oxide nanoparticles have electronic structures that allows coexistence of oxidation states 3+ and 4+ of cerium, which correlates to applicable redox reactions in biomedicine. Such cerium oxide nanoparticles have recently shown to exhibit antioxidant properties both in vitro and in vivo, via the mechanisms involving enzyme mimicking activity. This PhD project is a comprehensive investigation of cerium oxide nanoparticles as scaffold materials for gadolinium integration. Gadolinium is well adopted into the crystal structure of cerium oxide, enabling the combination of diagnostic and therapeutic properties into a single nanoparticle. The main focus of this thesis project is to design cerium oxide nanoparticles with gadolinium integration. A stepwise approach was employed as follows: 1) synthesis with controlled integration of gadolinium, 2) material characterization by means of composition crystal structure, size, and size distribution and 3) surface modification for stabilization. The obtained nanoparticles exhibit remarkable antioxidant capability in vitro and in vivo. They deliver strongly enhanced contrast per gadolinium in magnetic resonance imaging, compared to commercially available contrast agents. A soft shell of dextran is introduced to encapsulate the cerium oxide nanoparticles with integrated gadolinium, which protects and stabilizes the hard core and to increases their biocompatibility. The dextran-coating is clearly shown to reduce formation of a protein corona and it improves the dispersibility of the nanoparticles in cell media. Functionalization strategies are currently being studied to endow these nanoparticles with specific tags for targeting purposes. This will enable guidance of the nanoparticles to a specific tissue, for high local magnetic resonance contrast complemented with properties for on-site reduced inflammation. In conclusion, our cerium oxide nanoparticles with integrated gadolinium, exhibit combined therapeutic and diagnostic, i.e. theragnostic capabilities. This type of nanomaterial is highly promising for applications in the field of biomedical imaging.
Book Synopsis Iron Oxide Nanoparticle Surface Modification by : Richard Hoff
Download or read book Iron Oxide Nanoparticle Surface Modification written by Richard Hoff and published by . This book was released on 2019 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional nanomaterials can be engineered to aid in the diagnosis of diseases, enable efficient drug delivery, monitor treatment progress over time, and evaluate treatment outcomes. This strategy, known as theranostics, focuses on the combination of diagnostic and therapeutic techniques to provide new clinically safe and efficient personalized treatments. The evaluation of different nanomaterials' properties and their customization for specific medical applications has therefore been a significant area of interest within the scientific community. Iron oxide nanoparticles, specifically those based on iron (II, III) oxide (magnetite, Fe3O4), have been prominently investigated for biomedical, theranostic applications due to their documented superparamagnetism, high biocompatibility, and other unique physicochemical properties. The aim of this thesis is to establish a viable set of methods for preparing magnetite (iron oxide) nanoparticles through hydrothermal synthesis and modifying their surfaces with organic functional groups in order to both modulate surface chemistry and facilitate the attachment of molecules such as peptides via covalent bond formations. Modifying their surfaces with biomolecules such as peptides can further increase their uptake into cells, which is a necessary step in the mechanisms of their desired biomedical applications. The methods of nanoparticle synthesis, surface functionalization, and characterization involving electron microscopy (e.g., SEM, TEM), zeta potential measurements, size analysis (i.e., DLS), and FT-IR spectroscopy will be presented.
Book Synopsis Characterization of Iron Oxide Nanoparticles (IONPs) for Brain Targeted Delivery by : Zhizhi Sun
Download or read book Characterization of Iron Oxide Nanoparticles (IONPs) for Brain Targeted Delivery written by Zhizhi Sun and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The restrictive nature of the brain endothelial cells that form the blood-brain barrier (BBB) limits both the paracellular and transcellular passage of many molecules into the brain. Therefore, effective treatment of brain disorders requires a focus on improving drug permeability across the BBB. This thesis focuses on characterization and optimization of iron oxide nanoparticles (IONPs) as a potential platform for drug delivery to the brain. Given concerns with metal toxicity in the brain, we first examined the biocompatibility and cellular uptake profile of positively and negatively charged IONPs in brain endothelial cells, astrocytes, and neurons. These in vitro studies showed both IONP formulations were well tolerated at concentrations less than 100ug/mL, and that positively charged IONPs have a greater uptake profile than negatively charged IONPs across all cell types examined. It is hypothesized that transient disruption of the BBB combined with the application of a magnetic field, a process we have termed "Magnetic Field Enhanced Covective Diffusion" (MFECD), could be used to enhance IONPs penetration of the BBB. Using the cell culture model of the BBB, disruption of tight junctions with a hyperosmotic mannitol solution resulted in significant increases in permeability for the negatively charged IONP. Even further enhancement of negatively charged IONP permeability was observed when an external magnetic field was applied. Positively charged IONPs showed no significant change in permeability to osmotic disruption or magnetic field. Encouraged by the in vitro permeability studies, the pharmacokinetic properties of negatively charged IONPs was examined in healthy mice under control conditions or following transient BBB disruption using lysophosphatidic acid (LPA). Under normal conditions, IONPs had half-life of 6 minutes and liver and spleen were the major organs of IONP deposition, with limited distribution to the brain. Treatment with LPA significantly enhanced the brain accumulation of IONPs. In addition, examination of microglia and astrocyte activation showed transient BBB disruption and enhanced IONP accumulation in the brain did not lead to inflammation or toxicity. Together, our findings suggest transient disruption of the BBB, alone or coupled with MFECD, may be a safe and effective method for increasing IONP delivery to the brain.
Book Synopsis Synthesis and Functionalization of Nano- and Micro-particles for Sensing and Therapy in Living Cells by : Oriol Penon Esteva
Download or read book Synthesis and Functionalization of Nano- and Micro-particles for Sensing and Therapy in Living Cells written by Oriol Penon Esteva and published by . This book was released on 2014 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the present thesis Supramolecular chemistry is exploited to approach applications in the area of Nanomedicine, and it is, focused on the design and preparation of different micro and nanotools for sensing and therapy, in living cells. Initially, the combination of silicon surface chemistry with the incorporation of bioactive molecules has been investigated in order to obtain a potentially microtool suitable for cell tagging. Furthermore, the design and synthesis of organic compounds as intracellular chemosensors was also explored. On the other hand, this report also includes the synthesis and characterization of dissymmetrical porphyrin derivatives and their subsequent incorporation to metal nanoparticles (gold and iron oxide) for their use in photodynamic therapy (PDT), due to their capacity to produce reactive oxygen species after irradiation, inducing the cell death. The preparation of novel metallo-porphyrins as components of molecular machines was also achieved. First, the formation of self-assembled monolayers (SAM) on polysilicon surfaces was investigated, using different silanes to obtain a functionalization protocol which can be easily repetitive and effective. Thus, three silanes with different functional groups, an aldehyde, an epoxide and an activated ester, have been tested to prepare a SAM and subsequently, prompting us to immobilize a bioactive molecule. Different parameters of the functionalization methodology have been examined, such as the silanization time, deposition method, the type of solvent and silane concentration. Once the SAM formation was optimized, the immobilization of the protein what germ agglutinin (WGA) was achieved, because its ability of cell membrane recognition. The WGA used, included a fluorescent dye (Texas red) to be able to characterize the immobilization of the protein on a silicon surface by fluorescence microscopy, and similar successful results were obtained in the three different silanes used. The same methodology (SAM formation and WGA immobilization) was subsequent applied in silicon encoded microparticles designed for tagging cells. Experiments using mouse embryos have been performed to determine the extracellular adhesion level of the encoded microparticles, resulting above 90 % in all cases. Proper immobilization of WGA protein was the key factor in cell labeling, because WGA recognizes specifically certain carbohydrates expressed in the external membrane (zona pellucida) of the embryo. Synthesis and immobilization of an aminoanthracene derivative as pH sensor was carried out, and its subsequent immobilization on silicon microparticles was achieved. Fluorescence spectroscopy measurements demonstrated that the aminoanthracene derivative immobilized on silicon microparticles could be a potential microtool for sense intracellular pH. Fluorescence spectroscopy experiments showed an important increase at acid pH, whereas from pH 7 to pH 12 the fluorescence emission was very low. On the other hand, aminoanthracene incorporating an aza-crown ether was also prepared as a possible candidate for calcium sensing. Preliminary studies using fluorescence spectroscopy, demonstrated a good selectivity for calcium in comparison with other cations such as magnesium, sodium and potassium. Dissymmetrical porphyrin derivatives have been synthesized and then immobilized on gold and iron oxide nanoparticles, obtaining water soluble metallic nanoparticles incorporating the photosensitizer. The capacity to produce singlet oxygen to induce the cell death following irradiation was investigated, resulting porphyrin immobilized gold or iron oxide nanoparticles. Thus, the prepared porphyrin derivatives and their corresponding nanotools exhibited a high formation of singlet oxygen, resulting nanotools potentially suitable for PDT. Otherwise, anti-erbB2 antibody, a specific antibody for a membrane receptor overexpressed in breast cancer cells, was immobilized onto water soluble porphyrin-gold nanoparticles. Preliminary experiments in a breast cancer cell line, demonstrated the capacity of the porphyrin-antibody-gold nanoparticle to produce the cell death following irradiation. Finally a metallo-porphyrins derivative was synthesized and characterize as a promising component for molecular rotors.
Book Synopsis Synthesis and Characterization of High Quality Iron Oxide Nanoparticles of Controlled Size, Shape and Magnetic Properties by : Pablo Guardia Girós
Download or read book Synthesis and Characterization of High Quality Iron Oxide Nanoparticles of Controlled Size, Shape and Magnetic Properties written by Pablo Guardia Girós and published by . This book was released on 2009 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis, Surface Functionalization, and Biological Testing of Iron Oxide Nanoparticles for Development as a Cancer Therapeutic by : Stanley Eugene Gilliland (III)
Download or read book Synthesis, Surface Functionalization, and Biological Testing of Iron Oxide Nanoparticles for Development as a Cancer Therapeutic written by Stanley Eugene Gilliland (III) and published by . This book was released on 2015 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron oxide nanoparticles are highly researched for their use in biomedical applications such as drug delivery, diagnosis, and therapy. The inherent biodegradable and biocompatible nanoparticle properties make them highly advantageous in nanomedicine. The magnetic properties of iron oxide nanoparticles make them promising candidates for magnetic fluid hyperthermia applications. Designing an efficient iron oxide nanoparticle for hyperthermia requires synthetic, surface functionalization, stability, and biological investigations. This research focused on the following three areas: optimizing synthesis conditions for maximum radiofrequency induced magnetic hyperthermia, designing a simple and modifiable surface functionalization method for specific or broad biological stability, and in vitro and in vivo testing of surface functionalized iron oxide nanoparticles in delivering effective hyperthermia or radiotherapy. The benzyl alcohol modified seed growth method of synthesizing iron oxide nanoparticles using iron acetylacetonate as an iron precursor was investigated to identify significant nanoparticle properties that effect radiofrequency induced magnetic hyperthermia. Investigation of this synthesis under atmospheric conditions revealed a combination of thermal decomposition and oxidation-reduction mechanisms that can produce nanoparticles with larger crystallite sizes and decreased size distributions. Nanoparticles were easily surface functionalized with (3-Glycidyloxypropyl)trimethoxysilane (GLYMO) without the need for organic-aqueous phase transfer methods. The epoxy ring on GLYMO facilitated post-modifications via a base catalyzed epoxy ring opening to obtain nanoparticles with different terminal groups. Glycine, serine, [gamma]-aminobutryic acid (ABA), (S)-( - )-4-amino-2-hydroxybutyric acid (SAHBA), ethylenediamine, and tetraethylenepentamine were successful in modifying GLYMO coated-iron oxide nanoparticles to provide colloidal and varying biological stability while also allowing for further conjugation of chemotherapeutics or radiotherapeutics. The colloidal stability of cationic and anionic nanoparticles in several biologically relevant media was studied to address claims of increased cellular uptake for cationic nanoparticles. The surface functionalized iron oxide nanoparticles were investigated to determine effects on cellular uptake and viability. In vitro tests were used to confirm the ability of iron oxide nanoparticles to provide effective hyperthermia treatment. S-2-(4-Aminobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid (DOTA) was coupled to SAHBA and carboxymethylated polyvinyl alcohol surface functionalized iron oxide nanoparticles and radiolabeled with 177Lu. The capability of radiolabeled iron oxide nanoparticles for delivering radiation therapy to a U87MG murine orthotopic xenograft model of glioblastoma was initially investigated.
Book Synopsis Iron Oxide Nanoparticles for Biomedical Applications by : Sophie Laurent
Download or read book Iron Oxide Nanoparticles for Biomedical Applications written by Sophie Laurent and published by Elsevier. This book was released on 2017-10-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization and Application begins with several chapters covering the synthesis, stabilization, physico-chemical characterization and functionalization of iron oxide nanoparticles. The second part of the book outlines the various biomedical imaging applications that currently take advantage of the magnetic properties of iron oxide nanoparticles. Brief attention is given to potential iron oxide based therapies, while the final chapter covers nanocytotoxicity, which is a key concern wherever exposure to nanomaterials might occur. This comprehensive book is an essential reference for all those academics and professionals who require thorough knowledge of recent and future developments in the role of iron oxide nanoparticles in biomedicine.
Book Synopsis Protein-Nanoparticle Interactions by : Masoud Rahman
Download or read book Protein-Nanoparticle Interactions written by Masoud Rahman and published by Springer Science & Business Media. This book was released on 2013-06-24 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.
