Synthesis And Characterization Of Cyclometalated Ruthenium Ii Complexes And Assessment Of Their Potential As Pharmaceuticals

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Synthesis and Characterization of Cyclometalated Ruthenium (II) Complexes and Assessment of Their Potential as Pharmaceuticals

Author : Leslie Ann Morales
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (143 download)

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Book Synopsis Synthesis and Characterization of Cyclometalated Ruthenium (II) Complexes and Assessment of Their Potential as Pharmaceuticals by : Leslie Ann Morales

Download or read book Synthesis and Characterization of Cyclometalated Ruthenium (II) Complexes and Assessment of Their Potential as Pharmaceuticals written by Leslie Ann Morales and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclometalated Ruthenium (II) and RAPTA species were synthesized, characterized and evaluated on their photophysical properties and potential as anti-cancer agents. The binding affinity to yeast RNA of one of the newly synthesized compounds containing a thiophene group (LM5400) was compared to its literature precursor (Compound B) containing a phenyl group under gel electrophoresis. Results indicated that the bands of compounds; Compound A, LM3000, Compound B and LM5400 when incubated with yeast RNA, were similar to the control with the expectation of the band of LM5400 being more faint relative to the rest whenever samples were incubated for 24hrs. Photophysical experiments on cyclometalated ruthenium (II) compounds (CompoundA, LM3000, Compound B, LM5400) indicated that these compounds have an absorbance around 360 nm respectively but do not fluoresce due to extremely low emission values. Four hydrolysis studies were done on the cyclometalated ruthenium (II) species under various conditions and monitored via UV/Vis and H-NMR. Underall conditions, the absorbance and the NMR data the complexes with the j6-benzene ring (Compound A and LM3000) changed under aqueous and chloride solutions. In contrast, the absorbance of the complexes with the j6-cymene rings (Compound B and LM5400) only changed upon increased concentration. All compounds synthesized were characterized by NMR. Crystal structures were obtained for newly synthesized compounds, LM3000 and LM5400.

Synthesis and Characterization of Cyclometalated Ruthenium (II) Complexes for Applications in Photoactivated Cancer Therapy

Author : Julia A. McCain
Publisher :
ISBN 13 :
Total Pages : 168 pages
Book Rating : 4.:/5 (992 download)

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Book Synopsis Synthesis and Characterization of Cyclometalated Ruthenium (II) Complexes for Applications in Photoactivated Cancer Therapy by : Julia A. McCain

Download or read book Synthesis and Characterization of Cyclometalated Ruthenium (II) Complexes for Applications in Photoactivated Cancer Therapy written by Julia A. McCain and published by . This book was released on 2016 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synthesis and Characterization of Hybrid Drugs Based on Ruthenium Complex Moiety and Biologically Active Organic Compounds

Author : Michał Pawel Łomzik
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Synthesis and Characterization of Hybrid Drugs Based on Ruthenium Complex Moiety and Biologically Active Organic Compounds by : Michał Pawel Łomzik

Download or read book Synthesis and Characterization of Hybrid Drugs Based on Ruthenium Complex Moiety and Biologically Active Organic Compounds written by Michał Pawel Łomzik and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main goal of this thesis was synthesis and preliminary characterization of novel ruthenium(II) polypyridyl complexes bearing biologically active molecules as potential theranostic agents. Luminescence for the diagnostic applications, and cytotoxicity for the anticancer, therapeutic applications are considered as the theranostic properties. Four new ligands containing biologically active moieties - 5-(4-4'-methyl-[2,2'-bipyridine]-4-ylbut-1-yn-1-yl)pyridine-2-carbaldehyde semicarbazone (L1), 3-(5-4'-methyl-[2,2'-bipyridine]-4-ylpentyl)imidazolidine-2,4-dione (L2), 5,5-dimethyl-3-(5-4'-methyl-[2,2'-bipyridine]-4-ylpentyl)imidazolidine-2,4-dione (L3) and [1-(5-4'-methyl-[2,2'-bipyridine]-4-ylpentyl)-2,5-dioxoimidazolidin-4-yl]urea (L4) were synthesized and characterized. The ligands were used to obtain nine novel ruthenium(II) polypyridyl complexes. Six complexes were synthesized with ligand L1 ([Ru(bpy)2(L1)]2+, [Ru(Mebpy)2(L1)]2+, [Ru(tBubpy)2(L1)]2+, [Ru(Phbpy)2(L1)]2+, [Ru(dip)2(L1)]2+, [Ru(SO3dip)2(L1)]2-) and three with ligands L2, L3 and L4 ([Ru(bpy)2(L2)]2+, [Ru(bpy)2(L3)]2+, [Ru(bpy)2(L4)]2+) (bpy = 2,2'-bipyridine, Mebpy = 4,4'-dimethyl-2,2-bipyridine, tBubpy = 4,4'-tert-butyl-2,2'-bipyridine, Phbpy = 4,4'-diphenyl-2,2-bipyridine, dip = 4,7-diphenyl-1,10-phenantroline and SO3dip = 4,7-di-(4-sulfonatophenyl)-1,10-phenantroline). The spectroscopic and photophysical properties of those complexes were determined. The presence of ligands L1-L4 in the structure of the complex decreased luminescence quantum yield and luminescence lifetime in comparison with unmodified [Ru(bpy)3]2+ complex. The theoretical calculations have shown that ligands L1-L4 do not have influence on ruthenium core geometry. However, they increased the energy of the HOMO that resulted in a shorter band gap. The simulated electronic absorption spectra were in a good agreement with the experimental data. The interactions between the studied ruthenium complexes and human serum albumin (HSA) were investigated. All studied Ru(II) complexes exhibited strong affinity to HSA with the association constant 105 M-1s-1, which suggests formation of Ru complex-HSA adducts. It was also determined that ruthenium complexes most likely bind to the hydrophobic pocket of protein, located in Sudlow's site I in the subdomain II A. Preliminary cytotoxicity evaluation for the studied ruthenium complexes showed their cytotoxic activity towards cancer cell lines. Those results, together with good luminescence properties of the studied ruthenium complexes (luminescence lifetimes and luminescence quantum yield) make them interesting candidates for potential theranostic applications.

Ruthenium Chemistry

Author : Ajay Kumar Mishra
Publisher : CRC Press
ISBN 13 : 1351616501
Total Pages : 386 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Ruthenium Chemistry by : Ajay Kumar Mishra

Download or read book Ruthenium Chemistry written by Ajay Kumar Mishra and published by CRC Press. This book was released on 2018-01-17 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will describe Ruthenium complexes as chemotherapeutic agent specifically at tumor site. It has been the most challenging task in the area of cancer therapy. Nanoparticles are now emerging as the most effective alternative to traditional chemotherapeutic approach. Nanoparticles have been shown to be useful in this respect. However, in view of organ system complicacies, instead of using nanoparticles as a delivery tool, it will be more appropriate to synthesize a drug of nanoparticle size that can use blood transport mechanism to reach the tumor site and regress cancer. Due to less toxicity and effective bio-distribution, ruthenium (Ru) complexes are of much current interest. Additionally, lumiscent Ru-complexes can be synthesized in nanoparticle size and can be directly traced at tissue level. The book will contain the synthesis, characterization, and applications of various Ruthenium complexes as chemotherapeutic agents. The book will also cover the introduction to chemotherapy, classification of Ru- complexes with respect to their oxidation states and geometry, Ruthenium complexes of nano size: shape and binding- selectivity, binding of ruthenium complexes with DNA, DNA cleavage studies and cytotoxicity. The present book will be more beneficial to researchers, scientists and biomedical. Current book will empower specially to younger generation to create a new world of ruthenium chemistry in material science as well as in medicines. This book will be also beneficial to national/international research laboratories, and academia with interest in the area of coordination chemistry more especially to the Ruthenium compounds and its applications.

Ruthenium(II) Polypyridyl Complexes as Potential Anticancer Drugs

Author : Yanling Chen
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (859 download)

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Book Synopsis Ruthenium(II) Polypyridyl Complexes as Potential Anticancer Drugs by : Yanling Chen

Download or read book Ruthenium(II) Polypyridyl Complexes as Potential Anticancer Drugs written by Yanling Chen and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on biological activities of ruthenium polypyridyl complexes (RPCs) continues to attract interest as these complexes have shown promising anticancer activity both in vitro and in vivo.1−3 The mononuclear RPC, [(phen)2Ru(tatpp)]2+ (MP) and related dinuclear complex [(phen)2Ru(tatpp)Ru(phen)2]4+ (P) have been shown to both intercalate with DNA and shown potentiated DNA cleavage under anaerobic and reducing conditions4−5, as well as shown good selectivity and cytotoxicity towards malignant cell lines in vitro and tumors in vivo.5 Both complexes contain the redox-active tatpp ligand which is thought to be an essential component for the observed biological activities. This thesis is focused on developing improvements to the stereoselective syntheses of the chiral complexes, [delta][delta]-P and [delta]-MP. It is also investigated the synthesis of a new analogue [(phen)2Ru(tadbp)]2+ (B) and its chiral form [delta]-B which contains a modified tatpp ligand that is only capable of binding one Ru ion. Moreover this thesis explores the ability of these large complexes to traverse the cell membranes and get into cells and cell nuclei by isolating treated cells and nuclei and determining their ruthenium content by graphite furnace atomic absorption method (GFAAS). The GFAAS data show that the two examined complexes [delta][delta]-P and [delta]-MP are able to quickly penetrate into cancer cells (H-358) and concentrate in nuclei, which is postulated due to their high binding affinity to DNA.

Syntheses, Characterization, and Preliminary Evaluation of Potential Ruthenium Anticancer Complexes Containing Schiff Base Ligands

Download Syntheses, Characterization, and Preliminary Evaluation of Potential Ruthenium Anticancer Complexes Containing Schiff Base Ligands PDF Online Free

Author : Stephen Mensah
Publisher :
ISBN 13 : 9781687926043
Total Pages : 104 pages
Book Rating : 4.9/5 (26 download)

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Book Synopsis Syntheses, Characterization, and Preliminary Evaluation of Potential Ruthenium Anticancer Complexes Containing Schiff Base Ligands by : Stephen Mensah

Download or read book Syntheses, Characterization, and Preliminary Evaluation of Potential Ruthenium Anticancer Complexes Containing Schiff Base Ligands written by Stephen Mensah and published by . This book was released on 2019 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platinum-based drugs have over the years been administered in the treatment of tumours.Unfortunately, platinum resistance and the severe side effects associated with the treatments has necessitated the research for new anti-cancer drugs. Ruthenium(II) and Ruthenium(III) complexes have shown promise as useful alternative anticancer agents. The lead candidates include the Ru(II) complex RAPTA-C, a ruthenium(II)-arene complex [Ru(Îʺ6-p-cymene)Cl2(1,3,5-triaza-7-phosphaadamantane)] and the Ru(III) complex NAMI-A [imidazoleH][trans-Ru(imidazole) (dimethyl sulfoxide)Cl4]. Both compounds have shown potent cytotoxic activity in several primary human tumor models. Unfortunately, NAMI-A could not advance in clinical evaluations due to limited efficacy in vivo, while the clinical evaluation of RAPTA-C is unknown. Therefore, there is a need for novel cancer therapeutics that have high biological activity, are relatively easy to synthesize, and can readily be modified. This work focuses on the use of 2-acetylpyridine and 2-pyridinecarboxaldehyde for the synthesis, characterization, and preliminary evaluation of derivatives of both the RAPTA-C and NAMI-A anticancer complexes containing Schiff base ligands. Here, the results of the synthesis of these compounds and their subsequent characterization using 1H NMR, MS, fluorescence and UV-Vis spectroscopies are presented.

Synthesis and characterization of hetero-multinuclear ruthenium/platinum complexes and assessment of their potential as anticancer agents

Download Synthesis and characterization of hetero-multinuclear ruthenium/platinum complexes and assessment of their potential as anticancer agents PDF Online Free

Author : Isabelle Taylor
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (143 download)

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Book Synopsis Synthesis and characterization of hetero-multinuclear ruthenium/platinum complexes and assessment of their potential as anticancer agents by : Isabelle Taylor

Download or read book Synthesis and characterization of hetero-multinuclear ruthenium/platinum complexes and assessment of their potential as anticancer agents written by Isabelle Taylor and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synthesis and Characterization of Ruthenium(II)-hispolon Complexes

Author : Carmen Kloer
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (143 download)

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Book Synopsis Synthesis and Characterization of Ruthenium(II)-hispolon Complexes by : Carmen Kloer

Download or read book Synthesis and Characterization of Ruthenium(II)-hispolon Complexes written by Carmen Kloer and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Synthesis and Characterization of Octahedral Ruthenium(II) Complexes with Trans-Spanning Diphosphine Ligands

Author : Willie J. Perez
Publisher :
ISBN 13 :
Total Pages : 234 pages
Book Rating : 4.:/5 (348 download)

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Book Synopsis The Synthesis and Characterization of Octahedral Ruthenium(II) Complexes with Trans-Spanning Diphosphine Ligands by : Willie J. Perez

Download or read book The Synthesis and Characterization of Octahedral Ruthenium(II) Complexes with Trans-Spanning Diphosphine Ligands written by Willie J. Perez and published by . This book was released on 1995 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Metallodrugs

Author : Shahid Ul-Islam
Publisher : John Wiley & Sons
ISBN 13 : 1119640423
Total Pages : 432 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Advances in Metallodrugs by : Shahid Ul-Islam

Download or read book Advances in Metallodrugs written by Shahid Ul-Islam and published by John Wiley & Sons. This book was released on 2020-07-08 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.

Synthesis and Characterization of New Ruthenium (2.) Compounds with Potential Anticancer Activity

Author : Barbara Serli
Publisher :
ISBN 13 :
Total Pages : 151 pages
Book Rating : 4.:/5 (14 download)

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Book Synopsis Synthesis and Characterization of New Ruthenium (2.) Compounds with Potential Anticancer Activity by : Barbara Serli

Download or read book Synthesis and Characterization of New Ruthenium (2.) Compounds with Potential Anticancer Activity written by Barbara Serli and published by . This book was released on 2004 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synthesis and Characterization of Ruthenium (II) Polypyridyl Complexes

Author : Youxiang Wang
Publisher :
ISBN 13 :
Total Pages : 190 pages
Book Rating : 4.:/5 (326 download)

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Book Synopsis Synthesis and Characterization of Ruthenium (II) Polypyridyl Complexes by : Youxiang Wang

Download or read book Synthesis and Characterization of Ruthenium (II) Polypyridyl Complexes written by Youxiang Wang and published by . This book was released on 1994 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cyclometalation Reactions

Author : Iwao Omae
Publisher : Springer Science & Business Media
ISBN 13 : 4431546049
Total Pages : 214 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Cyclometalation Reactions by : Iwao Omae

Download or read book Cyclometalation Reactions written by Iwao Omae and published by Springer Science & Business Media. This book was released on 2014-01-23 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a review of cyclometalation reactions and organometallic intramolecular-coordination five-membered ring products, the most active type of reactions in synthetic organic reactions and their products. Included is the discovery of intramolecular-coordination bonds in cyclometalation reactions and the characteristics of those reactions, as well as the reasons that their five-membered ring compounds are very easily synthesized through such reactions. In addition, the applications of cyclometalation reactions and five-membered ring products, synthetic applications, catalysts, and other products are described. These topics are of special interest for industrial researchers.

Inorganic Chemical Biology

Author : Gilles Gasser
Publisher : John Wiley & Sons
ISBN 13 : 111851002X
Total Pages : 437 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Inorganic Chemical Biology by : Gilles Gasser

Download or read book Inorganic Chemical Biology written by Gilles Gasser and published by John Wiley & Sons. This book was released on 2014-06-23 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding, identifying and influencing the biological systems are the primary objectives of chemical biology. From this perspective, metal complexes have always been of great assistance to chemical biologists, for example, in structural identification and purification of essential biomolecules, for visualizing cellular organelles or to inhibit specific enzymes. This inorganic side of chemical biology, which continues to receive considerable attention, is referred to as inorganic chemical biology. Inorganic Chemical Biology: Principles, Techniques and Applications provides a comprehensive overview of the current and emerging role of metal complexes in chemical biology. Throughout all of the chapters there is a strong emphasis on fundamental theoretical chemistry and experiments that have been carried out in living cells or organisms. Outlooks for the future applications of metal complexes in chemical biology are also discussed. Topics covered include: • Metal complexes as tools for structural biology • IMAC, AAS, XRF and MS as detection techniques for metals in chemical biology • Cell and organism imaging and probing DNA using metal and metal carbonyl complexes • Detection of metal ions, anions and small molecules using metal complexes • Photo-release of metal ions in living cells • Metal complexes as enzyme inhibitors and catalysts in living cells Written by a team of international experts, Inorganic Chemical Biology: Principles, Techniques and Applications is a must-have for bioinorganic, bioorganometallic and medicinal chemists as well as chemical biologists working in both academia and industry.

Organotransition Metal Chemistry: From Bonding to Catalysis

Author : John F. Hartwig
Publisher :
ISBN 13 :
Total Pages : 1172 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Organotransition Metal Chemistry: From Bonding to Catalysis by : John F. Hartwig

Download or read book Organotransition Metal Chemistry: From Bonding to Catalysis written by John F. Hartwig and published by . This book was released on 2010-02-10 with total page 1172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on Collman et al.'s best-selling classic book, Principles and Applications of Organotransition Metal Chemistry, Hartwig's text consists of new or thoroughly updated and restructured chapters and provides an in-depth view into mechanism, reaction scope, and applications. It covers the most important developments in the field over the last twenty years with great clarity with a selective, but thorough and authoritative coverage of the fundamentals of organometallic chemistry, the elementary reactions of these complexes, and many catalytic processes occurring through organometallic intermediates, making this the Organotransition Metal Chemistry text for a new generation of scientists.

DNA Damage Detection In Situ, Ex Vivo, and In Vivo

Author : Vladimir V. Didenko
Publisher : Humana Press
ISBN 13 : 9781603274081
Total Pages : 0 pages
Book Rating : 4.2/5 (74 download)

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Book Synopsis DNA Damage Detection In Situ, Ex Vivo, and In Vivo by : Vladimir V. Didenko

Download or read book DNA Damage Detection In Situ, Ex Vivo, and In Vivo written by Vladimir V. Didenko and published by Humana Press. This book was released on 2010-11-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in organic chemistry, fluorescent microscopy, and materials science have created an entirely new range of techniques and probes for imaging DNA damage in molecular and cellular biology. In DNA Damage Detection In Situ, Ex Vivo, and In Vivo: Methods and Protocols, expert researchers explore the latest advances in the area, covering both recent and established techniques to detect and quantify DNA damage at scales ranging from subcellular to the level of a whole live organism. Chapters present all major assays used in molecular and cellular biology for the labeling of DNA damage in situ, ex vivo, and in vivo. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and current, DNA Damage Detection In Situ, Ex Vivo, and In Vivo: Methods and Protocols is an essential handbook for novice and experienced researchers in a variety of fields, including molecular and cellular biology, experimental and clinical pathology, toxicology, radiobiology, oncology, embryology, experimental pharmacology, drug design, and environmental science.

Handbook on Synthesis Strategies for Advanced Materials

Author : A. K. Tyagi
Publisher : Springer Nature
ISBN 13 : 9811618925
Total Pages : 922 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Handbook on Synthesis Strategies for Advanced Materials by : A. K. Tyagi

Download or read book Handbook on Synthesis Strategies for Advanced Materials written by A. K. Tyagi and published by Springer Nature. This book was released on 2021-10-22 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents state-of-the-art coverage of synthesis of advanced functional materials. Unconventional synthetic routes play an important role in the synthesis of advanced materials as many new materials are metastable and cannot be synthesized by conventional methods. This book presents various synthesis methods such as conventional solid-state method, combustion method, a range of soft chemical methods, template synthesis, molecular precursor method, microwave synthesis, sono-chemical method and high-pressure synthesis. It provides a comprehensive overview of synthesis methods and covers a variety of materials, including ceramics, films, glass, carbon-based, and metallic materials. Many techniques for processing and surface functionalization are also discussed. Several engineering aspects of materials synthesis are also included. The contents of this book are useful for researchers and professionals working in the areas of materials and chemistry.