Symposium Papers Bioorganic Chemistry

Author : Steven A. Benner
Publisher : Springer Science & Business Media
ISBN 13 : 3642735940
Total Pages : 180 pages
Book Rating : 4.6/5 (427 download)

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Download or read book Redesigning the Molecules of Life written by Steven A. Benner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: The organic chemist is rarely satisfied by a simple "explanation" of the reactivity of organic molecules. Rather, the chemist wants to go one step further, to "control" the behavior of molecules by altering their structure in a controlled way. This is, in fact, a rather stringent definition of "understanding," as it requires the "prediction" of behavior from structure (or structure from behavior). But it also places technical demands on the chemist. He must be able to synthesize the molecules he studies, characterize them at the atomic level of structural resolution, and then measure their behaviors to the precision that his explanation demands. Biological chemistry presents special problems in this regard. Although the tools for synthesis, purification, and structural characterization are now available for manipulating rather large biological macromolecules (proteins and nucleic acids in particular), the theory supporting these manipulations is inadequate. We certainly do not know enough to control generally the behavior of biological macromolecules; still worse, it is not clear that we know enough to design synthetic molecules to expand our understanding about how reactivity in such biological macromolecules might be controlled. Starting from scratch, there are simply too many oligopeptides to make; starting from native proteins, there are simply too many structural mutations that might be introduced.