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Author : Phyllis C. Spriggs
Publisher :
ISBN 13 :
Total Pages : 142 pages
Book Rating : 4.:/5 (976 download)
Download or read book Surmounting Barriers to the Bench written by Phyllis C. Spriggs and published by . This book was released on 1988 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Barbara J. Youngberg
Publisher : Jones & Bartlett Learning
ISBN 13 : 9780834210165
Total Pages : 548 pages
Book Rating : 4.2/5 (11 download)
Download or read book The Risk Manager's Desk Reference written by Barbara J. Youngberg and published by Jones & Bartlett Learning. This book was released on 1998 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Risk Manager's Desk Reference, Second Edition is the definitive guide to ensure quality in your organization and save thousands of dollars in costly lawsuits. It puts at your fingertips the information you need on integrating quality assurance and risk management, understanding risk management in a managed care environment, and program development. With this book you learn how to integrate patient support services and facilitate physician participation. This handy reference offers concise information on your most challenging concerns and various ethical issues.
Author : Freddie Pitcher, Jr.
Publisher : LSU Press
ISBN 13 : 0807178101
Total Pages : 192 pages
Book Rating : 4.8/5 (71 download)
Download or read book Breaking Barriers written by Freddie Pitcher, Jr. and published by LSU Press. This book was released on 2022-07-06 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Breaking Barriers, Judge Freddie Pitcher Jr. describes how he made history in Baton Rouge by becoming the first African American to be elected to judgeships at three different levels of the court system. Pitcher recounts his early years in Valley Park—a segregated and semi-rural neighborhood—where one of his cousins, a civil rights attorney, served as his role model and inspired him to become both a lawyer and an agent of change. Pitcher depicts what it was like to grow up in the segregated South and how racial discrimination fueled his drive to challenge the norms of the Baton Rouge judiciary later in life. Pitcher discusses how he forged together Black political organizations, the Black church community, and a group of white attorneys into a campaign coalition that ultimately helped him overcome the racial barriers that prevented Black people from ascending to the judiciary in Baton Rouge. He details the strategy used to win seats on both the Baton Rouge City Court and the 19th Judicial District Court at a time when many said a Black candidate could not win a city- or parish-wide election. He describes many of the challenges he faced as the first and only Black judge in Baton Rouge while highlighting some of the notable cases he tried and sharing his beliefs about judging and the judicial process. Pitcher’s story of rising from “the bench to the bar to the bench”—from the bench outside the local grocery store that he and his friends frequented as young boys, to the Louisiana bar, to the judicial bench—is informative and inspiring, shedding light on the perseverance and determination required of early African American candidates to overcome the many roadblocks to full participation in the political process related to the judiciary.
Author : Policy and Global Affairs
Publisher : National Academies Press
ISBN 13 : 0309067847
Total Pages : 60 pages
Book Rating : 4.3/5 (9 download)
Download or read book Overcoming Barriers to Collaborative Research written by Policy and Global Affairs and published by National Academies Press. This book was released on 1999-12-17 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report summarizes discussions and insights from the workshop on Overcoming Barriers to Collaborative Research held March 23-24, 1998, in Irvine, California. The workshop was organized by the Government-University-Industry Research Roundtable of the National Academy of Sciences, National Academy of Engineering, and the Institute of Medicine. The purpose of the meeting was to discuss barriers to university-industry cooperation and to explore concrete approaches to overcoming them. Practitioners from universities and industry, as well as government policy makers, participated in the two-day workshop.
Author : Leggett-Robinson, Pamela M.
Publisher : IGI Global
ISBN 13 : 1799848590
Total Pages : 199 pages
Book Rating : 4.7/5 (998 download)
Download or read book Overcoming Barriers for Women of Color in STEM Fields: Emerging Research and Opportunities written by Leggett-Robinson, Pamela M. and published by IGI Global. This book was released on 2020-06-26 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite a plethora of initiatives, policies, and procedures to increase their representation in STEM, women of color still remain largely underrepresented. In the face of institutional and societal bias, it is important to understand the various methods women of color use to navigate the STEM landscape as well as the role of their personal and professional identities in overcoming the systemic (intentional or unintentional) barriers placed before them. Overcoming Barriers for Women of Color in STEM Fields: Emerging Research and Opportunities is a collection of innovative research depicting the challenges of women of color professionals in STEM and identifying strategies used to overcome these barriers. The book examines the narrative of these difficulties through a reflective lens that also showcases how both the professional and personal lives of these women were changed in the process. Additionally, the text connects the process to the Butterfly Effect, a metamorphosis that brings about a dramatic change in character and perspective to those who go through it, which in the case of women of color is about rebirth, evolution, and renewal. While highlighting topics including critical race theory, institutional racism, and educational inequality, this book is ideally designed for administrators, researchers, students, and professionals working in the STEM fields.
Author : Yogeshwar Bachhav
Publisher : John Wiley & Sons
ISBN 13 : 352734781X
Total Pages : 468 pages
Book Rating : 4.5/5 (273 download)
Download or read book Targeted Drug Delivery written by Yogeshwar Bachhav and published by John Wiley & Sons. This book was released on 2022-10-17 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Drug Delivery Novel approaches in targeted drug delivery for both small molecule and biopharmaceutical drugs Targeted Drug Delivery explores a new frontier in drug research that has become a focus for developing novel medications. The work discusses a wide range of approaches for targeting small molecules as well as peptide and macromolecular drugs, from prodrugs to drug conjugates to drug carriers and devices, helping readers to stay up to date on the latest developments in the field. The following key topics are addressed: Antibody conjugates, prodrugs, and suicide gene therapeutics Protac technology for selectively degrading target proteins Delivery of nucleic acid drugs Novel drug carriers, such as liposomes, vesicles, and nanoparticles Unmet medical needs for which there is a large market potential, such as viral infections and cancer For chemists, pharmacologists, and professionals in the wider pharmaceutical industry, Targeted Drug Delivery is a comprehensive guide on how to solve the greatest challenge in treating many diseases: delivering a pharmaceutically active substance to the target tissue in the body.
Author :
Publisher :
ISBN 13 :
Total Pages : 940 pages
Book Rating : 4.F/5 ( download)
Download or read book Bench & Bar of Minnesota written by and published by . This book was released on 1994 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Official membership directory" in each volume.
Author : Sarah R. Kaplan
Publisher :
ISBN 13 :
Total Pages : 96 pages
Book Rating : 4.F/5 ( download)
Download or read book Overcoming Barriers to Permanency written by Sarah R. Kaplan and published by . This book was released on 1993 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gregory H. Watson
Publisher : John Wiley & Sons
ISBN 13 : 9780471018841
Total Pages : 310 pages
Book Rating : 4.0/5 (188 download)
Download or read book Business Systems Engineering written by Gregory H. Watson and published by John Wiley & Sons. This book was released on 1995-01-18 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to combining two powerful management techniques totransform any business organization into a masterpiece of businessefficiency. Lester Dean Thurow, Dean of MIT's Sloan School ofManagement, recently stated that benchmarking combined with processengineering will be the most important management technique of the1990s. Now, in this groundbreaking book, Gregory Watson describeshow top corporations worldwide have already successfullyimplemented that powerful cutting-edge technique--which he calls"business systems engineering"--to promote continuous improvement.More importantly, he clearly demonstrates how you can do the samein your organization. * Introduces business systems engineering, a dynamic new approachto rethinking and redesigning business processes to achievedramatic improvements in quality, cost, service, speed, andmore * Offers clear guidelines for using business systems engineeringtechniques to make your organization more dynamic, productive, andable to adapt to change in today's global marketplace * Incorporates key aspects of TQM, business process improvement,policy deployment, industrial engineering, teamwork, problemsolving, and information technology into one holistic system * Includes business systems engineering success stories, includingthose at Compaq, United Services Automobile Association andMotorola, as well as a survey of the effect of systems changeacross the global automobile industry
Author : Federico Mingozzi
Publisher : Frontiers Media SA
ISBN 13 : 2889195007
Total Pages : 97 pages
Book Rating : 4.8/5 (891 download)
Download or read book Immune responses to AAV vectors, from bench to bedside written by Federico Mingozzi and published by Frontiers Media SA. This book was released on 2015-06-30 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic. Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
Author :
Publisher : Elsevier
ISBN 13 : 0443235457
Total Pages : 360 pages
Book Rating : 4.4/5 (432 download)
Download or read book RNA Therapeutics Part B written by and published by Elsevier. This book was released on 2024-03-06 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA Therapeutics, Part B, Volume 204 updates on a new class of medication based on RNA molecules, with chapters on a variety of topics, including RNA therapeutics for cardiovascular disorders, RNA therapeutics for kidney injury, RNA therapeutics for beta-thalassemia, RNA therapeutics for infectious diseases, RNA therapeutics for reproductive diseases, Potential of RNA and transcriptomic data to drive drug repurposing for various diseases, RNA therapeutics for glioma/glioblastoma, RNA therapeutics for regenerative medicine, Advances in the liposome-based delivery systems for RNA therapeutics in cancer, Advances in the polymeric nanoparticulate delivery systems for RNA therapeutics in cancer, and more. - Covers RNA therapeutics' history and future perspectives - Discusses the processes of RNA therapeutical development - Presents recent applications of RNA therapeutic in clinics - Provides the advantages and disadvantages of RNA therapeutics
Author : Abigail M. Judge
Publisher : Oxford University Press
ISBN 13 : 0190235217
Total Pages : 353 pages
Book Rating : 4.1/5 (92 download)
Download or read book Overcoming Parent-Child Contact Problems written by Abigail M. Judge and published by Oxford University Press. This book was released on 2016-10-05 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there has been heightened interest in the clinical and legal management of families in which children resist contact with one parent and become aligned with the other following divorce. Families affected by these dynamics require disproportionate resources and time from mental health and legal professionals, and cases require a specialized clinical approach. Traditional models of individual and family therapy are not designed to address these issues, and strategies and resources for mental health and legal professionals have been extremely limited. Overcoming Parent-Child Contact Problems describes interventions for families experiencing a high conflict divorce impasse where a child is resisting contact with a parent. It examines in detail one such intervention, the Overcoming Barriers approach, involving the entire family and combining psycho-education and clinical intervention. The book is divided into two parts: Part I presents an overview of parental alienation, including clinical approaches and a critical analysis of the many challenges associated with traditional outpatient family-based interventions. Part II presents the Overcoming Barriers approach, describing core aspects of the intervention and ways to adapt its clinical techniques to outpatient practice. Overcoming Parent-Child Contact Problems is geared toward mental health clinicians and legal professionals who work with families in high conflict and where a child resists visitation with a parent.
Author : Rishabha Malviya
Publisher : CRC Press
ISBN 13 : 1040105998
Total Pages : 273 pages
Book Rating : 4.0/5 (41 download)
Download or read book Emerging Roles of Nanocarrier in Cancer Therapy written by Rishabha Malviya and published by CRC Press. This book was released on 2024-09-05 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the limitations of existing therapeutic approaches using nanoparticles. Emerging Roles of Nanocarriers in Cancer Therapy will further provide information for the development of successful cancer nanomedicine therapies. Features Explains different types of nanoparticles, targeting mechanisms, and approved nanotherapeutics for oncological implications in cancer treatment. Covers in detail the characteristics of various nanotechnology-based drug delivery systems. Discusses passive and active cellular targeting, ligand-based targeting of nanoparticles, and strategies to improve nanoparticle-cellular membrane interaction. Presents the application of nanotherapeutics, current challenges, and prospects, and describes the path of future research. Highlights smart strategies for improving the clinical impact of cancer nanomedicine. The text is primarily written for graduate students, and academic researchers in the fields of biotechnology, nanotechnology, drug delivery, pharmaceutical science, and pharmacology.
Author : Yashwant Pathak
Publisher : CRC Press
ISBN 13 : 1000580296
Total Pages : 317 pages
Book Rating : 4.0/5 (5 download)
Download or read book Gene Delivery Systems written by Yashwant Pathak and published by CRC Press. This book was released on 2022-07-01 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique volume in our Drugs and Pharmaceutical Sciences series covers the development of gene therapy today, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases. It also presents the current application of the CRISPR/Cas9 gene-editing technique which has revolutionized genome editing and which was awarded the 2020 Nobel Prize in Chemistry. Several new drug delivery systems are explored for the applications of gene therapy. These are found to be useful in treating chronic illnesses, including cancer and infectious diseases. Key Features: Overview of the development of gene therapy Provides the most up to date information on the development of gene therapy, from the technology involved to gene correction and genome editing Presents CRISPR gene therapy recent trends and applications Discusses siRNA, mRNA, and DNA plasmids
Author : Kan He
Publisher : Elsevier
ISBN 13 : 0128173394
Total Pages : 448 pages
Book Rating : 4.1/5 (281 download)
Download or read book Overcoming Obstacles in Drug Discovery and Development written by Kan He and published by Elsevier. This book was released on 2023-05-18 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overcoming Obstacles in Drug Discovery and Development uses real-world case studies to illustrate how critical thinking and problem solving skills are applied in the discovery and development of drugs. It also shows how developing critical thinking to overcome issues plays an essential role in the process. Modern drug discovery and development is a highly complex undertaking that requires scientific and professional expertise to be successful. After the identification of a molecular entity for treating a medical condition, challenges inevitably arise during the subsequent development to understand and characterize the biological profile; feedback from scientists is used to fine-tune the molecular entity to obtain an effective and safe product. In this process, the discovery team may identify unexpected safety issues and new medical disorders for treatment by the molecular entity. Invariably inherent in this complex undertaking are miscues, mistakes, and unexpected problems that can derail development and throw timetables into disarray, potentially leading to failure in the development of a medically useful drug. Addressing critical unexpected problems during development often requires scientists to utilize critical thinking and imaginative problem-solving skills. Overcoming Obstacles in Drug Discovery and Development will be essential to young scientists to help learn the skills to successfully face challenges, learn from mistakes, and further develop critical thinking skills. It will also be beneficial to experienced researchers who can learn from the case studies of successful and unsuccessful drug development. - Provides real-world case studies in drug discovery and the development of drugs - Illustrates the use of critical thinking and problem solving in approaching preclinical and clinical problems in drug discovery and development - Illustrates and analyses examples of successes and failures in drug discovery and development that have not previously been reported
Author : Prashant Kesharwani
Publisher : Woodhead Publishing
ISBN 13 : 0323855768
Total Pages : 558 pages
Book Rating : 4.3/5 (238 download)
Download or read book Aptamers Engineered Nanocarriers for Cancer Therapy written by Prashant Kesharwani and published by Woodhead Publishing. This book was released on 2022-09-25 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aptamers Engineered Nanocarriers for Cancer Therapy details the selection technologies, biological characteristics, and clinical uses of aptamer-based nano agents for cancer therapeutics. The book helps facilitate speedy solutions for some of the problems pertaining to the manufacture of nano-aptamers – such as toxicity, thermal stability, cost efficiency, tumor penetration and blood stability. Key chapters cover cell-SELEX technology for aptamer selection, mechanisms of multi-drug resistance of cancer, the relevance of aptamers as anticancer therapies, as well as the broad range of aptamer-functionalized nanostructures available. This book provides exciting insights into this relatively new approach to cancer therapeutics, and will be of interest to materials scientists, biomedical engineers, molecular biologists, biochemists and clinical scientists, with a focus on cancer therapy. - Reviews the mechanisms behind multi-drug resistance (MDR) in cancer and how aptamer-mediated novel therapeutic agents and strategies can facilitate MDR reversal - Covers a range of aptamers engineered nanostructures, including PLGA nanoparticles, silica nanoparticles, quantum dots, nucleic acid aptamers, and more - Discusses the challenges associated with using aptamers as cancer therapeutics and how this translates into clinical use
Author : Diana Furchtgott-Roth
Publisher : Rlpg/Galleys
ISBN 13 :
Total Pages : 218 pages
Book Rating : 4.:/5 (321 download)
Download or read book Overcoming Barriers to Entrepreneurship in the United States written by Diana Furchtgott-Roth and published by Rlpg/Galleys. This book was released on 2008 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents, chapter-by-chapter, evidence for and possible solutions to many of the most evident obstacles to entrepreneurs. It seeks to demonstrate that policy changes can have a significant effect on entrepreneurship in America by reducing barriers that block business creation.
