Summary Report On The Evaluation Of Short Term Tests For Carcinogens Collaborative Study On In Vivo Tests Published Under The Joint Sponsorship Of The United Nations Environment Programme The International Labour Organisation And The World Health Organization

Author : J Ashby (Ed)
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)

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Download or read book Evaluation of Short Term Tests for Carcinogens, Volume 1; Report of the International Programme on Chemical Safety's Collaborative Study on in Vivo Assays written by J Ashby (Ed) and published by . This book was released on 1988 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The IPCS in vivo collaborative study, overview and conclusions; The statistical analysis of in vivo genotoxicity data, case studies of the rat hepatocyte UDS and mouse bone marrow micronucleus assays; Benzo(a)pyrene and pyrene; 2-Acetylaminofluorene and 4-acetylaminofluorene; Summary report on the performance of sister chromatid exchange, micronucleus, and chromosome aberration tests in rodent bone marrow cells; Summary report on the performance of the in vivo mammalian cell cytogenetics chromosome aberrations, metaphase analysis assays; Evaluation of chromosomal aberrations in bone marrow of male IC3F1 mice; Analysis of chromosomal aberrations in bone marrow cells of C57BL/6 mice treated with benzo(a)pyrene, pyrene, 2-acetylaminofluorene, and 4-acetylaminofluorene; Induction of chromosomal aberrations in BALB/c mouse bone marrow cells; Metaphase analysis test results in male ICR Swiss mice; A study of the ability of benzo(a)pyrene, pyrene, 2-acetylaminofluorene and 4-acetylaminofluorene to damage bone marrow cell chromosomes in five inbred strains of mice; Induction of chromosomal aberrations in bone marrow cells and ascites tumor cells of mice by 2-acetylaminofluorene, 4-acetylaminofluorene and benzo(a)pyrene; A comparative analysis of the induction of chromosomal aberrations in the bone marrow cells of B6C3F1 mice; An in vivo cytogenetic test in bone marrow cells of the Alderley Park Wistar derived rat; Mutagenic activity of four compounds in chromosomal aberration assay using Chinese hamster bone marrow cells; Examination of metaphase chromosomes obtained from the bone marrow of Chinese hamsters (Cricetulus griseus); Summary report on the performance of the in vivo micronucleus assays; Bone marrow micronucleus tests on NMRI mice; Bone marrow micronucleus induction in HPBBL mice; Micronuclei induction in mouse bone marrow cells with benzo(a)pyrene, pyrene, 2-acetylaminofluorene and 4-acetylaminofluorene; Micronucleus test results for two carcinogen/noncarcinogen chemical pairs in male ICR Swiss mice; The micronucleus test in mutagen sensitive MS/Ae mice; The micronucleus test in strain C57BL/6J mice; Micronucleus test on benzo(a)pyrene and pyrene performed in NMRI mice; Micronucleus test in bone marrow cells of CBA male mice; Induction of micronuclei in BALB/c mouse bone marrow cells; Induction of micronuclei in polychromatic erythrocytes in bone marrow of adult IC3F1, hybrid male mice; Tests on two pairs of structural analogues in the mouse in vivo micronucleus assay; The clastogenic activity of benzo(a)pyrene, pyrene, 2-acetylaminofluorene and 4-acetylaminofluorene in the mouse bone marrow micronucleus test; Bone marrow micronucleus test in Swiss male mice; Micronucleus incidences induced in bone marrow erythrocytes of pregnant NMRI mice and in liver derived erythrocytes of their foetuses; Detection of micronucleated polychromatic erythrocytes in bone marrow of male mice; The peripheral blood erythrocyte micronucleus assay in weanling and foetal Swiss mice; Micronucleus test in bone marrow of rats exposed to 2-acetylaminofluorene or 4-acetylaminofluorene; Micronucleus test in the Alderley Park Wistar derived albino rat; Summary report on the performance of the in vivo sister chromatid exchange assays; A comparative analysis of the induction of sister chromatid exchanges in the bone marrow cells of B6C3F1 mice; Analysis of sister chromatid exchange in C57BL/6 mouse bone marrow cells following in vivo exposure to carcinogen/noncarcinogen chemical pairs; Detection of sister chromatid exchanges in bone marrow of male mice; In vivo sister chromatid exchanges in mouse bone marrow, test of four compounds in male and female CD-1 mice; Tests with Swiss albino mice to detect the induction of sister chromatid exchanges in bone marrow cells; Sister chromatid exchange induction in bone marrow cells of Swiss mice; In vivo sister chromatid exchange evaluation in Sprague Dawley rats; Analysis of sister chromatid exchange in C57B1/6 mouse peripheral blood lymphocytess following in vivo exposure to carcinogen/noncarcinogen pairs; Discrimination of structurally similar carcinogen/noncarcinogen analogues by analysis of sister chromatid exchange in vivo in bone marrow and intestinal epithelium of Chinese hamster; Introduction, liver specific assays; Summary report of liver specific short term tests; Summary report on the performance of the liver initiation and promotion assays; Early cytomorphological and cytochemical changes induced in liver by single large doses of 2-acetylaminofluorene and 4-acetylaminofluorene; Liver initiation assay, the rat liver foci bioassay of carcinogens and noncarcinogens; Ability of the test chemicals to initiate gamma glutamyltranspeptidase positive foci in female rats; In vivo promotion assay of four compounds on enhancement of the development of gamma glutamyl transpeptidase positive liver cell foci in male F344 rats; A liver cell transplantation assay for promoting activity in rats; Summary report on the performance of the in vivo DNA repair assays; A comparison of the response of carcinogen/noncarcinogen pairs in the rat and mouse hepatocyte DNA repair assays in vivo and in vitro; Activity of 2-acetylaminofluorene and 4-acetylaminofluorene in an in vitro and an in vivo/in vitro assay for unscheduled DNA synthesis in the rat liver; An evaluation of the ability of benzo(a)pyrene, pyrene, 2- and 4-acetylaminofluorene to induce unscheduled DNA synthesis and cell proliferation in the livers of male rats and mice treated in vivo; Unscheduled DNA synthesis in rat liver after in vivo treatment with 2-acetylaminofluorene or 4-acetylaminofluorene; Induction of unscheduled DNA synthesis and DNA replication in rat hepatocytes following in vivo administration of 2-actylaminofluorene and 4-acetylaminofluorene; Testing of 2-acetylaminofluorene and 4-acetylaminofluorene in the in vivo/in vitro rat hepatocyte/DNA repair assay and investigation of lactational exposure of neonatal rats to 2-acetylaminofluorene; In vivo-in vitro assay for quantifying hepatic DNA repair and S phase in F344 rats; Inactivity of benzo(a)pyrene in a weanling rat liver, unscheduled DNA synthesis assay; Summary report on the performance of cytogenetic assays in rat hepatic cells; Chromosome studies in hepatic cells from rats exposed to genotoxic chemicals; Micronucleus test with rat hepatocytes to detect induction of clastogenic damage; Summary report of the measurement of DNA strand breaks; DNA strand break induction in Fischer 344 rat hepatocytes as assessed by the alkaline elution assay; DNA strand breakage monitored by alkaline elution in the livers of male Wistar derived rats administered carcinogenic/noncarcinogenic analogues; Alkaline elution of rat liver DNA for benzo(a)pyrene, pyrene 2-acetylaminofluorene, and 4-acetylaminofluorene; Use of the fluorometric analysis of DNA unwinding (FADU) assay to detect DNA strand breaks in the liver of CD-1 mice exposed to carcinogens and a repair inhibitor.