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Study Of Metabotropic Glutamate Receptor 5 In Parkinsons Disease And L Dopa Induced Dyskinesia
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Book Synopsis Study of Metabotropic Glutamate Receptor 5 in Parkinson's Disease and L-DOPA-induced Dyskinesia by : Naila I. Ismayilova
Download or read book Study of Metabotropic Glutamate Receptor 5 in Parkinson's Disease and L-DOPA-induced Dyskinesia written by Naila I. Ismayilova and published by . This book was released on 2003 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Investigating Group III Metabotropic Glutamate Receptors as Novel Therapeutic Targets in Parkinson's Disease and Levodopa-induced Dyskinesia by :
Download or read book Investigating Group III Metabotropic Glutamate Receptors as Novel Therapeutic Targets in Parkinson's Disease and Levodopa-induced Dyskinesia written by and published by . This book was released on 2014 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Finally, since other antiglutamatergic strategies have proven successful, we investigated mGiu4 activation as a means to inhibit L-DOPA-induced dyskinesia expression or development in rodents. While this approach was ineffective at reversing established dyskinesia there was a hint that it might be efficacious at delaying the onset of this complication that will be worth investigating further. In conclusion, targeting the mGiu4 receptor has shown some beneficial effects in relation to Parkinson's disease but much remains to be discovered about the actions of these agents both within and outside of the basal ganglia before any clear potential is revealed.
Book Synopsis The Role of Metabotropic Glutamate Receptors (mGluRs) in the Pathophysiology of the Basal Ganglia by : Flora Mela
Download or read book The Role of Metabotropic Glutamate Receptors (mGluRs) in the Pathophysiology of the Basal Ganglia written by Flora Mela and published by . This book was released on 2005 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Levodopa-Induced Dyskinesia in Parkinson's Disease by : Susan H. Fox
Download or read book Levodopa-Induced Dyskinesia in Parkinson's Disease written by Susan H. Fox and published by Springer. This book was released on 2014-10-08 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide a single reference source on levodopa-induced dyskinesias (LID) from ‘bench to bedside’. Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors for LID are covered as a background to understanding risk factors for developing LID. The following chapters cover the latest preclinical studies aiming to understand the pathophysiology of LID at the cellular, neurochemical, neurophysiological and circuitry level with detailed discussion of mechanisms and future directions to take the field forward; clinical studies from phase II to phase IV; on going RCTs in LID and evidence-based medicine reviews of treatment options. Levodopa-Induced Dyskinesia in Parkinson’s Disease is aimed at an international audience of movement disorder neurologists; neuroscientists; trainees and graduate and post-graduate students.
Book Synopsis Parkinson's Disease: Current and Future Therapeutics and Clinical Trials by : Néstor Gálvez-Jiménez
Download or read book Parkinson's Disease: Current and Future Therapeutics and Clinical Trials written by Néstor Gálvez-Jiménez and published by Cambridge University Press. This book was released on 2016-03-24 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book emphasizes treatment options for Parkinson's disease, providing the necessary clinical and scientific basis for the foundations of solid therapeutics.
Book Synopsis A Synopsis of Parkinson's Disease by : Md, Frcpc, Frcp (hon), Abdul Qayyum Rana
Download or read book A Synopsis of Parkinson's Disease written by Md, Frcpc, Frcp (hon), Abdul Qayyum Rana and published by BoD – Books on Demand. This book was released on 2014-03-26 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinsons disease is a disabling neurological condition with both motor and non-motor symptoms for which no cure is available at this stage. This book is unique in covering the most important topics related to Parkinsons disease. Current research and updates about some non-motor symptoms, as well as surgical treatment of Parkinsons disease, in addition to the long term complications of pharmacological treatments have been presented. This book can be used by physicians, researchers and neuroscientists who want to learn new information about these topics related to Parkinsons disease. Authors of the individual chapters are well known in their fields and the book has been edited by a world renowned Parkinsons disease expert.
Book Synopsis Dual Modulation of MGlu2 and 5-HT2A Receptors as a Novel Approach to Alleviate L-DOPA Induced Dyskinesia by : Élodie Bourgeois-Cayer
Download or read book Dual Modulation of MGlu2 and 5-HT2A Receptors as a Novel Approach to Alleviate L-DOPA Induced Dyskinesia written by Élodie Bourgeois-Cayer and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "L-3,4-dihydroxyphenylalanine (L-DOPA) remains the most effective treatment for Parkinson’s disease (PD). However, chronic administration of L-DOPA leads to the emergence of motor complications such as dyskinesia in the vast majority of patients. Serotonin 2A (5-HT2A) receptor blockade is a validated approach to alleviate dyskinesia, but its effectiveness appears to be of limited magnitude. Recently, we have demonstrated that activation of metabotropic glutamate 2 (mGlu2) receptors reduce dyskinesia in the 6-hydroxydopamine (6-OHDA)-lesioned rat. Based on the fact that 5-HT2A and mGlu2 receptors form a functional hetero-complex, we hypothesised that combining EMD-281,014, the most selective 5-HT2A antagonist commercially available with LY-354,740, a selective mGlu2 orthosteric agonist (OA) and LY-487,379, the most selective mGlu2 positive allosteric modulator (PAM) commercially available, would be more effective at alleviating dyskinesia than modulating 5-HT2A and mGlu2 receptors separately.Rats were rendered hemi-parkinsonian by stereotaxic injection of 6-OHDA into the medial forebrain bundle. Following a recovery period, degree of parkinsonism was assessed using the cylinder test. Rats were then primed with daily administration of L-DOPA to induce stable axial, limb and oro-lingual (ALO) abnormal involuntary movements (AIMs). On experimental days, rats were administered L-DOPA in combination with previously determined effective doses of each of EMD-281,014 (vehicle, 0.03 and 0.1 mg/kg s.c), LY-354,740 (vehicle and 0.1 mg/kg s.c.), and LY-487,379 (vehicle and 0.1 mg/kg s.c.) after which ALO AIMs were assessed for 2 min, every 20 min, for 180 min. After a 3-day washout period, an acute low-dose of L-DOPA was administered with a combination of EMD-281,014/LY-354,740/LY-487,379, and the effect on L-DOPA anti-parkinsonian action was determined by the cylinder test.Combining EMD-281,014 0.1 mg/kg and LY-487,379 0.1mg/kg to L-DOPA significantly reduced ALO AIMs duration, by 10% (P ˂ 0.05), when compared to the vehicle. Other combinations, notably EMD-281,014 and LY-354,740, or EMD-281,014 with both LY-487,379 and LY-354,740, did not lead to an enhanced anti-dyskinetic effect. Combining EMD-281,014 with LY-354,740 and LY-487,379 did not have any effect on L-DOPA anti-parkinsonian action.Our results suggest that an additional anti-dyskinetic benefit was achieved when combining EMD-281,014 and LY-487,379, but not when combining EMD-281,014 with an mGlu2 OA or with an OA and a PAM, in the 6-OHDA-lesioned rat model of PD. Keywords: Parkinson’s disease, dyskinesia, mGlu2, 5-HT2A, L-DOPA, 6-OHDA-lesioned rat"--
Book Synopsis Characterizing the Modulation of MGluR5 in a 6-OHDA-induced Rat Model of Parkinson's Disease by : Peter Alexander John Lamb
Download or read book Characterizing the Modulation of MGluR5 in a 6-OHDA-induced Rat Model of Parkinson's Disease written by Peter Alexander John Lamb and published by . This book was released on 2008 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroPET imaging studies were conducted to investigate the role of metabotropic glutamate subtype-5 receptors (mGluR5) in Parkinson's disease (PD). Four analogical PET ligands were used to characterize modulation of mGluR5 function in a 6hydroxydopamine (6-OHDA) induced rat model of PD. Unilateral 6-OHDA lesions were made in the right medial forebrain bundle, and severity of these lesions was determined with [11]CFT. The binding characteristics of the PET ligands were analyzed using a modified distribution volume method of the Logan reference region model. Binding potential values were calculated on the striatum, hippocampus, and cortex, using the cerebellum as a reference tissue. On the right (with lesion) side of the striatum, ["C]CFT binding decreased. Three of the four investigated mGluR5 ligands ([11C]MPEP, [11C]M-PEPy, and [11C]MMPEP) also showed enhanced binding characteristics on the same side of the brain. The right hippocampus and cortex showed similar results. The mGluR5s' enhanced binding characteristics on the right side of the brain suggest a complementary and compensatory role of metabotropic glutamate receptors in the dopaminergic neurodegeneration of Parkinson's disease.
Book Synopsis Glutamate and Dopamine Transporter Modulation: Implications for the Treatment of Parkinson's Disease and L-dopa Induced Dyskinesia by : Tanya Chotibut
Download or read book Glutamate and Dopamine Transporter Modulation: Implications for the Treatment of Parkinson's Disease and L-dopa Induced Dyskinesia written by Tanya Chotibut and published by . This book was released on 2014 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Homeostatic Control of Brain Function by : Detlev Boison
Download or read book Homeostatic Control of Brain Function written by Detlev Boison and published by Oxford University Press. This book was released on 2016 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.
Book Synopsis Levodopa-induced Dyskinesias in Parkinson’s Disease: Current Knowledge and Future Scenarios by : Antonio Cerasa
Download or read book Levodopa-induced Dyskinesias in Parkinson’s Disease: Current Knowledge and Future Scenarios written by Antonio Cerasa and published by Frontiers Media SA. This book was released on 2015-05-13 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This topic aims to pool the most recent advances in the phenomenology and pathophysiology of levodopa-induced dyskinesias. The papers in this eBook have strongly contributed to reduce the gaps in our knowledge of LIDs pathogenesis.
Book Synopsis Metabotropic Glutamate Receptors in Psychiatric and Neurological Disorders by :
Download or read book Metabotropic Glutamate Receptors in Psychiatric and Neurological Disorders written by and published by Elsevier. This book was released on 2023-03-01 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabotropic Glutamate Receptors in Psychiatric and Neurological Disorders, Volume 168 in the International Review of Neurobiology series, highlights advances in the field, with this new volume presenting interesting chapters on topics such as mGlu receptors in Parkinson’s disease, Metabotropic glutamate receptors in estradiol-mediated motivated behaviors in females, mGlu regulation of sleep, Implications for sleep disruptions in psychiatric disorders, Mechanisms of mGlu receptor trafficking; alterations by methamphetamine, Group I mGlu and cocaine seeking, The role of mGlu receptors in fear and anxiety, Regulation of Alcohol Consumption, Reward, Dependence, and Perception by Metabotropic Glutamate Receptor Signaling, and mGlu5 as a biomarker for psychiatric disorders. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Neurobiology serials Updated release includes the latest information on metabotropic glutamate receptors in psychiatric and neurological disorders
Book Synopsis Drug Induced Movement Disorders by : Stewart Factor
Download or read book Drug Induced Movement Disorders written by Stewart Factor and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second revised edition of this text will update and present current state of the art clinical approaches to this subject. This book will continue to be the source text of information on drug-induced movement disorders authored and edited by the pioneers in the field. It will be an invaluable addition to the library of any neurologist.
Book Synopsis Synaptic Plasticity by : Michael R. Kreutz
Download or read book Synaptic Plasticity written by Michael R. Kreutz and published by Springer Science & Business Media. This book was released on 2012-02-18 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the current concepts of molecular mechanisms in synaptic plasticity and provides a comprehensive overview of cutting-edge research technology used to investigate the molecular dynamics of the synapses. It explores current concepts on activity-dependent remodeling of the synaptic cytoskeleton and presents the latest ideas on the different forms of plasticity in synapses and dendrites. Synaptic Plasticity in Health and Disease not only supplies readers with extensive knowledge on the latest developments in research, but also with important information on clinical and applied aspects. Changes in spine synapses in different brain disease states, so-called synaptopathies, are explained and described by experts in the field. By outlining basic research findings as well as physiological and pathophysiological impacts on synaptic plasticity, the book represents an essential state-of-the-art work for scientists in the fields of biochemistry, molecular biology and the neurosciences, as well as for doctors in neurology and psychiatry alike.
Book Synopsis The Glutamate/GABA-Glutamine Cycle by : Arne Schousboe
Download or read book The Glutamate/GABA-Glutamine Cycle written by Arne Schousboe and published by Springer. This book was released on 2016-11-25 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.
Book Synopsis Theory and Applications of Nonparenteral Nanomedicines by : Prashant Kesharwani
Download or read book Theory and Applications of Nonparenteral Nanomedicines written by Prashant Kesharwani and published by Academic Press. This book was released on 2020-09-30 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theory and Applications of Nonparenteral Nanomedicines presents thoroughly analysed data and results regarding the potential of nanomedicines conceived by diverse non-parenteral routes. In the context of nanotechnology-based approaches, various routes such as oral, pulmonary, transdermal, delivery and local administration of nanomedicine have been utilized for the delivery of nanomedicine. This book discusses the non-parenteral application of nanomedicine, its regulatory implications, application of mucus penetrating nanocarrier, and detailed chapters on development of nanomedicines developed for drug delivery by various route. Beginning with a brief introduction to the non-parenteral delivery of nanomedicine and the safety and regulatory implications of the nanoformulations, further chapters discuss the physiology of the biological barriers, the specificity of the nanocarriers as well as their multiple applications. Theory and Applications of Nonparenteral Nanomedicines helps clinical researchers, researchers working in pharmaceutical industries, graduate students, and anyone working in the development of non-parenteral nanomedicines to understand the recent progress in the design and development of nanoformulations compatible with non-parenteral applications. Contains a comprehensive review of non-parenteral nanomedicines Provides analysis of non-parenteral methods of nanomedicines including regulatory implications and future applications Explores a wide range of promising approaches for non-parenteral drug delivery using the latest advancement in nanomedicine written by experts in industry and academia
Book Synopsis Leucine-Rich Repeat Kinase 2 (LRRK2) by : Hardy J. Rideout
Download or read book Leucine-Rich Repeat Kinase 2 (LRRK2) written by Hardy J. Rideout and published by Springer. This book was released on 2017-03-28 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
