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Studies Towards The Total Synthesis Of The Chivosazoles And Development Of A Site Selective Cross Coupling Approach To Complex Molecule Synthesis
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Book Synopsis Studies Towards the Total Synthesis of the Chivosazoles and Development of a Site-selective Cross-coupling Approach to Complex Molecule Synthesis by : Jennifer Sek-Bik Kan
Download or read book Studies Towards the Total Synthesis of the Chivosazoles and Development of a Site-selective Cross-coupling Approach to Complex Molecule Synthesis written by Jennifer Sek-Bik Kan and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of the Chivosazoles by : Lisa Gibson
Download or read book Studies Towards the Total Synthesis of the Chivosazoles written by Lisa Gibson and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The chivosazoles, isolated in 1994 from the myxobacterium Sorangium cellulosum by Höfle and co-workers, are a family of polyketides that exhibit a range of potent biological activity including antifungal and cytoxicity against human cancer cell lines. This thesis details studies towards the total synthesis of the chivosazoles. Chapter 1 discusses the isolation, characterisation and biological activity of these compounds, as well as the first total synthesis of chivosazole F (12) by the Kalesse group. Chapter 2 describes the development of a highly convergent approach to assemble the chivosazoles from three key fragments A (69), B (70) and C (71), of similar size and complexity. A flexible endgame coupling of these fragments is proposed via a Stille- Suzuki-macrolactonisation or Stille-esterification-Suzuki sequence. The first generation route to access fragment A is described, utilising Paterson 1,4-syn boron aldol methodology and an Evans-Tishchenko 1,3-anti reduction to define the stereochemistry. The relative configuration of this subunit, as proposed by Kalesse, was independently confirmed by synthesis of C28-C35 degradation fragment 21. The C19-C22 stereotriad featured in fragment B was installed, again, using a boron-mediated aldol reaction followed by an Evans-Tishchenko reduction. The required oxazole moiety was formed via a Williams-Wipf cyclisation procedure. Having prepared fragments A and B, coupling conditions were established to form the northern hemisphere subunit and the NMR data of this region correlated favourably with that of the natural product. Chapter 3 describes the second-generation route to fragment A (69), featuring fewer steps and improved scalability for preparation of multi-gram quantities of this material. Different strategies for modification of the functional group at C16 on the oxazole ring for planned coupling with fragment C (71) were explored. Unexpected difficulties with the installation of this coupling handle are outlined, as well as a modification to our oxazole-formation strategy to overcome these challenges. As an alternative to eventual esterification or macrolactonisation at C1, Still-Genarri and Ando olefinations were investigated on model systems for formation of the C2-C3 (Z)-olefin. Advanced C7-C35 fragments are constructed via subsequent Stille cross-couplings in preparation for formation of the macrolactone core of the chivosazoles. Chapter 4 outlines three potential highly-convergent endgame strategies for ongoing studies. The experimental procedures and spectroscopic characterisation of the compounds discussed are found in Chapter 5 and the Appendix.
Book Synopsis Development of Cascade Cross-coupling/Diels-Alder Approaches for Complex Molecule Synthesis by : David Cain
Download or read book Development of Cascade Cross-coupling/Diels-Alder Approaches for Complex Molecule Synthesis written by David Cain and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of the Chivosazoles by : Jialu Jin
Download or read book Studies Towards the Total Synthesis of the Chivosazoles written by Jialu Jin and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of the Chivosazoles by : Mungyuen Li
Download or read book Studies Towards the Total Synthesis of the Chivosazoles written by Mungyuen Li and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Expansion and Automation of Iterative Cross-coupling: Total Synthesis of Synechoxanthin and Development of a Small Molecule Synthesizer by :
Download or read book Expansion and Automation of Iterative Cross-coupling: Total Synthesis of Synechoxanthin and Development of a Small Molecule Synthesizer written by and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Directed Towards the Stereoselective Total Synthesis of Miyakolide by : Jinhua Song
Download or read book Studies Directed Towards the Stereoselective Total Synthesis of Miyakolide written by Jinhua Song and published by . This book was released on 1999 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of Superstolide A. by : Yuichi Tateno
Download or read book Studies Towards the Total Synthesis of Superstolide A. written by Yuichi Tateno and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Stille Reaction by : Vittorio Farina
Download or read book The Stille Reaction written by Vittorio Farina and published by John Wiley & Sons. This book was released on 1998-09-18 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Die Stille-Reaktion ist eine der sehr wenigen Reaktionen, in denen unter milden Bedingungen Kohlenstoff-Kohlenstoff-Bindungen geknüpft werden können. Man verwendet die Reaktion häufig in der Synthese komplizierter Moleküle zur Verknüpfung größerer Molekülbausteine. Die Autoren diskutieren vom präparativen Standpunkt aus Grenzen, Einflüsse, strukturelle Effekte und die Wahl der geeigneten Reaktionsbedingungen. Mit ausführlichen Vorschriften und vielen Beispielen. (11/98)
Download or read book Macrolides written by Biljana Arsic and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-03-19 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrolide antibiotics represent a class of natural macrocyclic products, one of the most clinically important antibiotics. Unfortunately, the production and development of new macrolide antibiotics are not represented enough in the pharmaceutical industry today. The intention of the book is therefore not only to be a teaching tool for students and experts, but also to draw the attention of the general public to this extremely useful, cheap and relatively unharmful effective anti-macrobials, and potential anti-malarials. The authors introduce the different classes of macrolides and their derivatives, principles of their biological activity, their structure and interactions with biological targets as well as synthetic methods to produce new macrolide antibiotics of similar or improved properties. Special emphasis was put on conjugates of macrolides with nucleobases or nucleosides with numerous applications; among them the most important remains the attempt to overcome bacterial resistance.
Book Synopsis Retrosynthetic Analysis and Synthesis of Natural Products 1 by : Olivier Piva
Download or read book Retrosynthetic Analysis and Synthesis of Natural Products 1 written by Olivier Piva and published by John Wiley & Sons. This book was released on 2019-12-12 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: For chemists, attempting to mimic nature by synthesizing complex natural products from raw material is a challenge that is fraught with pitfalls. To tackle this unique but potentially rewarding task, researchers can rely on well-established reactions and methods of practice, or apply their own synthesis methods to verify their potential. Whatever the goal and its complexity, there are multiple ways of achieving it. We must now establish a strategic and effective plan that requires the minimum number of steps, but lends itself to widespread use. This book is structured around the study of a dozen target products (butyrolactone, macrolide, indole compound, cyclobutanic terpene, spiro- and polycyclic derivatives, etc.). For each product, the different disconnections are presented and the associated syntheses are analyzed step by step. The key reactions are described explicitly, followed by diagrams showing the range of impact of certain transformations. This set of data alone is conducive to understanding syntheses and indulging in this difficult, but worthwhile activity.
Book Synopsis Practical Medicinal Chemistry with Macrocycles by : Eric Marsault
Download or read book Practical Medicinal Chemistry with Macrocycles written by Eric Marsault and published by John Wiley & Sons. This book was released on 2017-09-12 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations
Book Synopsis Frustrated Lewis Pairs II by : Gerhard Erker
Download or read book Frustrated Lewis Pairs II written by Gerhard Erker and published by Springer. This book was released on 2013-12-12 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frustrated Lewis Pairs: From Dihydrogen Activation to Asymmetric Catalysis, by Dianjun Chen, Jürgen Klankermayer Coexistence of Lewis Acid and Base Functions: A Generalized View of the Frustrated Lewis Pair Concept with Novel Implications for Reactivity, by Heinz Berke, Yanfeng Jiang, Xianghua Yang, Chunfang Jiang, Subrata Chakraborty, Anne Landwehr New Organoboranes in "Frustrated Lewis Pair" Chemistry, by Zhenpin Lu, Hongyan Ye, Huadong Wang Paracyclophane Derivatives in Frustrated Lewis Pair Chemistry, by Lutz Greb, Jan Paradies Novel Al-Based FLP Systems, by Werner Uhl, Ernst-Ulrich Würthwein N-Heterocyclic Carbenes in FLP Chemistry, by Eugene L. Kolychev, Eileen Theuergarten, Matthias Tamm Carbon-Based Frustrated Lewis Pairs, by Shabana Khan, Manuel Alcarazo Selective C-H Activations Using Frustrated Lewis Pairs. Applications in Organic Synthesis, by Paul Knochel, Konstantin Karaghiosoff, Sophia Manolikakes FLP-Mediated Activations and Reductions of CO2 and CO, by Andrew E. Ashley, Dermot O’Hare Radical Frustrated Lewis Pairs, by Timothy H. Warren and Gerhard Erker Polymerization by Classical and Frustrated Lewis Pairs, by Eugene Y.-X. Chen Frustrated Lewis Pairs Beyond the Main Group: Transition Metal-Containing Systems, by D. Wass Reactions of Phosphine-Boranes and Related Frustrated Lewis Pairs with Transition Metal Complexes, by Abderrahmane Amgoune, Ghenwa Bouhadir, Didier Bourissou
Book Synopsis Comprehensive Organic Functional Group Transformations II by :
Download or read book Comprehensive Organic Functional Group Transformations II written by and published by Elsevier. This book was released on 2004-12-16 with total page 9196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Organic Functional Group Transformations II (COFGT-II) will provide the first point of entry to the literature for all scientists interested in chemical transformations. Presenting the vast subject of organic synthesis in terms of the introduction and interconversion of all known functional groups, COFGT-II provides a unique information source documenting all methods of efficiently performing a particular transformation. Organised by the functional group formed, COFGT-II consists of 144 specialist reviews, written by leading scientists who evaluate and summarise the methods available for each functional group transformation. Also available online via ScienceDirect – featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com. By systematically treating each functional group in turn the work also identifies what is not known, thus pointing the way to new research areas Follows the systematic layout of the successful 1995 COFGT reference work, based on the arrangement and bonding of hetero-atoms around a central carbon atom The work will save researchers valuable time in their research as each chapter is written by experts who have critically read and reviewed the literature and presented the best methods of forming every known functional group
Book Synopsis Palladium in Organic Synthesis by : Jiro Tsuji
Download or read book Palladium in Organic Synthesis written by Jiro Tsuji and published by Springer Science & Business Media. This book was released on 2005-07-06 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: with contributions by numerous experts
Book Synopsis Extracellular Glycolipids of Yeasts by : Ekaterina Kulakovskaya
Download or read book Extracellular Glycolipids of Yeasts written by Ekaterina Kulakovskaya and published by Academic Press. This book was released on 2013-12-11 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular Glycolipids of Yeasts: Biodiversity, Biochemistry, and Prospects provides a comprehensive view of the biochemistry, biological activity, and practical application of extracellular glycolipids of yeast. This book brings much-needed clarity to the complex topic of glycolipids and streamlines the rather confusing terminology used for glycolipids. It also provides a wealth of modern data on their composition, structure and properties, biosynthetic pathways, methods of isolation and identification, antifungal activity, and mechanisms of action. Studies of extracellular glycolipids of yeast now draw the attention of researchers in life science and biotechnology due to numerous recently revealed biological properties of these compounds. These compounds are scientifically and practically promising in medicine and agriculture due to their biosurfactant and fungicidal properties, as well as a number of other biological activities. Extracellular Glycolipids of Yeasts gives researchers studying biochemistry of microorganisms and related biologically active compounds a much-needed guide to the basic data that will aid in these increasingly generative pursuits. - Provides a clear overview of the basic data on yeast biosurfactants using a simple survey-style approach - Delivers comprehensive view of biochemistry, biological activity, and practical application of yeasts to aid in their scientific and practical use - Clarifies and simplifies the complex topic of glycolipids, and its often-confusing terminology
Book Synopsis Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates by : Al Postigo
Download or read book Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates written by Al Postigo and published by Elsevier. This book was released on 2018-09-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work.
