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Studies On The Phosphate Metabolism Of Brain
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Book Synopsis Studies on the Phosphate Metabolism of Brain by : Douglas Arthur Hems
Download or read book Studies on the Phosphate Metabolism of Brain written by Douglas Arthur Hems and published by . This book was released on 1966 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Phosphate Metabolism by : Shaul Massry
Download or read book Phosphate Metabolism written by Shaul Massry and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.
Book Synopsis Relationship of Brain Phosphate Metabolism and Cognition Using 31 Phosphorus Magnetic Resonance Spectroscopy at 7-Tesla in Alzheimer's Disease by : Namrata Das
Download or read book Relationship of Brain Phosphate Metabolism and Cognition Using 31 Phosphorus Magnetic Resonance Spectroscopy at 7-Tesla in Alzheimer's Disease written by Namrata Das and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial dysfunction, a neurometabolic marker, is considered an early marker in Alzheimer's disease (AD) that has speculated to precede toxic levels of amyloid and tau. Abnormal mitochondria function can negatively impact brain energy metabolism (BEM), oxidative and metabolic stress, leading to cell senescence and death. In-vitro cell line culture and postmortem AD studies suggest BEM abnormality, however have limited capability to capture the human brain's full complexity. Examining BEM in the in-vivo brain would confirm whether such abnormality is present and if so, to what extent, and how early it occurs in relation to the transitory stages of AD i.e., amnestic mild cognitive impairment (aMCI). The dissertation had three main goals. My first goal was to develop a methodology to measure BEM using advanced imaging technology such as 31-phosphorus magnetic resonance spectroscopy (31P MRS) at ultra-high-field (UHF) magnetic strength 7-T in human brain invivo. In the first phase, using partial volume-coil 31P MRS at 7-T over a brain region, i.e., parieto-occipital area, showed a well-separated high-resolution spectral display of thirteen metabolites signals, including energy phosphates and membrane phospholipid metabolites, in a single population of interest, i.e., aMCI. In my expanded research, I showed similar BEM data acquisition from the whole-brain volume-coil using same imaging technique. This work focused on three main energy phosphate metabolites-adenosine triphosphate (ATP), inorganic phosphate (Pi), and phosphocreatine (PCr). The measurements of these three metabolites were utilized to formulate three (3) BEM markers and two (2) regulatory co-factors [magnesium (Mg2+) and pH], including energy reserve index (PCr/t-ATP), energy consumption index (Pi/t-ATP), and metabolic state indicator (Pi/PCr). The next goal was to investigate if BEM markers and co-factors were significantly different across the three groups - cognitively normal (CN) (n=15), aMCI (n=15), and mild AD (n=11) in the four bilateral brain regions. The results showed that BEM markers was reduced in aMCI with further decrease in AD when compared to CN except metabolic state indicator. Interestingly, all the significant differences in BEM markers and regulatory co-factors were observed in the temporal region bilaterally, a vulnerable region where the AD pathology starts. The final goal was to study if the sensitive BEM markers and co-factors in the temporal lobe were associated with cognitive performance of memory, executive function (EF), attention, visuospatial skills, and language, respectively, across the groups. The findings showed a significant association of higher Mg2+ with improved memory, and EF in CN. On the other hand, in aMCI and mild AD, higher Mg2+ was related to lower performance in the same cognitive domains. Results suggest that in healthy brains, the Mg2+ supports the BEM mechanism, neuronal function and cognition. Whereas in aMCI and AD, the Mg2+ co-factor fails to support these systems. Overall, this work laid a foundation to investigate mitochondrial function using BEM in healthy and compromised brain in-vivo using novel and advanced imaging technology at UHF 7-T. Future work may explore ways to use this methodology using 31P MRS imaging technology to objectively measure the effectiveness of novel neurotherapeutics on mitochondrial function and dysfunction.
Book Synopsis Brain Energy Metabolism by : Johannes Hirrlinger
Download or read book Brain Energy Metabolism written by Johannes Hirrlinger and published by Humana Press. This book was released on 2014-09-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Energy Metabolism addresses its challenging subject by presenting diverse technologies allowing for the investigation of brain energy metabolism on different levels of complexity. Model systems are discussed, starting from the reductionist approach like primary cell cultures which allow assessing of the properties and functions of a single brain cell type with many different types of analysis, however, at the expense of neglecting the interaction between cell types in the brain. On the other end, analysis in animals and humans in vivo is discussed, maintaining the full complexity of the tissue and the organism but making high demands on the methods of analysis. Written for the popular Neuromethods series, chapters include the kind of detailed description and key implementation advice that aims to support reproducible results in the lab. Meticulous and authoritative, Brain Energy Metabolism provides an ideal guide for researchers interested in brain energy metabolism with the hope of stimulating more research in this exciting and very important field.
Book Synopsis The Pentose Phosphate Pathway by : Terry Wood
Download or read book The Pentose Phosphate Pathway written by Terry Wood and published by Elsevier. This book was released on 2012-12-02 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pentose Phosphate Pathway aims to explore the pentose phosphate cycle and the practical techniques applied in its investigation. The main focus of the book is the pentose phosphate cycle in animals as well as microorganisms, and does not discuss the one related to photosynthesis. The book covers the formulation of the pathway, its types, and its alternative formulations; the preparation, processes, and analysis of the pathway; and the enzymes involved. Also covered in the book are the intermediates in intact cells and tissues; distribution of enzymes among different tissues and species; the operation, regulation, and overall control of the pathway; and the clinical, nutritional, and metabolic aspects of the pathway. The text is recommended for biologists and biochemists who would like to understand further the pentose phosphate pathway and the processes related to it.
Book Synopsis In Vivo NMR Spectroscopy by : Robin A. de Graaf
Download or read book In Vivo NMR Spectroscopy written by Robin A. de Graaf and published by John Wiley & Sons. This book was released on 2019-03-11 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents basic concepts, experimental methodology and data acquisition, and processing standards of in vivo NMR spectroscopy This book covers, in detail, the technical and biophysical aspects of in vivo NMR techniques and includes novel developments in the field such as hyperpolarized NMR, dynamic 13C NMR, automated shimming, and parallel acquisitions. Most of the techniques are described from an educational point of view, yet it still retains the practical aspects appreciated by experimental NMR spectroscopists. In addition, each chapter concludes with a number of exercises designed to review, and often extend, the presented NMR principles and techniques. The third edition of In Vivo NMR Spectroscopy: Principles and Techniques has been updated to include experimental detail on the developing area of hyperpolarization; a description of the semi-LASER sequence, which is now a method of choice; updated chemical shift data, including the addition of 31P data; a troubleshooting section on common problems related to shimming, water suppression, and quantification; recent developments in data acquisition and processing standards; and MatLab scripts on the accompanying website for helping readers calculate radiofrequency pulses. Provide an educational explanation and overview of in vivo NMR, while maintaining the practical aspects appreciated by experimental NMR spectroscopists Features more experimental methodology than the previous edition End-of-chapter exercises that help drive home the principles and techniques and offer a more in-depth exploration of quantitative MR equations Designed to be used in conjunction with a teaching course on the subject In Vivo NMR Spectroscopy: Principles and Techniques, 3rd Edition is aimed at all those involved in fundamental and/or diagnostic in vivo NMR, ranging from people working in dedicated in vivo NMR institutes, to radiologists in hospitals, researchers in high-resolution NMR and MRI, and in areas such as neurology, physiology, chemistry, and medical biology.
Book Synopsis Clinical Pediatric Nephrology by : Kanwal Kher
Download or read book Clinical Pediatric Nephrology written by Kanwal Kher and published by CRC Press. This book was released on 2016-11-25 with total page 1110 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of a bestseller, this book provides insight from a wide array of international contributors in the field of pediatric nephrology. Copiously illustrated with photomicrographs and clinical diagrams, the third edition reflects current advances in the field. Each chapter contains a set of questions, directed at helping fellows succeed at the American Pediatric Nephrology Board examination. New information for this edition includes changes in treatment options for hyponatremia, and updates on hyperparathyroidism and transplantation. Text boxes highlight important "take home points" throughout the chapters. Clinical Pediatric Nephrology, Third Edition will be a valuable reference for clinicians in nephrology, pediatrics and urology, and any professional involved in the care of children with renal diseases seeking a reliable contemporary text.
Book Synopsis Handbook of Neurochemistry by : Abel Lajtha
Download or read book Handbook of Neurochemistry written by Abel Lajtha and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies on Phosphorylative Pathways of Galactose Metabolism in Rat Heart and Brain by : William Donald Lorne Musick
Download or read book Studies on Phosphorylative Pathways of Galactose Metabolism in Rat Heart and Brain written by William Donald Lorne Musick and published by . This book was released on 1974 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Magnesium in the Central Nervous System by : Robert Vink
Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Book Synopsis Neurological Research Supported by the National Institute of Neurological Diseases and Stroke by :
Download or read book Neurological Research Supported by the National Institute of Neurological Diseases and Stroke written by and published by . This book was released on 1969 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Glucose Sensing by : Chris D. Geddes
Download or read book Glucose Sensing written by Chris D. Geddes and published by Springer Science & Business Media. This book was released on 2007-12-29 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential reference for any laboratory working in the analytical fluorescence glucose sensing field. The increasing importance of these techniques is typified in one emerging area by developing non-invasive and continuous approaches for physiological glucose monitoring. This volume incorporates analytical fluorescence-based glucose sensing reviews, specialized enough to be attractive to professional researchers, yet appealing to a wider audience of scientists in related disciplines of fluorescence.
Book Synopsis Journal of Scientific & Industrial Research by :
Download or read book Journal of Scientific & Industrial Research written by and published by . This book was released on 1961 with total page 992 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Psychopharmacology Abstracts written by and published by . This book was released on 1978 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis EEG and Evoked Potentials in Psychiatry and Behavioral Neurology by : John R. Hughes
Download or read book EEG and Evoked Potentials in Psychiatry and Behavioral Neurology written by John R. Hughes and published by Butterworth-Heinemann. This book was released on 1983 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: EEG and Evoked Potentials in Psychiatry and Behavioral Neurology discusses the two techniques of examining brain function: electroencephalography (EEG) and evoked potentials. The book also addresses conditions that fall under the umbrella term """"behavioral sciences"""" and are associated with psychiatry and neurology. The book begins by discussing current definitions of organic brain syndrome in order to delineate more clearly the processes whose EEG correlates are to be described. It then outlines the various EEG correlates of impaired central nervous system (CNS) dysfunction for a variety ...
Book Synopsis Journal of Rehabilitation Research and Development by :
Download or read book Journal of Rehabilitation Research and Development written by and published by . This book was released on 1991 with total page 956 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Fluoride in Drinking Water by : National Research Council
Download or read book Fluoride in Drinking Water written by National Research Council and published by National Academies Press. This book was released on 2007-01-22 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most people associate fluoride with the practice of intentionally adding fluoride to public drinking water supplies for the prevention of tooth decay. However, fluoride can also enter public water systems from natural sources, including runoff from the weathering of fluoride-containing rocks and soils and leaching from soil into groundwater. Fluoride pollution from various industrial emissions can also contaminate water supplies. In a few areas of the United States fluoride concentrations in water are much higher than normal, mostly from natural sources. Fluoride is one of the drinking water contaminants regulated by the U.S. Environmental Protection Agency (EPA) because it can occur at these toxic levels. In 1986, the EPA established a maximum allowable concentration for fluoride in drinking water of 4 milligrams per liter, a guideline designed to prevent the public from being exposed to harmful levels of fluoride. Fluoride in Drinking Water reviews research on various health effects from exposure to fluoride, including studies conducted in the last 10 years.