Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Studies On The Mechanisms Of Ligand Induced Nuclear Localization Of Cellular Retinoic Acid Binding Protein Type Ii
Download Studies On The Mechanisms Of Ligand Induced Nuclear Localization Of Cellular Retinoic Acid Binding Protein Type Ii full books in PDF, epub, and Kindle. Read online Studies On The Mechanisms Of Ligand Induced Nuclear Localization Of Cellular Retinoic Acid Binding Protein Type Ii ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Studies on the Mechanisms of Ligand-induced Nuclear Localization of Cellular Retinoic Acid Binding Protein Type II by : Richard J. Sessler
Download or read book Studies on the Mechanisms of Ligand-induced Nuclear Localization of Cellular Retinoic Acid Binding Protein Type II written by Richard J. Sessler and published by . This book was released on 2006 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Retinoid Receptors and Cellular Retinoic Acid Binding Proteins by : Anuradha Samantha Budhu
Download or read book The Retinoid Receptors and Cellular Retinoic Acid Binding Proteins written by Anuradha Samantha Budhu and published by . This book was released on 2002 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Retinoid Signaling Pathways written by and published by Academic Press. This book was released on 2020-04-29 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Retinoid Signaling Pathways, Volume 637, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Sections in this release include The chemistry and biochemistry of Vitamin A and its natural derivative, Biosynthesis of retinoic acids, Biodegration of retinoic acids mediated by retinoid binding proteins, Retinoic acid homeostasis, Cryo Electron Microscopy to study retinol update via the STRA6 receptor, Immuno-detection of retinoic acid synthesis enzymes in the brain, classical pathway of gene regulation by retinoids, Protein-protein interactions in the regulation of retinoid acid receptors activity, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series - Includes the latest information on retinoid signaling pathways
Book Synopsis Retinoid Receptors and Cellular Retinoic Acid Binding Proteins by : Ding Dong
Download or read book Retinoid Receptors and Cellular Retinoic Acid Binding Proteins written by Ding Dong and published by . This book was released on 2000 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Biochemistry of Retinoic Acid Receptors I: Structure, Activation, and Function at the Molecular Level by : Mary Ann Asson-Batres
Download or read book The Biochemistry of Retinoic Acid Receptors I: Structure, Activation, and Function at the Molecular Level written by Mary Ann Asson-Batres and published by Springer. This book was released on 2014-06-24 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: A role for vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development and continued well-being and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. VOLUME I: Here, we present the first volume of a multi-volume series on Retinoic Acid Signaling that will cover all aspects of this broad and diverse field. One aim of Volume I is to present a compilation of topics related to the biochemistry of nuclear retinoic acid receptors, from their architecture when bound to DNA and associated with their coregulators to their ability to regulate target gene transcription. A second aim is to provide insight into recent advances that have been made in identifying novel targets and non-genomic effects of retinoic acid. Volume I is divided into ten chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
Book Synopsis Biochemical and NMR Studies of Human Cellular Retinoic Acid Binding Proteins by : Lincong Wang
Download or read book Biochemical and NMR Studies of Human Cellular Retinoic Acid Binding Proteins written by Lincong Wang and published by . This book was released on 1998 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cellular Retinoic Acid Binding Protein and Breast Cancer by :
Download or read book Cellular Retinoic Acid Binding Protein and Breast Cancer written by and published by . This book was released on 2004 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: In attempts to understand how the signaling by retinoic acid (the active vitamin A metabolite) is regulated we have been studying the retinoic acid binding protein called CRABP-II. These studies revealed that CRABP-II acts to enhance the transcriptional activities of RA and that it does so by directly delivering the hormone to its cognate transcription factor, RAR. Consequently CRABP-II dramatically sensitized cultured mammary carcinoma cells to RA-induced growth inhibition. Similarly, over-expression of CRABP-II inhibited mammary tumor growth in two different mouse models of cancer. CRABP-II may be a novel target for therapeutic and preventive strategies for retinoid-treatment of breast cancer. This project aims to delineate the mechanism by which CRABP-II modulates RA activity, especially as related to its ability to enhance the anti-proliferative action of the ligand. The first aim is to determine the extent to which CRABP-II acts in activating different isotypes of RAR. The second aim is to dissect the mechanism by which RA-induced growth inhibition is mediated. This will then allow for closer inspection of particular target genes that are under such control. The third aim is to understand the basis for RA-resistance of mammary carcinoma cells and how CRABP-II functions to overcome this resistance.
Book Synopsis The Retinoic Acid Receptors and Cellular Retinoic Acid Binding Protein II by : Leslie Jo Willmert
Download or read book The Retinoic Acid Receptors and Cellular Retinoic Acid Binding Protein II written by Leslie Jo Willmert and published by . This book was released on 2006 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms of Nuclear Translocation of Retinoid X Receptor and Its Partner Vitamin D Receptor by : Ming Xu
Download or read book Mechanisms of Nuclear Translocation of Retinoid X Receptor and Its Partner Vitamin D Receptor written by Ming Xu and published by . This book was released on 2005 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cellular Retinoic Acid-binding Protein 2 Cooperates with HuR to Stabilize RNA and Inhibit Tumor Growth by : Amanda C Vreeland
Download or read book Cellular Retinoic Acid-binding Protein 2 Cooperates with HuR to Stabilize RNA and Inhibit Tumor Growth written by Amanda C Vreeland and published by . This book was released on 2015 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular retinoic acid-binding protein 2 (CRABP2) enhances the transcriptional activation of the nuclear receptors termed retinoic acid receptors (RARs) by transporting retinoic acid (RA) from the cytosol to the nucleus and directly "channeling" it to RARs. One outcome of this cooperation is that CRABP2 enhances the RAR-mediated anti-carcinogenic activity of RA.Interestingly, it has been reported that CRABP2 also regulates the expression of some genes and displays pro-apoptotic activities in the absence of RA, using a mechanism that does not involve RAR. These observations suggest a novel function for the protein. The goal of this work was to determine the molecular mechanism by which apo-CRABP2 exerts its RA-independent activity and to examine whether it contributes to the tumor suppressive function of the protein. We found that apo-CRABP2 cooperates with the RNA-binding and stabilizing protein HuR to upregulate and stabilize mRNAs. CRABP2 directly interacts with HuR and enhances its affinity for target mRNAs. We found further that some transcripts that are co-regulated by CRABP2 and HuR include mRNAs for cancer-related proteins such as apoptotic peptidase activating factor-1, caspase 7, BRCA1, and BRCA2. Additional studies revealed that both functions of CRABP2 respectively mediated by RAR and by HuR contribute to the tumor suppressive activity of the protein.
Book Synopsis The Nuclear Receptor Superfamily by : Iain J. McEwan, PhD
Download or read book The Nuclear Receptor Superfamily written by Iain J. McEwan, PhD and published by Humana Press. This book was released on 2008-12-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acting principally to control patterns of gene expression, nuclear receptors play vital roles during embryonic development and in the regulation of metabolic and reproductive functions in adult life, which proves this superfamily of ligand-activated transcription factors to be a crucial part of biological life. In The Nuclear Receptor Superfamily: Methods and Protocols, expert researchers describe a range of molecular, structural and cell biological techniques currently used to investigate the structure-function of nuclear receptors, together with experimental approaches that may lead to new therapeutic strategies for treating nuclear receptor-associated diseases. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters in this volume contain brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, as well as notes from the experts to highlight tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, The Nuclear Receptor Superfamily: Methods and Protocols provides beneficial and time-saving guidance for all those undertaking research in this ever-growing field of study.
Book Synopsis X-ray Crystallographic Studies of Cellular Retinoic Acid-binding Protein II Mutants Designed as Rhodopsin Mimics by : Xiaofei Jia
Download or read book X-ray Crystallographic Studies of Cellular Retinoic Acid-binding Protein II Mutants Designed as Rhodopsin Mimics written by Xiaofei Jia and published by . This book was released on 2008 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Fat-Soluble Vitamins by : H. DeLuca
Download or read book The Fat-Soluble Vitamins written by H. DeLuca and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first demonstration of the existence of a vitamin and the full recognition of this fact are often attributed to the work of McCollum, who found that a sub stance in butterfat and cod-liver oil was necessary for growth and health of ani mals fed purified diets. It became obvious that an organic substance present in microconcentrations was vital to growth and reproduction of animals. Following the coining of the word vitamine by Funk, McCollum named this fat-soluble sub stance vitamin A. We can, therefore, state that vitamin A was certainly one of the first known vitamins, yet its function and the function of the other fat-soluble vitamins had remained largely unknown until recent years. However, there has been an explosion of investigation and new information in this field, which had remained quiescent for at least two or three decades. It is now obvious that the fat-soluble vitamins function quite differently from their water-soluble counter parts. We have learned that vitamin D functions by virtue of its being converted in the kidney to a hormone that functions to regulate calcium and phosphorus metabolism. This new endocrine system is in the process of being elucidated in detail, and in addition, the medical use of these hormonal forms of vitamin D in the treatment of a variety of metabolic bone diseases has excited the medical com munity.
Book Synopsis Nuclear Hormone Receptors by : Malcolm G. Parker
Download or read book Nuclear Hormone Receptors written by Malcolm G. Parker and published by . This book was released on 1991 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the supergene family made up of those nuclear hormone receptors which recognize thyroid and steroid hormones, vitamen D and retinoic acid and which are characterized by their ability to bind both ligands and the genes which respond to them.
Book Synopsis Fat-Soluble Vitamins by : Peter J. Quinn
Download or read book Fat-Soluble Vitamins written by Peter J. Quinn and published by Springer Science & Business Media. This book was released on 1998-09-30 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The subject for a volume on the fat-soluble vitamins needs no justification considering the importance of this group of nutrients and the rate of expan sion of our knowledge of its role in cell biology, genetics, and disease. The level of our understanding has clearly moved from knowing what fat soluble vitamins do to how they perform their functions. Hand in hand with a knowledge of their molecular mechanisms of action is the recognition that vitamins are used sparingly, and regeneration processes operate in certain cases to recycle vitamins from their metabolites. We have divided the volume into alphabetical sections beginning with vitamin A and the carotenoids through vitamins D, E, F, and K, and ending with coenzyme Q. The contributors are all acknowledged experts in their particular fields and have made significant contributions to published research results. All have worked assiduously to deliver the product of their labors on a restricted time scale and to provide the most up-to date information on their respective topics. We are truly grateful for their indulgence.
Book Synopsis Retinoids and Carotenoids in Dermatology by : Anders Vahlquist
Download or read book Retinoids and Carotenoids in Dermatology written by Anders Vahlquist and published by CRC Press. This book was released on 2007-06-20 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This up-to-date reference describes how retinoids and carotenoids function in the skin and how they can be utilized to prevent and treat a wide variety of skin diseases, as well as advance biomedical research in relation to cancer treatment and immunology. Providing an in-depth update on the pharmacology, pharmacodynamics, and new applications of
Download or read book Osmosensing and Osmosignaling written by and published by Elsevier. This book was released on 2007-10-01 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over fifty years the Methods in Enzymology series has been the critically acclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume features articles on the topic of osmosensing and osmosignaling written by experts in the field.
