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Studies On Biodegradable Nano Drug Delivery Systems For Photodynamic Therapy Of Cancer
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Book Synopsis Nanoparticle Drug Delivery Systems for Cancer Treatment by : Hala Gali-Muhtasib
Download or read book Nanoparticle Drug Delivery Systems for Cancer Treatment written by Hala Gali-Muhtasib and published by CRC Press. This book was released on 2020-02-19 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, nanoparticles—bionanomaterials with specific physicochemical properties—have gained a great deal of scientific interest owing to their unique structure. Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs. This book compiles and details cutting-edge research in nanomedicine from an interdisciplinary team of international cancer researchers who are currently revolutionizing drug delivery techniques through the development of nanomedicines and nanotheranostics. Edited by Hala Gali-Muhtasib and Racha Chouaib, two prominent cancer researchers, this book will appeal to anyone involved in nanotechnology, cancer therapy, or drug delivery research.
Book Synopsis Polymeric Systems for Photodynamic Therapy Technique by : Mohammadreza Saboktakin
Download or read book Polymeric Systems for Photodynamic Therapy Technique written by Mohammadreza Saboktakin and published by LAP Lambert Academic Publishing. This book was released on 2015-11-06 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photodynamic therapy (PDT) is a two-step treatment used to help treat symptoms caused by cancer or its treatment. It is called two-step since both a drug and laser treatment are used. PDT is most often used to help people who have cancer. Biodegradable nanoparticles have received much attention as possible drug-delivering agents. Their main advantages lie in high drug loading, the possibility of controlling the drug release, and a large variety of materials and manufacturing processes. This book describe biocompatible polymers as novel drug delivery systems for effective Photodynamic therapy technique.
Book Synopsis Nanomedicine for Cancer Therapy by : Piyush Kumar
Download or read book Nanomedicine for Cancer Therapy written by Piyush Kumar and published by Springer. This book was released on 2016-11-21 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Brief focuses on the cancer therapy available till date, from conventional drug delivery to nanomedicine in clinical trial. In addition, it reports on future generation based nanotherapeutics and cancer theranostic agent for effective therapeutic diagnosis and treatment. Breast cancer was chosen as the model system in this review. The authors give emphasis to multiple drug resistance (MDR) and its mechanism and how to overcome it using the nanoparticle approach.
Book Synopsis Cancer Drug Delivery Systems Based on the Tumor Microenvironment by : Yasuhiro Matsumura
Download or read book Cancer Drug Delivery Systems Based on the Tumor Microenvironment written by Yasuhiro Matsumura and published by Springer Nature. This book was released on 2020-01-07 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophysiology and pharmacology may be leading the development of antitumor drugs in the wrong direction and wasting a lot of money. Although there have been numerous reports of genetic and phenotypic changes in tumors, a large body of pathological and clinical evidence supports the conclusion that there are no pivotal changes in tumor cells that distinguish them consistently and reliably from normal dividing cells. Unlike using antibiotics against bacterial infection, therefore, anticancer agents (ACAs) need to be delivered selectively to tumor tissues and should be kept there long enough to reproduce the concentrations they reach in the Petri dish, which is a closed space where the cytocidal effects of any anticancer agents (ACAs) including molecular targeting agents are very strong. In the body, however, administered ACAs are cleared with the passage of time. Furthermore, most human cancers possess abundant stroma that hinders the penetration of drugs into the tumor microenvironment. Therefore, to overcome these difficulties, novel drug delivery systems have been designed, such as nanoparticles and ACA conjugated antibodies to stromal components and to cancer cell surface antigens. These advances are described in this book after the first section, which describes core features of the pathophysiology of the cancer microenvironment, on which these new developments are based.
Book Synopsis Gold Nanoparticles as Drug Delivery Vectors for Photodynamic Therapy of Cancers by : Yu Cheng
Download or read book Gold Nanoparticles as Drug Delivery Vectors for Photodynamic Therapy of Cancers written by Yu Cheng and published by . This book was released on 2011 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gold nanoparticle-drug conjugates have attracted increasing attention in drug delivery for photodynamic cancer therapy. The nanoparticle acts as a water-soluble and bio-compatible platform that allows the delivery of hydrophobic drugs to the site of therapy. Due to the favorable surface area, hundreds of molecules can be attached to a 5 nm gold nanoparticle. More importantly, the versatile nanoparticle surface plays a vital role in targeted drug delivery. In this dissertation, we focus on efficient drug vectors for cancer therapy by synthesizing PEGylated gold nanoparticle-phthalocyanine conjugates. Both covalent and non-covalent drug binding can be achieved by designing the functionality of the nanoparticle surface. Due to the design of the gold nanoparticle carrier, using amphiphilic polymers, the drug delivery can be facilitated based on its size and the enhanced permeability and retention in the tumor tissue. Compared to the covalent approach, the non-covalent delivery approach of the hydrophobic photodynamic therapy drug Pc 4 through gold nanoparticles has provided rapid release and enhanced photocytotoxicity in cancer cells. In vivo studies in cancer bearing mice have shown an efficient deep penetration of the drug into the target tumors by the nanoparticle carriers within hours. In addition, controlled drug delivery system using visible-NIR light is achieved by a masked Pc 4-gold nanoparticle conjugate system. Targeted drug delivery can be achieved by modification of the carrier surface with active targeting ligands. After modification of the gold nanoparticle-Pc 4 conjugates with an EGF peptide, drug uptake into the tumor cells is dramatically improved due to the combination of active and passive targeting compared to untargeted conjugates. A 10-fold increase of the drug accumulation in a brain tumor was observed for the targeted drug delivery system. This shows that the designed gold nanoparticle-based drug delivery vector is able to cross the blood brain tumor barrier to address the brain tumor owning to the EGF targeted effect. The biodistribution of the drug and gold nanoparticles in vivo was investigated over a time frame of seven days. The biodistribution of the drug was studied by monitoring its intrinsic fluorescence in the organs and the gold nanoparticle concentrations in the corresponding organs have been quantified as well. Both gold nanoparticles and the drug can be removed from the body through renal clearance and the hepatobiliary system within days after drug administration.
Book Synopsis Nanomedicine in Drug Delivery by : Arun Kumar
Download or read book Nanomedicine in Drug Delivery written by Arun Kumar and published by CRC Press. This book was released on 2013-06-05 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a clear need for innovative technologies to improve the delivery of therapeutic and diagnostic agents in the body. Recent breakthroughs in nanomedicine are now making it possible to deliver drugs and therapeutic proteins to local areas of disease or tumors to maximize clinical benefit while limiting unwanted side effects. Nanomedicine in D
Book Synopsis Nanobiomaterials by : Anil K. Sharma
Download or read book Nanobiomaterials written by Anil K. Sharma and published by CRC Press. This book was released on 2018-01-03 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume focuses on the ever-growing and ever-sophisticated use of nanobiomaterials in drug delivery. There have been significant developments in the delivery of the active pharmaceutical ingredients to target sites, thereby sparing the normal functioning biological systems from damage, and this volume highlights some of the most important developments in the field. The book first provides an overview of nanobiomaterials and then goes on to report on new developments in drug delivery and nanotechnology, nanobiomaterials as carriers in cancer therapy, and the diverse uses of nanobiomaterials. Broken into sections, the chapters cover: an overview of nanobiomaterials drug delivery and nanotechnology nanobiomaterials as carriers in cancer therapeutics diverse uses of nanobiomaterials This volume will be a valuable resource on drug delivery for pharmaceutical manufacturers, healthcare personnel, and researchers.
Book Synopsis Nanoparticle-Based Drug Delivery in Cancer Treatment by : Loutfy H. Madkour
Download or read book Nanoparticle-Based Drug Delivery in Cancer Treatment written by Loutfy H. Madkour and published by CRC Press. This book was released on 2022-02-27 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Key Features: Reviews recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Focuses on material platforms that establish NPs and both localized and controlled gene silencing Emphasizes the most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment Describes the most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.
Book Synopsis Nano Drug Delivery Strategies for the Treatment of Cancers by : Awesh K. Yadav
Download or read book Nano Drug Delivery Strategies for the Treatment of Cancers written by Awesh K. Yadav and published by Academic Press. This book was released on 2020-09-03 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nano Drug Delivery Strategies for the Treatment of Cancers discusses several current and promising approaches for the diagnosis and treatment of cancer by using the most recent developments in nanomedical technologies. The book presents introductory information about the biology of different types of cancer in order to provide the reader with knowledge on their specificities. In addition, it discusses various novel drug delivery systems, detailing their functionalities, expected outcomes and future developments in the field, focusing on brain, mouth and throat, breast, lung, liver, pancreas, stomach, colon, bool, skin and prostate cancers. The book is a valuable source for cancer researchers, oncologists, pharmacologists and nanotechnologists who are interested in novel drug delivery systems and devices for treatment of various types of cancer that take advantage of recent advances in this exciting field. Discusses a wide range of promising approaches for the diagnosis and treatment of cancer using the latest advancement in cutting-edge nanomedical technologies Provides foundational information on different types of cancer and their biology to help the reader choose the best nano drug delivery system for patients Presents novel drug delivery systems based on nanoparticles, microparticles, liposomes, self-assembling Micelles and block copolymer micelles
Book Synopsis Nano Drug Delivery for Cancer Therapy by : Firdos Alam Khan
Download or read book Nano Drug Delivery for Cancer Therapy written by Firdos Alam Khan and published by Springer Nature. This book was released on 2024-01-08 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the various modes and methods of nano-based drug delivery in different types of cancers such as colon, breast, cervical, ovarian, and lung cancer. It reviews the significance of nano drug delivery in cancer therapy, the application of nanoparticles in overcoming drug resistance, targeted therapy, and immunotherapy. The book also covers topics related to the synthesis of different types, shapes, and sizes of nanocarriers using synthetic and biological approaches. Further, a chapter explores the synthesis of nanocarriers loaded with anti-cancer drugs by using functionalization or conjugations and encapsulation methods. The book also examines the nanocarriers as delivery vehicles for chemotherapeutic agents against cancers using in vitro and animal models of cancers, preclinical trials for efficacy, and safety profiling of nanocarriers. Finally, future trends and innovation in nano drug delivery for cancer therapy, application of siRNA (nanoparticle-based RNA) therapy, ultrasound-linked nano-cancer therapeutics, and application of exosome-based cancer therapy topics are discussed. Towards the end, the book examines the limitations of nanocarriers, including the cell and tissue toxicity, genotoxicity, and scale-up of nanomaterials, health and environmental hazards associated with nanoformulation synthesis, respiratory diseases, government regulations, and ethical issues.
Book Synopsis Nanotechnology in Regenerative Medicine and Drug Delivery Therapy by : Haiyan Xu
Download or read book Nanotechnology in Regenerative Medicine and Drug Delivery Therapy written by Haiyan Xu and published by Springer Nature. This book was released on 2020-07-21 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on the application of nanotechnologies in scaffold-guided tissue regeneration and in drug delivery systems for use in immunotherapy and overcoming drug resistance in cancer treatment. It covers a variety of topics, including nanomaterials for immunomodulation and immnunotherapy; molecular studies on self-assembly for peptides and DNA and related applications in tumor diagnosis and therapeutics and against human pathogenic bacteria; magnetic and conductive scaffolds for guiding tissue regeneration; multiple functions of magnetic nanoparticles in drug delivery and regenerative medicine; and re-purposing of traditional medicine in nano-formulations. In addition, it discusses common effects of nanomaterials, including reactive oxygen species and protein corona. Providing valuable insights and the presenting the latest research advances, the book allows readers to gain a systematic understanding of the topic.
Book Synopsis Nanomaterial-Based Drug Delivery Carriers for Cancer Therapy by : Tao Feng
Download or read book Nanomaterial-Based Drug Delivery Carriers for Cancer Therapy written by Tao Feng and published by Springer. This book was released on 2016-12-09 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brief summarizes different types of organic and inorganic nanomaterials for drug delivery in cancer therapy. It highlights that precisely designed nanomaterials will be the next-generation therapeutic agents for cancer treatment.
Book Synopsis Nanomaterials for Photodynamic Therapy by : Prashant Kesharwani
Download or read book Nanomaterials for Photodynamic Therapy written by Prashant Kesharwani and published by Woodhead Publishing. This book was released on 2023-01-14 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomaterials for Photodynamic Therapy takes a unique approach to this area, with a key focus on the use of nanomaterials and nanocarriers for photodynamic therapy (PDT). The book introduces the history and mechanism of action behind PDT, covering the variety of sensitizers currently available. Subsequent chapters review existing and emerging nanomaterials for PDT, including hydrogel nanocomposites, fullerenes, quantum dots, polymeric micelles, and more. Challenges and translational aspects of PDT are also discussed, touching on the issues and hindrances of drug resistant cancers.The book bridges the gap between the physics and clinical aspects of PDT, offering a unique nanomaterials-focused perspective. This book will prove useful for materials scientists, biomedical engineers, electrical and optical engineers, and pharmaceutical scientists interested in cancer treatment. Reviews a broad range of nanomaterials for PDT, such as graphene oxide, dendrimers, solid lipid nanoparticles, and more Provides a helpful introduction to the history and mechanism of action behind PDT Discusses challenges in clinical translational, particularly in drug-resistant cancers
Book Synopsis Nanomedicine Unlocks Potential: Applying Nanotechnology to Detect, Deliver, and Defeat Cancer by : Aliasghar Tabatabaei Mohammadi
Download or read book Nanomedicine Unlocks Potential: Applying Nanotechnology to Detect, Deliver, and Defeat Cancer written by Aliasghar Tabatabaei Mohammadi and published by Nobel Sciences. This book was released on with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immune Cell-Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery by : Yixue Su
Download or read book Immune Cell-Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery written by Yixue Su and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Although tremendous efforts have been made on targeted drug delivery systems, current therapy outcomes still suffer from low circulating time and limited targeting efficiency. The integration of cell-mediated drug delivery and theranostic nanomedicine can potentially improve cancer management in both therapeutic and diagnostic aspects. Herein, by taking advantage of innate immune cell's ability to target tumor cells, we developed a novel drug delivery system by using macrophages as both nanoparticle-carriers and navigators to achieve cancer-specific drug delivery. Firstly, we fabricated theranostic nanoparticles from a unique biodegradable photoluminescent poly (lactic acid) (BPLP-PLA), which inherently possesses strong tunable fluorescence, biodegradability, and cytocompatibility. In order to minimize the damage of cancer drugs to carrier immune cells and other healthy cells, a BRAF V600E mutant melanoma specific drug (PLX4032) was loaded into BPLP-PLA nanoparticles. Muramyl tripeptide (MTP) was also conjugated onto the nanoparticles in order to improve the nanoparticle loading efficiency. The resulting nanoparticles were internalized within macrophages, which were tracked via the intrinsic fluorescence of BPLP-PLA to demonstrate potential in imaging-based diagnosis and therapy. Nanoparticle-carrying macrophages were able to bind with and deliver drugs to melanoma cells under both static incubation and dynamic shear-flow conditions. Finally, pharmacological studies indicated that the delivered PLX4032 loaded nanoparticles did not show cytotoxicity against macrophages, while effectively killing melanoma cells. Our "smart" immune cell-mediated drug delivery system demonstrates the advancement of intrinsically traceable and targeted cancer nanomedicine.
Book Synopsis Oleanolic Acid Delivery Using Biodegradable Nanoparticles for Cancer Therapy by : Kwun-Wai Dede Man
Download or read book Oleanolic Acid Delivery Using Biodegradable Nanoparticles for Cancer Therapy written by Kwun-Wai Dede Man and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Oleanolic Acid Delivery Using Biodegradable Nanoparticles for Cancer Therapy" by Kwun-wai, Dede, Man, 文冠慧, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Utilization of nanocarriers is having a significant impact on the diagnosis and treatment of cancer. It allows targeted administration to specific sites and sustained drug delivery. Therefore, this regimen greatly increases the therapeutic index and drug concentration in tumor tissues. Among all types, biomaterials-based nanocarriers, owing to their biocompatible nature, offers a potentially safer strategy to improve the survival of cancer patients. This thesis investigated the therapeutic activity of copolymeric nanoparticulate systems encapsulated with oleanolic acid (OA). Four types of biodegradable copolymers, namely, mPEG-P(D, L)LA, mPEG-P(L)LA, mPEG-P(D, L)LGA and mPEG-P(L)LGA, were employed to fabricate OA-loaded nanoparticles (OA-NPs) by nanoprecipitation. Physicochemical characterizations were performed using dynamic light scattering (DLS), transmission electron microscope(TEM)and high performance liquid chromatography (HPLC). Cytotoxicity of the formulations was evaluated on A549 (human alveolar carcinoma), HepG2 (human liver carcinoma) and BEAS-2B (normal bronchial epithelial) cells via 3-(4, 5-dimethylthiazolyl-2)-2, 5- diphenyltetrazolium bromide (MTT) assay. The induced cell death pathway was confirmed by fluorescence-activated cellsorting (FACS) flow cytometry. The synthesized NPs were spherical, with size dimensions of 40-70nm. The particle size increased to 230-260nm after the incorporation of OA. Polydispersity indices of less than 0.3 indicated the narrow size distribution of the negatively charged NPs. OA-NPs in suspension form were stable over 7 days of storage atboth in 4Cand 25C. Significant inhibitory effect was demonstrated by the OA-NPs on A549 and HepG2 cell lines through apoptosis (p mPEG-P(L)LGA >mPEG-P(D, L)LA > mPEG-P(L)LA NPs in decreasing order. The cytotoxic effect of OA-NPs on BEAS-2B cells was less than that on the two other cancer cell lines, while blank NPs (without OA incorporated) exhibited insignificant toxicity on all cell lines. This reflectedthe cytotoxic effect was ascribed to the encapsulated OA rather than the copolymeric NPs. Overall, our studies clearly revealed the specific anti-tumor capability of the developed OA-loaded nanoparticulate systems. DOI: 10.5353/th_b5388008 Subjects: Nanoparticles Drug carriers (Pharmacy) Cancer - Treatment
Book Synopsis Advanced Drug Delivery Systems in the Management of Cancer by : Kamal Dua
Download or read book Advanced Drug Delivery Systems in the Management of Cancer written by Kamal Dua and published by Elsevier. This book was released on 2021-06-24 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems
