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Author : Robert E. Brooks
Publisher :
ISBN 13 :
Total Pages : 20 pages
Book Rating : 4.3/5 (91 download)
Download or read book Studies in the Hyaluronidase - Hyaluronic Acid System written by Robert E. Brooks and published by . This book was released on 1949 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert Stern
Publisher : Academic Press
ISBN 13 : 0080921086
Total Pages : 467 pages
Book Rating : 4.0/5 (89 download)
Download or read book Hyaluronan in Cancer Biology written by Robert Stern and published by Academic Press. This book was released on 2009-03-07 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal. The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer. - Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer - Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination - Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance
Author : Nikolaos Labrou
Publisher : Springer Nature
ISBN 13 : 981137709X
Total Pages : 388 pages
Book Rating : 4.8/5 (113 download)
Download or read book Therapeutic Enzymes: Function and Clinical Implications written by Nikolaos Labrou and published by Springer Nature. This book was released on 2019-09-03 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This volume aims to overview these therapeutic enzymes, focusing in particular on more recently approved enzymes produced by recombinant DNA technology. This volume is composed of four sections. Section 1 provides an overview of the production process and biochemical characterization of therapeutic enzymes, while Section 2 focuses upon the engineering strategies and delivery methods of therapeutic enzymes. Section 3 highlights the clinical applications of approved therapeutic enzymes, including aspects on their structure, indications and mechanisms of action. Together with information on these mechanisms, safety and immunogenicity issues and various adverse events of the recombinant enzymes used for therapy are discussed. Section 4, provides discussion on the prospective and future developments of new therapeutic enzymes. This book is aimed at academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.
Author : Maria Claudia Almeida Issa
Publisher : Springer
ISBN 13 : 9783319168012
Total Pages : 0 pages
Book Rating : 4.1/5 (68 download)
Download or read book Botulinum Toxins, Fillers and Related Substances written by Maria Claudia Almeida Issa and published by Springer. This book was released on 2018-10-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series “Clinical Approach and Procedures in Cosmetic Dermatology” intends to be a practical guide in Cosmetic Dermatology. Procedures in cosmetic dermatology are very popular and useful in medicine, indicated to complement topical and oral treatments not only for photodamaged skin but also for other dermatosis such as acne, rosacea, scars, etc. Also, full-face treatments using peelings, lasers, fillers and toxins are increasingly being used, successfully substituting or postponing the need for plastic surgeries. Altogether, these techniques not only provide immediate results but also help patients to sustain long-term benefits, both preventing/treating dermatological diseases and maintaining a healthy and youthful skin. Throughout this series, different treatments in Cosmetic Dermatology will be discussed in detail covering the use of many pharmacological groups of cosmeceuticals, the new advances in nutraceuticals and emerging technologies and procedures. This volume, entitled “Botulin Toxin, Fillers and Related Substances” addresses the most important chemical approaches in cosmetic dermatology. Here are discussed in detail the use of Botulinum toxins and fillers, such as hyaluronic and polilatic acids.
Author : David Evered
Publisher : John Wiley & Sons
ISBN 13 : 0470513780
Total Pages : 308 pages
Book Rating : 4.4/5 (75 download)
Download or read book The Biology of Hyaluronan written by David Evered and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents state-of-the-art applications in hyaluronan research, from hyaluronan's physicochemical properties to its clinical role as a connective tissue marker and its surgical implications, particularly in ear, eye and orthopaedic surgery. Covers hyaluronan's synthesis and catabolism, its role in cells, its interactions with specific binding proteins, and its role in the embryonic nervous system.
Author :
Publisher : Academic Press
ISBN 13 : 9780128126387
Total Pages : 0 pages
Book Rating : 4.1/5 (263 download)
Download or read book Peptidomics of Cancer-Derived Enzyme Products written by and published by Academic Press. This book was released on 2017-10-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptidomics of Cancer-Derived Enzyme Products, Volume 42, the latest in The Enzymes series, is ideal for researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, with this volume featuring high-caliber, thematic articles on the topic of peptidomics of cancer-derived enzyme products. Specific chapters cover Circulating peptidome and tumor-resident proteolysis, Colon tumor secretopeptidome, Chemoenzymatic method for glycomics, Human plasma peptidome for pancreatic cancer, Lipoproteomics and quantitative proteomics, Salivaomics: Protein markers/extracellular RNA/DNA in saliva, and Enzyme-responsive vectors for cancer therapy.
Author : Kyle K. Seo
Publisher : Springer Nature
ISBN 13 : 981336212X
Total Pages : 283 pages
Book Rating : 4.8/5 (133 download)
Download or read book Facial Volumization with Fillers written by Kyle K. Seo and published by Springer Nature. This book was released on 2021-05-18 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to the use of injectable fillers for facial volumization. Traditionally, fillers have been used for anti-aging purposes such as for wrinkle treatments, but they are increasingly being applied in various ways to achieve beautification such as the augmentation of the nose, chin and lips, leveraging the volumizing effect of fillers. This trend is especially evident in Asian countries but can be expected to flourish elsewhere in the future. The book opens by explaining the specifics of pretreatment assessment and relevant aspects of the basic science of fillers. It then provides a detailed description of the anatomy, injection depth and injection amount relevant to each regional indication, easy to follow for even a novice injector, based on a rich assortment of anatomical illustrations, ultrasound imaging and cadaveric photos provided to assist their understanding. And guidance is also provided on combination treatments in conjunction with botulinum toxin, thread lifting, fat-dissolving injection, etc. Potential complications and countermeasures specific to volumization with fillers are identified. The book features a wealth of illustrations showing the relevant anatomy and before and after appearances, as well as video clips for each indication. Written by a specialist with extensive experience, it provides safe and effective guidance for both beginners and advanced practitioners.
Author : Giuseppe Bergamini
Publisher : Springer
ISBN 13 : 3319201433
Total Pages : 103 pages
Book Rating : 4.3/5 (192 download)
Download or read book Injection Laryngoplasty written by Giuseppe Bergamini and published by Springer. This book was released on 2015-10-20 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-illustrated book provides step-by-step guidance on the various techniques – microlaryngoscopic, fiberoptic endoscopic and transcutaneous – that can be employed for the purpose of injection laryngoplasty, a surgical procedure in which a foreign material is injected into the vocal fold. The anatomy and function of the region are first explained, with identification of the causes and means of evaluation of glottic and neoglottic insufficiency. Advice is then provided on the choice of material for injection laryngoplasty, including absorbable and long-lasting options, on the basis of careful analysis that takes into account both the recent literature and the authors’ own experiences. Detailed descriptions of the surgical indications and different procedures follow and for ease of reference, clear flow charts on diagnosis and indications are also included. The book concludes with chapters on the use of injection laryngoplasty specifically in the pediatric population and on postoperative care and speech therapy following the procedure. Injection Laryngoplasty will provide valuable assistance to all surgeons wishing to perform this kind of surgery.
Author : Hari G. Garg
Publisher : Elsevier
ISBN 13 : 0080472222
Total Pages : 625 pages
Book Rating : 4.0/5 (84 download)
Download or read book Chemistry and Biology of Hyaluronan written by Hari G. Garg and published by Elsevier. This book was released on 2004-07-14 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was probably the French chemist Portes, who first reported in 1880 that the mucin in the vitreous body, which he named hyalomucine, behaved differently from other mucoids in cornea and cartilage. Fifty four years later Karl Meyer isolated a new polysaccharide from the vitreous, which he named hyaluronic acid. Today its official name is hyaluronan, and modern-day research on this polysaccharide continues to grow. Expertly written by leading scientists in the field, this book provides readers with a broad, yet detailed review of the chemistry of hyaluronan, and the role it plays in human biology and pathology. Twenty-seven chapters present a sequence leading from the chemistry and biochemistry of hyaluronan, followed by its role in various pathological conditions, to modified hylauronans as potential therapeutic agents and finally to the functional, structural and biological properties of hyaluronidases. Chemistry and Biology of Hyaluronan covers the many interesting facets of this fascinating molecule, and all chapters are intended to reach the wider research community. - Comprehensive look at the chemistry and biology of hyaluronans - Essential to Chemists, Biochemists and Medical researchers - Broad yet detailed review of this rapidly growing research area
Author : Terry Swanson
Publisher : IP Communications
ISBN 13 : 0987290533
Total Pages : 593 pages
Book Rating : 4.9/5 (872 download)
Download or read book Wound Management for the Advanced Practitioner written by Terry Swanson and published by IP Communications. This book was released on 2014-10-21 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasingly, wound management is recognised as a specialised area of practice. Advances in wound-care products, surgical interventions, and social-support options create an often bewildering array of knowledge for healthcare practitioners. This textbook opens with a focus on the core elements of effective wound management: an understanding of how wounds heal and what inhibits wound healing, rigorous assessment, use of outcome measures, evidence-based approaches to practice, and an understanding of how clinical research is done. Key aspects of wound-bed preparation and management - diagnostic investigations, assessment and management of non-viable tissue, infected wounds, dressings and technology, pharmacological therapy, and acute wounds – are then elucidated. Optimal management of commonly-encountered wounds (venous leg ulceration, arterial and mixed arterial-venous ulceration, inflammatory ulcers, pressure injury, and the high-risk foot) and unusual wounds is described. The path to professionalisation of wound management in Australia is charted. The book ends with a list of wound care products (types, properties, uses, distributor-contact details). The editors of and specialist contributors to this text have aimed to build on the foundations provided by the numerous basic, introductory-level textbooks in the field to provide an authoritative, comprehensive, and up-to-date textbook for wound managers who wish to further develop their knowledge and skills.
Author : Alexander Dityatev
Publisher :
ISBN 13 : 9780444635488
Total Pages : 0 pages
Book Rating : 4.6/5 (354 download)
Download or read book Brain Extracellular Matrix in Health and Disease written by Alexander Dityatev and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Benjamin Gantenbein
Publisher : Mdpi AG
ISBN 13 : 9783036527543
Total Pages : 138 pages
Book Rating : 4.5/5 (275 download)
Download or read book Intervertebral Disc Regeneration written by Benjamin Gantenbein and published by Mdpi AG. This book was released on 2022-01-11 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a brief snapshot of recent research on the subject of intervertebral disc degeneration and how this specific organ could be regenerated. It provides stimuli to the reader in representing research from different angles in this cross-disciplinary field of spine surgeons, mechanical engineers and biologists. In particular, it is instructive as to how disc herniations could be successfully induced in vitro and, also, to how novel cell-based therapies using rare autochthonous stem cells could potentially be used in the future.
Author : Challa S. S. R. Kumar
Publisher : Wiley-VCH
ISBN 13 :
Total Pages : 448 pages
Book Rating : 4.3/5 (91 download)
Download or read book Nanomaterials for Cancer Therapy written by Challa S. S. R. Kumar and published by Wiley-VCH. This book was released on 2006-07-24 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first comprehensive overview on nanotechnological approaches to cancer therapy brings together therapeutic oncology and nanotechnology, showing the various strategic approaches to selectively eliminating cancerous cells without damaging the surrounding healthy tissue. The strategies covered include magnetic, optical, microwave and neutron absorption techniques, nanocapsules for active agents, nanoparticles as active agents, and active and passive targeting, while also dealing with fundamental aspects of how nanoparticles cross biological barriers. A valuable single source gathering the many articles published in specialized journals often difficult to locate for members of the other disciplines involved.
Author : Alice L. Mathis
Publisher :
ISBN 13 :
Total Pages : 20 pages
Book Rating : 4.3/5 (91 download)
Download or read book Studies in the Hyaluronidase - Hyaluronic Acid System written by Alice L. Mathis and published by . This book was released on 1949 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Renato V. Iozzo
Publisher : Springer Science & Business Media
ISBN 13 : 1592592090
Total Pages : 547 pages
Book Rating : 4.5/5 (925 download)
Download or read book Proteoglycan Protocols written by Renato V. Iozzo and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteoglycans are some of the most elaborate macromolecules of mammalian and lower organisms. The covalent attachment of at least five types of glycosami- glycan side chains to more than forty individual protein cores makes these molecules quite complex and endows them with a multitude of biological functions. Proteoglycan Protocols offers a comprehensive and up-to-date collection of prepa- tive and analytical methods for the in-depth analysis of proteoglycans. Featuring st- by-step detailed protocols, this book will enable both novice and experienced researchers to isolate intact proteoglycans from tissues and cultured cells, to establish the composition of their carbohydrate moieties, to generate strategies for prokaryotic and eukaryotic expression, to utilize methods for the suppression of specific proteoglycan gene expression and for the detection of mutant cells and degradation products, and to study specific interactions between proteoglycans and extracellular matrix proteins as well as growth factors and their receptors. The readers will find concise, yet comprehensive techniques carefully drafted by leading experts in the field. Each chapter commences with a general Introduction, followed by a detailed Materials section, and an easy-to-follow Methods section. An asset of each chapter is the extensive notation that includes troubleshooting tips and practical considerations that are often lacking in formal methodology papers. The reader will find this section most valuable because it is clearly provided by experienced scientists who have first-hand knowledge of the techniques they outline. In addition, most of the chapters are well illustrated with examples of typical data generated with each method.
Author : Prashant Kesharwani
Publisher : Academic Press
ISBN 13 : 0128122498
Total Pages : 480 pages
Book Rating : 4.1/5 (281 download)
Download or read book Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors written by Prashant Kesharwani and published by Academic Press. This book was released on 2018-04-20 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies. - Addresses the progress and challenges inherent in delivering drugs across the blood brain barrier and offers strategies to maximize effectiveness - Draws upon the experience and expertise of international scientists working in the fields of drug delivery and nanomedicine - Considers the future possibilities of nanotechnology for delivering nanocarriers that better diagnose and treat brain tumors
Author : Luc Téot
Publisher : Springer
ISBN 13 : 3709112419
Total Pages : 278 pages
Book Rating : 4.7/5 (91 download)
Download or read book Skin Necrosis written by Luc Téot and published by Springer. This book was released on 2015-03-16 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, wound care has gained increasing recognition as a distinct medical specialty. An understanding of the complex mechanisms involved in wound healing facilitates efficient assessment and treatment of patients with wounds, and skin necrosis can be considered the starting point in the entire healing process. This book is the first to discuss skin necrosis as a symptom related to a broad range of pathologies. Richly illustrated, it primarily provides therapeutic strategies and treatment algorithms for different clinical contexts. All chapters were written by renowned specialists in their respected fields and include detailed sample cases and essential take-home messages. In light of the highly interdisciplinary nature of wound management, Skin Necrosis offers an invaluable resource for wound care practitioners and health care professionals across the fields of surgery, dermatology, internal medicine, and nursing.
