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Structure Function Analysis Of The Eukaryotic Transcription Elongation Factor Tfiis
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Book Synopsis Structure/function Analysis of the Eukaryotic Transcription Elongation Factor, TFIIS by : Nell Belinda Shimasaki
Download or read book Structure/function Analysis of the Eukaryotic Transcription Elongation Factor, TFIIS written by Nell Belinda Shimasaki and published by . This book was released on 1999 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Structure and Function of Transcription Elongation Factor TFIIS and Methanobacterium Thermoautotrophicum Protein 1615 by : Valerie Booth
Download or read book Structure and Function of Transcription Elongation Factor TFIIS and Methanobacterium Thermoautotrophicum Protein 1615 written by Valerie Booth and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: TFIIS is a general transcription elongation factor that helps arrested RNA polymerase II elongation complexes to resume transcription, through a mechanism that involves stimulating cleavage of the nascent RNA transcript. Previously, it was shown that yeast TFIIS is comprised of three structural domains I, II and III and the NMR solution structure of domain II was solved. I determined the structure of domain III and used it, with the structure of domain II, to interpret the results of an alanine scanning mutagenesis study. These studies identified several structural features responsible for different aspects of TFIIS function, including a basic patch of domain II, which is responsible for binding polymerase, and three surface aromatic residues, which appear to be positioned to bind nucleic acids via base stacking interactions. The structure-function studies indicated that the linker region between domains II and III might have an important role in constraining the spatial relationship between the domains. Therefore, NMR dynamics studies of TFIIS and an inactive mutant were undertaken to characterize their motional features. These indicated that the linker acts as a semi-rigid spacer between the two domains and the mutant exhibits a marked decrease in the correlation between the motion of the two domains. Small-angle X-ray scattering data was used to determine the distance between domains II, and III and suggested that a portion of the linker likely forms a compact structure, which may act like a spring in the interaction with the polymerase complex. This interaction was modeled using the recently determined structure of yeast polymerase. TFIIS domain I, as well as the homologous domains of elongin A and CRSP70, appear to have a more general role in transcription than the stimulation of elongation. In order to probe their function, I determined the NMR solution structure of this domain and used it to model the structures of the homologous proteins. This led to the identification of a conserved, basic patch on the surface of the domain I which is a likely location for an interaction common to all three proteins. The final target of my thesis was the structure of 'Methanobactetium thermoautotophicum' (MT) protein 1615. This protein was originally purified as part of a structural genomics project and was chosen as a target for structure determination due to its homology to the human protein, TFAR19, which is involved in apoptosis. The solution structure revealed a novel fold and the surface properties indicated MT1615 might be able to bind DNA, a hypothesis which was confirmed by gel electrophoretic mobility shift assay. The protein also contains a putative protein binding helix which suggests that MT1615 and TFAR19 could be transcription factors.
Book Synopsis Eukaryotic Transcription Factors by : David S. Latchman
Download or read book Eukaryotic Transcription Factors written by David S. Latchman and published by Academic Press. This book was released on 2003-11-21 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors.This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality. Major families of eukaryotic transcription factors described Mechanisms of gene activation and repression analysed Structure-function relationships indicated Interaction between transcription factors and chromatin structure described Roles in inducible and cell type-specific gene expression Roles in development, differentiation and human diseases including cancer Methods of study in vitro and in vivo
Book Synopsis Structure/function Analysis of the Eukaryotic Transcription Factor SPT5 by : Christine Emigh-Hutton
Download or read book Structure/function Analysis of the Eukaryotic Transcription Factor SPT5 written by Christine Emigh-Hutton and published by . This book was released on 2006 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biochemical and Genetic Characterization of the Transcription Elongation Factor TFIIS from the Yeast Saccharomyces Cerevisiae by : Karen Renee Christie
Download or read book Biochemical and Genetic Characterization of the Transcription Elongation Factor TFIIS from the Yeast Saccharomyces Cerevisiae written by Karen Renee Christie and published by . This book was released on 1995 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulation of the process of transcriptional elongation is an important control mechanism in the expression of some genes. To fully understand this form of regulation will require better understanding of the functions of transcription elongation factors. The goal of this work was to characterize the transcription elongation factor TFIIS from Saccharomyces cerevisiae, originally called P37. I demonstrated that, like the mammalian TFIIS proteins, the yeast protein stimulates RNA polymerase II to cleave the nascent RNA transcript and to read-through an intrinsic block to elongation. Investigation of the protein-protein contacts between TFIIS and RNA polymerase II indicated that the carboxyl-terminal domain of the largest subunit, subunit four, and subunit seven of the polymerase are not required for TFIIS to promote cleavage and read-through by the polymerase. In addition the carboxyl-terminal half of the yeast TFIIS protein is sufficient for both of these in vitro activities. This result is consistent with the previous results demonstrating the carboxyl-terminus of mouse TFIIS was sufficient to activate RNA polymerase in vitro.
Book Synopsis Structure and Function of Transcription Elongation Factor TFIIS and Methanobacterium Thermoautotrophicum Protein 1615 by :
Download or read book Structure and Function of Transcription Elongation Factor TFIIS and Methanobacterium Thermoautotrophicum Protein 1615 written by and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Structural and Functional Studies on Human Transcriptional Elongation Factor TFIIS by : Choonju Jeon
Download or read book Structural and Functional Studies on Human Transcriptional Elongation Factor TFIIS written by Choonju Jeon and published by . This book was released on 1993 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Valerie Booth Publisher :National Library of Canada = Bibliothèque nationale du Canada ISBN 13 :9780612537842 Total Pages :318 pages Book Rating :4.5/5 (378 download)
Book Synopsis Structure and Function of Transcription Elongation Factor TFIIS and Methanobacterium Thermoautotrophicum Protein 1615 [microform] by : Valerie Booth
Download or read book Structure and Function of Transcription Elongation Factor TFIIS and Methanobacterium Thermoautotrophicum Protein 1615 [microform] written by Valerie Booth and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 2000 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transcription Factors in Eukaryotes by : Athanasios Papavassiliou
Download or read book Transcription Factors in Eukaryotes written by Athanasios Papavassiliou and published by International Thomson Publishing Services. This book was released on 1997 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genetic and Genomic Analyses of the Saccharomyces Cerevisiae Transcript Elongation Factor, TFIIS by : Caren Jody Stark
Download or read book Genetic and Genomic Analyses of the Saccharomyces Cerevisiae Transcript Elongation Factor, TFIIS written by Caren Jody Stark and published by . This book was released on 2003 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biochemical and Genetic Investigations of Transcript Initiation and Elongation in Saccharomyces Cerevisiae by : Rachel Naomi Fish
Download or read book Biochemical and Genetic Investigations of Transcript Initiation and Elongation in Saccharomyces Cerevisiae written by Rachel Naomi Fish and published by . This book was released on 2002 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Macromolecular Protein Complexes II: Structure and Function by : J. Robin Harris
Download or read book Macromolecular Protein Complexes II: Structure and Function written by J. Robin Harris and published by Springer Nature. This book was released on 2020-01-14 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book follows on from Volume 83 in the SCBI series (“Macromolecular Protein Complexes”), and addresses several important topics (such as the Proteasome, Anaphase Promoting Complex, Ribosome and Apoptosome) that were not previously included, together with a number of additional exciting topics in this rapidly expanding field of study. Although the first SCBI Protein Complex book focused on soluble protein complexes, the second (Vol. 87)addressed Membrane Complexes, and the third (Vol. 88) put the spotlight on Viral Protein and Nucleoprotein Complexes, a number of membrane, virus and even fibrillar protein complexes have been be considered for inclusion in the present book. A further book is also under preparation that follows the same pattern, in an attempt to provide a thorough coverage of the subject. Chapter 9 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Book Synopsis Mechanisms Of Gene Expression: Structure, Function And Evolution Of The Basal Transcriptional Machine by : Robert O J Weinzierl
Download or read book Mechanisms Of Gene Expression: Structure, Function And Evolution Of The Basal Transcriptional Machine written by Robert O J Weinzierl and published by World Scientific. This book was released on 1999-08-10 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: A detailed knowledge of the mechanisms underlying the transcriptional control of gene expression is of fundamental importance to many areas of contemporary biomedical research, ranging from understanding basic issues (such as control of embryonic development) to practical applications in industry and medicine. Although elementary concepts of gene expression are described in all general molecular biology textbooks, the depth of coverage is often rather limited and recent discoveries are sometimes not adequately taken into consideration.This book presents much of the current thinking concerning molecular mechanisms of transcriptional control in a form easily accessible to undergraduates with an understanding of basic molecular biology concepts. It contains detailed information about the various pro- and eukaryotic transcriptional machineries that has recently become available through the combined efforts of geneticists, biochemists and structural biologists. The book will thus not only serve as an undergraduate text but also offer something new and interesting to more advanced readers and professional scientists who want to keep up to date with rapid advances in this field.
Book Synopsis Proteins in Eukaryotic Transcription by :
Download or read book Proteins in Eukaryotic Transcription written by and published by Elsevier. This book was released on 2004-03-19 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Transcription is a key element of cellular and organ regulation. Proteins in Eukaryotic Transcription covers structure and function of all major elements associated with transcription. Mechanism of RNA polymerase I Transcription Structure and function of RNA Polymerase II Structure and function of the TFIID complex Functional properties of Chromatin Remodeling Enzymes Posttranslational modification
Book Synopsis The Expression, Regulation, and Structure/function Analysis of the Transcription Factor NGFI-A by : Cali Matheny
Download or read book The Expression, Regulation, and Structure/function Analysis of the Transcription Factor NGFI-A written by Cali Matheny and published by . This book was released on 1995 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Biology of B Cells by : Tasuku Honjo
Download or read book Molecular Biology of B Cells written by Tasuku Honjo and published by Academic Press. This book was released on 2014-12-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.
Download or read book Biochemistry and Cell Biology written by and published by . This book was released on 2006 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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