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Author : Arnold Froese
Publisher : New York : M. Dekker
ISBN 13 :
Total Pages : 320 pages
Book Rating : 4.3/5 (91 download)
Download or read book Structure and Function of Fc Receptors written by Arnold Froese and published by New York : M. Dekker. This book was released on 1983 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Wolf H. Fridman
Publisher : S Karger Ag
ISBN 13 : 9783805549592
Total Pages : 0 pages
Book Rating : 4.5/5 (495 download)
Download or read book Structures and Functions of Low Affinity Fc Receptors written by Wolf H. Fridman and published by S Karger Ag. This book was released on 1989 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (225 download)
Download or read book Structures and Functions of Low Affinity Fc Receptors written by and published by . This book was released on 1989 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Latha P. Ganesan
Publisher : Frontiers Media SA
ISBN 13 : 2889638758
Total Pages : 372 pages
Book Rating : 4.8/5 (896 download)
Download or read book Roles of Fc Receptors in Disease and Therapy written by Latha P. Ganesan and published by Frontiers Media SA. This book was released on 2020-07-22 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 81 pages
Book Rating : 4.:/5 (231 download)
Download or read book Fc Receptors written by and published by . This book was released on 1994 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hans L. Spiegelberg
Publisher :
ISBN 13 :
Total Pages : 28 pages
Book Rating : 4.:/5 (31 download)
Download or read book Structure and Function of Fc Receptors for IgE on Lymphocytes, Monocytes, and Macrophages written by Hans L. Spiegelberg and published by . This book was released on 1984 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Maree S. Powell
Publisher :
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.:/5 (221 download)
Download or read book Structure and Function of Soluble Fc Receptors written by Maree S. Powell and published by . This book was released on 1996 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jan G.J. Winkel
Publisher : Springer Science & Business Media
ISBN 13 : 9401150184
Total Pages : 320 pages
Book Rating : 4.4/5 (11 download)
Download or read book The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity written by Jan G.J. Winkel and published by Springer Science & Business Media. This book was released on 2012-02-02 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibodies are crucial to the fine specificity of the immune system. An effective functioning of these molecules requires interaction with immune cells. Receptors for antibodies, Fc receptors, provide this critical link between the humoral and cellular branches of the immune system. This book presents a comprehensive overview of the different Fc receptors currently recognized. The first part of the book contains state-of-the-art overviews on the biological role of FcR. The latest information on FcR heterogeneity, FcR physiology, FcR-ligand recognition, their crucial coordinating role in immunity, interactions with other immunoreceptors, and the role of FcR in immunoglobulin transport and catabolism are discussed. The clinical importance of FcR is developed in the second part of the book. The well-recognized roles of FcR in allergy, inflammation, infectious diseases, autoimmune disorders, and immunotherapeutic importance are reviewed. The information in this book is easily accessible and should be helpful for researchers and clinical specialists as a convenient overview of the field, as well as a comprehensive introduction for students starting in this area of research.
Author : Marc Daeron
Publisher : Springer
ISBN 13 : 3319079115
Total Pages : 426 pages
Book Rating : 4.3/5 (19 download)
Download or read book Fc Receptors written by Marc Daeron and published by Springer. This book was released on 2014-08-12 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after FcμR and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcγRIIB and FcαRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.
Author : Margaret Ackerman
Publisher : Academic Press
ISBN 13 : 0123948185
Total Pages : 376 pages
Book Rating : 4.1/5 (239 download)
Download or read book Antibody Fc written by Margaret Ackerman and published by Academic Press. This book was released on 2013-08-06 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. - Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro - Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies - Color illustrations enhance explanations of the immune system
Author : Peter Sun
Publisher : Elsevier Inc. Chapters
ISBN 13 : 012806028X
Total Pages : 30 pages
Book Rating : 4.1/5 (28 download)
Download or read book Antibody Fc written by Peter Sun and published by Elsevier Inc. Chapters. This book was released on 2013-08-06 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular mechanisms of antibody-mediated Fc receptor activation have long been an interest in both Fc receptor biology and antibody therapeutics. The structural efforts to elucidate antibody recognition by Fc receptors have led to the generation of several crystal structures of antibody Fc fragments complexed with Fc receptors. Collectively, these structures revealed a conserved receptor binding mode for IgG and IgE, distinct from those for the neonatal Fc receptor (FcRn), protein A, and protein G. Fcγ receptor recognition in the lower hinge region allows enhanced antigen recognition through dimeric Fabs but obligates immune-complex formation for receptor activation. It also provides the basis for Fcγ receptors to differentiate among IgG subclasses. More recently, pentraxins have also been shown to bind and activate Fc receptors, and structural efforts to elucidate pentraxin Fcγ receptor recognition have revealed surprising similarities between pentraxins and immunoglobulins in Fc receptor recognition. This review summarizes the structural findings that formed the basis of modern antibody–Fc receptor biology and recent advances of shared Fc receptor recognition by innate pentraxins.
Author : Biochemical Society. Biochemical Immunology Group
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (823 download)
Download or read book Structure and Function of Fc Receptors written by Biochemical Society. Biochemical Immunology Group and published by . This book was released on 1988 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mark D. Hulett
Publisher :
ISBN 13 :
Total Pages : 400 pages
Book Rating : 4.:/5 (221 download)
Download or read book Fc Receptors written by Mark D. Hulett and published by . This book was released on 1993 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Roy Jefferis
Publisher : MDPI
ISBN 13 : 3039438972
Total Pages : 440 pages
Book Rating : 4.0/5 (394 download)
Download or read book Structure and Function of Antibodies written by Roy Jefferis and published by MDPI. This book was released on 2021-02-05 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a detailed description of all kinds of therapeutic antibodies including IgGs, IgAs, IgEs, and IgMs, bispecific antibodies, chimeric antigen receptor antibodies, and antibody fragments. Details about how each of these antibodies interact with their ligands, the immune system, and their targets are provided. Additionally, this book delves into the details of antibody, Fc, and variable chain structures, and how subtle changes in structure, charge, flexibility, post-translational modification, and the ability to bind to natural antibody ligands can result in a significant impact on antibody activity and functionality. Finally, the book explains the critical quality attributes of modern therapeutic antibodies and how to ensure that antibodies entering development have the best possible chance of success.
Author : Tak W. Mak
Publisher : Academic Press
ISBN 13 : 0080534481
Total Pages : 1217 pages
Book Rating : 4.0/5 (85 download)
Download or read book The Immune Response written by Tak W. Mak and published by Academic Press. This book was released on 2005-11-11 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences. - Current and thorough 30 chapter reference reviewed by luminaries in the field - Unique 'single voice' ensures consistency of definitions and concepts - Comprehensive and elegant illustrations bring key concepts to life - Provides historical context to allow fuller understanding of key issues - Introductory chapters 1-4 serve as an 'Immunology Primer' before topics are discussed in more detail
Author : A.G. Lee
Publisher : Elsevier
ISBN 13 : 0080540341
Total Pages : 337 pages
Book Rating : 4.0/5 (85 download)
Download or read book Receptors of Cell Adhesion and Cellular Recognition written by A.G. Lee and published by Elsevier. This book was released on 1996-06-25 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 3 of Biomembranes covers receptors of cell adhesion and cellular recognition. Proteins in the plasma membrane of cells are heavily involved in processes of cell adhesion, but such proteins were not actually isolated and characterized until the mid-1970s. Since then, application of the methods of molecular biology has led to the recognition of four major classes of cell adhesion molecule (CAMs), the immunoglobulin super family, the cadherins, the integrins, and the selecting. A convenient system in which to study the importance of cell adhesion is in blood platelets where aggregation eventually leads to thrombus formation in a process involving a range of surface glycoproteins. Interaction with the extracellular matrix is exemplified by CD44, the receptor for hyaluronan, and a complex carbohydrate that is a major component of the extracellular matrix surrounding migrating and proliferating cells. Membrane-associated mucins have a variety of effects on cell adhesion. The super family of immunoglobulin related proteins also include the T cell receptors and the major histocompatibility complex (MHC), which, together with the receptors for immunoglobulins (the Fc receptors), are of fundamental importance in the processes of immunity. Volume 3 of Biomembranes explores the structures and functions of the molecules involved in these important functions of the cell.
Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
