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Stratified Informatics Analysis For Breast Cancer
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Book Synopsis Stratified Informatics Analysis for Breast Cancer by : Robert Lesurf
Download or read book Stratified Informatics Analysis for Breast Cancer written by Robert Lesurf and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Over the past decade, genomic technologies have promised to revolutionize breast cancer research with better predictions of disease progression and patient prognosis through the identification of novel molecular targets. These technologies have led to the discovery of numerous different genomic subtyping schemes, each purported to offer relevant information beyond traditional clinical features. Yet it remains unclear what these schemes have contributed to our understanding of breast cancer biology and the reasons for disease recurrence. To address this issue, we have built a novel framework termed Breast Signature Analysis Tool (BreSAT), along with a companion collection of breast cancer datasets, highly annotated signatures, statistics, and visualizations, designed for accurate and ease-of-use application in breast cancer. This framework represents a new way of cataloguing tumors according to their biological properties, as opposed to broad gene expression profiles. We have applied BreSAT and its associated catalogue of signatures to thousands of breast tumor samples, and identify that tumor properties associated with recurrence are confounded by association with other clinicopathological variables such as estrogen receptor status and the genomic subtype. In addition to identifying properties associated with recurrence in breast cancer, we have sought to discover the molecular markers that drive different tumor phenotypes. We identified that expression of the oncogene MET in mouse mammary glands leads to the generation of tumors with characteristics of human triple-negative breast cancer. Additionally, synergy between MET and loss of p53 in similar mouse model leads the development of tumors a claudin-low phenotype, that arise with a higher penetrance and lower latency. Moreover, MET activity is required for maintenance of the claudin-low morphological phenotype and metastatic capacity of cell lines, suggesting that MET may represent an avenue for targeted therapeutics in human patients with claudin-low breast tumors. Finally, we have discovered that molecular features of breast cancer progression from a non-invasive to an invasive state are confounded by tumor subtype. To find more accurate markers of disease progression, we identified tumor properties that differentiate non-invasive tumors from invasive ones within each subtype. We observed that there is little overlap, suggesting that distinct properties drive tumor progression in different subtypes. Furthermore, we were able to identify a small number of non-invasive breast tumors with molecular features that make them more likely to progress. Together, these discoveries are leading to a more comprehensive understanding of the molecular features that drive breast cancer biology, disease progression, and patient outcome." --
Book Synopsis Clinical Bioinformatics by : Ronald Trent
Download or read book Clinical Bioinformatics written by Ronald Trent and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Clinical Bioinformatics, Second Edition, leading experts in the field provide a series of articles focusing on software applications used to translate information into outcomes of clinical relevance. Recent developments in omics, such as increasingly sophisticated analytic platforms allowing changes in diagnostic strategies from the traditional focus on single or small number of analytes to what might be possible when large numbers or all analytes are measured, are now impacting patient care. Covering such topics as gene discovery, gene function (microarrays), DNA sequencing, online approaches and resources, and informatics in clinical practice, this volume concisely yet thoroughly explores this cutting-edge subject. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Clinical Bioinformatics, Second Edition serves as an ideal guide for scientists and health professionals working in genetics and genomics.
Book Synopsis Breast Cancer in Young Women by : Oreste Gentilini
Download or read book Breast Cancer in Young Women written by Oreste Gentilini and published by Springer Nature. This book was released on 2020-02-07 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed book covers all aspects concerning the clinical scenario of breast cancer in young women, providing physicians with the latest information on the topic. Young women are a special subset of patients whose care requires dedicated expertise. The book, written and edited by internationally recognized experts who have been directly involved in the international consensus guidelines for breast cancer in young women, pays particular attention to how the disease and its planned treatment can be effectively communicated to young patients. Highly informative and carefully structured, it provides both theoretical and practice-oriented insight for practitioners and professionals involved in the different phases of treatment, from diagnosis to intervention, to follow-up – without neglecting the important role played by prevention.
Book Synopsis National Cancer Control Programmes by : World Health Organization
Download or read book National Cancer Control Programmes written by World Health Organization and published by . This book was released on 1995 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae? by : Kulmira Nurgali
Download or read book Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae? written by Kulmira Nurgali and published by Frontiers Media SA. This book was released on 2018-06-12 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in anti-cancer chemotherapy over recent years have led to improved efficacy in curing or controlling many cancers. Some chemotherapy-related side-effects are well recognized and include: nausea, vomiting, bone marrow suppression, peripheral neuropathy, cardiac and skeletal muscle dysfunction and renal impairment. However, it is becoming clearer that some chemotherapy-related adverse effects may persist even in long term cancer survivors. Problems such as cognitive, cardiovascular and gastrointestinal dysfunction, and neuropathy may lead to substantial long term morbidity. Despite improvements in treatments to counteract acute chemotherapy-induced adverse effects, they are often incompletely effective. Furthermore, counter-measures for some acute side-effects and many potential longer term sequelae of anti-cancer chemotherapy have not been developed. Thus, new insights into prevalence and mechanisms of cancer chemotherapy-related side effects are needed and new approaches to improving tolerance and reduce sequelae of cancer chemotherapy are urgently needed. The present Research Topic focuses on adverse effects and sequelae of chemotherapy and strategies to counteract them.
Book Synopsis WHO List of Priority Medical Devices for Cancer Management by : World Health Organization
Download or read book WHO List of Priority Medical Devices for Cancer Management written by World Health Organization and published by . This book was released on 2017-05-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the model list and clearing house of appropriate, basic, and priority medical devices based on the list of clinical interventions selected from clinical guidelines on prevention, screening, diagnosis, treatment, palliative care, monitoring, and end of life care. This publication addresses medical devices that can be used for the management of cancer and specifically describes medical devices for six types of cancer: breast, cervical, colorectal, leukemia, lung, and prostate. This book is intended for ministries of health, public health planners, health technology managers, disease management, researchers, policy makers, funding, and procurement agencies and support and advocacy groups for cancer patients.
Book Synopsis Applied Bioinformatics by : Paul Maria Selzer
Download or read book Applied Bioinformatics written by Paul Maria Selzer and published by Springer Science & Business Media. This book was released on 2008-01-18 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: At last, here is a baseline book for anyone who is confused by cryptic computer programs, algorithms and formulae, but wants to learn about applied bioinformatics. Now, anyone who can operate a PC, standard software and the internet can also learn to understand the biological basis of bioinformatics, of the existence as well as the source and availability of bioinformatics software, and how to apply these tools and interpret results with confidence. This process is aided by chapters that introduce important aspects of bioinformatics, detailed bioinformatics exercises (including solutions), and to cap it all, a glossary of definitions and terminology relating to bioinformatics.
Book Synopsis Statistics and Informatics in Molecular Cancer Research by : Carsten Wiuf
Download or read book Statistics and Informatics in Molecular Cancer Research written by Carsten Wiuf and published by OUP Oxford. This book was released on 2009-06-18 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular understanding of cancer and cancer progression is at the forefront of many research programs today. High-throughput array technologies and other modern molecular techniques produce a wealth of molecular data about the structure, and function of cells, tissues, and organisms. Correctly analyzed and interpreted these data hold the promise of bringing new markers for prognostic and diagnostic use, for new treatment schemes, and of gaining new biological insight into the evolution of cancer and its molecular, pathological, and clinical consequences. Aimed at graduates and researchers, this book discusses novel advances in informatics and statistics in molecular cancer research. Through eight chapters from carefully chosen experts it brings the reader up to date with specific topics in cancer research, how the topics give rise to development of new informatics and statistics tools, and how the tools can be applied. The focus of the book is to give the reader an understanding of key concepts and tools, rather than focusing on technical issues. A main theme is the extensive use of array technologies in modern cancer research - gene expression and exon arrays, SNP and copy number arrays, and methylation arrays - to derive quantitative and qualitative statements about cancer, its progression and aetiology, and to understand how these technologies on one hand allow us learn about cancer tissue as a complex system and on the other hand allow us to pinpoint key genes and events as crucial for the development of the disease.
Book Synopsis HER2-Positive Breast Cancer by : Sara Hurvitz
Download or read book HER2-Positive Breast Cancer written by Sara Hurvitz and published by Elsevier Health Sciences. This book was released on 2018-07-26 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of clinically-focused topics and guidelines that are relevant to testing for HER2, which contributes to approximately 25% of breast cancers today. This concise resource by Drs. Sara Hurvitz, and Kelly McCann consolidates today’s available information on this growing topic into one convenient resource, making it an ideal, easy-to-digest reference for practicing and trainee oncologists.
Book Synopsis Cancer Control Opportunities in Low- and Middle-Income Countries by : Institute of Medicine
Download or read book Cancer Control Opportunities in Low- and Middle-Income Countries written by Institute of Medicine and published by National Academies Press. This book was released on 2007-01-26 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is low or absent on the health agendas of low- and middle-income countries (LMCs) despite the fact that more people die from cancer in these countries than from AIDS and malaria combined. International health organizations, bilateral aid agencies, and major foundations—which are instrumental in setting health priorities—also have largely ignored cancer in these countries. This book identifies feasible, affordable steps for LMCs and their international partners to begin to reduce the cancer burden for current and future generations. Stemming the growth of cigarette smoking tops the list to prevent cancer and all the other major chronic diseases. Other priorities include infant vaccination against the hepatitis B virus to prevent liver cancers and vaccination to prevent cervical cancer. Developing and increasing capacity for cancer screening and treatment of highly curable cancers (including most childhood malignancies) can be accomplished using "resource-level appropriateness" as a guide. And there are ways to make inexpensive oral morphine available to ease the pain of the many who will still die from cancer.
Book Synopsis Adjuvant Therapy for Breast Cancer by : Monica Castiglione
Download or read book Adjuvant Therapy for Breast Cancer written by Monica Castiglione and published by Springer Science & Business Media. This book was released on 2009-07-11 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.
Book Synopsis Medical Image Analysis and Informatics by : Paulo Mazzoncini de Azevedo-Marques
Download or read book Medical Image Analysis and Informatics written by Paulo Mazzoncini de Azevedo-Marques and published by CRC Press. This book was released on 2017-11-23 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the development of rapidly increasing medical imaging modalities and their applications, the need for computers and computing in image generation, processing, visualization, archival, transmission, modeling, and analysis has grown substantially. Computers are being integrated into almost every medical imaging system. Medical Image Analysis and Informatics demonstrates how quantitative analysis becomes possible by the application of computational procedures to medical images. Furthermore, it shows how quantitative and objective analysis facilitated by medical image informatics, CBIR, and CAD could lead to improved diagnosis by physicians. Whereas CAD has become a part of the clinical workflow in the detection of breast cancer with mammograms, it is not yet established in other applications. CBIR is an alternative and complementary approach for image retrieval based on measures derived from images, which could also facilitate CAD. This book shows how digital image processing techniques can assist in quantitative analysis of medical images, how pattern recognition and classification techniques can facilitate CAD, and how CAD systems can assist in achieving efficient diagnosis, in designing optimal treatment protocols, in analyzing the effects of or response to treatment, and in clinical management of various conditions. The book affirms that medical imaging, medical image analysis, medical image informatics, CBIR, and CAD are proven as well as essential techniques for health care.
Author :Management Association, Information Resources Publisher :IGI Global ISBN 13 :166847137X Total Pages :891 pages Book Rating :4.6/5 (684 download)
Book Synopsis Research Anthology on Medical Informatics in Breast and Cervical Cancer by : Management Association, Information Resources
Download or read book Research Anthology on Medical Informatics in Breast and Cervical Cancer written by Management Association, Information Resources and published by IGI Global. This book was released on 2022-07-01 with total page 891 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer research is currently a vital field of study as it affects a wide range of the population either directly or indirectly. Breast and cervical cancer are two prevalent types that pose a threat to women’s health and wellness. Due to this, further research on the importance of medical informatics within this field is necessary to ensure patients receive the best possible attention and care. The Research Anthology on Medical Informatics in Breast and Cervical Cancer provides current research and information on how medical informatics are utilized within the field of breast and cervical cancer and considers the best practices and challenges of its implementation. Covering key topics such as women’s health, wellness, oncology, and patient care, this major reference work is ideal for medical professionals, nurses, oncologists, policymakers, researchers, academicians, scholars, practitioners, instructors, and students.
Book Synopsis NMR-based Metabolomics by : Hector C Keun
Download or read book NMR-based Metabolomics written by Hector C Keun and published by Royal Society of Chemistry. This book was released on 2018-01-17 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the state of the art in the application of NMR spectroscopy to metabolomics and will be a key title for researchers and practitioners.
Book Synopsis Big Data Analysis and Artificial Intelligence for Medical Sciences by : Paola Lecca
Download or read book Big Data Analysis and Artificial Intelligence for Medical Sciences written by Paola Lecca and published by John Wiley & Sons. This book was released on 2024-07-29 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Big Data Analysis and Artificial Intelligence for Medical Sciences Overview of the current state of the art on the use of artificial intelligence in medicine and biology Big Data Analysis and Artificial Intelligence for Medical Sciences demonstrates the efforts made in the fields of Computational Biology and medical sciences to design and implement robust, accurate, and efficient computer algorithms for modeling the behavior of complex biological systems much faster than using traditional modeling approaches based solely on theory. With chapters written by international experts in the field of medical and biological research, Big Data Analysis and Artificial Intelligence for Medical Sciences includes information on: Studies conducted by the authors which are the result of years of interdisciplinary collaborations with clinicians, computer scientists, mathematicians, and engineers Differences between traditional computational approaches to data processing (those of mathematical biology) versus the experiment-data-theory-model-validation cycle Existing approaches to the use of big data in the healthcare industry, such as through IBM’s Watson Oncology, Microsoft’s Hanover, and Google’s DeepMind Difficulties in the field that have arisen as a result of technological changes, and potential future directions these changes may take A timely and up-to-date resource on the integration of artificial intelligence in medicine and biology, Big Data Analysis and Artificial Intelligence for Medical Sciences is of great benefit not only to professional scholars, but also MSc or PhD program students eager to explore advancement in the field.
Book Synopsis Bioinformatics and Functional Genomics by : Christina Marshall
Download or read book Bioinformatics and Functional Genomics written by Christina Marshall and published by . This book was released on 2019-06-19 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinformatics is a rapidly growing branch of science, which integrates the concepts of biology, engineering, mathematics and computer science in order to develop software tools. These tools are used in analyzing and interpreting biological data. Functional genomics is a sub-field of molecular biology, which uses the tools of bioinformatics to understand the diverse aspects of genes such as regulation of gene expression, DNA sequencing, gene transcription, protein-protein interactions, etc. There has been rapid progress in these fields and their applications are finding their way across multiple industries. This book is compiled in such a manner, that it will provide in-depth information about the theory and practice of bioinformatics and functional genomics. Students, researchers, experts, geneticists, biologists and biological engineers will benefit alike from this book.
Download or read book Breast Cancer written by Umberto Veronesi and published by Springer. This book was released on 2017-11-03 with total page 892 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with up-to-date information on important advances in the understanding of breast cancer and innovative approaches to its management. Current and emerging perspectives on genetics, biology, and prevention are first discussed in depth, and individual sections are then devoted to pathology, imaging, oncological surgery, plastic and reconstructive surgery, medical oncology, and radiotherapy. In each case the focus is on the most recent progress and/or state of the art therapies and techniques. Further topics to receive detailed consideration include particular conditions requiring multidisciplinary approaches, the investigation of new drugs and immunological agents, lifestyle and psychological aspects, and biostatistics and informatics. The book will be an excellent reference for practitioners, interns and residents in medical oncology, oncologic surgery, radiotherapy, pathology, and human genetics, researchers, and advanced medical students.
