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Stem Cells In Toxicology And Medicine
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Book Synopsis Stem Cells in Toxicology and Medicine by : Saura C. Sahu
Download or read book Stem Cells in Toxicology and Medicine written by Saura C. Sahu and published by John Wiley & Sons. This book was released on 2016-10-13 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine Presented by internationally recognized investigators in this exciting field of scientific research Provides an insight into the current trends and future directions of research in this rapidly developing new field A valuable and excellent source of authoritative and up-to-date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and government
Book Synopsis Human Stem Cell Toxicology by : James L Sherley
Download or read book Human Stem Cell Toxicology written by James L Sherley and published by Royal Society of Chemistry. This book was released on 2016 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicity against tissue stem cells (TSCs) is a major problem in drug development and environmental health science. Despite their essential function in all human cellular tissues, the nature of tissue stem cells is not fully understood. The small fraction of stem cells in tissues and the lack of specific biomarkers for their quantification present a formidable challenge to developing tools for their study and assays that can identify stem cell-toxic agents. Human Stem Cell Toxicology reveals TSC toxicity as a biomedical reality that is now well under siege by newly emerging ideas and technologies, despite these challenges. Chapters consider stem cell toxicity by environmental agents, pharmaceutical drug candidates, and marketed therapeutic medicines with adverse side effects. New insights to cellular, molecular, biochemical and chemical mechanisms of human tissue stem cell toxicity are brought together. Experimental and theoretical treatments are of specific topics, including approaches to monitoring TSC function, newly discovered TSC types and TSC toxicity resistance mechanisms are covered by expert authors. This book informs and champions the continued development of innovative technologies to predict the TSC toxicity of compounds before their use, whether in patients or the environment, by addressing emerging new cell-based approaches and concepts for technical innovation. This publication will be a useful reference for postgraduate students and researchers working in toxicology, pharmaceutical science, tissue cell biology and stem cell biology.
Book Synopsis Stem Cell-Derived Models in Toxicology by : Mike Clements
Download or read book Stem Cell-Derived Models in Toxicology written by Mike Clements and published by Methods in Pharmacology and To. This book was released on 2018-12-10 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Stem Cells and Cancer Stem Cells,Volume 3 by : M.A. Hayat
Download or read book Stem Cells and Cancer Stem Cells,Volume 3 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2011-11-22 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is pointed out that cancer stem cell is a cell type within a tumor that possesses the capacity of cell-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. It is emphasized that a cancer stem cell is a tumor initiating cell. That conventional chemotherapy kills most cells in a tumor, but cancer stem cells remain intact is discussed. Vast applications of stem cells, cancer stem cells, mesenchymal stem cells, and human pluripotent stem cells are discussed. Because human embryonic stem cells possess the potential of producing unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential in this volume. Because of the pluripotency of embryonic stem cells, this volume discusses various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological uses. The role of these cells in cell differentiation is also included. The role of cancer stem cells of breast, colon, and melanoma tumors in response to antitumor therapy is detailed. The role of cancer stem cells, specifically in the deadliest brain cancer, glioblastoma multiforme, is explained. Transplantation of bone marrow-derived stem cells for myocardial infarcation and use of mesenchymal stem cells in orthopedics are described.
Book Synopsis Stem Cells in Birth Defects Research and Developmental Toxicology by : Theodore P. Rasmussen
Download or read book Stem Cells in Birth Defects Research and Developmental Toxicology written by Theodore P. Rasmussen and published by John Wiley & Sons. This book was released on 2018-03-27 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains material contributed by forward-looking scientists who work at the interface of stem cell research and applied science with the aim to improve human fetal safety and the understanding of human developmental and degenerative disorders. Provides important platforms and contemporary accounts of the state of stem cell research in the fields of toxicology and teratology Considers both in vitro uses of stem cells as platforms for teratology and also stem cellopathies, which are in vivo developmental and degenerative disorders Helps the pharmaceutical industry and safety and environmental authorities validate the status quo of in vitro toxicity test systems based on human pluripotent stem cells and their derivatives
Book Synopsis Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology by : Saura C. Sahu
Download or read book Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology written by Saura C. Sahu and published by John Wiley & Sons. This book was released on 2014-04-22 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology provides an insight into the current trends and future directions of research in these rapidly developing scientific fields. Written by leading scientists and experts, the Handbook will be of interest to various scientific disciplines including toxicology, medicine, and pharmacology, as well as food, drug, and other regulatory sciences.
Download or read book Stem Cells written by Anna M. Wobus and published by Springer. This book was released on 2009-08-29 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This hugely important volume presents in a single text many novel aspects of stem cell biology with respect to scientific endeavors and future applications. During the past few years, stem cell research has metamorphosed into distinct and specialized avenues of research. What makes this book unique is that it not only covers these varied areas of research, but examines in detail some of the key pharmacological issues that up to now have not been addressed in a single volume.
Book Synopsis Stem Cell Protocols by : Ivan N. Rich
Download or read book Stem Cell Protocols written by Ivan N. Rich and published by Humana Press. This book was released on 2014-11-11 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents up-to-date methods that allow primary stem cells from a variety of sources to be isolated, cultured in vitro, detected and measured for specific applications. These applications range from those in basic, stem cell and veterinary research to toxicology, cellular therapy and regenerative medicine. There is a slight bias towards the blood-forming system as more is known about the blood-forming or hematopoietic system than any other primary stem cell system. These unique properties and characteristics are discussed and examined, mostly at the cellular level and in detail in this book. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Stem Cell Protocols provides novices with the fundamentals necessary to develop new technologies necessary for basic and clinical research in the future, and will aid professionals in finding new methodologies to provide a wider viewpoint and an even greater scope for their own research.
Book Synopsis Cell Culture Methods for In Vitro Toxicology by : Glyn Stacey
Download or read book Cell Culture Methods for In Vitro Toxicology written by Glyn Stacey and published by Springer Science & Business Media. This book was released on 2001-12-31 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Culture Methods for in vitro Toxicology introduces the reader to a range of techniques involved in the use of in vitro cell culture in toxicological studies. It deals with major cell types studied in the field of toxicology and will be useful for anyone wishing to start work with animal cell cultures or to refresh their knowledge relating to in vitro cell models. Fundamental chapters deal with the general biology of cytotoxicity and cell immortalisation these are key issues for in vitro systems addressing the `3Rs' principle. Up-to-date overviews deal with the use of cells from liver, brain and intestine. In addition, biochemical analysis of cell responses, biotransformation pathways in cells and recombinant approaches to the early detection of cell stress are also covered in detail. Prominent features of in vitro technologies also include regulation, biosafety and standardisation. Dedicated chapters deal with these issues in a practical way in order to lead the reader to the right source of information. This book provides an up-to-date, informative and practical review of cell culture methods for in vitro toxicology. It will be of equal benefit to students and experienced toxicologists with little experience of in vitro cell culture.
Book Synopsis Stem Cells and Cancer by : Rebecca G. Bagley
Download or read book Stem Cells and Cancer written by Rebecca G. Bagley and published by Springer Science & Business Media. This book was released on 2009-04-20 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significance of Stem Cells to Tumor Development Cancer stem cells remain a controversial topic and the criteria that define cancer stem cells are continuing to evolve. A recent surge in stem cell research has ignited a field of discovery into many human diseases including diabetes, neuropathologies, and cancer. By replacing specific differentiated cells that have either been lost or died, stem cell therapy proves to be a very promising approach to the treatment of many debilitating diseases. Though stem cells may provide therapeutic benefit under certain conditions, they are also often implicated in the initiation, progression, and therapeutic resistance of malignant disease. This first edition of Stem Cells and Cancer is intended to give a current perspective on the role of stem cells in cancer and strategies for novel therapies directed toward tumor stem cells. The current cancer stem cell hypothesis is presented in several chapters with distinctions made between the hierarchical and stochastic models of tumor cell development. "Stemness," self-renewal, pluripotency, clonality, and tumorigenicity are important concepts applied towards defining cancer stem cells. Signaling pathways such as Wnt, Sonic Hedgehog, Notch, and Bmi-1 that are involved in differentiation, proliferation, and survival are implicated in the malignant process. Additional chapters address the identification of cancer stem cell populations through the evaluation of molecular markers such as CD133, CD44, and CD24, for example, or by Hoescht dye exclusion to recognize ‘side populations.’ Mesenchymal and hematopoietic stem cells are described as well as mouse models that are employed to elucidate the properties and functionality of stem cells in cancer and the stem cell niche. This book encompasses a wide variety of human cancers that include but are not limited to leukemia, gliomas, breast, and prostate cancers. Resistance to conventional therapies, genetic versus epigenetic changes that affect therapeutic response and strategies to prevent disease recurrence are challenges have been incorporated into this volume. Stem Cells and Cancer represents a compendium of cutting edge research by experts in the field and will be instrumental in the study of this intriguing line of investigation for many years to come. Rebecca Bagley is a senior scientist at Genzyme Corporation and has worked in the biotechnology industry for 20 years with degrees in biology from Wellesley College and Harvard University. Her expertise in drug development spans a wide range of approaches including immunotherapies, gene and protein therapies, and small molecule delivery with publications in journals such as Molecular Cancer Therapeutics, Cancer Research, and Microvascular Research . Her current research focuses on stem cells, tumor vasculature, and target validation. Dr. Beverly A. Teicher is Vice President of Oncology Research at Genzyme Corporation. Dr. Teicher completed a PhD in Bioorganic Chemistry at the Johns Hopkins University and postdoctoral training at Yale University School of Medicine. Dr. Teicher joined Dana-Farber Cancer Institute as an Assistant Professor of Pathology and rose to Associate Professor of Medicine and Radiation Therapy, Harvard Medical School at Dana-Farber Cancer Institute and Joint Center for Radiation Therapy. Dr. Teicher is an active member of the international scientific community having authored or co-authored more than 400 scientific publications. She has edited eight books, is senior editor for the journal Clinical Cancer Research and is series editor for the Cancer Drug Discovery and Development book series.
Book Synopsis Stem Cells & Regenerative Medicine by : Krishnarao Appasani
Download or read book Stem Cells & Regenerative Medicine written by Krishnarao Appasani and published by Springer Science & Business Media. This book was released on 2010-11-01 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Defined as, “The science about the development of an embryo from the fertilization of the ovum to the fetus stage,” embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a “development cell.” That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.
Book Synopsis Stem Cell Study Organ-Specific Responses to Xenobiotics by : Shripriya Singh
Download or read book Stem Cell Study Organ-Specific Responses to Xenobiotics written by Shripriya Singh and published by Mohammed Abdul Malik. This book was released on 2024-02-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In "Stem Cell Study: Organ-Specific Responses to Xenobiotics," Shripriya Singh explores the exciting field of stem cell research and its applications in detecting organ-specific responses to xenobiotics. This book provides a comprehensive overview of the use of stem cells for toxicology studies and their potential for identifying organ-specific responses to xenobiotics. The book begins with an introduction to stem cells and their properties, followed by a discussion of the various types of xenobiotics and their effects on human health. Singh then delves into the techniques used for stem cell culture and differentiation, including 3D cell culture and microfluidic platforms. The book then moves on to the applications of stem cells in toxicology studies, focusing on the detection of organ-specific responses to xenobiotics. Singh discusses the use of various types of stem cells, such as induced pluripotent stem cells (iPSCs) and organoids, for toxicology studies. The author also presents case studies on the use of stem cells for detecting organ-specific responses to xenobiotics, such as the liver and the kidney. Overall, "Stem Cell Study: Organ-Specific Responses to Xenobiotics" is an informative and insightful book for researchers, scientists, and clinicians working in the field of toxicology and stem cell research. The author provides a comprehensive understanding of the potential of stem cells for detecting organ-specific responses to xenobiotics, which is crucial for improving drug development and human health.
Book Synopsis Stem Cells in Regenerative Medicine by : Alain A. Vertes
Download or read book Stem Cells in Regenerative Medicine written by Alain A. Vertes and published by John Wiley & Sons. This book was released on 2015-09-14 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a unique guide to emerging stem cell technologies and the opportunities for their commercialisation. It provides in-depth analyses of the science, business, legal, and financing fundamentals of stem cell technologies, offering a holistic assessment of this emerging and dynamic segment of the field of regenerative medicine. • Reviews the very latest advances in the technology and business of stem cells used for therapy, research, and diagnostics • Identifies key challenges to the commercialisation of stem cell technology and avenues to overcome problems in the pipeline • Written by an expert team with extensive experience in the business, basic and applied science of stem cell research This comprehensive volume is essential reading for researchers in cell biology, biotechnology, regenerative medicine, and tissue engineering, including scientists and professionals, looking to enter commercial biotechnology fields.
Book Synopsis Stem Cells and Cancer Stem Cells, Volume 5 by : M.A. Hayat
Download or read book Stem Cells and Cancer Stem Cells, Volume 5 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2012-02-22 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is pointed out that a cancer stem cell is a type within a tumor that possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells, which comprise the tumor. It is emphasized that a unique feature of cancer stem cells is that, although conventional chemotherapy kills most cells in a tumor, cancer stem cells remain intact. Vast applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, human mesenchymal stem cells, cancer stem cells, arterial stem cells, neural stem cells, cardiac stem cells, dental stem cells, limbal stem cells, and hematopoietic stem cells. Because human embryonic stem cells possess the potential to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential in this volume. These cells are used in tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. It is pointed out that the formation of embryoid bodies, which are three-dimensional aggregates of embryonic cells, is the initial step in the differentiation of these cells. Therapeutic implications of signalling pathways in cancer stem cells are pointed out. Targeting self-renewal pathways in cancer stem cells are also included. Application of mesenchymal stem cells for treating ischemic brain injury is explained. Neural stem cells proliferation into the surrounding area of the traumatic brain injury is explained.
Book Synopsis Stem Cells and Cancer Stem Cells, Volume 6 by : M.A. Hayat
Download or read book Stem Cells and Cancer Stem Cells, Volume 6 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2012-02-27 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The difference among pluripotent stem cells, multipotent stem cells, and unipotent stem cells is pointed out. Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells. Because of the potential of human embryonic stem cells to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential. Because of their pluripotency, these cells have been used in various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. The formation of embryoid bodies, which are three-dimensional aggregates of embryonic stem cells, is explained as this is the first step in cell differentiation. Such embryoid body culture has been widely used as a trigger for the in vitro differentiation of embryonic stem cells. The basic capacity of self-renewal of human embryogenic stem cells is explained. The role of TGF-beta in the propagation of human embryonic stem cells is discussed. The differentiation of human embryonic stem cells into neurons, hepatocytes, cardiomyocytes, and retinal cells is fully explained. Donor policies for hematopoietic stem cells are also explained.
Book Synopsis Novel Developments in Stem Cell Mobilization by : Stefan Fruehauf
Download or read book Novel Developments in Stem Cell Mobilization written by Stefan Fruehauf and published by Springer Science & Business Media. This book was released on 2012-02-15 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development effective antagonists. One antagonist, plerixafor, is clinically approved now for stem cell mobilization of lymphoma and myeloma patients. This allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoetic cells, i.e. leukemia cells. In preclinical studies a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. Clinical studies are under way. CXCR4 antagonists are an exciting new class of compounds which are also employed for the mobilization of angiogenic cells or for the treatment of solid tumors. In this book a concise review of the current status of knowledge and future developments will be presented.
Book Synopsis Stem Cells in Toxicology and Medicine by : Saura C. Sahu
Download or read book Stem Cells in Toxicology and Medicine written by Saura C. Sahu and published by John Wiley & Sons. This book was released on 2016-10-13 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine Presented by internationally recognized investigators in this exciting field of scientific research Provides an insight into the current trends and future directions of research in this rapidly developing new field A valuable and excellent source of authoritative and up-to-date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and government
