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Author : David John Finney
Publisher :
ISBN 13 :
Total Pages : 700 pages
Book Rating : 4.:/5 (318 download)
Download or read book Statistical Method in Biological Assay written by David John Finney and published by . This book was released on 1971 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Z. Govindarajulu
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805571194
Total Pages : 249 pages
Book Rating : 4.8/5 (55 download)
Download or read book Statistical Techniques in Bioassay written by Z. Govindarajulu and published by Karger Medical and Scientific Publishers. This book was released on 2001 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the face of the ever-increasing importance of statistical methods in medical research and practice, the first edition of this publication has provided a sound and deep understanding of statistical methods in bioassay to many students and researchers. In addition to the profound presentation of statistical methods of the first edition, here the reader will find new material stemming from the recent statistical literature as well as data reflecting modern trends in general applied statistical research. Examples are discussions on design and planning, e.g. choices of dose levels, and additional section in the chapter on Bayes methods, and a new chapter on sequential estimation for the logistic model. The book will be a valuable source of information to students in the experimental area of statistical aspects of biological assay, professional statisticians with an interest in research in this topic, teachers in statistics and biology, and investigators in the biological and medical sciences who use bioassay in their work.
Author : Uchenna Petronilla Ogoke
Publisher : IPS Intelligentsia Publishing Services
ISBN 13 : 9789912730
Total Pages : 72 pages
Book Rating : 4.7/5 (899 download)
Download or read book STATISTICAL THEORY AND ANALYSIS IN BIOASSAY written by Uchenna Petronilla Ogoke and published by IPS Intelligentsia Publishing Services. This book was released on 2021-08-21 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Theory and Analysis in Bioassay is a seven chapter monograph tailored essentially to meet the needs of graduate students, practitioners and researchers in the fields of medicine, pharmacology, biosciences/life sciences and related fields that employs the tools of biostatistics in bioassays and analysis. In this wise, we have taken time to discuss in details relevant topics; principles, methods and applications. Practice exercises are also included where necessary. The earlier chapters give background information, definition of terms, purpose, types, structure and relative potency in bioassay. An important theorem, Fieller’s theorem is proved in details with illustrative examples. The last two chapters are on dose-response relationship, fitting in parallelline assays and estimation. We are convinced that this monograph will meet the expectations of the readers while constructive criticisms that will improve another edition will be appreciated.
Author : C. I. Bliss
Publisher : Elsevier
ISBN 13 : 1483277011
Total Pages : 189 pages
Book Rating : 4.4/5 (832 download)
Download or read book The Statistics of Bioassay written by C. I. Bliss and published by Elsevier. This book was released on 2014-05-12 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Statistics of Bioassay: With Special Reference to the Vitamins, Volume II focuses on the processes, reactions, principles, and approaches involved in the biological assay of vitamins. The publication first offers information on the general principles of biological assay, dosage-response curve and its error, and designs for segregating nonrandom variation. Discussions focus on replacement of missing values, randomized groups, calculation of the line, analysis of the variation about the line, comparative biological assays, analytical biological assays, and determination of activity. The text then ponders on measurement of relative potency and correction of quantitative variables. The manuscript takes a look at assays where the variation in response is a function of the dose and slope-ratio assays. Topics include microbiological assays and the slope-ratio technique, analysis of balanced slope-ratio assays, analysis of assays with an all-or-none response, and graded response with unequal variance. The publication then tackles multiple or repeated assays, including quality control in repeated assays and combination of independent assays of a single unknown. The publication is a valuable source of information for researchers interested in the biological assay of vitamins.
Author : David J. Finney
Publisher : Charles Griffin Book
ISBN 13 : 9780195205671
Total Pages : 522 pages
Book Rating : 4.2/5 (56 download)
Download or read book Statistical Method in Biological Assay written by David J. Finney and published by Charles Griffin Book. This book was released on 1987 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: A standard work for 30 years, this book emphasizes experimental design and the practice of statistical estimation, making it especially valuable for those working as consultants in research and technology. The author describes the central statistical procedures for radioimmunoassay, and presents new ideas on the combination of bioassay results. He describes routine assay computations and illustrates recently developed programs for quantitative and quantal responses.
Author : D. J. Finny
Publisher : Springer
ISBN 13 :
Total Pages : 184 pages
Book Rating : 4.3/5 (91 download)
Download or read book Statistics for Biologists written by D. J. Finny and published by Springer. This book was released on 1980-10-30 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Problems, data, questions; Probability and other definitions; Combining probabilities; Significance, binomials, and X2; Continuous variates; Inference on means: the normal distribution; Unknown variance: the t-distribution; Design of experiments; Comparisons between means; Additional topics.
Author : Atta-ur-Rahman
Publisher : CRC Press
ISBN 13 : 1135287228
Total Pages : 214 pages
Book Rating : 4.1/5 (352 download)
Download or read book Bioassay Techniques for Drug Development written by Atta-ur-Rahman and published by CRC Press. This book was released on 2001-10-04 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of an activity-directed isolation process is to isolate bioactive compounds which may provide structural leads of therapeutic importance. Whereas the traditional process of drug development is long and expensive, simple and rapid bioassays can serve as the starting point for drug discovery. This book presents a range of "bench top" bioassa
Author : Hans-Michael Kaltenbach
Publisher : Springer Nature
ISBN 13 : 3030696413
Total Pages : 281 pages
Book Rating : 4.0/5 (36 download)
Download or read book Statistical Design and Analysis of Biological Experiments written by Hans-Michael Kaltenbach and published by Springer Nature. This book was released on 2021-04-15 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This richly illustrated book provides an overview of the design and analysis of experiments with a focus on non-clinical experiments in the life sciences, including animal research. It covers the most common aspects of experimental design such as handling multiple treatment factors and improving precision. In addition, it addresses experiments with large numbers of treatment factors and response surface methods for optimizing experimental conditions or biotechnological yields. The book emphasizes the estimation of effect sizes and the principled use of statistical arguments in the broader scientific context. It gradually transitions from classical analysis of variance to modern linear mixed models, and provides detailed information on power analysis and sample size determination, including ‘portable power’ formulas for making quick approximate calculations. In turn, detailed discussions of several real-life examples illustrate the complexities and aberrations that can arise in practice. Chiefly intended for students, teachers and researchers in the fields of experimental biology and biomedicine, the book is largely self-contained and starts with the necessary background on basic statistical concepts. The underlying ideas and necessary mathematics are gradually introduced in increasingly complex variants of a single example. Hasse diagrams serve as a powerful method for visualizing and comparing experimental designs and deriving appropriate models for their analysis. Manual calculations are provided for early examples, allowing the reader to follow the analyses in detail. More complex calculations rely on the statistical software R, but are easily transferable to other software. Though there are few prerequisites for effectively using the book, previous exposure to basic statistical ideas and the software R would be advisable.
Author : Bayo Lawal
Publisher : Springer
ISBN 13 : 3319055550
Total Pages : 799 pages
Book Rating : 4.3/5 (19 download)
Download or read book Applied Statistical Methods in Agriculture, Health and Life Sciences written by Bayo Lawal and published by Springer. This book was released on 2014-09-15 with total page 799 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook teaches crucial statistical methods to answer research questions using a unique range of statistical software programs, including MINITAB and R. This textbook is developed for undergraduate students in agriculture, nursing, biology and biomedical research. Graduate students will also find it to be a useful way to refresh their statistics skills and to reference software options. The unique combination of examples is approached using MINITAB and R for their individual strengths. Subjects covered include among others data description, probability distributions, experimental design, regression analysis, randomized design and biological assay. Unlike other biostatistics textbooks, this text also includes outliers, influential observations in regression and an introduction to survival analysis. Material is taken from the author's extensive teaching and research in Africa, USA and the UK. Sample problems, references and electronic supplementary material accompany each chapter.
Author : K. Paech
Publisher : Springer Science & Business Media
ISBN 13 : 3642649556
Total Pages : 639 pages
Book Rating : 4.6/5 (426 download)
Download or read book Modern Methods of Plant Analysis / Moderne Methoden der Pflanzenanalyse written by K. Paech and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : S.J. Welham
Publisher : CRC Press
ISBN 13 : 1439808783
Total Pages : 606 pages
Book Rating : 4.4/5 (398 download)
Download or read book Statistical Methods in Biology written by S.J. Welham and published by CRC Press. This book was released on 2014-08-22 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in simple language with relevant examples, Statistical Methods in Biology: Design and Analysis of Experiments and Regression is a practical and illustrative guide to the design of experiments and data analysis in the biological and agricultural sciences. The book presents statistical ideas in the context of biological and agricultural sciences to which they are being applied, drawing on relevant examples from the authors’ experience. Taking a practical and intuitive approach, the book only uses mathematical formulae to formalize the methods where necessary and appropriate. The text features extended discussions of examples that include real data sets arising from research. The authors analyze data in detail to illustrate the use of basic formulae for simple examples while using the GenStat® statistical package for more complex examples. Each chapter offers instructions on how to obtain the example analyses in GenStat and R. By the time you reach the end of the book (and online material) you will have gained: A clear appreciation of the importance of a statistical approach to the design of your experiments, A sound understanding of the statistical methods used to analyse data obtained from designed experiments and of the regression approaches used to construct simple models to describe the observed response as a function of explanatory variables, Sufficient knowledge of how to use one or more statistical packages to analyse data using the approaches described, and most importantly, An appreciation of how to interpret the results of these statistical analyses in the context of the biological or agricultural science within which you are working. The book concludes with a guide to practical design and data analysis. It gives you the understanding to better interact with consultant statisticians and to identify statistical approaches to add value to your scientific research.
Author : Alfred Bartolucci
Publisher : John Wiley & Sons
ISBN 13 : 1118736869
Total Pages : 259 pages
Book Rating : 4.1/5 (187 download)
Download or read book Introduction to Statistical Analysis of Laboratory Data written by Alfred Bartolucci and published by John Wiley & Sons. This book was released on 2015-12-02 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Statistical Analysis of Laboratory Data presents a detailed discussion of important statistical concepts and methods of data presentation and analysis Provides detailed discussions on statistical applications including a comprehensive package of statistical tools that are specific to the laboratory experiment process Introduces terminology used in many applications such as the interpretation of assay design and validation as well as “fit for purpose” procedures including real world examples Includes a rigorous review of statistical quality control procedures in laboratory methodologies and influences on capabilities Presents methodologies used in the areas such as method comparison procedures, limit and bias detection, outlier analysis and detecting sources of variation Analysis of robustness and ruggedness including multivariate influences on response are introduced to account for controllable/uncontrollable laboratory conditions
Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264076336
Total Pages : 20 pages
Book Rating : 4.2/5 (64 download)
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 441: Hershberger Bioassay in Rats A Short-term Screening Assay for (Anti)Androgenic Properties written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Hershberger Bioassay is an in vivo short–term screening test. It evaluates the ability of a chemical to elicit biological activities consistent with androgen agonists, antagonists or 5 á-reductase inhibitors. The current bioassay is based on the ...
Author : J Chayen
Publisher : Butterworth-Heinemann
ISBN 13 : 148316540X
Total Pages : 439 pages
Book Rating : 4.4/5 (831 download)
Download or read book Cytochemical Bioassays written by J Chayen and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochemical Bioassays: Techniques and Clinical Applications describes the techniques and clinical applications of cytochemical bioassays, particularly with respect to polypeptide hormones. This book discusses the clinical and research implications of studies that use these techniques. This text is comprised of 14 chapters; the first of which introduces the reader to the origins and general principles of cytochemical bioassays, along with their advantages. This discussion is followed by a chapter that explains what is meant by ""an assay""; for what purpose assays are done; the basic components of an assay method; and the nature of the difference between in vivo and in vitro hormone bioassays, in vitro ligand assays, and enzyme assays. Attention then turns to the techniques of cytochemical bioassays and the cytochemical bioassay procedures for adrenocorticotropic hormones; thyroid-stimulating hormones; the thyroid-stimulating antibody of Graves' disease; thyroid growth stimulating and blocking immunoglobulins; and luteinizing hormones. The next chapters focus on the technique and clinical relevance of a cytochemical bioassay for gastrin-like activity and for measurement of antidiuretic hormones, parathyroid hormones, angiotensin II, natriuretic hormones, and hypothalamic regulating hormones. This book will be of interest to clinicians and practitioners of biology, biochemistry, and endocrinology.
Author : Ludwig Hothorn
Publisher : Springer Science & Business Media
ISBN 13 : 364248736X
Total Pages : 161 pages
Book Rating : 4.6/5 (424 download)
Download or read book Statistical Methods in Toxicology written by Ludwig Hothorn and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains selected papers from a workshop on modern statistical methods in toxicology held during the EUROTOX '90 conference in Leipzig. The papers deal with the biostatistical evaluation of the commonly used toxicological assays, i.e. mutagenicity, long-term carcinogenicity, embryotoxicity and chronic toxicity assays. The biological background is considered in detail, and most of the related statistical approaches described. In five overview papers, the present state of the art of the related topics is given, while in several contributed papers new approaches are discussed. The most important features are: - A new view on the per-litter analysis problem in em- bryotoxicity assays. - A highly sophisticated treatment of the so-called muta-tox problem in mutagenicity assays. - A detailed discussion of the multiplicity problem based on the closed testing procedure. This volume provides readers with an overview of modern biostatistical methods for several toxicological assays and is in part intended for direct, practical use.
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309171148
Total Pages : 221 pages
Book Rating : 4.3/5 (91 download)
Download or read book Small Clinical Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Author : Callum G. Fraser
Publisher : Amer. Assoc. for Clinical Chemistry
ISBN 13 : 9781890883492
Total Pages : 172 pages
Book Rating : 4.8/5 (834 download)
Download or read book Biological Variation written by Callum G. Fraser and published by Amer. Assoc. for Clinical Chemistry. This book was released on 2001 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
