Statistical Mechanics Protein Structure And Protein Substrate Interactions

Download Statistical Mechanics Protein Structure And Protein Substrate Interactions full books in PDF, epub, and Kindle. Read online Statistical Mechanics Protein Structure And Protein Substrate Interactions ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Statistical Mechanics, Protein Structure, and Protein Substrate Interactions

Author : Sebastian Doniach
Publisher : Springer Science & Business Media
ISBN 13 : 1489913491
Total Pages : 400 pages
Book Rating : 4.4/5 (899 download)

DOWNLOAD NOW!

Book Synopsis Statistical Mechanics, Protein Structure, and Protein Substrate Interactions by : Sebastian Doniach

Download or read book Statistical Mechanics, Protein Structure, and Protein Substrate Interactions written by Sebastian Doniach and published by Springer Science & Business Media. This book was released on 2013-11-22 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of factors have come together in the last couple of decades to define the emerging interdisciplinary field of structural molecular biology. First, there has been the considerable growth in our ability to obtain atomic-resolution structural data for biological molecules in general, and proteins in particular. This is a result of advances in technique, both in x-ray crystallography, driven by the development of electronic detectors and of synchrotron radiation x-ray sources, and by the development ofNMR techniques which allow for inference of a three-dimensional structure of a protein in solution. Second, there has been the enormous development of techniques in DNA engineering which makes it possible to isolate and clone specific molecules of interest in sufficient quantities to enable structural measurements. In addition, the ability to mutate a given amino acid sequence at will has led to a new branch of biochemistry in which quantitative measurements can be made assessing the influence of a given amino acid on the function of a biological molecule. A third factor, resulting from the exponential increase in computing power available to researchers, has been the emergence of a growing body of people who can take the structural data and use it to build atomic-scale models of biomolecules in order to try and simulate their motions in an aqueous environment, thus helping to provide answers to one of the most basic questions of molecular biology: the relation of structure to function.

Statistical Mechanics, Protein Structure, and Protein Substrate Interactions

Author : Sebastian Doniach
Publisher :
ISBN 13 : 9781489913500
Total Pages : 420 pages
Book Rating : 4.9/5 (135 download)

DOWNLOAD NOW!

Book Synopsis Statistical Mechanics, Protein Structure, and Protein Substrate Interactions by : Sebastian Doniach

Download or read book Statistical Mechanics, Protein Structure, and Protein Substrate Interactions written by Sebastian Doniach and published by . This book was released on 2014-09-01 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protein Actions

Author : Ken Dill
Publisher : Garland Science
ISBN 13 : 1351815008
Total Pages : pages
Book Rating : 4.3/5 (518 download)

DOWNLOAD NOW!

Book Synopsis Protein Actions by : Ken Dill

Download or read book Protein Actions written by Ken Dill and published by Garland Science. This book was released on 2017-09-19 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Actions: Principles and Modeling is aimed at graduates, advanced undergraduates, and any professional who seeks an introduction to the biological, chemical, and physical properties of proteins. Broadly accessible to biophysicists and biochemists, it will be particularly useful to student and professional structural biologists and molecular biophysicists, bioinformaticians and computational biologists, biological chemists (particularly drug designers) and molecular bioengineers. The book begins by introducing the basic principles of protein structure and function. Some readers will be familiar with aspects of this, but the authors build up a more quantitative approach than their competitors. Emphasizing concepts and theory rather than experimental techniques, the book shows how proteins can be analyzed using the disciplines of elementary statistical mechanics, energetics, and kinetics. These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science.

Lectures on Statistical Physics and Protein Folding

Author : Kerson Huang
Publisher : World Scientific
ISBN 13 : 9812561439
Total Pages : 159 pages
Book Rating : 4.8/5 (125 download)

DOWNLOAD NOW!

Book Synopsis Lectures on Statistical Physics and Protein Folding by : Kerson Huang

Download or read book Lectures on Statistical Physics and Protein Folding written by Kerson Huang and published by World Scientific. This book was released on 2005 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces an approach to protein folding from the point of view of kinetic theory. There is an abundance of data on protein folding, but few proposals are available on the mechanism driving the process. Here, presented for the first time, are suggestion on possible research directions, as developed by the author in collaboration with C. C. Lin. The first half of this invaluable book contains a concise but relatively complete review of relevant topics in statistical mechanics and kinetic theory. It includes standard topics such as thermodynamics, the Maxwell-Boltzmann distribution, and ensemble theory. Special discussions include the dynamics of phase transitions, and Brownian motion as an illustration of stochastic processes. The second half develops topics in molecular biology and protein structure, with a view to discovering mechanisms underlying protein folding. Attention is focused on the energy flow through the protein in its folded state. A mathematical model, based on the Brownian motion of coupled harmonic oscillators, is worked out in the appendix.

Protein Physics

Author : Alexei V. Finkelstein
Publisher : Elsevier
ISBN 13 : 0081012365
Total Pages : 528 pages
Book Rating : 4.0/5 (81 download)

DOWNLOAD NOW!

Book Synopsis Protein Physics by : Alexei V. Finkelstein

Download or read book Protein Physics written by Alexei V. Finkelstein and published by Elsevier. This book was released on 2016-06-22 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Physics: A Course of Lectures covers the most general problems of protein structure, folding and function. It describes key experimental facts and introduces concepts and theories, dealing with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states. The book systematically summarizes and presents the results of several decades of worldwide fundamental research on protein physics, structure, and folding, describing many physical models that help readers make estimates and predictions of physical processes that occur in proteins. New to this revised edition is the inclusion of novel information on amyloid aggregation, natively disordered proteins, protein folding in vivo, protein motors, misfolding, chameleon proteins, advances in protein engineering & design, and advances in the modeling of protein folding. Further, the book provides problems with solutions, many new and updated references, and physical and mathematical appendices. In addition, new figures (including stereo drawings, with a special appendix showing how to use them) are added, making this an ideal resource for graduate and advanced undergraduate students and researchers in academia in the fields of biophysics, physics, biochemistry, biologists, biotechnology, and chemistry. Fully revised and expanded new edition based on the latest research developments in protein physics Written by the world's top expert in the field Deals with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states Summarizes, in a systematic form, the results of several decades of worldwide fundamental research on protein physics and their structure and folding Examines experimental data on protein structure in the post-genome era

Reviews in Computational Chemistry, Volume 17

Author : Kenny B. Lipkowitz
Publisher : John Wiley & Sons
ISBN 13 : 0471458813
Total Pages : 431 pages
Book Rating : 4.4/5 (714 download)

DOWNLOAD NOW!

Book Synopsis Reviews in Computational Chemistry, Volume 17 by : Kenny B. Lipkowitz

Download or read book Reviews in Computational Chemistry, Volume 17 written by Kenny B. Lipkowitz and published by John Wiley & Sons. This book was released on 2003-05-08 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational chemistry is increasingly used in most areas of molecular science including organic, inorganic, medicinal, biological, physical, and analytical chemistry. Researchers in these fields who do molecular modelling need to understand and stay current with recent developments. This volume, like those prior to it, features chapters by experts in various fields of computational chemistry. Two chapters focus on molecular docking, one of which relates to drug discovery and cheminformatics and the other to proteomics. In addition, this volume contains tutorials on spin-orbit coupling and cellular automata modeling, as well as an extensive bibliography of computational chemistry books. FROM REVIEWS OF THE SERIES "Reviews in Computational Chemistry remains the most valuable reference to methods and techniques in computational chemistry."—JOURNAL OF MOLECULAR GRAPHICS AND MODELLING "One cannot generally do better than to try to find an appropriate article in the highly successful Reviews in Computational Chemistry. The basic philosophy of the editors seems to be to help the authors produce chapters that are complete, accurate, clear, and accessible to experimentalists (in particular) and other nonspecialists (in general)."—JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Computational Methods for Protein Folding, Volume 120

Author : Richard A. Friesner
Publisher : John Wiley & Sons
ISBN 13 : 0471465232
Total Pages : 544 pages
Book Rating : 4.4/5 (714 download)

DOWNLOAD NOW!

Book Synopsis Computational Methods for Protein Folding, Volume 120 by : Richard A. Friesner

Download or read book Computational Methods for Protein Folding, Volume 120 written by Richard A. Friesner and published by John Wiley & Sons. This book was released on 2004-04-07 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first attempts to model proteins on a computer began almost thirty years ago, our understanding of protein structure and dynamics has dramatically increased. Spectroscopic measurement techniques continue to improve in resolution and sensitivity, allowing a wealth of information to be obtained with regard to the kinetics of protein folding and unfolding, and complementing the detailed structural picture of the folded state. Concurrently, algorithms, software, and computational hardware have progressed to the point where both structural and kinetic problems may be studied with a fair degree of realism. Despite these advances, many major challenges remain in understanding protein folding at both the conceptual and practical levels. Computational Methods for Protein Folding seeks to illuminate recent advances in computational modeling of protein folding in a way that will be useful to physicists, chemists, and chemical physicists. Covering a broad spectrum of computational methods and practices culled from a variety of research fields, the editors present a full range of models that, together, provide a thorough and current description of all aspects of protein folding. A valuable resource for both students and professionals in the field, the book will be of value both as a cutting-edge overview of existing information and as a catalyst for inspiring new studies. Computational Methods for Protein Folding is the 120th volume in the acclaimed series Advances in Chemical Physics, a compilation of scholarly works dedicated to the dissemination of contemporary advances in chemical physics, edited by Nobel Prize-winner Ilya Prigogine.

Biocomputing And Emergent Computation - Proceedings Of Bcec97

Author : Bjorn Olsson
Publisher : World Scientific
ISBN 13 : 9814545600
Total Pages : 312 pages
Book Rating : 4.8/5 (145 download)

DOWNLOAD NOW!

Book Synopsis Biocomputing And Emergent Computation - Proceedings Of Bcec97 by : Bjorn Olsson

Download or read book Biocomputing And Emergent Computation - Proceedings Of Bcec97 written by Bjorn Olsson and published by World Scientific. This book was released on 1997-08-26 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains papers presented at the BCEC97 conference, held in Skövde, Sweden, in September 1997. The conference brought together researchers from biology and computer science to discuss the use of computational techniques in biology, as well as the use of biological metaphors in computing. Examples of the work presented in these papers include computer simulations of embryogenesis; algorithms for protein folding prediction; problem solving using DNA computation; neural-network learning in retina implants; and optimisation algorithms inspired by natural evolution.

Coherent Optical Interactions in Semiconductors

Author : R.T. Phillips
Publisher : Springer Science & Business Media
ISBN 13 : 1475797486
Total Pages : 362 pages
Book Rating : 4.4/5 (757 download)

DOWNLOAD NOW!

Book Synopsis Coherent Optical Interactions in Semiconductors by : R.T. Phillips

Download or read book Coherent Optical Interactions in Semiconductors written by R.T. Phillips and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NATO Advanced Research Workshop on Coherent Optical Processes in Semiconductors was held in Cambridge, England on August 11-14,1993. The idea of holding this Workshop grew from the recent upsurge in activity on coherent transient effects in semiconductors. The development of this field reflects advances in both light sources and the quality of semiconductor structures, such that tunable optical pulses are now routinely available whose duration is shorter than the dephasing time for excitonic states in quantum wells. It was therefore no surprise to the organisers that as the programme developed, there emerged a heavy emphasis on time-resolved four-wave mixing, particularly in quantum wells. Nevertheless, other issues concerned with coherent effects ensured that several papers on related problems contributed some variety. The topics discussed at the workshop centred on what is a rather new field of study, and benefited enormously by having participants representing many of the principal groups working in this area. Several themes emerged through the invited contributions at the Workshop. One important development has been the careful examination of the two-level model of excitonic effects; a model which has been remarkably successful despite the expected complexities arising from the semiconductor band structure. Indeed, modest extensions to the two level model have been able to offer a useful account for some of the complicated polarisation dependence of four-wave mixing signals from GaAs quantum wells. This work clearly is leading to an improved understanding of excitons in confined systems.

Division of Basic Sciences Annual Research Directory

Author : National Cancer Institute (U.S.). Division of Basic Sciences
Publisher :
ISBN 13 :
Total Pages : 476 pages
Book Rating : 4.:/5 (319 download)

DOWNLOAD NOW!

Book Synopsis Division of Basic Sciences Annual Research Directory by : National Cancer Institute (U.S.). Division of Basic Sciences

Download or read book Division of Basic Sciences Annual Research Directory written by National Cancer Institute (U.S.). Division of Basic Sciences and published by . This book was released on 1996 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Protein Folding Problem and Tertiary Structure Prediction

Author : Kenneth M.Jr. Merz
Publisher : Springer Science & Business Media
ISBN 13 : 1468468316
Total Pages : 585 pages
Book Rating : 4.4/5 (684 download)

DOWNLOAD NOW!

Book Synopsis The Protein Folding Problem and Tertiary Structure Prediction by : Kenneth M.Jr. Merz

Download or read book The Protein Folding Problem and Tertiary Structure Prediction written by Kenneth M.Jr. Merz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: A solution to the protein folding problem has eluded researchers for more than 30 years. The stakes are high. Such a solution will make 40,000 more tertiary structures available for immediate study by translating the DNA sequence information in the sequence databases into three-dimensional protein structures. This translation will be indispensable for the analy sis of results from the Human Genome Project, de novo protein design, and many other areas of biotechnological research. Finally, an in-depth study of the rules of protein folding should provide vital clues to the protein fold ing process. The search for these rules is therefore an important objective for theoretical molecular biology. Both experimental and theoretical ap proaches have been used in the search for a solution, with many promising results but no general solution. In recent years, there has been an exponen tial increase in the power of computers. This has triggered an incredible outburst of theoretical approaches to solving the protein folding problem ranging from molecular dynamics-based studies of proteins in solution to the actual prediction of protein structures from first principles. This volume attempts to present a concise overview of these advances. Adrian Roitberg and Ron Elber describe the locally enhanced sam pling/simulated annealing conformational search algorithm (Chapter 1), which is potentially useful for the rapid conformational search of larger molecular systems.

Laser Interactions with Atoms, Solids and Plasmas

Author : Richard M. More
Publisher : Springer Science & Business Media
ISBN 13 : 1489915761
Total Pages : 476 pages
Book Rating : 4.4/5 (899 download)

DOWNLOAD NOW!

Book Synopsis Laser Interactions with Atoms, Solids and Plasmas by : Richard M. More

Download or read book Laser Interactions with Atoms, Solids and Plasmas written by Richard M. More and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this NATO Advanced Study Institute was to bring together scientists and students working in the field of laser matter interactions in order to review and stimulate developmentoffundamental science with ultra-short pulse lasers. New techniques of pulse compression and colliding-pulse mode-locking have made possible the construction of lasers with pulse lengths in the femtosecond range. Such lasers are now in operation at several research laboratories in Europe and the United States. These laser facilities present a new and exciting research direction with both pure and applied science components. In this ASI the emphasis is on fundamental processes occurring in the interaction of short laser pulses with atoms, molecules, solids, and plasmas. In the case of laser-atom (molecule) interactions, high power lasers provide the first access to extreme high-intensity conditions above 10'8 Watts/em', a new frontier for nonlinear interaction of photons with atoms and molecules. New phenomena observed include multiphoton ionization processes, atomic collisions in the presence of a strong laser field, Coulomb explosion following rapid ionization of a molecule and the production of high harmonics of the laser source. Another important topic reviewed in this ASI is the lasercooling ofatoms.

Modelling of Biomolecular Structures and Mechanisms

Author : A. Pullman
Publisher : Springer Science & Business Media
ISBN 13 : 9401104972
Total Pages : 468 pages
Book Rating : 4.4/5 (11 download)

DOWNLOAD NOW!

Book Synopsis Modelling of Biomolecular Structures and Mechanisms by : A. Pullman

Download or read book Modelling of Biomolecular Structures and Mechanisms written by A. Pullman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gathering together a number of the best experts in the world, the 27th Jerusalem Symposium was devoted to the theme of the modelling of biomolecular structures and mechanisms. As a result of recent growth in both importance and audience, the papers contained in this volume present a thorough evaluation of the status of the present knowledge in this field. The main topics covered by this year's Symposium include nucleic acids and their interactions, proteins and their interaction, membranes and their interactions, enzymatic processes and the pharmacological and medical aspects of these subjects. Readers will benefit from the interdisciplinary approach which provides an extensive coverage of both theoretical and experimental advances.

Evolutionary Methods in Biotechnology

Author : Susanne Brakmann
Publisher : John Wiley & Sons
ISBN 13 : 3527604626
Total Pages : 227 pages
Book Rating : 4.5/5 (276 download)

DOWNLOAD NOW!

Book Synopsis Evolutionary Methods in Biotechnology by : Susanne Brakmann

Download or read book Evolutionary Methods in Biotechnology written by Susanne Brakmann and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Miniturization and high throughput assay technology have brought the power of molecular evolution to the bioscience laboratory. Applied wisely, the evolutionary approach can quickly yield the desired result even where other methods have failed. From library generation by random or directed mutagenesis to screening and selection techniques -- the crucial steps for successful evolutionary biotechnology are described in detail in this practical guide that also includes valuable troubleshooting hints on frequently encountered problems. Modern methods for the surface display of peptides and proteins, selective enrichment of nucleic acid aptamers and high-throughput screening of industrial biocatalysts are explained, and computer-based methods for in silico protein and RNA engineering are described as an alternative to in vitro approaches. A special section covers the patenting regulations with regard to biotechnological innovations derived from directed evolution. As an added bonus, a CD-ROM is included that contains software tools for library design, selection of mutagenesis positions, and various predictive algorithms. In short, this practice oriented handbook is an indispensable tool for every scientist working in this interdisciplinary research area.

Recent Developments In Theoretical Studies Of Proteins

Author : Ron Elber
Publisher : World Scientific
ISBN 13 : 9814500720
Total Pages : 411 pages
Book Rating : 4.8/5 (145 download)

DOWNLOAD NOW!

Book Synopsis Recent Developments In Theoretical Studies Of Proteins by : Ron Elber

Download or read book Recent Developments In Theoretical Studies Of Proteins written by Ron Elber and published by World Scientific. This book was released on 1996-10-16 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts provide a unique and broad perspective of the theoretical tools available today to analyze protein structure and function. Topics at the frontier of computational biophysics, such as dynamics and thermodynamics of proteins, reaction path studies, optimization techniques, analytical theories of protein folding, sequence alignment algorithms and electrostatics of proteins are discussed in a pedagogical and complete way. Those entering the field will find the book to be a useful introduction. It will also serve as a complementary text to existing ones that focus on just one of the above subjects.

Deterministic Chaos in General Relativity

Author : David Hobill
Publisher : Springer Science & Business Media
ISBN 13 : 1475799934
Total Pages : 472 pages
Book Rating : 4.4/5 (757 download)

DOWNLOAD NOW!

Book Synopsis Deterministic Chaos in General Relativity by : David Hobill

Download or read book Deterministic Chaos in General Relativity written by David Hobill and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonlinear dynamical systems play an important role in a number of disciplines. The physical, biological, economic and even sociological worlds are comprised of com plex nonlinear systems that cannot be broken down into the behavior of their con stituents and then reassembled to form the whole. The lack of a superposition principle in such systems has challenged researchers to use a variety of analytic and numerical methods in attempts to understand the interesting nonlinear interactions that occur in the World around us. General relativity is a nonlinear dynamical theory par excellence. Only recently has the nonlinear evolution of the gravitational field described by the theory been tackled through the use of methods used in other disciplines to study the importance of time dependent nonlinearities. The complexity of the equations of general relativity has been (and still remains) a major hurdle in the formulation of concrete mathematical concepts. In the past the imposition of a high degree of symmetry has allowed the construction of exact solutions to the Einstein equations. However, most of those solutions are nonphysical and of those that do have a physical significance, many are often highly idealized or time independent.

Radionuclide Peptide Cancer Therapy

Author : Marco Chinol
Publisher : CRC Press
ISBN 13 : 1000611574
Total Pages : 382 pages
Book Rating : 4.0/5 (6 download)

DOWNLOAD NOW!

Book Synopsis Radionuclide Peptide Cancer Therapy by : Marco Chinol

Download or read book Radionuclide Peptide Cancer Therapy written by Marco Chinol and published by CRC Press. This book was released on 2016-04-19 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering lower toxicity and higher accuracy than conventional therapies, this source offers illustrative coverage of this new method to treat tumors associated with brain, breast, lung, and neuroendocrine cancers. Accompanied by a CD offering color images, radiolabeling procedures, and tips on radiopharmceutical administration, this source will off