Stanford Studies In The Medical Sciences

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Discovering Precision Health

Author : Lloyd Minor
Publisher : John Wiley & Sons
ISBN 13 : 1119672740
Total Pages : 277 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Discovering Precision Health by : Lloyd Minor

Download or read book Discovering Precision Health written by Lloyd Minor and published by John Wiley & Sons. This book was released on 2020-01-23 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today we are on the brink of a much-needed transformative moment for health care. The U.S. health care system is designed to be reactive instead of preventive. The result is diagnoses that are too late and outcomes that are far worse than our level of spending should deliver. In recent years, U.S. life expectancy has been declining. Fundamental to realizing better health, and a more effective health care system, is advancing the disruptive thinking that has spawned innovation in Silicon Valley and throughout the world. That's exactly what Stanford Medicine has done by proposing a new vision for health and health care. In Discovering Precision Health, Lloyd Minor and Matthew Rees describe a holistic approach that will set health care on the right track: keep people healthy by preventing disease before it starts and personalize the treatment of individuals precisely, based on their specific profile. With descriptions of the pioneering work undertaken at Stanford Medicine, complemented by fascinating case studies of innovations from entities including the Chan Zuckerberg Biohub, GRAIL, and Impossible Foods, Minor and Rees present a dynamic vision for the future of individual health and health care. Youll see how tools from smartphone technology to genome sequencing to routine blood tests are helping avert illness and promote health. And you'll learn about the promising progress already underway in bringing greater precision to the process of predicting, preventing, and treating a range of conditions, including allergies, mental illness, preterm birth, cancer, stroke, and autism. The book highlights how biomedical advances are dramatically improving our ability to treat and cure complex diseases, while emphasizing the need to devote more attention to social, behavioral, and environmental factors that are often the primary determinants of health. The authors explore thought-provoking topics including: The unlikely role of Google Glass in treating autism How gene editing can advance precision in treating disease What medicine can learn from aviation liHow digital tools can contribute to health and innovation Discovering Precision Health showcases entirely new ways of thinking about health and health care and can help empower us to lead healthier lives.

Essentials of Clinical Research

Author : Stephen P. Glasser
Publisher : Springer
ISBN 13 : 3319054708
Total Pages : 462 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Essentials of Clinical Research by : Stephen P. Glasser

Download or read book Essentials of Clinical Research written by Stephen P. Glasser and published by Springer. This book was released on 2014-06-02 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: In its extensively revised and updated Second Edition, this book provides a solid foundation for readers interested in clinical research. Discussion encompasses genetic, pharmacoepidemiologic and implementation research. All chapters have been updated with new information and many new tables have been added to elucidate key points. The book now offers discussion on how to handle missing data when analyzing results, and coverage of Adaptive Designs and Effectiveness Designs and new sections on Comparative Effectiveness Research and Pragmatic Trials. Chapter 6 includes new material on Phase 0 Trials, expanded coverage of Futility Trials, a discussion of Medical Device approval, Off Label Drug use and the role of the FDA in regulating advertising. Additional new information includes the role of pill color and shape in association with the placebo effect and an examination of issues surrounding minority recruitment. The final chapter offers a new section on manuscript preparation along with a discussion of various guidelines being adopted by journals: CONSORT, STROBE, PRISMA, MOOSE and others; and coverage of Conflicts of Interest, Authorship, Coercive Citation, and Disclosures in Industry-Related Associations. Building on the strengths of its predecessor in its comprehensive approach and authoritative advice, the new edition offers more of what has made this book a popular, trusted resource for students and working researchers alike.

Special Treatment

Author : Anna Ruddock
Publisher : Stanford University Press
ISBN 13 : 1503628264
Total Pages : 334 pages
Book Rating : 4.5/5 (36 download)

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Book Synopsis Special Treatment by : Anna Ruddock

Download or read book Special Treatment written by Anna Ruddock and published by Stanford University Press. This book was released on 2021-07-06 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: The All India Institute of Medical Sciences (AIIMS) is iconic in the landscape of Indian healthcare. Established in the early years of independence, this enormous public teaching hospital rapidly gained fame for the high-quality treatment it offered at a nominal cost; at present, an average of ten thousand patients pass through the outpatient department each day. With its notorious medical program acceptance rate of less than 0.01%, AIIMS also sits at the apex of Indian medical education. To be trained as a doctor here is to be considered the best. In what way does this enduring reputation of excellence shape the institution's ethos? How does elite medical education sustain India's social hierarchies and the health inequalities entrenched within? In the first-ever ethnography of AIIMS, Anna Ruddock considers prestige as a byproduct of norms attached to ambition, aspiration, caste, and class in modern India, and illustrates how the institution's reputation affects its students' present experiences and future career choices. Ruddock untangles the threads of intellectual exceptionalism, social and power stratification, and health inequality that are woven into the health care taught and provided at AIIMS, asking what is lost when medicine is used not as a social equalizer but as a means to cultivate and maintain prestige.

The Puzzle Solver

Author : Tracie White
Publisher : Legacy Lit
ISBN 13 : 0316492493
Total Pages : 240 pages
Book Rating : 4.3/5 (164 download)

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Book Synopsis The Puzzle Solver by : Tracie White

Download or read book The Puzzle Solver written by Tracie White and published by Legacy Lit. This book was released on 2021-01-05 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Father, His Son, and an Unrelenting Quest for a Cure At the age of twenty-seven, Whitney Dafoe was forced to give up his life as a photographer who traveled the world. Bit by bit a mysterious illness stole away the pieces of his life: First, it took the strength of his legs, then his voice, and his ability to eat. Finally, even the sound of a footstep in his room became unbearable. The Puzzle Solver follows several years in which he desperately sought answers from specialist after specialist, where at one point his 6'3" frame dropped to 115 lbs. For years, he underwent endless medical tests, but doctors told him there was nothing wrong. Then, finally, a diagnosis: Chronic Fatigue Syndrome, also known as myalgic encephalomyelitis. In the 80s, when an outbreak of people immobilized by an indescribable fatigue were reported near Lake Tahoe, Nevada, doctors were at a loss to explain the symptoms. The condition would alternatively be nicknamed Raggedy Ann Syndrome or the Yuppie Disease, and there was no cure or answers about treatment. They were to remain sick. But there was one answer: Whitney's father, Ron Davis, PhD, a world-class geneticist at Stanford University whose legendary research helped crack the code of DNA, suddenly changed the course of his career in a race against time to cure his son's debilitating condition. In The Puzzle Solver, journalist Tracie White, who first wrote a viral and award-winning piece on Davis and his family in Stanford Medicine, tells his story. In gripping prose, she masterfully takes readers along on this journey with Davis to solve one of the greatest mysteries in medicine. In a piercing investigative narrative, closed doors are opened, and masked truths are exposed as Davis uncovers new proof confirming that Chronic Fatigue Syndrome is a biological disease. At the heart of this book is a moving story that goes far beyond medicine, this is a story about how the power of love -- and science -- can shine light in even the darkest, most hidden, corners of the world.

Biodesign

Author : Stefanos Zenios
Publisher : Cambridge University Press
ISBN 13 : 0521517427
Total Pages : 779 pages
Book Rating : 4.5/5 (215 download)

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Book Synopsis Biodesign by : Stefanos Zenios

Download or read book Biodesign written by Stefanos Zenios and published by Cambridge University Press. This book was released on 2010 with total page 779 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognize market opportunities, master the design process, and develop business acumen with this 'how-to' guide to medical technology innovation. Outlining a systematic, proven approach for innovation - identify, invent, implement - and integrating medical, engineering, and business challenges with real-world case studies, this book provides a practical guide for students and professionals.

Genomics and Personalized Medicine

Author : Michael Snyder
Publisher : Oxford University Press
ISBN 13 : 0190234784
Total Pages : 185 pages
Book Rating : 4.1/5 (92 download)

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Book Synopsis Genomics and Personalized Medicine by : Michael Snyder

Download or read book Genomics and Personalized Medicine written by Michael Snyder and published by Oxford University Press. This book was released on 2016-02-09 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2001 the Human Genome Project succeeded in mapping the DNA of humans. This landmark accomplishment launched the field of genomics, the integrated study of all the genes in the human body and the related biomedical interventions that can be tailored to benefit a person's health. Today genomics, part of a larger movement toward personalized medicine, is poised to revolutionize health care. By cross-referencing an individual's genetic sequence -- their genome -- against known elements of "Big Data," elements of genomics are already being incorporated on a widespread basis, including prenatal disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside, the promise of the genomics revolution is limitless. This entry in the What Everyone Needs to Know series offers an authoritative resource on the prospects and realities of genomics and personalized medicine. As this science continues to alter traditional medical paradigms, consumers are faced with additional options and more complicated decisions regarding their health care. This book provides the essential information everyone needs.

Taking Action Against Clinician Burnout

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309495474
Total Pages : 335 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Taking Action Against Clinician Burnout by : National Academies of Sciences, Engineering, and Medicine

Download or read book Taking Action Against Clinician Burnout written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-01-02 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patient-centered, high-quality health care relies on the well-being, health, and safety of health care clinicians. However, alarmingly high rates of clinician burnout in the United States are detrimental to the quality of care being provided, harmful to individuals in the workforce, and costly. It is important to take a systemic approach to address burnout that focuses on the structure, organization, and culture of health care. Taking Action Against Clinician Burnout: A Systems Approach to Professional Well-Being builds upon two groundbreaking reports from the past twenty years, To Err Is Human: Building a Safer Health System and Crossing the Quality Chasm: A New Health System for the 21st Century, which both called attention to the issues around patient safety and quality of care. This report explores the extent, consequences, and contributing factors of clinician burnout and provides a framework for a systems approach to clinician burnout and professional well-being, a research agenda to advance clinician well-being, and recommendations for the field.

The End of Food Allergy

Author : Kari Nadeau MD, PhD
Publisher : Penguin
ISBN 13 : 0593189523
Total Pages : 354 pages
Book Rating : 4.5/5 (931 download)

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Book Synopsis The End of Food Allergy by : Kari Nadeau MD, PhD

Download or read book The End of Food Allergy written by Kari Nadeau MD, PhD and published by Penguin. This book was released on 2020-09-29 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: A life-changing, research-based program that will end food allergies in children and adults forever. The problem of food allergy is exploding around us. But this book offers the first glimpse of hope with a powerful message: You can work with your family and your doctor to eliminate your food allergy forever. The trailblazing research of Dr. Kari Nadeau at Stanford University reveals that food allergy is not a life sentence, because the immune system can be retrained. Food allergies--from mild hives to life-threatening airway constriction--can be disrupted, slowed, and stopped. The key is a strategy called immunotherapy (IT)--the controlled, gradual reintroduction of an allergen into the body. With innovations that include state-of-the-art therapies targeting specific components of the immune system, Dr. Nadeau and her team have increased the speed and effectiveness of this treatment to a matter of months. New York Times bestselling author Sloan Barnett, the mother of two children with food allergies, provides a lay perspective that helps make Dr. Nadeau's research accessible for everyone. Together, they walk readers through every aspect of food allergy, including how to find the right treatment and how to manage the ongoing fear of allergens that haunts so many sufferers, to give us a clear, supportive plan to combat a major national and global health issue.

The Pathway to Publishing: A Guide to Quantitative Writing in the Health Sciences

Author : Stephen Luby
Publisher : Springer Nature
ISBN 13 : 3030981754
Total Pages : 188 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis The Pathway to Publishing: A Guide to Quantitative Writing in the Health Sciences by : Stephen Luby

Download or read book The Pathway to Publishing: A Guide to Quantitative Writing in the Health Sciences written by Stephen Luby and published by Springer Nature. This book was released on 2022-05-30 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Writing manuscripts is central to the advance of scientific knowledge. For an early career aspiring scientist, writing first author manuscripts is an opportunity to develop critical skills and to credential their expertise. Writing manuscripts, however, is difficult, doubly so for scientists who use English as a second language. Many science students intentionally avoid a writing-intensive curriculum. Careful, thorough reviews of draft manuscripts are difficult to secure, and experienced scientific supervisors face more demands on their time than they have time available. Weak draft manuscripts discourage supervising scientists investing the time to coach revisions. It is easier for experienced scientists to ignore the request, or to simply rewrite the article. Early career scientists are motivated to address these barriers but specific advice is difficult to find, and much of this advice is behind a pay wall. This essential, open access text presents writing lessons organized as common errors, providing students and early-career researchers with an efficient way to learn, and mentors with a quick-reference guide to reviewing. Error descriptions include specific examples drawn from real-world experiences of other early-career writers, and suggestions for how to successfully address and avoid these in the future. Versions of this book have been used by Stanford University, UC Davis, Johns Hopkins, and numerous international institutions and organizations for over a decade.

The Genome Odyssey

Author : Dr. Euan Angus Ashley
Publisher : Celadon Books
ISBN 13 : 1250234972
Total Pages : 221 pages
Book Rating : 4.2/5 (52 download)

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Book Synopsis The Genome Odyssey by : Dr. Euan Angus Ashley

Download or read book The Genome Odyssey written by Dr. Euan Angus Ashley and published by Celadon Books. This book was released on 2021-02-23 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: In The Genome Odyssey, Dr. Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease. Since the Human Genome Project was completed in 2003, the price of genome sequencing has dropped at a staggering rate. It’s as if the price of a Ferrari went from $350,000 to a mere forty cents. Through breakthroughs made by Dr. Ashley’s team at Stanford and other dedicated groups around the world, analyzing the human genome has decreased from a heroic multibillion dollar effort to a single clinical test costing less than $1,000. For the first time we have within our grasp the ability to predict our genetic future, to diagnose and prevent disease before it begins, and to decode what it really means to be human. In The Genome Odyssey, Dr. Ashley details the medicine behind genome sequencing with clarity and accessibility. More than that, with passion for his subject and compassion for his patients, he introduces readers to the dynamic group of researchers and doctor detectives who hunt for answers, and to the pioneering patients who open up their lives to the medical community during their search for diagnoses and cures. He describes how he led the team that was the first to analyze and interpret a complete human genome, how they broke genome speed records to diagnose and treat a newborn baby girl whose heart stopped five times on the first day of her life, and how they found a boy with tumors growing inside his heart and traced the cause to a missing piece of his genome. These patients inspire Dr. Ashley and his team as they work to expand the boundaries of our medical capabilities and to envision a future where genome sequencing is available for all, where medicine can be tailored to treat specific diseases and to decode pathogens like viruses at the genomic level, and where our medical system as we know it has been completely revolutionized.

Ethnogeriatrics

Author : Lenise Cummings-Vaughn
Publisher : Springer
ISBN 13 : 3319165585
Total Pages : 261 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Ethnogeriatrics by : Lenise Cummings-Vaughn

Download or read book Ethnogeriatrics written by Lenise Cummings-Vaughn and published by Springer. This book was released on 2016-10-05 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is divided into five parts and fifteen chapters that address these topics by examining ethnogeriatric foundations, research issues, clinical care in ethnogeriatrics, education and policy. Expertly written chapters, by practicing geriatricians, gerontologists, clinician researchers and clinician educators, present a systematic approach to recognizing, analyzing and addressing the challenges of meeting the healthcare needs of a diverse population and authors discuss ways in which to engage the community by increasing research participation and by investigating the most prevalent diseases found in ethnic minorities. Ethnogeriatrics discusses issues related to working with culturally diverse elders that tend not to be addressed in typical training curricula and is essential reading for geriatricians, hospitalists, advance practice nurses, social workers and others who are part of a multidisciplinary team that provides high quality care to older patients.

Divine Variations

Author : Terence Keel
Publisher : Stanford University Press
ISBN 13 : 1503604373
Total Pages : 246 pages
Book Rating : 4.5/5 (36 download)

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Book Synopsis Divine Variations by : Terence Keel

Download or read book Divine Variations written by Terence Keel and published by Stanford University Press. This book was released on 2018-01-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Divine Variations offers a new account of the development of scientific ideas about race. Focusing on the production of scientific knowledge over the last three centuries, Terence Keel uncovers the persistent links between pre-modern Christian thought and contemporary scientific perceptions of human difference. He argues that, instead of a rupture between religion and modern biology on the question of human origins, modern scientific theories of race are, in fact, an extension of Christian intellectual history. Keel's study draws on ancient and early modern theological texts and biblical commentaries, works in Christian natural philosophy, seminal studies in ethnology and early social science, debates within twentieth-century public health research, and recent genetic analysis of population differences and ancient human DNA. From these sources, Keel demonstrates that Christian ideas about creation, ancestry, and universalism helped form the basis of modern scientific accounts of human diversity—despite the ostensible shift in modern biology towards scientific naturalism, objectivity, and value neutrality. By showing the connections between Christian thought and scientific racial thinking, this book calls into question the notion that science and religion are mutually exclusive intellectual domains and proposes that the advance of modern science did not follow a linear process of secularization.

What Every Science Student Should Know

Author : Justin L. Bauer
Publisher : University of Chicago Press
ISBN 13 : 022619888X
Total Pages : 296 pages
Book Rating : 4.2/5 (261 download)

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Book Synopsis What Every Science Student Should Know by : Justin L. Bauer

Download or read book What Every Science Student Should Know written by Justin L. Bauer and published by University of Chicago Press. This book was released on 2016-05-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2012, the White House put out a call to increase the number of STEM graduates by one million. Since then, hundreds of thousands of science students have started down the path toward a STEM career. Yet, of these budding scientists, more than half of all college students planning to study science or medicine leave the field during their academic careers. This guide is the perfect personal mentor for any aspiring scientist. Like an experienced lab partner or frank advisor, the book points out the pitfalls while providing encouragement. Chapters cover the entire college experience, including choosing a major, mastering study skills, doing scientific research, finding a job, and, most important, how to foster and keep a love of science.

Ethics for Health Professionals

Author : Carla Caldwell Stanford
Publisher : Jones & Bartlett Publishers
ISBN 13 : 1449678327
Total Pages : 228 pages
Book Rating : 4.4/5 (496 download)

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Book Synopsis Ethics for Health Professionals by : Carla Caldwell Stanford

Download or read book Ethics for Health Professionals written by Carla Caldwell Stanford and published by Jones & Bartlett Publishers. This book was released on 2014 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ethics for Health Professionals provides a foundational understanding of ethics for healthcare students and clinicians. With a conversational tone and features within each chapter that add to its appeal including quotes, interesting facts, case studies, and more, this indispensable text offers an enjoyable, eased reading style while supplying information that can be practically and easily put into practice once the student enters the field. Many ideals can also be carried over to one's personal life in terms of ethical principles and decision making. Pedagogical features include chapter objectives, boxed articles, quotes, case studies, key terms, chapter summary, assessment review questions. Website links are also included for additional reference. Students will learn basic information while develop a meaningful understanding of ethics, its importance and application in the world of health sciences. CONTENTS * Overview of the history of ethics * Blanchard and Peale's 3-step model * Ecological Model * Approaches to ethics * Applying ethics to the health care professional * Patient Care Partnership * Vulnerable Populations * Confidentiality * The Medical Record * Patients' rights under HIPAA and privacy standards * Ethics and the Workplace * Liability and Health Care * Matters of Life and Death Ethics for Health Professionals also covers additional contemporary topics in health care including: * Integrity in Research (Including conflict of interest and Institutional Review Boards) * Central Electronic Medical Record Registry * Stem Cell Research * Euthanasia, Abortion, Assisted Suicide * How to Choose a Reliable Website for Information Gathering

Jaws

Author : Sandra Kahn
Publisher : Stanford University Press
ISBN 13 : 1503606465
Total Pages : 267 pages
Book Rating : 4.5/5 (36 download)

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Book Synopsis Jaws by : Sandra Kahn

Download or read book Jaws written by Sandra Kahn and published by Stanford University Press. This book was released on 2018-04-10 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: There's a silent epidemic in western civilization, and it is right under our noses. Our jaws are getting smaller and our teeth crooked and crowded, creating not only aesthetic challenges but also difficulties with breathing. Modern orthodontics has persuaded us that braces and oral devices can correct these problems. While teeth can certainly be straightened, what about the underlying causes of this rapid shift in oral evolution and the health risks posed by obstructed airways? Sandra Kahn and Paul R. Ehrlich, a pioneering orthodontist and a world-renowned evolutionist, respectively, present the biological, dietary, and cultural changes that have driven us toward this major health challenge. They propose simple adjustments that can alleviate this developing crisis, as well as a major alternative to orthodontics that promises more significant long-term relief. Jaws will change your life. Every parent should read this book.

Ethics and the Business of Bioscience

Author : Margaret L. Eaton
Publisher : Stanford University Press
ISBN 13 : 9780804742504
Total Pages : 556 pages
Book Rating : 4.7/5 (425 download)

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Book Synopsis Ethics and the Business of Bioscience by : Margaret L. Eaton

Download or read book Ethics and the Business of Bioscience written by Margaret L. Eaton and published by Stanford University Press. This book was released on 2004 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Businesses that produce bioscience productsgene tests and therapies, pharmaceuticals, vaccines, and medical devicesare regularly confronted with ethical issues concerning these technologies. Conflicts exist between those who support advancements in bioscience and those who fear the consequences of unfettered scientific license. As the debate surrounding bioscience grows, it will be increasingly important for business managers to consider the larger consequences of their work. This groundbreaking book follows industry research, development, and marketing of medical and bioscience products across a variety of fields, including biotechnology, pharmaceuticals, and bio-agriculture. Compelling and current case studies highlight the ethical decisions business managers frequently face. With the increasing visibility and public expectation placed on businesses in this sector, managers need to understand the ethical and social issues. This book addresses that need and provides a framework for incorporating ethical analysis in business decision making.

The Fountain of Knowledge

Author : Shiri M. Breznitz
Publisher : Stanford University Press
ISBN 13 : 0804791929
Total Pages : 200 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis The Fountain of Knowledge by : Shiri M. Breznitz

Download or read book The Fountain of Knowledge written by Shiri M. Breznitz and published by Stanford University Press. This book was released on 2014-07-30 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today, universities around the world find themselves going beyond the traditional roles of research and teaching to drive the development of local economies through collaborations with industry. At a time when regions with universities are seeking best practices among their peers, Shiri M. Breznitz argues against the notion that one university's successful technology transfer model can be easily transported to another. Rather, the impact that a university can have on its local economy must be understood in terms of its idiosyncratic internal mechanisms, as well as the state and regional markets within which it operates. To illustrate her argument, Breznitz undertakes a comparative analysis of two universities, Yale and Cambridge, and the different outcomes of their attempts at technology commercialization in biotech. By contrasting these two universities—their unique policies, organizational structure, institutional culture, and location within distinct national polities—she makes a powerful case for the idea that technology transfer is dependent on highly variable historical and environmental factors. Breznitz highlights key features to weigh and engage in developing future university and economic development policies that are tailor-made for their contexts.