Standing Operating Procedures For Developing Acute Exposure Guideline Levels For Hazardous Chemicals

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Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309170869
Total Pages : 224 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals by : National Research Council

Download or read book Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals written by National Research Council and published by National Academies Press. This book was released on 2001-05-25 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals contains a detailed and comprehensive methodology for developing acute exposure guideline levels (AEGLs) for toxic substances from inhalation exposures. The book provides guidance on what documents and databases to use, toxicity endpoints that need to be evaluated, dosimetry corrections from animal to human exposures, selection of appropriate uncertainty factors to address the variability between animals and humans and within the human population, selection of modifying factors to address data deficiencies, time scaling, and quantitative cancer risk assessment. It also contains an example of a summary of a technical support document and an example of AEGL derivation. This book will be useful to persons in the derivation of levels from other exposure routesâ€"both oral and dermalâ€"as well as risk assessors in the government, academe, and private industry.

Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030907553X
Total Pages : 225 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals by : National Research Council

Download or read book Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals written by National Research Council and published by National Academies Press. This book was released on 2001-06-25 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals contains a detailed and comprehensive methodology for developing acute exposure guideline levels (AEGLs) for toxic substances from inhalation exposures. The book provides guidance on what documents and databases to use, toxicity endpoints that need to be evaluated, dosimetry corrections from animal to human exposures, selection of appropriate uncertainty factors to address the variability between animals and humans and within the human population, selection of modifying factors to address data deficiencies, time scaling, and quantitative cancer risk assessment. It also contains an example of a summary of a technical support document and an example of AEGL derivation. This book will be useful to persons in the derivation of levels from other exposure routesâ€"both oral and dermalâ€"as well as risk assessors in the government, academe, and private industry.

Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309263905
Total Pages : 20 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels by : National Research Council

Download or read book Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels written by National Research Council and published by National Academies Press. This book was released on 2012-01-01 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1991, the Environmental Protection Agency (EPA) and the Agency for Toxic Substances and Disease Registry (ATSDR) asked the National Research Council (NRC) to provide technical guidance for establishing community emergency exposure levels for extremely hazardous substances (EHSs) pursuant to the Superfund Amendments and Reauthorization Act of 1986. In response to that request, the NRC published Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances in 1993. Subsequently, Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Substances was published in 2001; it provided updated procedures, methods, and other guidelines used by the National Advisory Committee (NAC) on Acute Exposure Guideline Levels (AEGLs) for hazardous substances for assessing acute adverse health effects. Using both these reports, the NAC-consisting of members from the EPA, the Department of Defense (DOD), the Department of Energy (DOE), the Department of Transportation (DOT), other federal and state governments, the chemical industry, academia, and other organizations from the private sector-developed AEGLs for approximately 270 EHSs. In 1998, EPA and DOD requested that the NRC independently review the AEGLs developed by NAC. In response to that request, the NRC organized within its Committee on Toxicology the Committee on Acute Exposure Guideline Levels, which prepared this report. This report, Twenty-First Interim Report of the Committee on Acute Exposure Guideline Levels: Part B, summarizes the committee's conclusions and recommendations for improving AEGL documents for several chemicals and chemical classes not mentioned in Twenty-First Interim Report of the Committee on Acute Exposure Guideline Levels: Part A.

Twenty-second Interim Report of the Committee on Acute Exposure Guideline Levels

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309290600
Total Pages : 57 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Twenty-second Interim Report of the Committee on Acute Exposure Guideline Levels by : National Research Council

Download or read book Twenty-second Interim Report of the Committee on Acute Exposure Guideline Levels written by National Research Council and published by National Academies Press. This book was released on 2013-08-05 with total page 57 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1991, the Environmental Protection Agency (EPA) and the Agency for Toxic Substances and Disease Registry (ATSDR) asked the National Research Council (NRC) to provide technical guidance for establishing community emergency exposure levels for extremely hazardous substances (EHSs) pursuant to the Superfund Amendments and Reauthorization Act of 1986. As a result the NRC published Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances in 1993 and Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Substances in 2001; providing updated procedures, methods, and other guidelines used by the National Advisory Committee (NAC) on Acute Exposure Guideline Levels (AEGLs) for hazardous substances for assessing acute adverse health effects. Stemming from this report the NAC has developed AEGLs for at least 270 EHSs. There are currently three AEGLs: AEGL-1, AEGL-2, and AEGL-3. AEGL-1 is the airborne concentration of a substance above which it is predicted that the general population could experience notable discomfort, irritation, or certain asymptomatic nonsensory effects. These effects are not disabling and are transient and reversible once exposure is stopped. AEGL-2 is the airborne concentration (of a substance above which it is predicted that the general population could experience irreversible, long-lasting adverse health effects or an impaired ability to escape. AEGL-3 is the airborne concentration of a substance above which it is predicted that the general population could experience life threatening health effects or death. On April 22-24 2013, the NRC-established Committee on Acute Exposure Guideline Levels 2013 met to review AEGL documents approved by the NAC. The committee members were selected for their expertise in toxicology, medicine, industrial hygiene, biostatistics, and risk assessment. Twenty-second Interim Report of the Committee on Acute Exposure Guideline Levels presents a review of AEGLs for various chemicals including acrylonitrile, halogen fluorides, tellurium hexafluoride, and thionyl chloride.

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309283086
Total Pages : 291 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Acute Exposure Guideline Levels for Selected Airborne Chemicals by : National Research Council

Download or read book Acute Exposure Guideline Levels for Selected Airborne Chemicals written by National Research Council and published by National Academies Press. This book was released on 2013-05-26 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extremely hazardous substances (EHSs) can be released accidentally as a result of result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where EHSs are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents. As part of its efforts to develop acute exposure guideline levels for EHSs, EPA and the Agency for Toxic Substances and Disease Registry (ATSDR) in 1991 requested that the National Research Council (NRC) develop guidelines for establishing such levels. In response to that request, the NRC published Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances in 1993. Subsequently, Standard Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Substances was published in 2001, providing updated procedures, methodologies, and other guidelines used by the National Advisory Committee (NAC) on Acute Exposure Guideline Levels for Hazardous Substances and the Committee on Acute Exposure Guideline Levels (AEGLs) in developing the AEGL values. Using the 1993 and 2001 NRC guidelines reports, the NAC-consisting of members from EPA, the Department of Defense (DOD), the Department of Energy (DOE), the Department of Transportation (DOT), other federal and state governments, the chemical industry, academia, and other organizations from the private sector-has developed AEGLs for more than 270 EHSs. In 1998, EPA and DOD requested that the NRC independently review the AEGLs developed by NAC. In response to that request, the NRC organized within its Committee on Toxicology (COT) the Committee on Acute Exposure Guideline Levels, which prepared this report. This report is the fourteenth volume in that series. Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 14 summarizes the committee's conclusions and recommendations.

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309219876
Total Pages : 322 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Acute Exposure Guideline Levels for Selected Airborne Chemicals by : National Research Council

Download or read book Acute Exposure Guideline Levels for Selected Airborne Chemicals written by National Research Council and published by National Academies Press. This book was released on 2011-10-28 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extremely hazardous substances (EHSs)² can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where EHSs are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents. As part of its efforts to develop acute exposure guideline levels for EHSs, EPA and the Agency for Toxic Substances and Disease Registry (ATSDR) in 1991 requested that the National Research Council (NRC) develop guidelines for establishing such levels. In response to that request, the NRC published Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances in 1993. Subsequently, Standard Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Substances was published in 2001, providing updated procedures, methodologies, and other guidelines used by the National Advisory Committee (NAC) on Acute Exposure Guideline Levels for Hazardous Substances and the Committee on Acute Exposure Guideline Levels (AEGLs) in developing the AEGL values. In 1998, EPA and DOD requested that the NRC independently review the AEGLs developed by NAC. In response to that request, the NRC organized within its Committee on Toxicology (COT) the Committee on Acute Exposure Guideline Levels, which prepared this report. Acute Exposure Guideline Levels for Selected Airborne Chemicals is the tenth volume of the series and documents for N,N-dimethylformamide, jet propellant fuels 5 and 8, methyl ethyl ketone, perchloromethyl mercaptan, phosphorus oxychloride, phosphorus trichloride, and sulfuryl chloride.

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309368979
Total Pages : 224 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Acute Exposure Guideline Levels for Selected Airborne Chemicals by : National Research Council

Download or read book Acute Exposure Guideline Levels for Selected Airborne Chemicals written by National Research Council and published by National Academies Press. This book was released on 2015-04-09 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extremely hazardous substances can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where these substances are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents. Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 19 identifies, reviews, and interprets relevant toxicologic and other scientific data for selected AEGL documents for cyanide salts, diketene, methacrylaldehyde, pentaborane, tellurium hexafluoride, and tetrafluoroethylene in order to develop acute exposure guideline levels (AEGLs) for these high-priority, acutely toxic chemicals. AEGLs represent threshold exposure limits (exposure levels below which adverse health effects are not likely to occur) for the general public and are applicable to emergency exposures ranging from 10 minutes (min) to 8 h. Three levels - AEGL-1, AEGL-2, and AEGL-3 - are developed for each of five exposure periods (10 min, 30 min, 1 h, 4 h, and 8 h) and are distinguished by varying degrees of severity of toxic effects. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites.

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309449154
Total Pages : 195 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Acute Exposure Guideline Levels for Selected Airborne Chemicals by : National Academies of Sciences, Engineering, and Medicine

Download or read book Acute Exposure Guideline Levels for Selected Airborne Chemicals written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-10-26 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extremely hazardous substances can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where these substances are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents. Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 20 reviews and updates the technical support document on acute exposure guideline levels (AEGLs) for selected chloroformates. This update focuses on establishing AEGL-3 values for n-propyl chloroformate and isopropyl chloroformate, but will also consider whether any new data are available that would affect the proposed values for the other 10 chloroformates. AEGLs represent threshold exposure limits (exposure levels below which adverse health effects are not likely to occur) for the general public and are applicable to emergency exposures ranging from 10 minutes (min) to 8 h. Three levels - AEGL-1, AEGL-2, and AEGL-3 - are developed for each of five exposure periods (10 min, 30 min, 1 h, 4 h, and 8 h) and are distinguished by varying degrees of severity of toxic effects. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites.

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030915233X
Total Pages : 465 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Acute Exposure Guideline Levels for Selected Airborne Chemicals by : National Research Council

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309182700
Total Pages : 292 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Acute Exposure Guideline Levels for Selected Airborne Chemicals by : National Research Council

Nineteenth Interim Report of the Committee on Acute Exposure Guideline Levels

Author : Committee on Acute Exposure Guideline Levels
Publisher : National Academies Press
ISBN 13 : 0309187621
Total Pages : 218 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Nineteenth Interim Report of the Committee on Acute Exposure Guideline Levels by : Committee on Acute Exposure Guideline Levels

Download or read book Nineteenth Interim Report of the Committee on Acute Exposure Guideline Levels written by Committee on Acute Exposure Guideline Levels and published by National Academies Press. This book was released on 2011-01-27 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present report is the committee's 19th interim report. It summarizes the committee's conclusions and recommendations for improving NAC's AEGL documents for the following chemicals and chemical classes: acrylonitrile, benzonitrile, boron tribromide, BZ (3-quinuclidinyl benzilate), chloroarsenicals, chloroformates, bis-chloromethylether, chloromethylether, chlorosilanes (26 selected compounds), cyanogen, ethyl mercaptan, hexafluoroacetone, lewisites, mercury vapor, nitric acid, nitric oxide, nitrogen dioxide, nitrogen tetroxide, oleum, phenyl mercaptan, propargyl alcohol, selenium hexafluoride, silane, sulfer trioxide, sulfuric acid, tear gas, tert-octyl mercaptan, tetramethoxy silane, thionyl chloride, trimethoxysilane, trimethylbenzenes (1,2,4-; 1,2,5-;and 1,3,5-TMB), and vinyl chloride.

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309291259
Total Pages : 245 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Acute Exposure Guideline Levels for Selected Airborne Chemicals by : National Research Council

Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (817 download)

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Book Synopsis Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels by :

Download or read book Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels written by and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 20

Author : National Research Council (U.S.). Committee on Acute Exposure Guideline Levels
Publisher :
ISBN 13 :
Total Pages : 234 pages
Book Rating : 4.:/5 (18 download)

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Book Synopsis Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 20 by : National Research Council (U.S.). Committee on Acute Exposure Guideline Levels

Download or read book Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 20 written by National Research Council (U.S.). Committee on Acute Exposure Guideline Levels and published by . This book was released on with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309290252
Total Pages : 293 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Acute Exposure Guideline Levels for Selected Airborne Chemicals by : National Research Council

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030917774X
Total Pages : 320 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Acute Exposure Guideline Levels for Selected Airborne Chemicals by : National Research Council

Twenty-second Interim Report of the Committee on Acute Exposure Guideline Levels

Author :
Publisher :
ISBN 13 : 9780309290579
Total Pages : 44 pages
Book Rating : 4.2/5 (95 download)

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Book Synopsis Twenty-second Interim Report of the Committee on Acute Exposure Guideline Levels by :

Download or read book Twenty-second Interim Report of the Committee on Acute Exposure Guideline Levels written by and published by . This book was released on 2013 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1991, the Environmental Protection Agency (EPA) and the Agency for Toxic Substances and Disease Registry (ATSDR) asked the National Research Council (NRC) to provide technical guidance for establishing community emergency exposure levels for extremely hazardous substances (EHSs) pursuant to the Superfund Amendments and Reauthorization Act of 1986. As a result the NRC published Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances in 1993 and Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Substances in 2001; providing updated procedures, methods, and other guidelines used by the National Advisory Committee (NAC) on Acute Exposure Guideline Levels (AEGLs) for hazardous substances for assessing acute adverse health effects. Stemming from this report the NAC has developed AEGLs for at least 270 EHSs. There are currently three AEGLs: AEGL-1, AEGL-2, and AEGL-3. AEGL-1 is the airborne concentration of a substance above which it is predicted that the general population could experience notable discomfort, irritation, or certain asymptomatic nonsensory effects. These effects are not disabling and are transient and reversible once exposure is stopped. AEGL-2 is the airborne concentration (of a substance above which it is predicted that the general population could experience irreversible, long-lasting adverse health effects or an impaired ability to escape. AEGL-3 is the airborne concentration of a substance above which it is predicted that the general population could experience life threatening health effects or death. On April 22-24 2013, the NRC-established Committee on Acute Exposure Guideline Levels 2013 met to review AEGL documents approved by the NAC. The committee members were selected for their expertise in toxicology, medicine, industrial hygiene, biostatistics, and risk assessment. Twenty-second Interim Report of the Committee on Acute Exposure Guideline Levels presents a review of AEGLs for various chemicals including acrylonitrile, halogen fluorides, tellurium hexafluoride, and thionyl chloride.