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Specificity In Biological Interactions
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Book Synopsis Specificity in Biological Interactions by : A. Pullman
Download or read book Specificity in Biological Interactions written by A. Pullman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of a Working Group at the Pontifical Academy of Sciences, November 9-11, 1983
Book Synopsis Specificity in Biological Interactions by : Carols Chagas
Download or read book Specificity in Biological Interactions written by Carols Chagas and published by . This book was released on 1984 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemical Specificity in Biological Interactions by : Frank R. N. Gurd
Download or read book Chemical Specificity in Biological Interactions written by Frank R. N. Gurd and published by . This book was released on 1954 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemical Specificity in Biological Interactions by :
Download or read book Chemical Specificity in Biological Interactions written by and published by . This book was released on 1954 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Working Group on Specificity in Biological Interactions (1983, Roma) Publisher : ISBN 13 : Total Pages :318 pages Book Rating :4.:/5 (157 download)
Book Synopsis Working Group on Specificity in Biological Interactions by : Working Group on Specificity in Biological Interactions (1983, Roma)
Download or read book Working Group on Specificity in Biological Interactions written by Working Group on Specificity in Biological Interactions (1983, Roma) and published by . This book was released on 1984 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Working Group on Specificity in Biological Interactions by : Carlos Chagas
Download or read book Working Group on Specificity in Biological Interactions written by Carlos Chagas and published by . This book was released on 1984 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Specificity in Biological Interactions by : C. Chagas
Download or read book Specificity in Biological Interactions written by C. Chagas and published by . This book was released on 1984 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Specific Interaction and Biological Recognition Processes by : Zeno Simon
Download or read book Specific Interaction and Biological Recognition Processes written by Zeno Simon and published by CRC Press. This book was released on 1993-06-16 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specific Interaction and Biological Recognition Processes is devoted to two major aspects of biological processes: specificity in biological recognition and the recognition processes themselves. Topics covered in specificity include the theoretical basis for specificity in biological recognition; the thermodynamic and chemical equilibrium background; and consideration of the relationship between size of combining sites and specificity. The use of semi-emperical potentials for calculating interaction energies and the potential of quantum chemistry methods for calculating receptor-effector affinities are also discussed. The various recognition processes described include DNA replication, transcription, translation, enzymatic reactions, transmembrane transport processes, mechanisms of action of hormones and other chemical messengers, and self-nonself recognition in immunology. Specific Interaction and Biological Recognition Processes will be a useful reference for molecular biologists, biochemists, enzymologists, immunologists oncologists, pharmaceutical researchers, and others interested in the topic.
Book Synopsis Essentials of Glycobiology by : Ajit Varki
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Book Synopsis Molecular Structure and Biological Specificity by : Linus Pauling
Download or read book Molecular Structure and Biological Specificity written by Linus Pauling and published by . This book was released on 1957 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Specificity in Protein-Protein Interactions: High-Throughput Characterization of Rationally Designed and Naturally Evolved Coiled-Coil Networks by : William Clifford Boldridge
Download or read book Specificity in Protein-Protein Interactions: High-Throughput Characterization of Rationally Designed and Naturally Evolved Coiled-Coil Networks written by William Clifford Boldridge and published by . This book was released on 2021 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the major effectors of cellular processes, proteins are crucial to all biology. Although proteins are regulated in many fashions, protein-protein interactions are ubiquitous across different classes of proteins. In particular, proteins must interact specifically with certain partners to recapitulate the biology that constitutes life, despite cells containing hundreds of thousands of proteoforms, some fraction of which are highly similar to the intended target. Understanding how specificity in protein-protein interactions occurs has been challenging to investigate because prior techniques were limited to in throughput and ability to pinpoint sequences of interest. We create a high-throughput two-hybrid assay that marries gene synthesis with a next-generation sequencing readout, allowing us to investigate only those interactions of interest with a single experiment providing a quantitative characterization of tens of thousands of interactions. We use this to first to investigate specificity in designed coiled-coils--small alpha-helical proteins which despite a simple hydrophobic interface exhibit high a high-degree of specificity. After validating our assay on a previously published set of coiled-coils, we iteratively find increasingly large sets of orthogonal proteins, proteins where each on-target interaction is specifically preferred to all off-target interactions. In total we screen more than 26,000 interactions in three experiments, and use our data and improve coiled-coil design algorithms while also finding the largest sets of orthogonal proteins to date. While specificity can be designed with large changes to the protein sequence, nature must come by specificity through the slow tinkering of evolution. To investigate the origins of specificity in nature we characterized a bZip family descended from an ancestral homodimer where the extant paralogs do not heterodimerize. We use ancestral reconstruction to trace protein-protein interactions in the coiled-coil domain across the PAR and E4BP4 family, back to the ancestor of humans and cnidarians. We find specificity does not appear once, but rather eight times across our tree, and while the process begins immediately, the final acquisition of specificity takes substantial time. Finally we find that once interactions are lost they never return, and that there is no direct selection for the acquisition of specificity between paralogs.
Book Synopsis Quantum Biochemistry and Specific Interactions by : Zeno Simon
Download or read book Quantum Biochemistry and Specific Interactions written by Zeno Simon and published by Taylor & Francis. This book was released on 1976 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 2004. Routledge is an imprint of Taylor & Francis, an informa company.
Book Synopsis Molecular Basis of Specificity in Nucleic Acid-Drug Interactions by : A. Pullman
Download or read book Molecular Basis of Specificity in Nucleic Acid-Drug Interactions written by A. Pullman and published by Springer. This book was released on 2012-10-29 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the central problems in the study of the mechanism of DNA-ligand interactions is the existence and nature of sequence specificity with respect to the base pairs of DNA. The presence of such a specificity could be of particular significance because it might possibly mean the involvement of specific genes in the effectiveness of the different drugs. The elucidation of the factors responsible for the specificity could then be important for the development of compounds susceptible to contribute to the control of gene expression and also to the development of rationally conceived, improved new generations of effective and specific chemotherapeutic agents. Important recent achievements, experimental and theoretical, in the analysis of such sequence specificities open prospects for possible rapid progress in this field. The 23rd Jerusalem symposium was devoted to the exploration of these recent achievements in relation to many types of ligand, with special emphasis on antitumor drugs. All major types of interaction, intercalation, groove binding, covalent linking, coordination, have been considered. So was also the effect of the interaction on the structure and properties of the nucleic acids and the relationship between the interaction and biological or pharmacological activities. We feel that this Volume presents a relatively complete up-to-date account of the state of the art in this important field of research.
Book Synopsis Computational Systems Biology by : Andres Kriete
Download or read book Computational Systems Biology written by Andres Kriete and published by Academic Press. This book was released on 2013-11-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. - Logical information flow aids understanding of basic building blocks of life through disease phenotypes - Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns - Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation - Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.
Book Synopsis Specificity of Embryological Interactions by : D. R. Garrod
Download or read book Specificity of Embryological Interactions written by D. R. Garrod and published by . This book was released on 2014-09-01 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fuzziness written by Monika Fuxreiter and published by Springer Science & Business Media. This book was released on 2012-03-07 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.
