Special Issue On Diabetes Mellitus And Its Complications From Molecular Biology To Clinical Medicine

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Molecular Biology of Diabetes

Author : Boris Draznin
Publisher : Springer Science & Business Media
ISBN 13 : 1461202418
Total Pages : 411 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Molecular Biology of Diabetes by : Boris Draznin

Download or read book Molecular Biology of Diabetes written by Boris Draznin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a rapidly evolving and extremely important area of medical science, it is often difficult for the student, teacher, and researcher to keep abreast of all the important advances. The purpose of Molecular Biology ofDiabetes, Parts I and II is to bring to these individuals the latest knowledge of diabetes-related research in a comprehensive, yet concise manner. To this end, we have assembled chapters, written by most of the world's experts in the field, that we believe compre hensively survey and synthesize a coherent understanding of the subject. Studies of the etiology of type I and type II diabetes are extremely exciting and essential, since we hope to one day prevent the disease using gene therapy. These aspects are covered in Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion. In type II diabetes, an abnormality in pancreatic secretion exists concomitantly with peripheral insulin resistance. This abnor mality of insulin secretion is believed to be related to a defect(s) in glucose sensing. Uncoupling of glucose sensing from insulin secre tion may be the crucial step in the pathogenesis of noninsulin-depen dent diabetes. In this volume, we have invited authors to describe their studies on all known factors affecting ~-cell function, including autoimmunity and genetics of diabetes, as well as molecular mecha nisms of insulin synthesis and secretion. In the last few years, the most rapidly advancing area of research in diabetes has been, in fact, related to insulin action.

Dietary Intake and Type 2 Diabetes

Author : Omorogieva Ojo
Publisher : MDPI
ISBN 13 : 3039217046
Total Pages : 322 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Dietary Intake and Type 2 Diabetes by : Omorogieva Ojo

Download or read book Dietary Intake and Type 2 Diabetes written by Omorogieva Ojo and published by MDPI. This book was released on 2019-12-05 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prevalence of diabetes is on the increase in the UK and worldwide, partly due to changes in lifestyle which predispose individuals to overweight and obesity. It is estimated that about 90% of the currently diagnosed adults have type 2 diabetes, and based on the World Health Organisation (WHO) report, about 422 million adults were living with diabetes in 2014 compared with 108 million in 1980; this condition caused about 1.5 million deaths in 2012. In the United States of America, it is estimated that about 30.3 million adults are living with diabetes, with a further 1.5 million new diabetes cases diagnosed every year, representing an increasing prevalence of this condition. Diabetes represents a major public health challenge, despite advances in technology and the pharmaceutical industry. These problems may be in the form of acute or long-term complications. Therefore, in order to attenuate the problems of diabetes, management strategies usually include lifestyle changes such as increased physical activity and dietary interventions. Studies which evaluate the role of nutrition in the management of type 2 diabetes often involve human and animal models as these approaches enable us to have a broader and more in-depth understanding of the condition. In some cases, diabetes may co-exist with other conditions, such as stroke, and these may present unique challenges with regard to nutritional interventions. This Special Issue aims to evaluate the risk factors associated with type 2 diabetes and the role of the diet in the management of people with this condition. This evidence is drawn from both human and animal studies.

Fundus Autofluorescence

Author : Noemi Lois
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451152809
Total Pages : 303 pages
Book Rating : 4.4/5 (511 download)

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Book Synopsis Fundus Autofluorescence by : Noemi Lois

Download or read book Fundus Autofluorescence written by Noemi Lois and published by Lippincott Williams & Wilkins. This book was released on 2012-02-13 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring over 250 illustrations, this detailed full-color textbook provides up-to-date information on the use of fundus autofluorescence imaging in evaluation of retinal disease. Chapters describe the techniques available to image and quantify fundus autofluorescence and the autofluorescence patterns observed in the healthy eye and in various retinal diseases. Emphasis is on the value of fundus autofluorescence as a diagnostic and prognostic tool and its clinical utility in the context of other imaging techniques, such as fluorescein and indocyanine green angiography and optical coherence tomography. Each chapter also discusses the value of fundus autofluorescence in understanding the pathogenesis of the condition, and provides a comprehensive update on all aspects of the condition. A companion Website will offer the fully searchable text and an image bank.

Diabetes Mellitus

Author : Derek LeRoith
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781740975
Total Pages : 1608 pages
Book Rating : 4.7/5 (49 download)

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Book Synopsis Diabetes Mellitus by : Derek LeRoith

Download or read book Diabetes Mellitus written by Derek LeRoith and published by Lippincott Williams & Wilkins. This book was released on 2004 with total page 1608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updated, this Third Edition encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus. Chapters by leading experts integrate the latest basic science and clinical research on diabetes mellitus and its complications. The text is divided into ten major sections, including extensive sections on therapeutics, diabetes during pregnancy, and complications. New chapters cover stem cell therapy for type 1 diabetes; genetics and treatment of obesity; new therapies to promote insulin action; vasculopathy; islet cell protocols; triglycerides in muscle; hypoglycemia in the adult; and the Diabetes Prevention Program.

International Textbook of Diabetes Mellitus

Author : R. A. DeFronzo
Publisher : John Wiley & Sons
ISBN 13 : 1118387678
Total Pages : 1200 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis International Textbook of Diabetes Mellitus by : R. A. DeFronzo

Download or read book International Textbook of Diabetes Mellitus written by R. A. DeFronzo and published by John Wiley & Sons. This book was released on 2015-03-11 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.

Medical Management of Diabetes Mellitus

Author : William T. Cefalu
Publisher : CRC Press
ISBN 13 : 9781420001631
Total Pages : 776 pages
Book Rating : 4.0/5 (16 download)

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Book Synopsis Medical Management of Diabetes Mellitus by : William T. Cefalu

Download or read book Medical Management of Diabetes Mellitus written by William T. Cefalu and published by CRC Press. This book was released on 2000-02-17 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a how-to manual for practicing physicians and health care providers, nurse educators, nutritionists, and physicians in training in the management of persons with diabetes mellitus. Experts with strong clinical and teaching backgrounds provide up-to-date recom-mendations and rationale of the most effective diagnostic and therapeutic approaches to diabetes mellitus and its multiorgan micro- and macrovascular complications for patients of all ages.Gives five practical guidelines for nutrition therapy that supplies realistic recommendations!With contributions from nearly 60 clinicians who reveal a constellation of disorders with different signs, symptoms, clinical characteristics, and therapies, Medical Management of Diabetes Mellitusreviews the autoimmune process and genetics of type 1 and type 2 diabetes offers an overview of the medications that impair glucose metabolism causing hypo- or hyperglycemia covers pathogenesis, clinical presentation, and diagnosis with specialized laboratory tests surveys therapeutic modalities, their mechanisms of action, and rationale for use focuses on outcomes and how they are tracked stresses early detection and therapy of end-organ complications discusses the effect of intensive diabetes management on reducing retinopathy, nephropathy, and neuropathy considers incorporating psychiatric techniques into the treatment of diabetes compares and contrasts diabetes in children, adults, and the elderly and more!Containing over 850 references, tables, drawings, and photographs, Medical Management of Diabetes Mellitus is a cross-disciplinary reference perfect for family practice physicians, internists, pediatricians, endocrinologists, pharmacologists, nutritionists, physiologists, dietitians, obesity specialists, psychiatrists, and medical school students in these disciplines.

Toward Precision Medicine

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309222222
Total Pages : 142 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Toward Precision Medicine by : National Research Council

Download or read book Toward Precision Medicine written by National Research Council and published by National Academies Press. This book was released on 2012-01-16 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Diabetes

Author : Shamim I. Ahmad
Publisher : Springer Science & Business Media
ISBN 13 : 1461454417
Total Pages : 515 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Diabetes by : Shamim I. Ahmad

Download or read book Diabetes written by Shamim I. Ahmad and published by Springer Science & Business Media. This book was released on 2013-04-12 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes is a complex disease and is also one of the most common. It is very difficult to reach an accurate estimate for the global prevalence of diabetes since the standards and methods of data collection vary widely in different parts of the world. In addition, many potential sufferers are not included in the count because according to an estimate about 50% of cases remain undiagnosed for up to 10 years. However, according to an estimate for 2010, globally, there are about 285 million people (amounting to 6.4% of the adult population) suffering from this disease. This number is estimated to increase to 439 million by 2030 if no cure is found. The general increase in life expectancy, leading to an ageing population, and the global rise in obesity are two main reasons for the increase. With the basic platform set, Editor presents his views and advice to the readers, especially to diabetic patients suffering from T2DM, on the basis of his observations and information collected from other diabetics.

Diabetes and Cardiovascular Disease

Author : Thomas D. Giles
Publisher :
ISBN 13 : 9780970478801
Total Pages : 182 pages
Book Rating : 4.4/5 (788 download)

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Book Synopsis Diabetes and Cardiovascular Disease by : Thomas D. Giles

Download or read book Diabetes and Cardiovascular Disease written by Thomas D. Giles and published by . This book was released on 2000-10 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Machine Learning and Data Mining

Author : Igor Kononenko
Publisher : Horwood Publishing
ISBN 13 : 9781904275213
Total Pages : 484 pages
Book Rating : 4.2/5 (752 download)

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Book Synopsis Machine Learning and Data Mining by : Igor Kononenko

Download or read book Machine Learning and Data Mining written by Igor Kononenko and published by Horwood Publishing. This book was released on 2007-04-30 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Good data mining practice for business intelligence (the art of turning raw software into meaningful information) is demonstrated by the many new techniques and developments in the conversion of fresh scientific discovery into widely accessible software solutions. Written as an introduction to the main issues associated with the basics of machine learning and the algorithms used in data mining, this text is suitable foradvanced undergraduates, postgraduates and tutors in a wide area of computer science and technology, as well as researchers looking to adapt various algorithms for particular data mining tasks. A valuable addition to libraries and bookshelves of the many companies who are using the principles of data mining to effectively deliver solid business and industry solutions.

Mitochondrial Dysfunction

Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Current Topics in Diabetes Research

Author : Francesco Belfiore
Publisher :
ISBN 13 :
Total Pages : 306 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Current Topics in Diabetes Research by : Francesco Belfiore

Download or read book Current Topics in Diabetes Research written by Francesco Belfiore and published by . This book was released on 1993 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Features up-to-date reviews of the most advanced clinical methods currently being used to evaluate the metabolic and biological alterations accompanying diabetic disease. Additionally, the volume analyzes the complex plurimetabolic syndrome, commonly known as syndrome X.

Diabetes and Obesity in Women

Author : E. Albert Reece
Publisher : LWW
ISBN 13 : 9781496390547
Total Pages : 0 pages
Book Rating : 4.3/5 (95 download)

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Book Synopsis Diabetes and Obesity in Women by : E. Albert Reece

Download or read book Diabetes and Obesity in Women written by E. Albert Reece and published by LWW. This book was released on 2018-09-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Originally published as Diabetes in Women, this comprehensive text on diagnosing, preventing, and treating diabetes in women performed well initially before interest petered out and customers began turning away from expensive single-topic books"--

Adipose Tissue and Inflammation

Author : Atif B. Awad
Publisher : CRC Press
ISBN 13 : 142009131X
Total Pages : 318 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Adipose Tissue and Inflammation by : Atif B. Awad

Download or read book Adipose Tissue and Inflammation written by Atif B. Awad and published by CRC Press. This book was released on 2009-10-08 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: The American Obesity Association identifies obesity's link to numerous medical conditions, including hypertension, type 2 diabetes, cardiovascular disease, several cancers, and a host of inflammatory disorders. Evidence indicates that inflammation has more than a corollary relation with obesity; that in fact, obesity itself manifests a low-grade, m

Textbook of Diabetes

Author : Richard I. G. Holt
Publisher : John Wiley & Sons
ISBN 13 : 1118912020
Total Pages : 1104 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Textbook of Diabetes by : Richard I. G. Holt

Download or read book Textbook of Diabetes written by Richard I. G. Holt and published by John Wiley & Sons. This book was released on 2017-03-06 with total page 1104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its fifth edition, the Textbook of Diabetes has established itself as the modern, well-illustrated, international guide to diabetes. Sensibly organized and easy to navigate, with exceptional illustrations, the Textbook hosts an unrivalled blend of clinical and scientific content. Highly-experienced editors from across the globe assemble an outstanding set of international contributors who provide insight on new developments in diabetes care and information on the latest treatment modalities used around the world. The fifth edition features an array of brand new chapters, on topics including: Ischaemic Heart Disease Glucagon in Islet Regulation Microbiome and Diabetes Diabetes and Non-Alcoholic Fatty Liver Disease Diabetes and Cancer End of Life Care in Diabetes as well as a new section on Psychosocial aspects of diabetes. In addition, all existing chapters are fully revised with the very latest developments, including the most recent guidelines from the ADA, EASD, DUK and NICE. Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates Via the companion website, readers can access a host of additional online materials such as: 200 interactive MCQ's to allow readers to self-assess their clinical knowledge every figure from the book, available to download into presentations fully searchable chapter pdfs Once again, Textbook of Diabetes provides endocrinologists and diabetologists with a fresh, comprehensive and multi-media clinical resource to consult time and time again.

Animal Models in Diabetes Research

Author : Hans-Georg Joost
Publisher : Humana Press
ISBN 13 : 9781627030670
Total Pages : 0 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Animal Models in Diabetes Research by : Hans-Georg Joost

Download or read book Animal Models in Diabetes Research written by Hans-Georg Joost and published by Humana Press. This book was released on 2012-08-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, human studies have made enormous contributions towards an understanding of the genetic basis of diabetes mellitus; however, most of the experimentation needed for the invention and testing of novel therapeutic approaches cannot be performed in humans. Thus, there is no alternative to appropriate animal models. In Animal Models in Diabetes Research, expert researchers explore the current status of the most important models and procedures in order to provide a timely resource in experimental diabetology. The first half of the volume serves as a comprehensive overview on our current knowledge of the pathogenesis and pathophysiology of diabetes in animal models through a series of reviews in model strains. The book then continues with vital, established protocols that are employed in the characterization and study of animal models of diabetes. As a volume in the highly successful Methods in Molecular BiologyTM series, this work contains the type of detailed description and key implementation advice necessary to achieve successful results. Authoritative and cutting-edge, Animal Models in Diabetes Research delivers essential content that will be an important resource to advance diabetes research in the years to come.

Beyond the Molecular Frontier

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309168392
Total Pages : 238 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Beyond the Molecular Frontier by : National Research Council

Download or read book Beyond the Molecular Frontier written by National Research Council and published by National Academies Press. This book was released on 2003-03-19 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.