Space Pharmacology

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Publisher : Springer Science & Business Media
ISBN 13 : 1461433959
Total Pages : 119 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Space Pharmacology by : Virginia E. Wotring

Download or read book Space Pharmacology written by Virginia E. Wotring and published by Springer Science & Business Media. This book was released on 2012-03-18 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Space Pharmacology” is a review of the current knowledge regarding the use of pharmaceuticals during spaceflights. It is a comprehensive review of the literature, addressing each area of pharmacokinetics and each major physiological system in turn. Every section begins with a topic overview, and is followed by a discussion of published data from spaceflight, and from ground experiments meant to model the spaceflight situation. Includes a discussion looking forward to the new medical challenges we are likely to face on longer duration exploration missions. This book is a snapshot of our current knowledge that also highlights areas of unknown.

Handbook of Space Pharmaceuticals

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Publisher : Springer
ISBN 13 : 9783030055271
Total Pages : 0 pages
Book Rating : 4.0/5 (552 download)

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Book Synopsis Handbook of Space Pharmaceuticals by : Yashwant Pathak

Download or read book Handbook of Space Pharmaceuticals written by Yashwant Pathak and published by Springer. This book was released on 2022-05-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume handbook, directed at medical professionals and students who are involved in developing the space industry or are academicians doing research in this area, covers current pharmaceutical knowledge about the difference in medication efficacy in space versus on Earth and includes trial results and best practices for the space research and travel industry. The well-known contributors come from an interdisciplinary background and address all aspects of the subject, from the physiological impact of spaceflight to the effects of radiation. As the commercial space industry expands its operations in industry and tourism, the field of space pharmaceuticals is growing commensurately. Existing pharmacological research from space is thoroughly covered in this book, and Earth applications are also described. Potential pharmacological solutions are posed along with the known challenges and examples from existing studies, which are detailed at length. This major reference work is a comprehensive and important medical resource for all space industry players.

Space Physiology and Medicine

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Publisher :
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.:/5 (317 download)

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Book Synopsis Space Physiology and Medicine by : Arnauld E. Nicogossian

Download or read book Space Physiology and Medicine written by Arnauld E. Nicogossian and published by . This book was released on 1982 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: 2009 life science book award from IAA.

Handbook of Space Pharmaceuticals

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Publisher : Springer
ISBN 13 : 9783030055257
Total Pages : 0 pages
Book Rating : 4.0/5 (552 download)

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Book Synopsis Handbook of Space Pharmaceuticals by : Yashwant V. Pathak

Download or read book Handbook of Space Pharmaceuticals written by Yashwant V. Pathak and published by Springer. This book was released on 2022-04-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook, directed at medical professionals and students who are involved in developing the space industry or are academicians doing research in this area, covers current pharmaceutical knowledge about the difference in medication efficacy in space versus on Earth and includes trial results and best practices for the space research and travel industry. The well-known contributors come from an interdisciplinary background and address all aspects of the subject, from the physiological impact of spaceflight to the effects of radiation. As the commercial space industry expands its operations in industry and tourism, the field of space pharmaceuticals is growing commensurately. Existing pharmacological research from space is thoroughly covered in this book, and Earth applications are also described. Potential pharmacological solutions are posed along with the known challenges and examples from existing studies, which are detailed at length. This major reference work is a comprehensive and important medical resource for all space industry players.

Human Health and Performance Risks of Space Exploration Missions

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Publisher : U. S. National Aeronautics & Space Administration
ISBN 13 :
Total Pages : 396 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Human Health and Performance Risks of Space Exploration Missions by : Jancy C. McPhee

Download or read book Human Health and Performance Risks of Space Exploration Missions written by Jancy C. McPhee and published by U. S. National Aeronautics & Space Administration. This book was released on 2009 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Foundations of Space Biology and Medicine: Space medicine and biotechnology

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Publisher :
ISBN 13 :
Total Pages : 426 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Foundations of Space Biology and Medicine: Space medicine and biotechnology by :

Download or read book Foundations of Space Biology and Medicine: Space medicine and biotechnology written by and published by . This book was released on 1975 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Space Biology and Medicine

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Publisher : Elsevier
ISBN 13 : 9780080877310
Total Pages : 250 pages
Book Rating : 4.8/5 (773 download)

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Book Synopsis Advances in Space Biology and Medicine by : S.L. Bonting

Download or read book Advances in Space Biology and Medicine written by S.L. Bonting and published by Elsevier. This book was released on 1999-12-20 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past several years there has been a shortage of flight opportunities for biological and medical projects. And those that were available usually had severe restrictions on instrumentation, number of subjects, duration, time allotted for performing the experiments, a possibility for repetition of experiments. It is our hope and expectation that this will change once the international Space Station is in full operation. The advantages of a permanent space station, already demonstrated by the Russian Mir station, are continuous availability of expert crew and a wide range of equipment, possibility of long-term experiments where this is waranted, increased numbers of subjects through larger laboratory space, proper controls in the large 1-G centrifuge, easier repeatability of experiments when needed. The limited number of flight opportunities during recent years probably explains why it has taken so long to acquire a sufficient number of high quality contributions for this seventh volume of Advances in Space Biology and Medicine. While initially the series wassailed at annually appearing volumes, we are now down to a biannual appearance. Hopefully, it will be possible to return to annual volumes in the future when results from space station experimentation at beginning to pour in. The first three chapters of this volume deal with muscle. Fejtek and Wassersug provide a survey of all studies on muscle of rodents flown in space, and include an interesting demography of this aspect of space research. Riley reviews our current knowledge of the effects of long-term spaceflight and re-entry on skeletal muscle, and considers the questions still to be answered before we can be satisfied that long-term space missions, such as on the space station, can be safely undertaken. Stein reviews our understanding of the nutritional and hormonal aspects of muscle loss in spaceflight, and concludes that the protein loss in space could be deleterious to health during flight and after return. Strollo summarizes our understanding of the major endocrine systems on the ground, then considers what we know about their functioning in space, concluding that there is much to be learned about the changes taking place during spaceflight. The many problems of providing life support (oxygen regeneration and food supply) during extended stay on the Moon, on Mars, or in space by means of plant cultivation are discussed by Salisbury. The challenges of utilizing electrophoresis in microgravity for the separation of cells and proteins are illustrated and explained by Bauer and colleagues. Finally, the chapter on teaching of space life sciences by Schmitt shows that this field of science has come of age, but also that its multidisciplinary character poses interesting challenges to teaching it.

Foundations of Space Biology and Medicine: Space as a habitat

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Publisher :
ISBN 13 :
Total Pages : 566 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Foundations of Space Biology and Medicine: Space as a habitat by :

Download or read book Foundations of Space Biology and Medicine: Space as a habitat written by and published by . This book was released on 1975 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Strategy for Research in Space Biology and Medicine Into the Next Century

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Publisher :
ISBN 13 :
Total Pages : 320 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis A Strategy for Research in Space Biology and Medicine Into the Next Century by : Committee on Space Biology and Medicine

Download or read book A Strategy for Research in Space Biology and Medicine Into the Next Century written by Committee on Space Biology and Medicine and published by . This book was released on 1998-09-22 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Committee on Space Biology and Medicine reviewed and updated prior reports to suggest strategies for research in space biology and medicine based on information gathered since 1987. The report provides a review of biology and medicine that can be studied in the space environment, discusses the fundamental research issues and questions with space biology and medicine disciplines, identifies the most promising experimental challenges in those disciplines, evaluates the potential for space research to provide advances within each discipline, and prioritizes research topics to the extent feasible. Disciplines include sciences which study plant, animal, and human systems at the molecular, cellular, system, and whole-organism levels. The section about physiology, gravity, and space includes cell biology; developmental biology; plants, gravity, and space; sensorimotor integration; bone physiology; skeletal muscle; cardiovascular and pulmonary systems; endocrinology; and immunology. The section about additional space environment issues includes radiation hazards and behavioral issues. The final section examines setting priorities in research and programmatic and policy issues.

Bioavailability and Pharmacodynamics of Promethazine on Long Duration Missions to the International Space Station

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Author :
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781720403364
Total Pages : 30 pages
Book Rating : 4.4/5 (33 download)

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Book Synopsis Bioavailability and Pharmacodynamics of Promethazine on Long Duration Missions to the International Space Station by : National Aeronautics and Space Administration (NASA)

Download or read book Bioavailability and Pharmacodynamics of Promethazine on Long Duration Missions to the International Space Station written by National Aeronautics and Space Administration (NASA) and published by Createspace Independent Publishing Platform. This book was released on 2018-05-29 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: Space motion sickness (SMS) is often treated in space with promethazine (PMZ). Common side effects of PMZ administration (50 mg intramuscular) on the ground are drowsiness and impaired cognitive performance. Anecdotal reports indicate that these effects are absent or less pronounced in space. This suggests that the availability of PMZ to the body (bioavailability) and/or the response of the body to PMZ (pharmacodynamics) may change during space flight. Opportunities for clinical research in space are limited. The study described here is our response to a NASA Research Announcement for proposals for flight-based research needed to improve, or answer specific questions about, diagnosis and therapy during space flight, and post-flight rehabilitation. We propose here to evaluate noninvasive methods for determining the bioavailability and pharmacodynamics of PMZ. The specific objectives of the proposed research are to 1) compare pharmacokinetic and pharmacodynamic parameters of PMZ, estimated from saliva and plasma levels after administration of PMZ, 2) estimate the relative bioavailability of the three dosage forms of PMZ that are often administered to control motion sickness symptoms in space, and 3) establish the dose-response relationship of PMZ. We will estimate the bioavailability of an intramuscular injection (IM), oral tablet, and rectal suppository of PMZ in noma1 subjects during ambulatory and antiorthostatic bed rest (ABR) conditions using novel stable isotope techniques. We will compare and contrast the bioavailability of PMZ during normal and microgravity conditions to examine changes in drug absorption and bioavailability during microgravit. Results of this study will validate methods for an approved in-flight investigation with this medication awaiting an opportunity for manifestation..Putcha, Lakshmi and Boyd, Jason L. and Cintron, Nitza and Berens, Kurt L.Johnson Space CenterAEROSPACE MEDICINE; DOSAGE; DRUGS; MOTION SICKNESS; SPACE ADAPTATION SYNDROME; I

Clinical pharmacology in space

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Publisher :
ISBN 13 :
Total Pages : 161 pages
Book Rating : 4.:/5 (17 download)

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Book Synopsis Clinical pharmacology in space by :

Download or read book Clinical pharmacology in space written by and published by . This book was released on 1991 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Principles of Clinical Medicine for Space Flight

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Publisher : Springer Science & Business Media
ISBN 13 : 0387681647
Total Pages : 592 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis Principles of Clinical Medicine for Space Flight by : Michael R. Barratt

Download or read book Principles of Clinical Medicine for Space Flight written by Michael R. Barratt and published by Springer Science & Business Media. This book was released on 2008-03-20 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the years, a large body of knowledge has developed regarding the ways in which space flight affects the health of the personnel involved. Now, for the first time, this clinical knowledge on how to diagnose and treat conditions that either develop during a mission or because of a mission has been compiled by Drs. Michael Barratt and Sam L. Pool of the NASA/Johnson Space Center. Complete with detailed information on the physiological and psychological affects of space flight as well as how to diagnose and treat everything from dental concerns to decompression to dermatological problems encountered, this text is a must have for all those associated with aerospace medicine.

Recapturing a Future for Space Exploration

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Publisher : National Academies Press
ISBN 13 : 0309163846
Total Pages : 464 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Recapturing a Future for Space Exploration by : National Research Council

Download or read book Recapturing a Future for Space Exploration written by National Research Council and published by National Academies Press. This book was released on 2012-01-30 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than four decades have passed since a human first set foot on the Moon. Great strides have been made in our understanding of what is required to support an enduring human presence in space, as evidenced by progressively more advanced orbiting human outposts, culminating in the current International Space Station (ISS). However, of the more than 500 humans who have so far ventured into space, most have gone only as far as near-Earth orbit, and none have traveled beyond the orbit of the Moon. Achieving humans' further progress into the solar system had proved far more difficult than imagined in the heady days of the Apollo missions, but the potential rewards remain substantial. During its more than 50-year history, NASA's success in human space exploration has depended on the agency's ability to effectively address a wide range of biomedical, engineering, physical science, and related obstacles-an achievement made possible by NASA's strong and productive commitments to life and physical sciences research for human space exploration, and by its use of human space exploration infrastructures for scientific discovery. The Committee for the Decadal Survey of Biological and Physical Sciences acknowledges the many achievements of NASA, which are all the more remarkable given budgetary challenges and changing directions within the agency. In the past decade, however, a consequence of those challenges has been a life and physical sciences research program that was dramatically reduced in both scale and scope, with the result that the agency is poorly positioned to take full advantage of the scientific opportunities offered by the now fully equipped and staffed ISS laboratory, or to effectively pursue the scientific research needed to support the development of advanced human exploration capabilities. Although its review has left it deeply concerned about the current state of NASA's life and physical sciences research, the Committee for the Decadal Survey on Biological and Physical Sciences in Space is nevertheless convinced that a focused science and engineering program can achieve successes that will bring the space community, the U.S. public, and policymakers to an understanding that we are ready for the next significant phase of human space exploration. The goal of this report is to lay out steps and develop a forward-looking portfolio of research that will provide the basis for recapturing the excitement and value of human spaceflight-thereby enabling the U.S. space program to deliver on new exploration initiatives that serve the nation, excite the public, and place the United States again at the forefront of space exploration for the global good.

Concepts in Biochemical Pharmacology

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Publisher : Springer Science & Business Media
ISBN 13 : 3642463142
Total Pages : 509 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Concepts in Biochemical Pharmacology by : P.S. Randall

Download or read book Concepts in Biochemical Pharmacology written by P.S. Randall and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part 3 of the Handbook of Experimental Pharmacology (Concepts in Biochem ical Pharmacology) applies the principles enunciated in Parts 1 and 2 to clinical pharmacology and toxicology. The major objective is to elucidate the many factors that determine the relationships between pharmacokinetic aspects of the disposition and metabolism of drugs and their therapeutic or toxic actions in man. Because of the more restricted information obtainable in human studies, this volume reflects the editors' bias that an understanding of pharmacokinetics is fundamental for assessing pharmacologic or toxicologic effects of drugs in humans. The first chapter is a unique primer on when to apply and how to use pharmaco kinetic tools in human pharmacology. The second chapter explains the general assumptions underlying pharmacokinetic approaches both in simple terms for the novice and in mathematical form for the more sophisticated reader. Several chapters on determinants of drug concentration and activity discuss drug absorption, drug latentiation, drugs acting through metabolites, entero hepatic drug circulation, influence of route of drug administration on response, genetic variations in drug disposition and response, age differences in absorption, distribution and excretion of drugs, and pathologic and physiologic factors affecting absorption, distribution and excretion of drugs and drug response. The focus of these chapters is data obtained in human, rather than animal, studies. Most of the chapters contain new material never summarized previously.

Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2012 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1481645625
Total Pages : 619 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2012 Edition by :

Download or read book Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2013-01-10 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Molecular Pharmacology. The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Molecular Pharmacology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Improving and Accelerating Therapeutic Development for Nervous System Disorders

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Publisher : National Academies Press
ISBN 13 : 0309292492
Total Pages : 107 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Improving and Accelerating Therapeutic Development for Nervous System Disorders by : Institute of Medicine

Download or read book Improving and Accelerating Therapeutic Development for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2014-02-06 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

NASA Technical Translation

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Publisher :
ISBN 13 :
Total Pages : 842 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis NASA Technical Translation by :

Download or read book NASA Technical Translation written by and published by . This book was released on 1970 with total page 842 pages. Available in PDF, EPUB and Kindle. Book excerpt: