Solid Phase Synthesis Of Self Assembling Multivalent Pi Conjugated Peptides

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Solid-phase Synthesis of Self-assembling Multivalent [pi]-conjugated Peptides

Author :
Publisher :
ISBN 13 :
Total Pages : 11 pages
Book Rating : 4.:/5 (982 download)

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Book Synopsis Solid-phase Synthesis of Self-assembling Multivalent [pi]-conjugated Peptides by :

Download or read book Solid-phase Synthesis of Self-assembling Multivalent [pi]-conjugated Peptides written by and published by . This book was released on 2017 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here, we present a completely solid-phase synthetic strategy to create three- and four-fold peptide-appended [pi]-electron molecules, where the multivalent oligopeptide presentation is dictated by the symmetries of reactive handles placed on discotic [pi]-conjugated cores. Carboxylic acid and anhydride groups were viable amidation and imidation partners, respectively, and oligomeric [pi]-electron discotic cores were prepared through Pd-catalyzed cross-couplings. Due to intermolecular hydrogen bonding between the three or four peptide axes, these [pi]-peptide hybrids self-assemble into robust one-dimensional nanostructures with high aspect ratios in aqueous solution. The preparation of these systems via solid-phase methods will be detailed along with their self-assembly properties, as revealed by steady-state spectroscopy and transmission electron microscopy and electrical characterization using field-effect transistor measurements.

Peptide Self-Assembly and Engineering

Author : Xuehai Yan
Publisher : John Wiley & Sons
ISBN 13 : 3527841253
Total Pages : 933 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Peptide Self-Assembly and Engineering by : Xuehai Yan

Download or read book Peptide Self-Assembly and Engineering written by Xuehai Yan and published by John Wiley & Sons. This book was released on 2024-02-09 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Self-Assembly and Engineering State-of-the-art research in peptide self-assembly, with coverage of fundamental aspects of how peptides self-assemble and an extensive number of applications Peptide Self-Assembly and Engineering: Fundamentals, Structures, and Applications (2V set) covers the latest progresses in the field of peptide self-assembly and engineering, including the fundamental principles of peptide self-assembly, new theory of nucleation and growth, thermodynamics and kinetics, materials design rules, and precisely controlled structures and unique functions. The broad contents from this book enable readers to obtain a systematical and comprehensive knowledge in the field of peptide self-assembly and engineering. Contributed by the leading scientists and edited by a highly qualified academic and an authority in the field, Peptide Self-Assembly and Engineering includes information on: Emerging areas in peptide assembly, such as immune agents, bioelectronics, energy conversion, flexible sensors, biomimetic catalysis, and more Existing applications in biomedical engineering, nanotechnology, and photoelectronics, including tissue engineering, drug delivery, and biosensing devices History of peptide self-assembly for design of functional materials and peptides’ unique mechanical, optical, electronic, and biological properties Various solvent conditions, such as pH, ionic strength, and polarity, that can affect the structure and stability of peptide assemblies A very comprehensive reference covering the latest progresses in the field of peptide self-assembly and engineering, Peptide Self-Assembly and Engineering is an essential resource for all scientists performing research intersecting with the subject, including biochemists, biotechnologists, pharmaceutical chemists, protein chemists, materials scientists, and medicinal chemists.

Self-Assembly of Peptides, Peptoids, Sugars, & Dendrimers

Author : Martin Conda-Sheridan
Publisher : American Chemical Society
ISBN 13 : 0841299587
Total Pages : 242 pages
Book Rating : 4.8/5 (412 download)

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Book Synopsis Self-Assembly of Peptides, Peptoids, Sugars, & Dendrimers by : Martin Conda-Sheridan

Download or read book Self-Assembly of Peptides, Peptoids, Sugars, & Dendrimers written by Martin Conda-Sheridan and published by American Chemical Society. This book was released on 2023-07-05 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this primer is to discuss the chemistry of self-assembly. It introduces some of the common reactions you need to know to prepare a desired molecule that can self-assemble (or various molecules that can be mixed to create a self-assembled system). The focus is on four self-assembled systems composed of peptides, peptoids, sugars, and dendrimers.

Solid-Phase Synthesis

Author : Fernando Albericio
Publisher : CRC Press
ISBN 13 : 9780824703592
Total Pages : 852 pages
Book Rating : 4.7/5 (35 download)

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Book Synopsis Solid-Phase Synthesis by : Fernando Albericio

Download or read book Solid-Phase Synthesis written by Fernando Albericio and published by CRC Press. This book was released on 2000-04-28 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules.

Fmoc Solid Phase Peptide Synthesis

Author : W. Chan
Publisher : Oxford University Press
ISBN 13 : 019156589X
Total Pages : 371 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis Fmoc Solid Phase Peptide Synthesis by : W. Chan

Download or read book Fmoc Solid Phase Peptide Synthesis written by W. Chan and published by Oxford University Press. This book was released on 1999-12-16 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems at the time of publication of this earlier work have now for the most part, been solved. As a result, innovators in the field have focussed their efforts to develop methodologies and chemistry for the synthesis of more complex structures. The focus of this new volume is much broader, and covers the essential procedures for the production of linear peptides and more advanced techniques for preparing cyclic, side-chain modified, phospho- and glycopeptides. Many other methods also deserving attention have been included: convergent peptide synthesis; peptide-protein conjugation; chemoselective ligation; and chemoselective purification. The difficult preparation of cysteine and methionine-containing peptides is also covered, as well as methods for overcoming aggregation during peptide chain assembly. Many of the techniques developed for the production of large arrays of peptides by parallel synthesis, such as t-bag, SPOT and PIN synthesis, have naturally been included. Finally, a survey of available automated instrumentation has also been provided.

Studies in Solid Phase Peptide Synthesis and Self-assembly of Cyclic Peptides

Author : Katri Rosenthal-Aizman
Publisher :
ISBN 13 : 9789172657274
Total Pages : 65 pages
Book Rating : 4.6/5 (572 download)

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Book Synopsis Studies in Solid Phase Peptide Synthesis and Self-assembly of Cyclic Peptides by : Katri Rosenthal-Aizman

Download or read book Studies in Solid Phase Peptide Synthesis and Self-assembly of Cyclic Peptides written by Katri Rosenthal-Aizman and published by . This book was released on 2003 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Solid-Phase Peptide Synthesis

Author : Gregg B. Fields
Publisher : Academic Press
ISBN 13 :
Total Pages : 828 pages
Book Rating : 4.X/5 (4 download)

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Book Synopsis Solid-Phase Peptide Synthesis by : Gregg B. Fields

Download or read book Solid-Phase Peptide Synthesis written by Gregg B. Fields and published by Academic Press. This book was released on 1997-10-21 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volumehas been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 275 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchers in all fields of life sciences. Key Features * Solid-phase peptide synthesis * Applications of peptides for structural and biological studies * Characterization of synthetic peptides

Supramolecular Nanotechnology

Author : Omar Azzaroni
Publisher : John Wiley & Sons
ISBN 13 : 3527834052
Total Pages : 1801 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Supramolecular Nanotechnology by : Omar Azzaroni

Download or read book Supramolecular Nanotechnology written by Omar Azzaroni and published by John Wiley & Sons. This book was released on 2023-04-25 with total page 1801 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supramolecular Nanotechnology Provides up-to-date coverage of both current knowledge and new developments in the dynamic and interdisciplinary field of supramolecular nanotechnology In recent years, supramolecular nanotechnology has revolutionized research in chemistry, physics, and materials science. These easily manipulated molecular units enable the synthesis of novel nanomaterials for use in a wide range of current and potential applications including electronics, sensors, drug delivery, and imaging. Supramolecular Nanotechnology presents a state-of-the-art overview of functional self-assembling nanomaterials based on organic and polymeric molecules. Featuring contributions by an international panel of experts in the field, this comprehensive volume covers the design of self-assembled materials, their synthesis and diverse fabrication methods, the characterization of supramolecular architectures, and current and emerging applications in chemistry, biology, and medicine. Detailed chapters discuss the synthesis of peptide-based supramolecular structures and polymeric self-assembling materials, their characterization, advanced microscopy techniques, nanostructures made of porphyrins, polyelectrolytes, silica, their application in catalysis and cancer, atomistic and coarse-grained simulations, and more. Presents cutting-edge research on rationally designed, self-assembled supramolecular structures Discusses the impact of supramolecular nanotechnology on current and future research and technology Highlights applications of self-assembled supramolecular systems in catalysis, biomedical imaging, cancer therapies, and regenerative medicine Provides synthetic strategies for preparing the molecular assemblies and various characterization techniques for assessing the supramolecular morphology Describes theoretical modeling and simulation techniques for analyzing supramolecular nanostructures Supramolecular Nanotechnology: Advanced Design of Self-Assembled Functional Materials is essential reading for materials scientists and engineers, polymer and organic chemists, pharmaceutical scientists, molecular physicists and biologists, and chemical engineers.

De Novo Peptide Design

Author : Vibin Ramakrishnan
Publisher : Academic Press
ISBN 13 : 0323985432
Total Pages : 297 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis De Novo Peptide Design by : Vibin Ramakrishnan

Download or read book De Novo Peptide Design written by Vibin Ramakrishnan and published by Academic Press. This book was released on 2022-09-17 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: De novo Peptide Design: Principles and Applications presents the latest developments in the fields of therapeutic peptides and bio-nanotechnology. The title focuses on the design of peptides, particularly how peptides may be tailored to specific functions. It includes computational and experimental protocols to assist in the design of peptides. Sections cover the basics of protein and peptide structure, modeling and simulation, solid phase peptide synthesis, peptide-based antibiotics, drug delivery, peptide nanomaterials, aromatic interactions directing nano-assembly, protein/peptide aggregation, therapeutic interventions against protein/peptide aggregation diseases, peptide based hydrogels, computational tools and algorithms for peptide design, and experimental protocols in peptide chemistry. In addition, the book covers key aspects in peptide design, providing a solution for researchers working within the 'peptidic universe' to create new therapeutic agents. - Gives comprehensive coverage, including peptide design, modeling, synthesis and applications - Presents emerging topics in the design of peptide-based therapeutics - Details the latest developments in the fields of therapeutic peptides and bio-nanotechnology - Considers peptide design and the tailoring of peptides to specific functions - Offers computational tools and algorithms for peptide design and experimental protocols for peptide chemistry

Peptide Synthesis and Applications

Author : John Howl
Publisher : Springer Science & Business Media
ISBN 13 : 1592598773
Total Pages : 263 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Peptide Synthesis and Applications by : John Howl

Download or read book Peptide Synthesis and Applications written by John Howl and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hands-on experts describe in step-by-step detail the key methodologies of contemporary peptide synthesis and illustrate their numerous applications. The techniques presented include protocols for chemical ligation, the synthesis of cyclic and phosphotyrosine-containing peptides, lipoamino acid- and sugar-conjugated peptides, and peptide purification and analyses. Additional chapters detail methodologies and instrumentation for high-throughput peptide synthesis, many different applications of peptides as novel research tools and biological probes, and the design and application of fluorescent substrate-based peptides that can be used to determine the selectivity and activity of peptidases. A practical guide to the identification of proteins using mass spectrometric analyses of peptide mixtures is also included.

Innovation and Perspectives in Solid Phase Synthesis

Author : Roger Epton
Publisher :
ISBN 13 :
Total Pages : 778 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Innovation and Perspectives in Solid Phase Synthesis by : Roger Epton

Download or read book Innovation and Perspectives in Solid Phase Synthesis written by Roger Epton and published by . This book was released on 1994 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemical Approaches to the Synthesis of Peptides and Proteins

Author : Paul Lloyd-Williams
Publisher : CRC Press
ISBN 13 : 1000151689
Total Pages : 306 pages
Book Rating : 4.0/5 (1 download)

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Book Synopsis Chemical Approaches to the Synthesis of Peptides and Proteins by : Paul Lloyd-Williams

Download or read book Chemical Approaches to the Synthesis of Peptides and Proteins written by Paul Lloyd-Williams and published by CRC Press. This book was released on 2020-08-18 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications. This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.

Peptide-Based Materials

Author : Timothy Deming
Publisher : Springer Science & Business Media
ISBN 13 : 3642271391
Total Pages : 184 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Peptide-Based Materials by : Timothy Deming

Download or read book Peptide-Based Materials written by Timothy Deming and published by Springer Science & Business Media. This book was released on 2012-01-10 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Polypeptides by Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides, by Jianjun Cheng and Timothy J. Deming.- Peptide Synthesis and Self-Assembly, by S. Maude, L. R. Tai, R. P. W. Davies, B. Liu, S. A. Harris, P. J. Kocienski and A. Aggeli.- Elastomeric Polypeptides, by Mark B. van Eldijk, Christopher L. McGann, Kristi L. Kiick andJan C. M. van Hest.- Self-Assembled Polypeptide and Polypeptide Hybrid Vesicles: From Synthesis to Application, by Uh-Joo Choe, Victor Z. Sun, James-Kevin Y. Tan and Daniel T. Kamei.- Peptide-Based and Polypeptide-Based Hydrogels for Drug Delivery and Tissue Engineering, by Aysegul Altunbas and Darrin J. Pochan.-

Peptide Self-Assembly

Author : Bradley L. Nilsson
Publisher : Humana
ISBN 13 : 9781493992928
Total Pages : 452 pages
Book Rating : 4.9/5 (929 download)

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Book Synopsis Peptide Self-Assembly by : Bradley L. Nilsson

Download or read book Peptide Self-Assembly written by Bradley L. Nilsson and published by Humana. This book was released on 2019-05-24 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details methods and protocols on b-sheet assemblies and collagen. Divided into three parts chapters focus on expanding use of solid-state NMR as a powerful method to enhance structural understanding of self-assembled peptide materials, methods for the design, synthesis, and application of self-assembled peptide materials, and structural and mechanistic analyses of pathological amyloid systems that provide novel ways to assess function of the various possible aggregates as well to determine how the structure of these materials correlates to function/dysfunction in the biological context. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Peptide Self-Assembly: Methods and Protocols aims to capture modern methods that span the breadth of the exciting and expanding field of peptide self-assembly.

Solid Phase Peptide Synthesis

Author : John Morrow Stewart
Publisher :
ISBN 13 :
Total Pages : 204 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Solid Phase Peptide Synthesis by : John Morrow Stewart

Download or read book Solid Phase Peptide Synthesis written by John Morrow Stewart and published by . This book was released on 1984 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Major Methods of Peptide Bond Formation

Author : Erhard Gross
Publisher : Elsevier
ISBN 13 : 1483217965
Total Pages : 454 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Major Methods of Peptide Bond Formation by : Erhard Gross

Download or read book Major Methods of Peptide Bond Formation written by Erhard Gross and published by Elsevier. This book was released on 2014-05-10 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Peptides: Analysis, Synthesis, Biology, Volume 1: Major Methods of Peptide Bond Formation provides comprehensive and critical reviews of important developments in three major areas of peptide research—analysis, synthesis, and biology. This book discusses the nature of the peptide bond, coupling between amino acid residues, and catalysis of active ester reactions. The formation of hydrazides, reactions of carbodiimides with amines, and mixed carbonic anhydride method of peptide synthesis are also elaborated. This publication likewise covers the control of racemization during peptide synthesis, strategies for minimizing racemization during amide-forming steps, and assays for chiral purity. This volume is suitable for students, specialists, and scientists from a broad range of disciplines concerned with peptides.

Innovation and Perspectives in Solid Phase Synthesis

Author : Roger Epton
Publisher :
ISBN 13 :
Total Pages : 670 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Innovation and Perspectives in Solid Phase Synthesis by : Roger Epton

Download or read book Innovation and Perspectives in Solid Phase Synthesis written by Roger Epton and published by . This book was released on 1990 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work, based upon papers given at an international symposium, contains information on solid phase bio-organic synthesis. Descriptions of recent developments in the synthesis of specific biological macromolecules are given, along with data on artificial enzymes and more.