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Author : Ryan Nicholas Gutenkunst
Publisher :
ISBN 13 :
Total Pages : 310 pages
Book Rating : 4.:/5 (259 download)
Download or read book Sloppiness, Modeling, and Evolution in Biochemical Networks written by Ryan Nicholas Gutenkunst and published by . This book was released on 2008 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 1006 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 1006 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Marco Pellegrini
Publisher : Frontiers Media SA
ISBN 13 : 288963650X
Total Pages : 270 pages
Book Rating : 4.8/5 (896 download)
Download or read book Network Bioscience, 2nd Edition written by Marco Pellegrini and published by Frontiers Media SA. This book was released on 2020-03-27 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Network science has accelerated a deep and successful trend in research that influences a range of disciplines like mathematics, graph theory, physics, statistics, data science and computer science (just to name a few) and adapts the relevant techniques and insights to address relevant but disparate social, biological, technological questions. We are now in an era of 'big biological data' supported by cost-effective high-throughput genomic, transcriptomic, proteomic, metabolomic data collection techniques that allow one to take snapshots of the cells' molecular profiles in a systematic fashion. Moreover recently, also phenotypic data, data on diseases, symptoms, patients, etc. are being collected at nation-wide level thus giving us another source of highly related (causal) 'big data'. This wealth of data is usually modeled as networks (aka binary relations, graphs or webs) of interactions, (including protein-protein, metabolic, signaling and transcription-regulatory interactions). The network model is a key view point leading to the uncovering of mesoscale phenomena, thus providing an essential bridge between the observable phenotypes and 'omics' underlying mechanisms. Moreover, network analysis is a powerful 'hypothesis generation' tool guiding the scientific cycle of 'data gathering', 'data interpretation, 'hypothesis generation' and 'hypothesis testing'. A major challenge in contemporary research is the synthesis of deep insights coming from network science with the wealth of data (often noisy, contradictory, incomplete and difficult to replicate) so to answer meaningful biological questions, in a quantifiable way using static and dynamic properties of biological networks.
Author : Jayajit Das
Publisher : CRC Press
ISBN 13 : 1498717411
Total Pages : 355 pages
Book Rating : 4.4/5 (987 download)
Download or read book Systems Immunology written by Jayajit Das and published by CRC Press. This book was released on 2018-09-03 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Taken together, the body of information contained in this book provides readers with a bird’s-eye view of different aspects of exciting work at the convergence of disciplines that will ultimately lead to a future where we understand how immunity is regulated, and how we can harness this knowledge toward practical ends that reduce human suffering. I commend the editors for putting this volume together." –Arup K. Chakraborty, Robert T. Haslam Professor of Chemical Engineering, and Professor of Physics, Chemistry, and Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA New experimental techniques in immunology have produced large and complex data sets that require quantitative modeling for analysis. This book provides a complete overview of computational immunology, from basic concepts to mathematical modeling at the single molecule, cellular, organism, and population levels. It showcases modern mechanistic models and their use in making predictions, designing experiments, and elucidating underlying biochemical processes. It begins with an introduction to data analysis, approximations, and assumptions used in model building. Core chapters address models and methods for studying immune responses, with fundamental concepts clearly defined. Readers from immunology, quantitative biology, and applied physics will benefit from the following: Fundamental principles of computational immunology and modern quantitative methods for studying immune response at the single molecule, cellular, organism, and population levels. An overview of basic concepts in modeling and data analysis. Coverage of topics where mechanistic modeling has contributed substantially to current understanding. Discussion of genetic diversity of the immune system, cell signaling in the immune system, immune response at the cell population scale, and ecology of host-pathogen interactions.
Author : Susan Mertins
Publisher : Frontiers Media SA
ISBN 13 : 283255346X
Total Pages : 137 pages
Book Rating : 4.8/5 (325 download)
Download or read book Network-based Mathematical Modeling in Cell and Developmental Biology written by Susan Mertins and published by Frontiers Media SA. This book was released on 2024-08-22 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vast amount of knowledge in Cell Signaling gathered through reductionist efforts and omics technology is poised to approach a Systems Biology understanding of precise representations of cell structure and function and predictions at multi-scale levels despite the complexity. Super-resolution microscopy and single cell analysis are also providing opportunities to explore both spatial and temporal landscapes. Notably, many basic biological processes have been studied capturing mechanistic detail with the goal to understand cellular proliferation and differentiation, gene regulation, morphogenesis, metabolism, and cell-cell communication. Similarly, at the intracellular level, addressing functions such as self-assembly, phase separation, and transport is leading to insights not readily understood as linear pathways. Therefore, network-based mathematical modeling, delineating dynamic biochemical reactions through ordinary and partial differential equations, promises to discover emergent biological properties not heretofore expected.
Author : Eberhard Voit
Publisher : Garland Science
ISBN 13 : 1351332945
Total Pages : 481 pages
Book Rating : 4.3/5 (513 download)
Download or read book A First Course in Systems Biology written by Eberhard Voit and published by Garland Science. This book was released on 2017-09-05 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: A First Course in Systems Biology is an introduction for advanced undergraduate and graduate students to the growing field of systems biology. Its main focus is the development of computational models and their applications to diverse biological systems. The book begins with the fundamentals of modeling, then reviews features of the molecular inventories that bring biological systems to life and discusses case studies that represent some of the frontiers in systems biology and synthetic biology. In this way, it provides the reader with a comprehensive background and access to methods for executing standard systems biology tasks, understanding the modern literature, and launching into specialized courses or projects that address biological questions using theoretical and computational means. New topics in this edition include: default modules for model design, limit cycles and chaos, parameter estimation in Excel, model representations of gene regulation through transcription factors, derivation of the Michaelis-Menten rate law from the original conceptual model, different types of inhibition, hysteresis, a model of differentiation, system adaptation to persistent signals, nonlinear nullclines, PBPK models, and elementary modes. The format is a combination of instructional text and references to primary literature, complemented by sets of small-scale exercises that enable hands-on experience, and large-scale, often open-ended questions for further reflection.
Author : John H. Byrne
Publisher : Academic Press
ISBN 13 : 0123982677
Total Pages : 692 pages
Book Rating : 4.1/5 (239 download)
Download or read book From Molecules to Networks written by John H. Byrne and published by Academic Press. This book was released on 2014-05-23 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced. All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography). Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results. - The first treatment of cellular and molecular neuroscience that includes an introduction to mathematical modeling and simulation approaches - 80% updated and new content - New Chapter on "Biophysics of Voltage-Gated Ion Channels" - New Chapter on "Synaptic Plasticity" - Includes a chapter on the Neurobiology of Disease - Highly referenced, comprehensive and quantitative - Full color, professional graphics throughout - All graphics are available in electronic version for teaching purposes
Author : Roberto Narcisi
Publisher : Frontiers Media SA
ISBN 13 : 2889457907
Total Pages : 185 pages
Book Rating : 4.8/5 (894 download)
Download or read book Understanding and Modulating Bone and Cartilage Cell Fate for Regenerative Medicine written by Roberto Narcisi and published by Frontiers Media SA. This book was released on 2019-04-04 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : William Erik Sherwood
Publisher :
ISBN 13 :
Total Pages : 574 pages
Book Rating : 4.E/5 ( download)
Download or read book Phase Response in Networks of Bursting Neurons written by William Erik Sherwood and published by . This book was released on 2008 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Richard Dawkins
Publisher : Oxford University Press, USA
ISBN 13 : 9780192860927
Total Pages : 372 pages
Book Rating : 4.8/5 (69 download)
Download or read book The Selfish Gene written by Richard Dawkins and published by Oxford University Press, USA. This book was released on 1989 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science need not be dull and bogged down by jargon, as Richard Dawkins proves in this entertaining look at evolution. The themes he takes up are the concepts of altruistic and selfish behaviour; the genetical definition of selfish interest; the evolution of aggressive behaviour; kinshiptheory; sex ratio theory; reciprocal altruism; deceit; and the natural selection of sex differences. 'Should be read, can be read by almost anyone. It describes with great skill a new face of the theory of evolution.' W.D. Hamilton, Science
Author : Scott A. Sisson
Publisher : CRC Press
ISBN 13 : 1351643460
Total Pages : 513 pages
Book Rating : 4.3/5 (516 download)
Download or read book Handbook of Approximate Bayesian Computation written by Scott A. Sisson and published by CRC Press. This book was released on 2018-09-03 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the world becomes increasingly complex, so do the statistical models required to analyse the challenging problems ahead. For the very first time in a single volume, the Handbook of Approximate Bayesian Computation (ABC) presents an extensive overview of the theory, practice and application of ABC methods. These simple, but powerful statistical techniques, take Bayesian statistics beyond the need to specify overly simplified models, to the setting where the model is defined only as a process that generates data. This process can be arbitrarily complex, to the point where standard Bayesian techniques based on working with tractable likelihood functions would not be viable. ABC methods finesse the problem of model complexity within the Bayesian framework by exploiting modern computational power, thereby permitting approximate Bayesian analyses of models that would otherwise be impossible to implement. The Handbook of ABC provides illuminating insight into the world of Bayesian modelling for intractable models for both experts and newcomers alike. It is an essential reference book for anyone interested in learning about and implementing ABC techniques to analyse complex models in the modern world.
Author : Pierre-Alain Braillard
Publisher : Springer
ISBN 13 : 9401798222
Total Pages : 434 pages
Book Rating : 4.4/5 (17 download)
Download or read book Explanation in Biology written by Pierre-Alain Braillard and published by Springer. This book was released on 2015-06-10 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patterns of explanation in biology have long been recognized as different from those deployed in other scientific disciplines, especially that of physics. Celebrating the diversity of interpretative models found in biology, this volume details their varying types as well as explaining their relationships to one another. It covers the key differentials with other sciences in the nature of explanation, such as the existence in biology of varieties unheard of in the physical sciences, such as teleological, evolutionary and even functional explanations. Offering a wealth of fresh analysis of the phenomenon, chapters examine aspects ranging from the role of mathematics in explaining cell development to the complexities thrown up by evolutionary-developmental biology, where explanation is altered by multidisciplinarity itself. They cover major domains such as ecology and systems biology, as well as contemporary trends, such as the mechanistic explanations spawned by progress in molecular biology. With contributions from researchers of many different nationalities, the book provides a many-angled perspective on a revealing feature of the discipline of biology.
Author : Bernhard Palsson
Publisher : Cambridge University Press
ISBN 13 : 1107038855
Total Pages : 551 pages
Book Rating : 4.1/5 (7 download)
Download or read book Systems Biology written by Bernhard Palsson and published by Cambridge University Press. This book was released on 2015-01-26 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive single-authored textbook on genome-scale models and the bottom-up approach to systems biology.
Author : Liesbet Geris
Publisher : Springer
ISBN 13 : 3319212966
Total Pages : 471 pages
Book Rating : 4.3/5 (192 download)
Download or read book Uncertainty in Biology written by Liesbet Geris and published by Springer. This book was released on 2015-10-26 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational modeling allows to reduce, refine and replace animal experimentation as well as to translate findings obtained in these experiments to the human background. However these biomedical problems are inherently complex with a myriad of influencing factors, which strongly complicates the model building and validation process. This book wants to address four main issues related to the building and validation of computational models of biomedical processes: 1. Modeling establishment under uncertainty 2. Model selection and parameter fitting 3. Sensitivity analysis and model adaptation 4. Model predictions under uncertainty In each of the abovementioned areas, the book discusses a number of key-techniques by means of a general theoretical description followed by one or more practical examples. This book is intended for graduate students and researchers active in the field of computational modeling of biomedical processes who seek to acquaint themselves with the different ways in which to study the parameter space of their model as well as its overall behavior.
Author : Bairong Shen
Publisher : Springer
ISBN 13 : 9811015031
Total Pages : 331 pages
Book Rating : 4.8/5 (11 download)
Download or read book Translational Biomedical Informatics written by Bairong Shen and published by Springer. This book was released on 2016-10-31 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to essential methods and applications in translational biomedical informatics, which include biomedical big data, cloud computing and algorithms for understanding omics data, imaging data, electronic health records and public health data. The storage, retrieval, mining and knowledge discovery of biomedical big data will be among the key challenges for future translational research. The paradigm for precision medicine and healthcare needs to integratively analyze not only the data at the same level – e.g. different omics data at the molecular level – but also data from different levels – the molecular, cellular, tissue, clinical and public health level. This book discusses the following major aspects: the structure of cross-level data; clinical patient information and its shareability; and standardization and privacy. It offers a valuable guide for all biologists, biomedical informaticians and clinicians with an interest in Precision Medicine Informatics.
Author : Arul Jayaraman
Publisher : Artech House
ISBN 13 : 1596934069
Total Pages : 329 pages
Book Rating : 4.5/5 (969 download)
Download or read book Methods in Bioengineering written by Arul Jayaraman and published by Artech House. This book was released on 2009 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This cutting-edge volume provides a detailed look at the two main aspects of systems biology: the design of sophisticated experimental methods and the development of complex models to analyze the data. Focusing on methods that are being used to solve current problems in biomedical science and engineering, this comprehensive, richly illustrated resource shows you how to: design of state-of-the art methods for analyzing biological systems Implement experimental approaches for investigating cellular behavior in health and disease; use algorithms and modeling techniques for quantitatively describing biomedical problems; and integrate experimental and computational approaches for a more complete view of biological systems." --Book Jacket.
Author : Erica Jen
Publisher : Oxford University Press
ISBN 13 : 0195165330
Total Pages : 306 pages
Book Rating : 4.1/5 (951 download)
Download or read book Robust Design written by Erica Jen and published by Oxford University Press. This book was released on 2005 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Robust Design' brings together an eminent group of authors in a wide range of fields presenting aspects of robustness in biological, ecological and computational systems.
