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Skin Sensitisation Testing For The Purpose Of Hazard Identification And Risk Assessment
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Author :Organisation for Economic Co-operation and Development Publisher :Organisation for Economic Co-operation and Development ; [Montréal : Renouf] ISBN 13 :9789264122215 Total Pages : pages Book Rating :4.1/5 (222 download)
Book Synopsis OECD Guidelines for Testing of Chemicals by : Organisation for Economic Co-operation and Development
Download or read book OECD Guidelines for Testing of Chemicals written by Organisation for Economic Co-operation and Development and published by Organisation for Economic Co-operation and Development ; [Montréal : Renouf]. This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Guideline No. 497: Defined Approaches on Skin Sensitisation by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Guideline No. 497: Defined Approaches on Skin Sensitisation written by OECD and published by OECD Publishing. This book was released on 2023-07-04 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Defined Approach (DA) consists of a selection of information sources (e.g in silico predictions, in chemico, in vitro data) used in a specific combination, and resulting data are interpreted using a fixed data interpretation procedure (DIP) (e.g. a mathematical, rule-based model). DAs use methods in combination and are intended to overcome some limitations of the individual, stand-alone methods.
Book Synopsis Reducing, Refining and Replacing the Use of Animals in Toxicity Testing by : Dave Allen
Download or read book Reducing, Refining and Replacing the Use of Animals in Toxicity Testing written by Dave Allen and published by Royal Society of Chemistry. This book was released on 2013-10-31 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.
Book Synopsis Contact Dermatitis by : Peter J. Frosch
Download or read book Contact Dermatitis written by Peter J. Frosch and published by Springer Science & Business Media. This book was released on 2006 with total page 1176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying CD-ROM includes "all clinical photographs and important diagrams"--p. [vii].
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 429: Skin Sensitisation Local Lymph Node Assay by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 429: Skin Sensitisation Local Lymph Node Assay written by OECD and published by OECD Publishing. This book was released on 2010-07-23 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basic principle underlying the Local Lymph Node Assay (LLNA) in mouse is that sensitizers induce a primary proliferation of lymphocytes in the auricular lymph nodes draining the site of chemical application. This proliferation is proportional to ...
Book Synopsis Environmental Pollutant Exposures and Public Health by : R M Harrison
Download or read book Environmental Pollutant Exposures and Public Health written by R M Harrison and published by Royal Society of Chemistry. This book was released on 2020-10-27 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Both genes and environment have profound effects upon our health. While some environmental factors such as polluted air are high in the public consciousness, there are many other pathways for people’s exposure to toxic chemicals, such as through food, water and contaminated land. It is not only chemicals that can affect health; environmental radioactivity, pathogenic organisms and our changing climate also have implications for public health, and all contribute to the global burden of disease, leading to both disability and deaths of millions of people annually across the world. An understanding of the pathways of environmental exposure, and its effects upon health is key to developing regulations and behaviours that reduce or prevent exposure, and the consequent impacts upon health. Covering topics from dietary exposure to chemicals through to the health effects of climate change, this book brings together contributors from around the world to highlight the latest science on the impacts of environmental pollutant exposure upon public health.
Book Synopsis Skin Sensitization in Chemical Risk Assessment by : World Health Organization
Download or read book Skin Sensitization in Chemical Risk Assessment written by World Health Organization and published by World Health Organization. This book was released on 2008 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Harmonization Project Document presents the conclusions of an IPCS Workshop on Skin Sensitization in Chemical Risk Assessment. The workshop focused on the question of methods for dose-response assessment, to evaluate the relative ability of a chemical to induce sensitization in the skin, and hence inform risk assessment for humans. In addition this publication includes a series of short articles on this topic by leading experts in the field. The conclusions of the workshop cover such aspects as the nature and utility for risk assessment of the data produced by non-animal test methods (such as quantitative structure-activity relationships), in vitro testing approaches, animal test methods, and epidemiological studies. While traditional animal test methods used for identification and regulation of skin sensitizers have focused on determining whether or not a substance is a sensitizer, this report describes the use of tests for deriving more informative potency information. This book will be useful to toxicologists, researchers, regulatory authorities and industry.
Book Synopsis OECD Series on Testing and Assessment Guidance Document on the Reporting of Defined Approaches to be Used Within Integrated Approaches to Testing and Assessment by : OECD
Download or read book OECD Series on Testing and Assessment Guidance Document on the Reporting of Defined Approaches to be Used Within Integrated Approaches to Testing and Assessment written by OECD and published by OECD Publishing. This book was released on 2017-04-13 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides a set of principles for reporting defined approaches to testing and assessment that can be used as one of ...
Book Synopsis Textbook of Contact Dermatitis by : R.J.G. Rycroft
Download or read book Textbook of Contact Dermatitis written by R.J.G. Rycroft and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 829 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ideally every patient with eczema should be patch tested and the importance of this investigation is now universally accepted. The simplicity of the technique belies its many pitfalls, the greatest being to lack the knowledge required to select the correct allergens and to interpret the results. The introduction, nearly 20 years ago, of the journal Contact Dermatitis greatly stimulated the reporting of the clinical side of contact dermatitis but a vast amount of laboratory work has also been published in other journals on the mechanisms and theory of these reactions. The literature on the subject is now quite vast and a comprehensive book on the clinical and research aspects of contact dermatitis has been sorely needed. This textbook was carefully planned to gather together what is known of the subject into a cohesive whole and it has succeeded admirably. It consists of 22 chapters written by 41 contributors, each selected for their special study of particular subjects. Every feature of contact dermatitis has been covered, beginning with its history and even concluding with the names and addresses of those worldwide who have a specific interest in the subject. The text is illustrated and well laid out; it has been broken up into clearly demarcated sections making it easy to read and its information readily accessible. One's own writing concentrates the mind but editing the texts of authors from so many different countries was a task of considerable proportions.
Book Synopsis The History of Alternative Test Methods in Toxicology by :
Download or read book The History of Alternative Test Methods in Toxicology written by and published by Academic Press. This book was released on 2018-10-20 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.
Book Synopsis Mixture Toxicity by : Cornelis A. M. van Gestel
Download or read book Mixture Toxicity written by Cornelis A. M. van Gestel and published by CRC Press. This book was released on 2016-04-19 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an
Book Synopsis A Comprehensive Guide to Toxicology in Nonclinical Drug Development by : Ali S. Faqi
Download or read book A Comprehensive Guide to Toxicology in Nonclinical Drug Development written by Ali S. Faqi and published by Academic Press. This book was released on 2016-11-03 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. - Provides unique content that is not always covered together in one comprehensive resource, including chapters on stem cells, abuse liability, biomarkers, inhalation toxicology, biostatistics, and more - Updated with the latest international guidelines for nonclinical toxicology in both small and large molecules - Incorporates practical examples in order to illustrate day-to-day activities and the expectations associated with working in nonclinical toxicology
Author :Jean-Pierre Lepoittevin Publisher :Springer Science & Business Media ISBN 13 :3642803318 Total Pages :270 pages Book Rating :4.6/5 (428 download)
Book Synopsis Allergic Contact Dermatitis by : Jean-Pierre Lepoittevin
Download or read book Allergic Contact Dermatitis written by Jean-Pierre Lepoittevin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Allergic Contact Dermatitis presents all up-to-date chemical and physio-chemical concepts for the study and understanding of allergic contact dermatitis (ACD). The book covers all aspects of ACD - skin penetration and metabolism, identification of sensitizers and hapten-protein interaction, including new concepts of increasing importance such as molecular recognition and quantitative structure-activity relationships. In addition, comprehensive references are provided, making this the most complete available text-book for dermatologists. Allergic Contact Dermatitis reaches an equilibrium between fundamental concepts and clinical applications and thus presents an essential guideline to dermatologists, allergologists, biochemists and toxicologists.
Book Synopsis Toxicological Risk Assessment of Chemicals by : Elsa Nielsen
Download or read book Toxicological Risk Assessment of Chemicals written by Elsa Nielsen and published by CRC Press. This book was released on 2008-02-21 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk
Book Synopsis Alternatives to Animal Testing by : Hajime Kojima
Download or read book Alternatives to Animal Testing written by Hajime Kojima and published by Springer. This book was released on 2018-12-27 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.
Book Synopsis Contact Allergy Predictive Tests in Guinea Pigs by : Klaus E. Andersen
Download or read book Contact Allergy Predictive Tests in Guinea Pigs written by Klaus E. Andersen and published by S Karger Ag. This book was released on 1985 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Allergic Contact Dermatitis in the Guinea Pig by : Bertil Magnusson
Download or read book Allergic Contact Dermatitis in the Guinea Pig written by Bertil Magnusson and published by Charles C. Thomas Publisher. This book was released on 1970 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:
