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Signal Transduction And Bacterial Virulence
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Book Synopsis Signal Transduction and Bacterial Virulence by : Rino Rappuoli
Download or read book Signal Transduction and Bacterial Virulence written by Rino Rappuoli and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to survive, bacteria must constantly monitor their structure and physiology. Adaptive behaviours are established by using environmental sensors and response regulators. These communication modules regulate a wide variety of signals including host detection and invasion, cell cycle, metabolite utilization, starvation and many others. The purpose of this volume is to give an overview of the various systems and to introduce recent advances in understanding selected systems of pathogenic bacteria.
Book Synopsis Signal Transduction and Bacterial Virulence by : Rino Rappuoli
Download or read book Signal Transduction and Bacterial Virulence written by Rino Rappuoli and published by R G Landes Company. This book was released on 1995-01-01 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Bacterial Signal Transduction: Networks and Drug Targets by : Ryutaro Utsumi
Download or read book Bacterial Signal Transduction: Networks and Drug Targets written by Ryutaro Utsumi and published by Springer Science & Business Media. This book was released on 2008-12-05 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fascinating book encourages many microbiologists and students to enter the new world of signal transduction in microbiology. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been unearthed.
Book Synopsis Bacterial Sensing and Signaling by : Mattias Collin
Download or read book Bacterial Sensing and Signaling written by Mattias Collin and published by Karger Medical and Scientific Publishers. This book was released on 2009-01-01 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last fifteen years it has become increasingly obvious that bacteria are not as simple and solitary as once believed. Rather, an accumulating body of work shows that bacteria are highly complicated and social organisms, constantly sensing their surroundings and altering both their environments and behaviors to ensure survival. Direct communication between bacteria turns out to be quite common, as are coordinated intra- and interspecies responses that include the formation of highly sophisticated microbial communities. In fact, threats to bacterial survival from assaults ranging from nutrient deprivation and oxygen depletion tothe defenses of eukaryotic hostsare all managed through the integration of a dizzying array of complex sensory and communication systems with the appropriate bacterial behaviors. This volume provides an update of the current knowledgeinthe expanding field ofbacterial sensing and signaling, highlighting its most important and interesting aspects. In twelve state-of-the-art articles, respected international experts address topics such as quorum sensing and secondary messengers, chemotaxis and magnetoaerotaxis, two-component phosphotransferase systems, bacterial virulence mechanisms, thermoregulation, and more. The final chapter represents a unique description of the tools available to manipulate many of the sensing and signaling systems described in this volume. Bacterial Sensing and Signaling is recommended reading for students, scientists and clinicians with interests in microbiology, immunology, ecology, biotechnology and a range of other disciplines.
Book Synopsis Two-component Signal Transduction by : James A. Hoch
Download or read book Two-component Signal Transduction written by James A. Hoch and published by Amer Society for Microbiology. This book was released on 1995 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human enteroviruses, particularly the polio viruses, have had a significant role in the history of medicine and microbiology; and continue to cause clinical problems, as well as provide targets for molecular investigation. This book offers a link between the basic science and clinical medicine.
Book Synopsis Bacterial Cell-to-Cell Communication by : Donald R. Demuth
Download or read book Bacterial Cell-to-Cell Communication written by Donald R. Demuth and published by Cambridge University Press. This book was released on 2006-02-23 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many bacterial diseases are caused by organisms growing together as communities or biofilms. These microorganisms have the capacity to coordinately regulate specific sets of genes by sensing and communicating amongst themselves utilizing a variety of signals. This book examines the mechanisms of quorum sensing and cell-to-cell communication in bacteria and the roles that these processes play in regulating virulence, bacterial interactions with host tissues, and microbial development. Recent studies suggest that microbial cell-to-cell communication plays an important role in the pathogenesis of a variety of disease processes. Furthermore, some bacterial signal molecules may possess immunomodulatory activity. Thus, understanding the mechanisms and outcomes of bacterial cell-to-cell communication has important implications for appreciating host-pathogen interactions and ultimately may provide new targets for antimicrobial therapies that block or interfere with these communication networks.
Book Synopsis Molecular Pathogenesis and Signal Transduction by Helicobacter pylori by : Nicole Tegtmeyer
Download or read book Molecular Pathogenesis and Signal Transduction by Helicobacter pylori written by Nicole Tegtmeyer and published by Springer. This book was released on 2017-01-23 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the current state of research concerning bacterial virulence factors and the infection biology of Helicobacter pylori, which is the leading cause of peptic ulcers and gastric cancer worldwide. The chapters include cutting-edge findings on this fascinating microbe and discuss the general strategies of H. pylori infection and persistence, news on important H. pylori virulence factors, crosstalk with the microbiota, hot novel models and signaling mechanisms, risk factors of gastric disease and stomach cancer, and the impact of H. pylori infection on non-gastric diseases. Written by internationally respected scientists, this book will appeal to clinicians, researchers and advanced students alike.
Book Synopsis Bacterial Signaling by : Reinhard Krämer
Download or read book Bacterial Signaling written by Reinhard Krämer and published by John Wiley & Sons. This book was released on 2009-12-09 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a comprehensive insight into cellular signaling processes in bacteria with a special focus on biotechnological implications, this is the first book to cover intercellular as well as intracellular signaling and its relevance for biofilm formation, host pathogen interactions, symbiotic relationships, and photo- and chemotaxis. In addition, it deals in detail with principal bacterial signaling mechanisms -- making this a valuable resource for all advanced students in microbiology. Dr. Krämer is a world-renowned expert in intracellular signaling and its implications for biotechnology processes, while Dr. Jung is an expert on intercellular signaling and its relevance for biomedicine and agriculture.
Author :Society for General Microbiology. Symposium Publisher :Cambridge University Press ISBN 13 :9780521813884 Total Pages :308 pages Book Rating :4.8/5 (138 download)
Book Synopsis Signals, Switches, Regulons, and Cascades by : Society for General Microbiology. Symposium
Download or read book Signals, Switches, Regulons, and Cascades written by Society for General Microbiology. Symposium and published by Cambridge University Press. This book was released on 2002-04-18 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description
Book Synopsis Molecular Mechanisms of Bacterial Virulence by : Clarence I. Kado
Download or read book Molecular Mechanisms of Bacterial Virulence written by Clarence I. Kado and published by Springer Science & Business Media. This book was released on 1993-12-31 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt: Host recognition and attachment mechanisms; Pathogen ingression and invasive mechanisms; Elaboration of pathogenic factors; Regulation of virulence genes and signal transduction; Mechanisms against host defenses.
Book Synopsis Implication of Quorum Sensing System in Biofilm Formation and Virulence by : Pallaval Veera Bramhachari
Download or read book Implication of Quorum Sensing System in Biofilm Formation and Virulence written by Pallaval Veera Bramhachari and published by Springer. This book was released on 2019-01-28 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the importance and significance of Quorum sensing (QS), it’s critical roles in regulating diverse cellular functions in microbes, including bioluminescence, virulence, pathogenesis, gene expression, biofilm formation and antibiotic resistance. Microbes can coordinate population behavior with small molecules called autoinducers (AHL) which serves as a signal of cellular population density, triggering new patterns of gene expression for mounting virulence and pathogenesis. Therefore, these microbes have the competence to coordinate and regulate explicit sets of genes by sensing and communicating amongst themselves utilizing variety of signals. This book descry emphasizes on how bacteria can coordinate an activity and synchronize their response to external signals and regulate gene expression. The chapters of the book provide the recent advancements on various functional aspects of QS systems in different gram positive and gram negative organisms. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with quorum sensing signal molecules viz. virulence, pathogenesis, antibiotic synthesis, biosurfactants production, persister cells, cell signaling and biofilms, intra and inter-species communications, host-pathogen interactions, social interactions & swarming migration in biofilms.
Book Synopsis Virulence and Gene Regulation by : Juan-Luis Ramos
Download or read book Virulence and Gene Regulation written by Juan-Luis Ramos and published by Springer Science & Business Media. This book was released on 2004-06-17 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pseudomonas comprises three volumes covering the biology of pseudomonads in a wide context, including the niches they inhabit, the taxonomic relations among members of this group, the molecular biology of gene expression in different niches and under different environmental conditions, the analysis of virulence traits in plants, animals and human pathogens as well as the determinants that make some strains useful for biotechnological applications and promotion of plant growth. There has been growing interest in pseudomonads and a particular urge to understand the biology underlying the complex metabolism of these ubiquitous microbes. These bacteria are capable of colonizing a wide range of niches, including the soil, the plant rhizosphere and phylosphere, and animal tissues; more recently they have attracted attention because of their capacity to form biofilms, a characteristic with potentially important medical and environmental implications. The three volumes cover the following topics: - Taxonomy, - Genomics, - Life styles, - Cell Architecture, - Virulence, - Regulation, - Macromolecules, - Alternative Respiratory Substrates, - Catabolism and Biotransformations. Pseudomonas will be of use to all researchers working on these bacteria, particularly those studying microbiology, plant crops, pathogenesis, and chemical engineering. Advanced students in biology, medicine and agronomy will also find these three volumes a valuable reference during their studies.
Book Synopsis Bacterial Cell-to-cell Communication by : Donald R. Demuth
Download or read book Bacterial Cell-to-cell Communication written by Donald R. Demuth and published by . This book was released on 2006 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Paradigms of Infectious Disease by : Cheryl A. Nickerson
Download or read book Molecular Paradigms of Infectious Disease written by Cheryl A. Nickerson and published by Springer Science & Business Media. This book was released on 2006-11-28 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an overview of host genetic factors that provide complete or partial resistance to infection, that influence the clinical outcome of infection, or that confer the capacity to remain healthy during infection. This book covers the most recent advances in the field and explores how progress in knowing the genetic basis of infectious diseases could lead to new insights in understanding and combating them.
Book Synopsis Bacterial Regulatory Networks by : Alain Filloux
Download or read book Bacterial Regulatory Networks written by Alain Filloux and published by Caister Academic Press Limited. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory networks enable bacteria to adapt to almost every environmental niche on earth. Regulation is achieved by a network of interactions among diverse types of molecules including DNA, RNA, proteins and metabolites. The primary role of regulatory networks in bacteria is to control the response to environmental changes, such as nutritional status and environmental stress. A complex organization of networks allows the organism to coordinate and integrate multiple environmental signals. Renowned authors under the expert guidance of the editor Alain A.M. Filloux, have contributed authoritative, up-to-date reviews of the current research and theories on regulatory networks in bacteria. The volume contains critical reviews written by the leading research scientists in this topical field. The authors fully explore various regulatory networks, discuss variations of common themes and provide fresh insights into bacterial regulatory mechanisms. Topics include: the sigma network in Escherichia coli, control of bacterial virulence, ECF sigma factors, quorum sensing, cyclic di-GMP, RNA-mediated regulation, the H-NS regulator, two-component regulatory systems, bacterial chemotaxis, regulation of iron homeostasis, anaerobic regulatory networks, bacterial bistable regulatory networks, and evolution of transcription factors and regulatory networks. This book is essential reading for everyone interested in gene expression and regulation in bacteria and is a recommended text for all microbiology libraries.
Book Synopsis Bacterial Disease Resistance in Plants by : P. Vidhyasekaran
Download or read book Bacterial Disease Resistance in Plants written by P. Vidhyasekaran and published by CRC Press. This book was released on 2002-11-15 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapter 1. Molecular Recognition Processes Between Plant and Bacterial Pathogens Physical Contact of Plant Cells is Necessary for Bacterial Recognition Molecules Responsible for Physical Contact Many Bacterial Pathogens Induce Necrosis on Hosts and Nonhosts Bacterial Pathogens Grow in Both Host and Nonhost Plants Bacterial Pathogens Induce Leakage of Nutrients in Both Host and Nonhost Plants Bacterial Genes Involved in Recognition of Hosts and Nonhosts Coregulation of hrp, avr and Other Pathogenicity Genes Transcription of Bacterial Pathogenicity Genes in Planta Plant-Derived Molecules May Be Involved in Induction of Bacterial Genes Some Plant Signals May Direct Synthesis of Elicitors Secretion of Elicitors From Bacterial Cells in Plants The Role of hrp and avr Genes in Early Recognition Process in Plant-Bacterial Pathogen Interactions Other Signal Molecules of Bacterial Pathogens The Signal Transduction System Systemic Signal Induction Is Cell Death Involved in Signal Transduction Pathway? How Pathogens Avoid or Overcome Host Defense Mechanisms Induced by the Signal Transduction System? Possible Role of Signal Transduction System in Evasion of Host Recognition by Phytopathogenic Bacteria During Pathogenesis Chapter 2. Host Defense Mechanisms: Cell Wall-the First Barrier and a Source of Defense Signal Molecules The First Barrier to Bacterial Infection in Plants Structure of the Plant Cell Wall Pectic Polysaccharides Cellulose Hemicellulos Cell Wall Proteins Bacterial Genes Encoding Extracellular Enzymes Bacterial Genes Regulating Production of Extracellular Enzymes Bacterial Genes Regulating Secretion of Extracellular Enzymes Secretion of Proteases The Signaling System in Induction of Bacterial Extracellular Enzymes Plant Cell Wall Components Involved in Defense Mechanisms Against Bacterial Pathogens Bacterial Extracellular Enzymes Induce Host Defense Mechanisms Pectic Fragments Induce Virulence Genes in Bacterial and Defense Genes in Plants Pectic Enzymes Vary in Inducing Resistance or Susceptibility Polygalacturonase-Inhibiting Proteins Cell Wall Modifications and Bacterial Disease Resistance Chapter 3. Active Oxygen Species Mechanism of Production of Active Oxygen Species Signals for Induction of Active Oxygen Species in Bacteria-Infected Plants Bacterial Infection Leads to Production of Active Oxygen Species in Plants Active Oxygen Species May Induce Lipid Peroxidation Increases in Active Oxygen Species Lead to Activation of Lipoxygenase Active Oxygen Species Production Leads to Cell Membrane Damage Active Oxygen Species May Directly Kill Bacterial Pathogens Bacterial Pathogens May Tolerate Toxicity of Active Oxygen Species Antioxidants of the Host May Protect Bacterial Pathogens Against Active Oxygen Species The Possible Role of Active Oxygen Species in Disease Resistance Chapter 4. Inducible Plant Proteins Nomenclature of Pathogen-Inducible Plant Proteins Occurrence of PR Proteins in Various Plants Classification of PR Proteins Bacterial Pathogens Induce PR Proteins Molecular Mechanisms of Induction of PR Proteins Compartmentalization of PR Proteins in Plant Tissues The Role of PR Proteins in Bacterial Disease Resistance The Second Group of Pathogen-Inducible Proteins: Constitutive, but Increasingly Induced Hydroxyproline-Rich Glycoproteins Lectins Not All Inducible Proteins Need Be Involved in Inducing Bacterial Disease Resistance Chapter 5. Inducible Secondary Metabolites What Are Inducible Secondary Metabolites? Bacterial Pathogens Induce Accumulation of Secondary Metabolites in Infected Tissues Phytoalexins Accumulate in Plants After Irreversible Cell Membrane Damage Phytoalexins Accumulate Only Locally and Not Systemically Mode of Syntheses of Phytoalexins Evidences That Induced Secondary Metabolites Are Involved in Bacterial Disease Resistance Phytoalexins May Be Suppressed, Degraded, or Inactivated in Susceptible Interactions Some Phytoalexins May Not Have Any Role in Disease Resistance Constitutive, but Induced Secondary Metabolites During Pathogenesis Chapter 6. Biotechnological Applications: Molecular Manipulation of Bacterial Disease Resistance Manipulation of Signal Transduction System for Induction of Disease Resistance Manipulation of Resistance Genes Involved in Signal Transduction System Manipulation of Signal Transduction System by Elicitors Manipulation of Signal Transduction System by Using Chemicals Manipulation of Signal Transduction System by Using Rhizobacterial Strains Manipulation of Signal Transduction System by Enhanced Biosynthesis of Salicylic Acid Manipulation of Signal Transduction System by Inducing Accelerated Cell Death Manipulation of Signal Transduction System by Enhanced Biosynthesis of Cytokinins Manipulation of Inducible Proteins for Induction of Bacterial Disease Resistance Suppression of Virulence Factors of Bacterial Pathogens to Manage Bacterial Diseases Exploitation of Insect Genes Encoding Antibacterial Proteins for Bacterial Disease Management Exploitation of Bacteriophage Genes for Bacterial Disease Management Exploitation of Genes from Human Beings, Hens, and Crabs for Management of Plant Bacterial Diseases References Index.
Author :Peter Jonathan McAlea Ceponis Publisher :Library and Archives Canada = Bibliothèque et Archives Canada ISBN 13 :9780612943933 Total Pages :428 pages Book Rating :4.9/5 (439 download)
Book Synopsis Cytokine Signal Transduction Responses in Epithelial Cells to Gastrointestinal Bacterial Pathogens [microform] by : Peter Jonathan McAlea Ceponis
Download or read book Cytokine Signal Transduction Responses in Epithelial Cells to Gastrointestinal Bacterial Pathogens [microform] written by Peter Jonathan McAlea Ceponis and published by Library and Archives Canada = Bibliothèque et Archives Canada. This book was released on 2004 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lastly, I delineated host and bacterial mechanisms involved in EHEC-mediated suppression of Stat1. Bacterial, but not host cell, protein synthesis, adhesion to host cells, and generation of a soluble factor(s) after bacterial contact with host cells are all involved. Sucrose density gradient fractionation showed that EHEC disrupts IFNgamma receptor chain alpha association with cholesterol-enriched membrane microdomains, and immunolabelling confirmed altered subcellular localization. Overall, a combination of host cell-derived and bacterial factors is associated with suppression of Stat1 activation. The bacterial enteropathogens Helicobacter pylori and enterohemorrhagic Escherichia coli (EHEC) O157:H7 cause considerable morbidity and mortality in humans. To establish infection and elicit disease, these bacteria modulate host epithelial cell signal transduction, but the precise mechanisms remain unclear. Some microbes inhibit cytokine-induced Janus kinase and signal transducer and activator of transcription (Jak-Stat) pathways important to host immunity. Accordingly, the objectives of my research were: (1) to determine if H. pylori and EHEC suppress cytokine-induced Stat signalling in epithelial cells in vitro, and (2) to delineate both bacterial and host cell mechanisms involved. In summary, these studies demonstrate, for the first time, that bacterial enteropathogens suppress cytokine-induced signal transduction pathways in gastrointestinal epithelial cells. This could represent a unique immune evasion strategy employed by these bacteria. First, I determined that H. pylori infection of gastric epithelial cells suppressed interleukin (IL)-4-induced Stat6 activation. Complementary techniques showed infection inhibits IL-4-induced Stat6 tyrosine phosphorylation, DNA-binding, and nuclear translocation independent of bacterial virulence factors CagA, CagE, and VacA. IL-4 receptor and Jak1 expression were unaffected. Moreover, H. pylori suppressed IFN-gamma (IFNgamma)-induced Stat1 tyrosine phosphorylation. These findings indicate that H. pylori suppression of cytokine signalling could influence disease outcome. Next, I showed that EHEC O157:H7 suppresses IFNgamma-induced Stat1 DNA-binding, tyrosine phosphorylation, but not nuclear translocation, in colonic epithelial cells. Stat1 suppression required live bacteria, but was independent of Shiga-like toxins, intimin, type III secretion, or plasmid-encoded factors. Functionally, EHEC suppressed IFNgamma-inducible expression of a Stat1-dependent gene. Furthermore, EHEC serotype O113:H21 also suppressed Stat1 activation, but enteropathogenic E. coli or commensal E. coli did not. Together with the H. pylori results, this indicates that specific pathogens suppress cytokine signalling.
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