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Shear Horizontal Surface Acoustic Wave Microsensor For Class A Viral And Bacterial Detection
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Book Synopsis Shear Horizontal Surface Acoustic Wave Microsensor for Class A Viral and Bacterial Detection by :
Download or read book Shear Horizontal Surface Acoustic Wave Microsensor for Class A Viral and Bacterial Detection written by and published by . This book was released on 2008 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid autonomous detection of pathogenic microorganisms and bioagents by field deployable platforms is critical to human health and safety. To achieve a high level of sensitivity for fluidic detection applications, we have developed a 330 MHz Love wave acoustic biosensor on 36{sup o} YX Lithium Tantalate (LTO). Each die has four delay-line detection channels, permitting simultaneous measurement of multiple analytes or for parallel detection of single analyte containing samples. Crucial to our biosensor was the development of a transducer that excites the shear horizontal (SH) mode, through optimization of the transducer, minimizing propagation losses and reducing undesirable modes. Detection was achieved by comparing the reference phase of an input signal to the phase shift from the biosensor using an integrated electronic multi-readout system connected to a laptop computer or PDA. The Love wave acoustic arrays were centered at 330 MHz, shifting to 325-328 MHz after application of the silicon dioxide waveguides. The insertion loss was -6 dB with an out-of-band rejection of 35 dB. The amplitude and phase ripple were 2.5 dB p-p and 2-3{sup o} p-p, respectively. Time-domain gating confirmed propagation of the SH mode while showing suppression of the triple transit. Antigen capture and mass detection experiments demonstrate a sensitivity of 7.19 ± 0.74{sup o} mm2/ng with a detection limit of 6.7 ± 0.40 pg/mm2 for each channel.
Book Synopsis Detection of Bioagents Using a Shear Horizontal Surface Acoustic Wave Biosensor by :
Download or read book Detection of Bioagents Using a Shear Horizontal Surface Acoustic Wave Biosensor written by and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A biosensor combining the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents. In a preferred embodiment, a lithium tantalate based SAW transducer with silicon dioxide waveguide sensor platform featuring three test and one reference delay lines was used to adsorb antibodies directed against Coxsackie virus B4 or the negative-stranded category A bioagent Sin Nombre virus (SNV). Rapid detection of increasing concentrations of viral particles was linear over a range of order of magnitude for both viruses, and the sensor's selectivity for its target was not compromised by the presence of confounding Herpes Simplex virus type 1 The biosensor was able to delect SNV at doses lower than the load of virus typically found in a human patient suffering from hantavirus cardiopulmonary syndrome (HCPS).
Download or read book Biosignal Processing written by and published by BoD – Books on Demand. This book was released on 2022-12-21 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biosignal processing is an important tool in medicine. As such, this book presents a comprehensive overview of novel methods in biosignal theory, biosignal processing algorithms and applications, and biosignal sensors. Chapters examine biosignal processing for glucose detection, tissue engineering, electrocardiogram processing, soft tissue tomography, and much more. The book also discusses applications of artificial intelligence and machine learning for biosignal processing.
Book Synopsis High-frequency Shear-horizontal Surface Acoustic Wave Sensor by :
Download or read book High-frequency Shear-horizontal Surface Acoustic Wave Sensor written by and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A Love wave sensor uses a single-phase unidirectional interdigital transducer (IDT) on a piezoelectric substrate for leaky surface acoustic wave generation. The IDT design minimizes propagation losses, bulk wave interferences, provides a highly linear phase response, and eliminates the need for impedance matching. As an example, a high frequency (.about. 300-400 MHz) surface acoustic wave (SAW) transducer enables efficient excitation of shear-horizontal waves on 36.degree. Y-cut lithium tantalate (LTO) giving a highly linear phase response (2.8.degree. P-P). The sensor has the ability to detect at the pg/mm.sup. 2 level and can perform multi-analyte detection in real-time. The sensor can be used for rapid autonomous detection of pathogenic microorganisms and bioagents by field deployable platforms.
Book Synopsis Investigation of a Shear Horizontal Surface Acoustic Wave Sensor System for Liquid Media by : Andrew Paul Campitelli
Download or read book Investigation of a Shear Horizontal Surface Acoustic Wave Sensor System for Liquid Media written by Andrew Paul Campitelli and published by . This book was released on 1997 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis ZnO/GaAs-based Acoustic Waves Microsensor for the Detection of Bacteria in Complex Liquid Media by : Juliana Chawich
Download or read book ZnO/GaAs-based Acoustic Waves Microsensor for the Detection of Bacteria in Complex Liquid Media written by Juliana Chawich and published by . This book was released on 2019 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis was conducted in the frame of an international collaboration between Université de Bourgogne Franche-Comté in France and Université de Sherbrooke in Canada. It addresses the development of a miniaturized biosensor for the detection and quantification of bacteria in complex liquid media. The targeted bacteria is Escherichia coli (E. coli), regularly implicated in outbreaks of foodborne infections, and sometimes fatal.The adopted geometry of the biosensor consists of a gallium arsenide (GaAs) membrane with a thin layer of piezoelectric zinc oxide (ZnO) on its front side. The contribution of ZnO structured in a thin film is a real asset to achieve better performances of the piezoelectric transducer and consecutively a better sensitivity of detection. A pair of electrodes deposited on the ZnO film allows the generation of an acoustic wave propagating in GaAs under a sinusoidal voltage, at a given frequency. The backside of the membrane is functionalized with a self-assembled monolayer (SAM) of alkanethiols and antibodies anti-E. coli, providing the specificity of detection. Thus, the biosensor benefits from the microfabrication and bio-functionalization technologies of GaAs, validated within the research team, and the promising piezoelectric properties of ZnO, to potentially achieve a highly sensitive and specific detection of the bacteria of interest. The challenge is to be able to detect and quantify these bacteria at very low concentrations in a complex liquid and/or biological sample.The research work partly focused on the deposition and characterization of piezoelectric ZnO thin films on GaAs substrates. The effect of the crystalline orientation of GaAs and the use of a titanium / platinum buffer layer between ZnO and GaAs were studied using different structural (X-ray diffraction, Raman spectroscopy, secondary ionization mass spectrometry), topographic (atomic force microscopy), optical (ellipsometry) and electrical characterizations. After the realization of the electrical contacts on top of the ZnO film, the GaAs membrane was micromachined using chemical wet etching. Once fabricated, the transducer was tested in air and liquid medium by electrical measurements, in order to determine the resonance frequencies for thickness shear mode. A protocol for surface bio-functionalization, validated in the laboratory, was applied to the back of the biosensor for anchoring SAMs and antibodies, while protecting the top side. Furthermore, different conditions of antibody grafting such as the concentration, pH and incubation time, were tested to optimize the immunocapture of bacteria. In addition, the impact of the pH and the conductivity of the solution to be tested on the response of the biosensor has been determined. The performances of the biosensor were evaluated by detection tests of the targeted bacteria, E. coli, while correlating electrical measurements with fluorescence microscopy. Detection tests were completed by varying the concentration of E. coli in environments of increasing complexity. Various types of controls were performed to validate the specificity criteria. Thanks to its small size, low cost of fabrication and rapid response, the proposed biosensor has the potential of being applied in clinical diagnostic laboratories for the detection of E. coli.
Book Synopsis Investigation of Langasite Pure Shear Horizontal Surface Acoustic Wave Biosensors by : Eric Jon Berkenpas
Download or read book Investigation of Langasite Pure Shear Horizontal Surface Acoustic Wave Biosensors written by Eric Jon Berkenpas and published by . This book was released on 2005 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of Shear Horizontal Surface Acoustic Wave with Silicon Dioxide Nanoparticles Waveguide Sendor for Escherichia Coli O157: H7 Detection by : Seng Teik Ten
Download or read book Development of Shear Horizontal Surface Acoustic Wave with Silicon Dioxide Nanoparticles Waveguide Sendor for Escherichia Coli O157: H7 Detection written by Seng Teik Ten and published by . This book was released on 2017 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: There were four main scopes in this research works. All the research scopes were arranged in the flow order; one had to be completed before the next one started. The first scopes involved simulation using COMSOL Multiphysics software with Dell Workstation which was the most computational power in the university, Precision T7600 with 2.0 GHz eight core processor with 64GB, 1600 MHz DDR3 ECC RDIMM memory. The simulation was undertaken to determine whether IDT parameters (number of finger pairs, aperture and delay length) were able to affect the SHSAW mass loading sensitivity.
Book Synopsis Sensing Glass Transitions in Thin Polymer Films on Acoustic Wave Microsensors by : JW. Grate
Download or read book Sensing Glass Transitions in Thin Polymer Films on Acoustic Wave Microsensors written by JW. Grate and published by . This book was released on 1994 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acoustic wave microsensors are capable of sensing transition behaviors of homogeneous amorphous polymers applied as thin films to the surface of the sensor. The device and wave characteristics of four such microsensors, and examples of their uses in monitoring polymer properties, are described. The devices are the thickness-shear mode (TSM), surface acoustic wave (SAW), flexural plate wave (FPW), and shear horizontal acoustic plate mode (SH-APM) devices. Using the FPW device, the change in the polymer coefficient of thermal expansion at the static glass transition temperature is sensed as a change in slope of the frequency-temperature plot. This behavior reflects the fact that the frequency measures acoustic velocity, which decreases as the polymer modulus decreases. Modulus decreases as the polymer volume increases. Frequency-dependent relaxation properties are detected with a sigmoidal change in slope of the frequency-temperature plot and a minimum in signal amplitude. The minimum in signal amplitude is analogous to the maximum in the loss tangent in dynamic mechanical analysis, or the maximum in sound damping in bulk-wave ultrasonic studies.
Book Synopsis Surface-Launched Acoustic Wave Sensors by : Michael Thompson
Download or read book Surface-Launched Acoustic Wave Sensors written by Michael Thompson and published by Wiley-Interscience. This book was released on 1997-04-11 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concerns the design, operation and application of devices capable of generating acoustic waves in the ultrasonic frequency range. It emphasizes the study of chemical and/or biochemical systems imposed on the surface of such devices, whether operated in the gas- or liquid-phase, i.e. on acoustic wave chemical and biological sensors. It focuses on devices that employ acoustic waves launched and received on the same surface. It touches upon such diverse areas as acoustic wave physics, applied mathematics, chemistry, electronics, fluid mechanics, materials science and polymer science.
Book Synopsis An Atomic Layer Deposition Passivated Surface Acoustic Wave Sensor for Bacterial Biofilm Growth Monitoring by : Young Wook Kim
Download or read book An Atomic Layer Deposition Passivated Surface Acoustic Wave Sensor for Bacterial Biofilm Growth Monitoring written by Young Wook Kim and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis An Investigation of Polymer-coated Surface Acoustic Wave Microsensor Arrays for the Determination of Organic Solvent Vapors by : Meng-Da Hsieh
Download or read book An Investigation of Polymer-coated Surface Acoustic Wave Microsensor Arrays for the Determination of Organic Solvent Vapors written by Meng-Da Hsieh and published by . This book was released on 2003 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Aluminum Nitride Acoustic Wave Sensors for Bacteria Detection in Liquids by : Matthew Brandon Garten
Download or read book Aluminum Nitride Acoustic Wave Sensors for Bacteria Detection in Liquids written by Matthew Brandon Garten and published by . This book was released on 2004 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Surface Acoustic Wave Microsensor System for Thermogravimetric Measurements of Thin Polymer Films by : Russell D. Mileham
Download or read book A Surface Acoustic Wave Microsensor System for Thermogravimetric Measurements of Thin Polymer Films written by Russell D. Mileham and published by . This book was released on 1997 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Theoretical And Experimental Investigations To Improve The Performance Of Surface Acoustic Wave (SAW) Biosensors by : Mandek Richardson
Download or read book Theoretical And Experimental Investigations To Improve The Performance Of Surface Acoustic Wave (SAW) Biosensors written by Mandek Richardson and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this dissertation is to improve the performance of surface acoustic wave (SAW) biosensors for use in point-of-care-testing (POCT) applications. SAW biosensors have the ability to perform fast, accurate detection of an analyte in real time without the use of labels. However, the technology suffers from the inability to differentiate between specific and non-specific binding. Due to this limitation, direct testing of bodily fluids using SAW sensors to accurately determine an analyte's concentration is difficult. In addition, these sensors are challenged by the need to detect small concentrations of a biomarker that are typically required to give a clinical diagnosis. Sensitivity, selectivity and reliability are three critical aspects for any sensing platform. To improve sensitivity the delay path of a SAW sensor has been modified with microcavities filled with various materials. These filled cavities increased sensitivity by confining wave energy to the surface by way of constructive interference and waveguiding. Thus, the improved sensitivity will result in a lower limit of detection. In addition, insertion loss is decreased as a consequence of increased wave confinement to the surface. Sensor selectivity and reliability are adversely affected by non-specific binding of unwanted species present in a sample. To address this issue a multifunctional SAW sensor is presented. The sensor consists of two SAW delay lines oriented orthogonal to each on ST-quartz in order to generate two distinct wave modes. One wave mode is used for sensing while the other is used to remove loosely bound material. By using the same transduction mechanism for both removal and sensing, the sensor chip is simplified and complex electronics are avoided. The findings of this research involve the technological advances for SAW biosensors that make their use in POCT possible.
Book Synopsis Cyclodextrin-based Surface Acoustic Wave Chemical Microsensors by :
Download or read book Cyclodextrin-based Surface Acoustic Wave Chemical Microsensors written by and published by . This book was released on 1996 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclodextrin thin films were fabricated using either self-assembled monolayer (SAM) or solgel techniques. The resulting host receptor thin films on the substrates of surface acoustic wave (SAW) resonators were studied as method of tracking organic toxins in vapor phase. The mass loading of surface-attached host monolayers on SAW resonators gave frequency shifts corresponding to typical monolayer surface coverages for SAM methods and ''multilayer'' coverages for sol-gel techniques. Subsequent exposure of the coated SAW resonators to organic vapors at various concentrations, typically 5,000 parts per millions (ppm) down to 100 parts per billions (ppb) by mole, gave responses indicating middle-ppb-sensitivity ((approximately)50 ppb) for those sensor-host-receptors and organic-toxin pairs with optimum mutual matching of polarity, size, and structural properties.
Book Synopsis Biosensors for Virus Detection by : Adil Denizli
Download or read book Biosensors for Virus Detection written by Adil Denizli and published by IOP Publishing Limited. This book was released on 2021-12-13 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developments and applications of biosensor platforms for analysis of viral infections including Coronavirus, HIV, Hepatitis, Ebola, Zika, Norovirus, Influenza, SARS etc. Embraces properties, fabrication, and recent research regarding optical, electrochemical, piezoelectric, fluorescence, thermal, magnetic and micromechanical sensor families.
