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Author : Gary L. Juskowiak II
Publisher : Gary L. Juskowiak II
ISBN 13 :
Total Pages : 446 pages
Book Rating : 4./5 ( download)
Download or read book Sequence-Specific Reactivity of Short Peptides written by Gary L. Juskowiak II and published by Gary L. Juskowiak II. This book was released on 2009-05-27 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gary Lee Juskowiak (II.)
Publisher :
ISBN 13 : 9781109154429
Total Pages : pages
Book Rating : 4.1/5 (544 download)
Download or read book Sequence-specific Reactivity of Short Peptides written by Gary Lee Juskowiak (II.) and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation covers the development of combinatorial peptide library methodology to screen for short peptides with enhanced and sequence-specific reactivity; the design, synthesis, and screening of small molecule fluorescent probes for short peptide tags; and the identification of peptides with enhanced and sequence-specific reactivity. Chapter 1 covers short peptides identified from a one-bead one-compound (OBOC) library that become fluorescent under photooxidative conditions. Only one peptide (AKPWGGDA) reproduced its fluorogenic reactivity in solution phase and the fluorescent photoproduct of this peptide was identified as a 4-aminoquinoline-2-carboxylic acid, which was presumably derived from tryptophan. Chapter 2 reviews the literature on peptide tags used for fluorescently labeling proteins in living cells with a specific emphasis on the biarsenical tetracysteine system. Chapter 3 reviews the literature on the sequence-specific structure and reactivity of short peptides. It also presents elements that may be applicable to enhanced and sequence-specific reactivity between short peptide tags and small molecule probes. Chapter 4 covers OBOC and SPOT peptide library methodology developed in order to screen for the sequence-specific reactivity of short peptides with small molecule fluorescent probes. These methodological advancements were primarily in the synthesis, screening, and tandem mass spectrometry sequencing of OBOC peptide libraries, and, in particular, cysteine-rich OBOC libraries. Chapter 5 covers the design, synthesis, and screening of small molecule fluorescent probes that contained the dansyl fluorophore and esters that target lysine residues in short peptide tags. Short peptides were discovered that exhibited enhanced and sequence-specific reactivity with these fluorescent probes, and, in particular, with a tetrahydroisoquinoline N-hydroxysuccinimide ester probe in an OBOC library, in a SPOT library, and in solution phase. However, the sequence-specific reactivity of the short peptide tags is reduced outside of the bead environment. Chapter 6 covers the design, synthesis, and screening of small molecule fluorogenic probes. These fluorogenic probes consisted of FlAsH, amino coumarin alkyl esters, and benzoyl quinoline carboxyaldehydes. Short peptides were discovered that exhibited enhanced and sequence-specific reactivity for FlAsH and the amino coumarin alkyl ester probes.
Author : Hans-Georg Rammensee
Publisher : Springer Science & Business Media
ISBN 13 : 3662221624
Total Pages : 467 pages
Book Rating : 4.6/5 (622 download)
Download or read book MHC Ligands and Peptide Motifs written by Hans-Georg Rammensee and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is centered on a comprehensive list of MHC peptide motifs and ligands as known to date, together with selected T cell epitopes, arranged in an easy-to-read fashion. This information is put into context by chapters on MHC gene organization, MHC structure, T cell epitope prediction, antigen processing and T cell responses. In addition, the book provides a great deal of complementary information: amino acid sequences of MHC class I alpha1 and alpha2 domains and of class II alpha1 and beta1 domains, the established or predicted composition and specificity of MHC pockets, notes on MHC nomenclature including old assignments and reference to useful internet addresses. A handy reference manual that should be helpful for all those dealing with MHC-associated peptides.
Author : Gunnar Houen
Publisher : Humana
ISBN 13 : 9781493929986
Total Pages : 0 pages
Book Rating : 4.9/5 (299 download)
Download or read book Peptide Antibodies written by Gunnar Houen and published by Humana. This book was released on 2015-10-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extensive volume covers basic and advanced aspects of peptide antibody production, characterization and uses. Although peptide antibodies have been available for many years, they continue to be a field of active research and method development. For example, peptide antibodies which are dependent on specific posttranslational modifications are of great interest, such as phosphorylation, citrullination and others, while different forms of recombinant peptide antibodies are gaining interest, notably nanobodies, single chain antibodies, TCR-like antibodies, among others. Within this volume, those areas are covered, as well as several technical and scientific advances: solid phase peptide synthesis, peptide carrier conjugation and immunization, genomics, transcriptomics, proteomics and elucidation of the molecular basis of antigen presentation and recognition by dendritic cells, macrophages, B cells and T cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Peptide Antibodies: Methods and Protocols serves as an ideal reference for researchers exploring this vital and expansive area of study.
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 0123786312
Total Pages : 3223 pages
Book Rating : 4.1/5 (237 download)
Download or read book Encyclopedia of Biological Chemistry written by and published by Academic Press. This book was released on 2013-01-08 with total page 3223 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 4-volume Encyclopedia of Biological Chemistry, Second Edition, represents the current state of a dynamic and crucial field of study. The Encyclopedia pulls together over 500 articles that help define and explore contemporary biochemistry, with content experts carefully chosen by the Editorial Board to assure both breadth and depth in its coverage. Editors-In-Chief William J. Lennarz and M. Daniel Lane have crafted a work that proceeds from the acknowledgement that understanding every living process-from physiology, to immunology, and genetics-is impossible without a grasp on the basic chemistry that provides its underpinning. Each article in the work provides an up-to-date snapshot of a given topic, written by experts, as well as suggestions for further readings for students and researcher wishing to go into greater depth. Available on-line via SciVerse ScienceDirect, the functionality of the Encyclopedia will provide easy linking to referenced articles, electronic searching, as well an online index and glossary to aid comprehension and searchability. This 4-volume set, thoroughly up-to-date and comprehensive, expertly captures this fast-moving field Curated by two esteemed editors-in-chief and an illustrious team of editors and contributors, representing the state of the field Suggestions for further readings offer researchers and students avenues for deeper exploration; a wide-ranging glossary aids comprehension
Author : Stefano Leporatti
Publisher : Frontiers Media SA
ISBN 13 : 2889663183
Total Pages : 193 pages
Book Rating : 4.8/5 (896 download)
Download or read book Functionalized Nanocarriers for Theranostics written by Stefano Leporatti and published by Frontiers Media SA. This book was released on 2020-12-31 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author : Mario Barbosa
Publisher : Woodhead Publishing
ISBN 13 : 008100852X
Total Pages : 392 pages
Book Rating : 4.0/5 (81 download)
Download or read book Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair written by Mario Barbosa and published by Woodhead Publishing. This book was released on 2017-09-25 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology. Presents an all-inclusive and authoritative coverage of the important role which protein and peptides play as biomaterials for tissue regeneration Explores protein and peptides from the fundamentals, to processing and applications Written by an international group of leading biomaterials researchers
Author : William Robert Bowie
Publisher : Cambridge University Press
ISBN 13 : 9780521390828
Total Pages : 628 pages
Book Rating : 4.3/5 (98 download)
Download or read book Chlamydial Infections written by William Robert Bowie and published by Cambridge University Press. This book was released on 1990-05-25 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proceedings of the 6th International Symposium on Chlamydial Infections, published by Cambridge University Press in 1986, became an essential source of reference for researchers and clinicians interested in infections caused by this important group of organisms. This, the latest volume arising from the 7th Symposium, follows the successful pattern of its predecessor to provide a wide-ranging and contemporary account of Chlamydial research. Chlamydia continues to be a major cause of sexually transmitted disease and infertility in man, with growing awareness that there may be an important co-factor in the spread of AIDS. Ocular chlamydia infection is the world's prime cause of preventable blindness. This has prompted major research into new methods of diagnosing and preventing chlamydial disease. At the same time a new species of Chlamydia has been designated, Chlamydia pneumoniae, whose clinical impact is under detailed investigation.
Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author : Yehuda Shoenfeld
Publisher : Elsevier
ISBN 13 : 0444632727
Total Pages : 1071 pages
Book Rating : 4.4/5 (446 download)
Download or read book Infection and Autoimmunity written by Yehuda Shoenfeld and published by Elsevier. This book was released on 2015-01-27 with total page 1071 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune diseases are conditions where the immune system attacks the body organs instead of foreign invaders. This book deals with the various mechanisms by which infectious agents can trigger autoimmunity such as molecular mimicry and polyclonal activation. An overview is given with regard to bacteria, viruses, and parasites associated with autoimmunity, and a summary is given on classical autoimmune diseases and the infecting agents that can induce them. Includes completely updated and new chapters Brings the reader up to date and allows easy access to individual topics in one place Identifies infectious agents as pathogenic or protective in many autoimmune diseases
Author : Paul Lloyd-Williams
Publisher : CRC Press
ISBN 13 : 9780849391422
Total Pages : 306 pages
Book Rating : 4.3/5 (914 download)
Download or read book Chemical Approaches to the Synthesis of Peptides and Proteins written by Paul Lloyd-Williams and published by CRC Press. This book was released on 1997-04-23 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications. This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.
Author : Bernardo Baldisserotto
Publisher : CRC Press
ISBN 13 : 0429526601
Total Pages : 330 pages
Book Rating : 4.4/5 (295 download)
Download or read book Fish Osmoregulation written by Bernardo Baldisserotto and published by CRC Press. This book was released on 2019-05-20 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fish lives in environments with a wide variety of chemical characteristics (fresh, brackish and seawater, acidic, alkaline, soft and hard waters). From an osmoregulatory point of view, fish have developed several mechanisms to live in these different environments. Fish osmoregulation has always attracted considerable attention and in the last years several studies have increased our knowledge of this physiological process. In this book several specialists have analyzed and reviewed the new data published regarding fish osmoregulation. The chapters present an integrative synthesis of the different aspects of this field focusing on osmoregulation in specific environments or situations, function of osmoregulatory organs, general mechanisms and endocrine control. In addition, interactions of osmoregulatory mechanisms with the immune system, diet and metabolism were also reviewed. New emerging techniques to study osmoregulation has also been analysed.
Author : Wilhelm T.S. Huck
Publisher : Springer Science & Business Media
ISBN 13 : 0387256563
Total Pages : 249 pages
Book Rating : 4.3/5 (872 download)
Download or read book Nanoscale Assembly written by Wilhelm T.S. Huck and published by Springer Science & Business Media. This book was released on 2006-07-11 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology has received tremendous interest over the last decade, not only from the scientific community but also from a business perspective and from the general public. Although nanotechnology is still at the largely unexplored frontier of science, it has the potential for extremely exciting technological innovations that will have an enormous impact on areas as diverse as information technology, medicine, energy supply and probably many others. The miniturization of devices and structures will impact the speed of devices and information storage capacity. More importantly, though, nanotechnology should lead to completely new functional devices as nanostructures have fundamentally different physical properties that are governed by quantum effects. When nanometer sized features are fabricated in materials that are currently used in electronic, magnetic, and optical applications, quantum behavior will lead to a set of unprecedented properties. The interactions of nanostructures with biological materials are largely unexplored. Future work in this direction should yield enabling technologies that allows the study and direct manipulation of biological processes at the (sub) cellular level.
Author : Armin Saalmueller
Publisher : Frontiers Media SA
ISBN 13 : 2889665321
Total Pages : 151 pages
Book Rating : 4.8/5 (896 download)
Download or read book Recent Advances in Veterinary Immunology Concepts and Methodology written by Armin Saalmueller and published by Frontiers Media SA. This book was released on 2021-03-03 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Author :
Publisher : Elsevier
ISBN 13 : 0323960197
Total Pages : 2450 pages
Book Rating : 4.3/5 (239 download)
Download or read book Encyclopedia of Food Allergy written by and published by Elsevier. This book was released on 2024-06-12 with total page 2450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Food Allergy, organized in 10 sections, with ~200 chapters, and written by world-renowned clinician-scientist authors, is the most comprehensive resource for food allergy ever compiled. With online and physical presence, intuitive and easily accessible organization of information, the reader can quickly access overview and general topics as well as detailed information to inform solutions to clinical or research questions. Research topics provide the necessary background for the novice as well as the details required for those in the field. Clinical topics provide comprehensive and practical information, with generous use of tables, figures, and key points/clinical pearls, to inform clinical decision-making, and promote evidence-based management decisions. Food allergy may affect up to 10% of the population in developed countries and appears to be increasing in prevalence worldwide, with many food allergies proving life-long, severe and potentially fatal. The last decade has witnessed a sea change response to the impact of food allergy through basic science research on the immunology, food science research on the triggers, clinical approaches to daily management, treatment and prevention, and an increasing understanding of the psychosocial and societal implications and how to address them. With the expanding breadth and depth of the field, there is no existing comprehensive resource available for those professionals interested in learning about or contributing to food allergy research and clinical care. This is a complete resource covering broad and detailed aspects of food allergy and adverse food reactions for clinicians, researchers, regulators, food industry, students and other stakeholders who need and will benefit from a rich resource with in-depth and practical information. Presents in-depth, comprehensive coverage from an outstanding international author base of domain experts Ideal for new researchers and clinicians who will have a single resource that includes general topics to get them started Includes access to detailed information in their areas of work AND for many related topics that will help improve their research or clinical care
Author : W. Chan
Publisher : OUP Oxford
ISBN 13 : 0199637245
Total Pages : 371 pages
Book Rating : 4.1/5 (996 download)
Download or read book Fmoc Solid Phase Peptide Synthesis written by W. Chan and published by OUP Oxford. This book was released on 1999-12-16 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The focus of this new volume is much broader, and covers the essential procedures.
